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公开(公告)号：US08723110B2
公开(公告)日：2014-05-13
申请号：US13218800
申请日：2011-08-26
IPC分类号： H01J49/00
CPC分类号： H01J49/165 , H01J49/0431 , H01J49/107 , H01J49/168 , H01J49/26
摘要： An apparatus for generating ions includes an Electrospray ionization source configured to provide a spray of charged droplets from a sample solution during operation of the apparatus; an atmospheric pressure chemical ionization (APCI) source including a corona discharge needle configured to produce a corona discharge that further ionizes the spray during operation of the apparatus; and a gas delivery system configured to deliver a gas flow to the corona discharge needle during operation of the apparatus, wherein the gas flow comprises a reagent ion gas which facilitates ionization of the spray by the corona discharge.
摘要翻译： 一种用于产生离子的装置包括：电喷雾离子化源，其构造成在装置运行期间提供来自样品溶液的带电液滴的喷雾; 包括电晕放电针的大气压化学电离源（APCI），其被配置为产生电晕放电，所述电晕放电在所述装置的操作期间进一步电离所述喷雾; 以及气体输送系统，其构造成在所述装置的操作期间将气流输送到所述电晕放电针，其中所述气流包括试剂离子气体，所述试剂离子气体有助于所述电晕放电引起所述喷雾的离子化。
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公开(公告)号：US07081621B1
公开(公告)日：2006-07-25
申请号：US10989821
申请日：2004-11-15
IPC分类号： B01D59/44
CPC分类号： H01J49/04
摘要： A thin laminated high transmission electro-optical lens populated with a plurality of apertures in communication with its laminates used to improve the collection, focusing, and selection of ions generated from atmospheric pressure sources, such as electrospray, atmospheric pressure chemical ionization, inductively coupled plasma, discharge, photoionization and atmospheric pressure matrix assisted laser desorption ionization. The laminated lens is made of alternating layers of electrically insulating and metal laminates. The geometry of the lens may be planar or shaped into various curve shapes, any of which act to optimize both the direct current (DC) and alternate current (AC) electric field geometries and strengths across the lens for transferring virtually all the ions from the ion source into an ion-focusing region adjacent and upstream of a high pressure or atmospheric pressure interface to a mass spectrometer, ion mobility analyzer, or combination thereof. Embodiments of this invention are methods and devices for improving sensitivity of mass spectrometry when coupled to high pressure or atmospheric pressure ionization sources.
摘要翻译： 薄层叠高透射电光透镜，填充有与其层叠体连通的多个孔，用于改善从大气压源（例如电喷雾，大气压化学电离，电感耦合等离子体）产生的离子的收集，聚焦和选择 ，放电，光电离和大气压矩阵辅助激光解吸电离。 层压透镜由电绝缘和金属层压体的交替层制成。 透镜的几何形状可以是平面的或成形为各种曲线形状，其中任何一种都用于优化透镜上的直流（DC）和交流（AC）电场几何形状和强度，以将几乎所有的离子从 离子源输入到与质谱仪，离子迁移率分析仪或其组合的高压或大气压界面相邻和上游的离子聚焦区域。 本发明的实施例是当与高压或大气压电离源耦合时，用于提高质谱的灵敏度的方法和装置。
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公开(公告)号：US07060976B2
公开(公告)日：2006-06-13
申请号：US11173377
申请日：2005-07-02
CPC分类号： H01J49/067 , H01J49/0404
摘要： Improvements have been made for selective collecting, focusing, and directing of ions and/or charged particles generated at atmospheric or near atmospheric pressure sources, such as but not limited to, electrospray; atmospheric pressure discharge ionization, chemical ionization, photoionization, and matrix assisted laser desorption ionization; and inductively coupled plasma ionization. A multiple-aperture laminated structure is place at the interface of two pressure regions. Electric fields geometries and strengths across the laminated structure and diameters of the apertures; all of which act to optimize the transfer of the ions from the higher pressure region into the lower pressure region while reducing the gas-load on the lower pressure region. Embodiments of this invention are methods and devices for improving sensitivity of mass spectrometry when coupled to atmospheric, near atmospheric, or higher pressure ionization sources by reducing the gas-load on the vacuum system.
摘要翻译： 已经改进了在大气压或近大气压源（例如但不限于电喷雾）下产生的离子和/或带电粒子的选择性收集，聚焦和引导; 大气压放电电离，化学电离，光电离和基体辅助激光解吸电离; 和电感耦合等离子体电离。 多孔层叠结构位于两个压力区的界面处。 横跨层叠结构和孔直径的电场几何形状和强度; 所有这些都用于优化离子从较高压力区域转移到较低压力区域，同时降低低压区域上的气体负载。 本发明的实施方案是当通过减少真空系统上的气体负载耦合到大气压，接近大气压或更高压力的电离源时，提高质谱的灵敏度的方法和装置。
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公开(公告)号：US06878930B1
公开(公告)日：2005-04-12
申请号：US10785441
申请日：2004-02-23
IPC分类号： H01J37/00 , H01J37/30 , H01J37/301 , H01J37/317 , H01J49/10
CPC分类号： H01J49/10 , B82Y10/00 , B82Y40/00 , H01J37/3007 , H01J37/301 , H01J37/3174 , H01J37/3175 , H01J37/3178 , H01J2237/08 , H01J2237/164 , H01J2237/303 , H01J2237/31732 , H01J2237/3174 , H01J2237/31776
摘要： The present invention includes a delivery means of material to be deposited onto thin film surfaces with precise spatial, temporal, compositional, and energy resolution for controlled reactions, patterning (2-dimensional and 3-dimensional), and removal of materials or reaction products of materials from thin film surfaces. The device includes a near atmospheric pressure means of generating ions, ion clusters, or charged particles as a material form to deliver said materials onto substrate surfaces. The device relies on shaped, patterned, conformal ion lenses, and individually addressable lens elements of a lens arrays to create an integrated deposition system for printed patterns of thin films. The devices and methods provide a novel approach to delivering materials to a surface, removing materials from a surface, or creating new materials at or on the surface. These methods and devices may be used in applications of thin film deposition, micro-electronics and semi-conductor manufacturing, printing, surface interfacial layers, coating, painting, sample and reagent treatment, preparation for sensors, chemical analysis, and fabricating 2- and 3-dimensional structures and devices.
摘要翻译： 本发明包括将被沉积到薄膜表面上的材料的输送装置，其具有精确的空间，时间，组成和能量分辨率，用于受控反应，图案化（二维和三维）以及去除材料或反应产物 薄膜表面材料。 该装置包括产生离子，离子簇或带电粒子作为材料形式的近似大气压装置，以将所述材料输送到衬底表面上。 该器件依赖于成形的，图案化的共形离子透镜，以及透镜阵列的单独可寻址的透镜元件，以创建用于印刷图案的薄膜的集成沉积系统。 这些装置和方法提供了将材料递送到表面，从表面去除材料或在表面上或表面上产生新材料的新颖方法。 这些方法和装置可用于薄膜沉积，微电子和半导体制造，印刷，表面界面层，涂层，涂装，样品和试剂处理，传感器准备，化学分析和2-和 三维结构和设备。
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公开(公告)号：US20080296493A1
公开(公告)日：2008-12-04
申请号：US12156254
申请日：2008-05-30
IPC分类号： H01J49/10
CPC分类号： H01J49/062
摘要： An improved ion sampling tube designed to increase the amount of current delivered into the vacuum system of a mass spectrometer or other gas-phase ion or particle detectors or collectors. A device and method is disclosed that utilizes a tube with a high flow of ion entrained gas passing through the said tube. Said ions are directed from the tubular gas flow through an ion selective aperture and into an adjacent region and subsequently directed into a lower pressure region for detection or collection. The method is useful for enhancing the detection of analytes in solutions that are either nebulized or electrosprayed, and analytes present in gases. The method is also useful for isolating ionic species from the ion source from neutral gases and particles that may interfere or interact with analyte species. The method also decouples the high flow of the atmospheric pressure ion source from the low flow ion transmission into vacuum.
摘要翻译： 改进的离子采样管设计用于增加输送到质谱仪或其它气相离子或颗粒检测器或收集器的真空系统中的电流量。 公开了一种利用具有高流量的离子夹带气体的管通过所述管的装置和方法。 所述离子从管状气流引导通过离子选择孔并进入相邻区域，并随后被引导到较低压力区域进行检测或收集。 该方法可用于增强在雾化或电喷雾的溶液中的分析物和气体中存在的分析物的检测。 该方法还可用于将离子源与中性气体和可能干扰或与分析物物质相互作用的颗粒分离。 该方法还将大气压离子源的高流量与低流量离子传输分离成真空。
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6.发明授权公开(公告)号：US08258470B2
公开(公告)日：2012-09-04
申请号：US12653449
申请日：2009-12-14
IPC分类号： H01J49/42
CPC分类号： H01J49/067
摘要： An improved ion optical lens designed to increase the amount of ion current delivered into a multi-pole ion detector or transfer device, such as quadrupole mass analyzer, an ion guide, collision cell, etc. A device and method is disclosed that utilizes a tubular entrance lens to introduce ions into or sample ions at a field-free or near field-free region disposed at the junction of two sets of multi-pole assemblies operating with radio frequency potentials shifted 180 degrees out of phase with respect to each other. The method is useful for increasing the transport of ions into as they enter into or exit out of a multi-pole mass analyzer, such as a quadrupole mass analyzer, an ion guide, collision cell, etc.
摘要翻译： 一种改进的离子光学透镜，设计用于增加输送到多极离子检测器或转移装置中的离子电流量，例如四极质量分析器，离子导向器，碰撞池等。本发明公开了一种利用管状 入射透镜，以在设置在两组多极组件的接合处的无场或无场自由区域处引入离子或将离子引入离子，所述两组组件以相对于彼此偏移180度异相的射频电位工作。 该方法对于增加离子在进入或离开多极质量分析器（例如四极质谱仪，离子导向器，碰撞池等）时的输送是有用的。
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7.发明授权Laminated lens for introducing gas-phase ions into the vacuum systems of mass spectrometers 失效用于将气相离子引入质谱仪真空系统的层压透镜公开(公告)号：US06949740B1
公开(公告)日：2005-09-27
申请号：US10661842
申请日：2003-09-12
CPC分类号： H01J49/067
摘要： An improved lens for collecting and focusing dispersed charged particles or ions having a stratified array of elements at atmospheric or near-atmospheric pressure, each element having successively smaller apertures forming a tapered terminus, wherein the electrostatic DC potentials are applied to each element necessary for focusing ions through the stratified array for introducing charged particles and ions into the vacuum system of a mass spectrometer. Embodiments of this invention are methods and devices for improving sensitivity of mass spectrometry when coupled to both high and low electrostatic field atmospheric pressure ionization sources.
摘要翻译： 一种改进的透镜，用于收集和聚焦在大气压或近似大气压下具有分层阵列元素的分散的带电粒子或离子，每个元件具有连续较小的孔形成渐缩的末端，其中静电DC电势被施加到聚焦所需的每个元件 离子通过分层阵列将带电粒子和离子引入质谱仪的真空系统中。 本发明的实施例是当耦合到高静电场和低静电场大气压电离源时提高质谱的灵敏度的方法和装置。
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8.发明授权公开(公告)号：US08178833B2
公开(公告)日：2012-05-15
申请号：US12156254
申请日：2008-05-30
IPC分类号： H01J49/06
CPC分类号： H01J49/062
摘要： An improved ion sampling tube designed to increase the amount of current delivered into the vacuum system of a mass spectrometer or other gas-phase ion or particle detectors or collectors. A device and method is disclosed that utilizes a tube with a high flow of ion entrained gas passing through the said tube. Said ions are directed from the tubular gas flow through an ion selective aperture and into an adjacent region and subsequently directed into a lower pressure region for detection or collection. The method is useful for enhancing the detection of analytes in solutions that are either nebulized or electrosprayed, and analytes present in gases. The method is also useful for isolating ionic species from the ion source from neutral gases and particles that may interfere or interact with analyte species. The method also decouples the high flow of the atmospheric pressure ion source from the low flow ion transmission into vacuum.
摘要翻译： 改进的离子采样管设计用于增加输送到质谱仪或其它气相离子或颗粒检测器或收集器的真空系统中的电流量。 公开了一种利用具有高流量的离子夹带气体的管通过所述管的装置和方法。 所述离子从管状气流引导通过离子选择孔并进入相邻区域，并随后被引导到较低压力区域进行检测或收集。 该方法可用于增强在雾化或电喷雾的溶液中的分析物和气体中存在的分析物的检测。 该方法还可用于将离子源与中性气体和可能干扰或与分析物物质相互作用的颗粒分离。 该方法还将大气压离子源的高流量与低流量离子传输分离成真空。
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公开(公告)号：US07960711B1
公开(公告)日：2011-06-14
申请号：US12009474
申请日：2008-01-18
IPC分类号： H01J49/00
CPC分类号： H01J49/165 , H01J49/045 , H01J49/067
摘要： An improved electrospray ion source for increasing the current generated from the electrospray process and of the type having a needle (10), a counter-electrode (20), a saddle or outer electrode (30), and concurrent flow of gas (92). A method and device is disclosed that utilizes a controlled electrospray nebulizer where an aerosol comprised of charged droplets and gas-phase ions is sprayed into a field-free or near field-free desolvation or reaction region (120). This process results in the production and ultimate destination of charged aerosols and gas-phase ions in field-free or near field-free regions (120, 201, 210, 240, 340) where they can be directed towards and into a sampling aperture or tube; directed into a reaction region resulting in to the production of reaction products; or directed and deposited on surfaces resulting in the production of desorbed products by means of a concurrent flow of gas or nebulizing gas (92, 94, 96), a potential difference between the regions of production and destination, counter-current flow of gas, or a combination thereof. The method is useful for increasing the detection of analytes in solutions that are electrosprayed and analyzed with mass spectrometry.
摘要翻译： 用于增加从电喷雾过程产生的电流和具有针（10），对电极（20），鞍座或外电极（30）的类型的改进的电喷雾离子源和气体（92）的同时流动， 。 公开了一种利用受控电喷雾雾化器的方法和装置，其中由带电液滴和气相离子组成的气雾被喷射到无场或无场的去溶剂化或反应区域（120）中。 该过程导致在无场或无场自由区域（120,201,210,240,340）中的带电气溶胶和气相离子的生产和最终目的地，其中它们可以被引向并进入取样孔或 管; 引入反应区域导致反应产物的产生; 或引导和沉积在表面上，导致通过气体或雾化气体（92,94,96）的同时流动产生解吸附产物，生产区域和目的地之间的电位差，气体的逆流， 或其组合。 该方法可用于增加电化学分析和分析溶液中分析物的检测。
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10.发明申请公开(公告)号：US20100288919A1
公开(公告)日：2010-11-18
申请号：US12653449
申请日：2009-12-14
IPC分类号： B01D59/44
CPC分类号： H01J49/067
摘要： An improved ion optical lens designed to increase the amount of ion current delivered into a multi-pole ion detector or transfer device, such as quadrupole mass analyzer, an ion guide, collision cell, etc. A device and method is disclosed that utilizes a tubular entrance lens to introduce ions into or sample ions at a field-free or near field-free region disposed at the junction of two sets of multi-pole assemblies operating with radio frequency potentials shifted 180 degrees out of phase with respect to each other. The method is useful for increasing the transport of ions into as they enter into or exit out of a multi-pole mass analyzer, such as a quadrupole mass analyzer, an ion guide, collision cell, etc.
摘要翻译： 一种改进的离子光学透镜，设计用于增加输送到多极离子检测器或转移装置中的离子电流量，例如四极质量分析器，离子导向器，碰撞池等。本发明公开了一种利用管状 入射透镜，以在设置在两组多极组件的接合处的无场或无场自由区域处引入离子或将离子引入离子，所述两组组件以相对于彼此偏移180度异相的射频电位工作。 该方法对于增加离子在进入或离开多极质量分析器（例如四极质谱仪，离子导向器，碰撞池等）时的输送是有用的。
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