专利检索 ap:("Chongqing Sun" OR "Jeffrey A. Robl" OR "Mark E. Salvati" OR "Tammy Wang" OR "Lawrence Hamann" OR "David Augeri") AND inv:"Mark E. Salvati" 第 1 页

1.

发明授权
Bicyclic modulators of androgen receptor function 有权
标题翻译：雄激素受体功能的双环调节剂

公开(公告)号：US06670386B2

公开(公告)日：2003-12-30

申请号：US10209461

申请日：2002-07-31

申请人： Chongqing Sun , Jeffrey A. Robl , Mark E. Salvati , Tammy Wang , Lawrence Hamann , David Augeri

发明人： Chongqing Sun , Jeffrey A. Robl , Mark E. Salvati , Tammy Wang , Lawrence Hamann , David Augeri

IPC分类号： A01K4352

CPC分类号： C07D207/16 , C07D471/04 , C07D487/04 , C07D513/04

摘要： The invention provides compounds of the formula I wherein the substitutents are as described herein. Further provided are methods of using such compounds for the treatment of nuclear hormone receptor-associated conditions, such as age related diseases, for example sarcopenia, and also provided are pharmaceutical compositions containing such compounds.

摘要翻译： 本发明提供式I化合物，其中取代基如本文所述。进一步提供的是使用这些化合物治疗核激素受体相关病症（例如年龄相关疾病，例如肌肉减少症）的方法，并且还提供药物组合物含有这些化合物。

2.

发明授权
Bicyclic modulators of androgen receptor function 失效

公开(公告)号：US06992102B2

公开(公告)日：2006-01-31

申请号：US10685020

申请日：2003-10-14

申请人： Lawrence Hamann , David Augeri , Chongqing Sun , Jeffrey A. Robl , Mark E. Salvati , Tammy Wang

发明人： Lawrence Hamann , David Augeri , Chongqing Sun , Jeffrey A. Robl , Mark E. Salvati , Tammy Wang

IPC分类号： A61K31/40 , C07D207/00

CPC分类号： C07D207/16 , C07D471/04 , C07D487/04 , C07D513/04

摘要： The invention provides compounds of the formula I wherein the substitutents are as described herein.Further provided are methods of using such compounds for the treatment of nuclear hormone receptor-associated conditions, such as age related diseases, for example sarcopenia, and also provided are pharmaceutical compositions containing such compounds.

3.

发明授权
Fused cyclic succinimide compounds and analogs thereof, modulators of nuclear hormone receptor function 有权
标题翻译：稠合的环状琥珀酰亚胺化合物及其类似物，核激素受体功能的调节剂

公开(公告)号：US07655688B2

公开(公告)日：2010-02-02

申请号：US11311731

申请日：2005-12-19

申请人： Mark E. Salvati , Ricardo M. Attar , Marco M. Gottardis , James Aaron Balog , Dacia A. Pickering , Rogelio L. Martinez , Chongqing Sun

发明人： Mark E. Salvati , Ricardo M. Attar , Marco M. Gottardis , James Aaron Balog , Dacia A. Pickering , Rogelio L. Martinez , Chongqing Sun

IPC分类号： A61K31/40 , A61K31/47 , A61K31/34

CPC分类号： A61K31/675 , A61K31/403 , A61K31/407

摘要： Fused cyclic compounds, methods of using such compounds in the treatment of nuclear hormone receptor-associated conditions such as cancer and immune disorders, and pharmaceutical compositions containing such compounds.

摘要翻译： 稠合的环状化合物，使用这些化合物治疗核激素受体相关病症如癌症和免疫疾病的方法，以及含有这些化合物的药物组合物。

4.

发明授权
Hexahydroimidazopyrazin-3-one compounds useful as modulators of androgen receptor function 有权
标题翻译：六氢咪唑并吡嗪-3-酮化合物可用作雄激素受体功能的调节剂

公开(公告)号：US07776859B2

公开(公告)日：2010-08-17

申请号：US11546965

申请日：2006-10-12

申请人： James Aaron Balog , Mark E. Salvati , Brian E. Fink

发明人： James Aaron Balog , Mark E. Salvati , Brian E. Fink

IPC分类号： A61K31/4985

CPC分类号： C07D487/04

摘要： The present invention is directed to compounds having the formula (I), and/or pharmaceutically-acceptable salts thereof, useful in the treatment of androgen-receptor associated conditions, wherein Ar is aryl, substituted aryl, heteroaryl, or substituted heteroaryl; L is a linker as defined in the specification; R1 may be hydrogen, cyano, alkyl, substituted alkyl, aryl, substituted aryl, cycloalkyl, substituted cycloalkyl, heterocyclo, substituted heterocyclo, heteroaryl, or substituted heteroaryl, as defined in the specification; R2 is hydrogen, lower alkyl, or substituted lower alkyl; and R3, R4 and R5 are optionally non-interfering substituents as defined in the specification.

摘要翻译： 本发明涉及可用于治疗雄激素受体相关病症的式（I）化合物和/或其药学上可接受的盐，其中Ar为芳基，取代的芳基，杂芳基或取代的杂芳基; L是说明书中定义的接头; R 1可以是如本说明书中定义的氢，氰基，烷基，取代的烷基，芳基，取代的芳基，环烷基，取代的环烷基，杂环，取代的杂环，杂芳基或取代的杂芳基; R2是氢，低级烷基或取代的低级烷基; 并且R 3，R 4和R 5是本说明书中定义的任选的非干扰取代基。

5.

发明授权
Fused cyclic modulators of nuclear hormone receptor function 有权

公开(公告)号：US07432267B2

公开(公告)日：2008-10-07

申请号：US11168223

申请日：2005-06-28

申请人： Mark E. Salvati , James Aaron Balog , Weifang Shan , Sören Giese , Lalgudi S. Harikrishnan

发明人： Mark E. Salvati , James Aaron Balog , Weifang Shan , Sören Giese , Lalgudi S. Harikrishnan

IPC分类号： C07D487/08 , A61K31/498

CPC分类号： C07D487/08 , A61K31/00 , A61K31/407 , A61K31/655 , A61K31/675 , C07D487/14 , A61K2300/00

摘要： Disclosed are compounds having the formula (I): including compounds of formulae (Ia) and (Ib): wherein G is an optionally substituted aryl or heterocyclo, L is an optional linker, M is a bond, O, CR7R7′ or NR10, and M′ is a bond or NR10, with the proviso that at least one of M or M′ must be a bond; E is C=Z2, CR7CR7′, SO2, P═OR2, or P═OOR2; Z1 is O, S, NH, or NR6; A1 is CR7 or N; A2 is CR7 or N; Y is J-J′-J″ where J is (CR7R7′)n and n=0−3, J′ is a bond or O, S, S═O, SO2, NH, NR6, C═O, CO═O, NR1C═O, CR7R7′, C═CR8R8′, R2P═O, OPOOR2, OPO2, OSO2, C═N, NHNH, NHNR6, NR6NH, N═N, cycloalkyl or substituted cycloalkyl, cycloalkenyl or substituted cycloalkenyl, heterocyclo or substituted heterocyclo or aryl or substituted aryl, and J″ is (CR7R7′)n and n=0−3; and W, Q, R2, R6, R7, R7′, R8, R8′, R9, R9′, and R10 are as defined in the specification and/or claims herein, to methods of using such compounds in the treatment of nuclear hormone receptor-associated conditions such as cancer and immune disorders, and to pharmaceutical compositions containing such compounds.

6.

发明授权
Pyrrolopyridazine compounds and methods of use thereof for the treatment of proliferative disorders 有权
标题翻译：吡咯并哒嗪化合物及其用于治疗增殖性疾病的方法

公开(公告)号：US07030112B2

公开(公告)日：2006-04-18

申请号：US10672850

申请日：2003-09-26

申请人： Mark E. Salvati , Carl R. Illig , Kenneth Jerome Wilson , Jinsheng Chen , Sanath K. Meegalla , Mark James Wall

发明人： Mark E. Salvati , Carl R. Illig , Kenneth Jerome Wilson , Jinsheng Chen , Sanath K. Meegalla , Mark James Wall

IPC分类号： C07D487/04 , C07D487/14 , A61K31/5025 , A61P5/28 , A61P35/00

CPC分类号： C07D487/04 , A61K31/5025 , A61K45/06 , C07D519/00 , A61K2300/00

摘要： Disclosed are pyrrolopyridazine compounds of the formula, wherein the substituents are defined herein, methods of preparing such compounds, and their use for the treatment of proliferative, inflammatory, and other disorders.

摘要翻译： 公开了下式的吡咯并哒嗪化合物，其中取代基在本文中定义，制备此类化合物的方法及其用于治疗增殖性，炎症性和其它障碍的用途。

7.

发明授权
Process for preparing azacycloalkanoylaminothiazoles 有权
标题翻译：制备氮杂环烷酰氨基噻唑的方法

公开(公告)号：US06639074B2

公开(公告)日：2003-10-28

申请号：US10100129

申请日：2002-03-18

申请人： Bang-Chi Chen , Kyoung S. Kim , S. David Kimball , Raj N. Misra , Mark E. Salvati , Joseph E. Sundeen , Hai-Yun Xiao , Rulin Zhao

发明人： Bang-Chi Chen , Kyoung S. Kim , S. David Kimball , Raj N. Misra , Mark E. Salvati , Joseph E. Sundeen , Hai-Yun Xiao , Rulin Zhao

IPC分类号： C07D47100

CPC分类号： C07D417/12 , A61K31/427 , A61K31/454 , C07D231/12 , C07D233/56 , C07D249/08 , C07D417/14

摘要： The present invention relates to new, efficient processes for the preparation of 5-(2-oxazolylalkylthio)-2-azacycloalkanoylaminothiazole compounds of formula I or a pharmaceutically acceptable salt thereof, wherein: R is alkyl, aryl or heteroaryl; R1, R2, R3, R4 and R5 are each independently hydrogen, alkyl, aryl or heteroaryl; R6 and R7 are each independently hydrogen, alkyl, aryl, heteroaryl, halogen, hydroxy or alkoxy; R8 is hydrogen, alkyl, aryl, heteroaryl, CONR9R10, COR11 or COOR12; R9, R10, R11 and R12 are each independently hydrogen, alkyl or aryl; m equals 0 to 5; and n equals 0 to 5, which are novel, potent inhibitors of cyclin dependent kinases (cdks). The present invention further concerns new key intermediate compounds, a quaternary ammonium salt of formula III′ and a 2-oxazolylalkyl derivative of formula IX.

摘要翻译： 本发明涉及制备式I的5-（2-恶唑基烷硫基）-2-氮杂环烷酰氨基噻唑化合物或其药学上可接受的盐的新的，有效的方法，其中：R是烷基，芳基或杂芳基; R 1，R 2 R 3，R 4和R 5各自独立地为氢，烷基，芳基或杂芳基; R 6和R 7各自独立地为氢，烷基，芳基，杂芳基，卤素，羟基或烷氧基; R 8是氢，烷基，芳基，杂芳基，CONR 9 R 10，COR 11或COOR 12; R 9，R 10，R 11 且R 12各自独立地为氢，烷基或芳基; m等于0至5; 和等于0至5，这是细胞周期蛋白依赖性激酶（cdks）的新型有效抑制剂。本发明还涉及新的关键中间体化合物，式III'的季铵盐和式IX的2-恶唑基烷基衍生物。

8.

发明授权
Substituted 3-cyanoquinolines 有权

公开(公告)号：US06288082B1

公开(公告)日：2001-09-11

申请号：US09406573

申请日：1999-09-24

申请人： Allan Wissner , Hwei-Ru Tsou , Dan M. Berger , Middleton B. Floyd, Jr. , Philip R. Hamann , Nan Zhang , Mark E. Salvati , Philip Frost

发明人： Allan Wissner , Hwei-Ru Tsou , Dan M. Berger , Middleton B. Floyd, Jr. , Philip R. Hamann , Nan Zhang , Mark E. Salvati , Philip Frost

IPC分类号： A61K3147

CPC分类号： C07D401/12 , C07D215/48 , C07D417/12

摘要： This invention provides compounds of formula I having the structure wherein G1, G2, R1, R4, Z, n, and X are defined in the specification or a pharmaceutically acceptable salt thereof which are useful as antineoplastic agents and in the treatment of polycystic kidney disease.