-
1.发明授权Methods of identifying g-coupled receptors associated with macrophage-trophic HIV, and diagnostic and therapeutic uses thereof 失效鉴定与巨噬细胞营养型HIV相关的g-偶联受体的方法及其诊断和治疗用途公开(公告)号：US06258527B1
公开(公告)日：2001-07-10
申请号：US08861105
申请日：1997-05-21
IPC分类号： C12Q170
CPC分类号： G01N33/56988 , A01K2207/15 , A01K2217/00 , A01K2217/05 , A01K2217/075 , A01K2217/30 , A01K2227/105 , A01K2267/0337 , C07K14/7158 , C12N15/8509 , G01N33/5008 , G01N33/502 , G01N33/5041 , G01N33/5047 , G01N33/505 , G01N33/5055 , G01N33/5091
摘要： Entry of HIV-1 into target cells requires cell surface CD4 as well as additional host cell cofactors. A cofactor required for infection with virus adapted for growth in transformed T cell lines was recently identified and named fusin. Fusin, however, does not promote entry of macrophage-tropic viruses that are believed to be the key pathogenic strains in vivo. It has now been determined that the principal cofactor for entry mediated by the envelope glycoproteins of primary macrophage-tropic strains of HIV-1 is CC-CKR5, a receptor for the &bgr;-chemokines RANTES, MIP-1&agr;, and MIP-1&bgr;.
摘要翻译： HIV-1进入靶细胞需要细胞表面CD4以及额外的宿主细胞辅因子。 最近鉴定了一种在转化的T细胞系中适应生长的病毒感染所需的辅因子，并命名为fusin。 然而，Fusin不促进被认为是体内关键致病菌株的巨噬细胞 - 嗜性病毒的进入。 现在已经确定，由HIV-1的初级巨噬细胞 - 嗜热菌株的包膜糖蛋白介导的进入的主要辅助因子是CC-CKR5，β-趋化因子RANTES，MIP-1α和MIP-1β的受体。
-
2.发明授权Methods of identifying g-couple receptors associated with macrophage-trophic HIV, and diagnostic and therapeutic uses thereof 有权识别与巨噬细胞营养型HIV相关的g-偶合受体的方法及其诊断和治疗用途公开(公告)号：US07129055B2
公开(公告)日：2006-10-31
申请号：US09734221
申请日：2000-12-11
IPC分类号： C01N33/53 , C01N33/533 , C12N15/00 , C12N15/48 , C12N15/07 , C12N15/09 , C12N5/28 , C07K16/28
CPC分类号： G01N33/56988 , A01K2207/15 , A01K2217/00 , A01K2217/05 , A01K2217/075 , A01K2217/30 , A01K2227/105 , A01K2267/0337 , C07K14/7158 , C12N15/8509 , G01N33/5008 , G01N33/502 , G01N33/5041 , G01N33/5047 , G01N33/505 , G01N33/5055 , G01N33/5091
摘要： Entry of HIV-1 into target cells requires cell surface CD4 as well as additional host cell cofactors. A cofactor required for infection with virus adapted for growth in transformed T cell lines was recently identified and named fusin. Fusin, however, does not promote entry of macrophage-tropic viruses that are believed to be the key pathogenic strains in vivo. It has now been determined that the principal cofactor for entry mediated by the envelope glycoproteins of primary macrophage-tropic strains of HIV-1 is CC-CKR5, a receptor for the β-chemokines RANTES, MIP-1α, and MIP-1β.
摘要翻译： HIV-1进入靶细胞需要细胞表面CD4以及额外的宿主细胞辅因子。 最近鉴定了一种在转化的T细胞系中适应生长的病毒感染所需的辅因子，并命名为fusin。 然而，Fusin不促进被认为是体内关键致病菌株的巨噬细胞 - 嗜性病毒的进入。 现在已经确定，由HIV-1的初级巨噬细胞 - 嗜热菌株的包膜糖蛋白介导的进入的主要辅助因子是CC-CKR5，β-趋化因子RANTES，MIP-1α和MIP-1β的受体。
-
3.发明授权G-coupled receptors associated with macrophage-trophic HIV, and diagnostic and therapeutic uses thereof 失效与巨噬细胞营养性HIV相关的G-偶联受体及其诊断和治疗用途
公开(公告)号：US5939320A
公开(公告)日：1999-08-17
申请号：US666020
申请日：1996-06-19
IPC分类号： C07K14/715 , C12N15/85 , G01N33/50 , G01N33/569 , C12N5/06 , C12N5/08 , C12N5/10
CPC分类号： G01N33/502 , C07K14/7158 , C12N15/8509 , G01N33/5008 , G01N33/5041 , G01N33/5047 , G01N33/505 , G01N33/5055 , G01N33/5091 , G01N33/56988 , A01K2207/15 , A01K2217/00 , A01K2217/05 , A01K2217/30 , A01K2227/105 , A01K2267/02 , A01K2267/0337 , A01K2267/0393
摘要： Entry of HIV-1 into target cells requires cell surface CD4 as well as additional host cell cofactors. A cofactor required for infection with virus adapted for growth in transformed T cell lines was recently identified and named fusin. Fusin, however, does not promote entry of macrophage-tropic viruses that are believed to be the key pathogenic strains in vivo. It has now been determined that the principal cofactor for entry mediated by the envelope glycoproteins of primary macrophage-tropic strains of HIV-1 is CC-CKR5, a receptor for the .beta.-chemokines RANTES, MIP-1.alpha., and MIP-1.beta..
摘要翻译： HIV-1进入靶细胞需要细胞表面CD4以及额外的宿主细胞辅因子。 最近鉴定了一种在转化的T细胞系中适应生长的病毒感染所需的辅因子，并命名为fusin。 然而，Fusin不促进被认为是体内关键致病菌株的巨噬细胞 - 嗜性病毒的进入。 现在已经确定，由HIV-1的初级巨噬细胞 - 热带菌株的包膜糖蛋白引入的主要辅助因子是CC-CKR5，β-chemokines RANTES，MIP-1α和MIP-1β的受体 。
-
4.发明授权G-coupled receptors associated with retroviral entry into cells, and therapeutic uses thereof 有权与逆转录病毒进入细胞相关的G偶联受体及其治疗用途公开(公告)号：US06696244B2
公开(公告)日：2004-02-24
申请号：US09852156
申请日：2001-05-09
IPC分类号： C12Q170
CPC分类号： G01N33/56988 , A01K67/0275 , A01K2217/072 , A01K2267/0393 , A61K39/39 , C07K14/7158 , C07K16/2866 , C12N2740/16043 , C12N2810/6054 , G01N33/74 , G01N2333/726
摘要： The present invention provides two new HIV/SIV translocation promoting agents, Bonzo and BOB. The present invention also provides the amino acid and DNA sequences of human, African green monkey, and pigtail macaque of the receptor protein Bonzo. Mammalian cells transfected with Bonzo and/or BOB and human CD4 as well as antibodies to the receptor Bonzo are also included. Furthermore, a method of identifying other such translocation promoting agents is also disclosed. Diagnostic and therapeutic uses of the translocation promoting agents of the present invention are also provided. Furthermore, the present invention provides methods of identifying agents that can modulate the expression and/or function of Bonzo/STRL33. Such agents can be used to either treat inflamation, or alternatively, to enhance the immune response.
摘要翻译： 本发明提供两种新的HIV / SIV易位促进剂Bonzo和BOB。 本发明还提供了受体蛋白质Bonzo的人，非洲绿猴和猪尾猕猴的氨基酸和DNA序列。 还包括用Bonzo和/或BOB和人CD4转染的哺乳动物细胞以及受体Bonzo的抗体。 此外，还公开了鉴定其他这种易位促进剂的方法。 还提供了本发明的易位促进剂的诊断和治疗用途。 此外，本发明提供鉴定可以调节Bonzo / STRL33的表达和/或功能的试剂的方法。 这种药剂可用于治疗炎症，或者替代地增强免疫应答。
-
5.发明授权Alternative G-coupled receptors associated with retroviral entry into cells, methods of identifying the same, and diagnostic and therapeutic uses thereof 失效与逆转录病毒进入细胞相关的替代G-偶联受体，鉴定其的方法及其诊断和治疗用途公开(公告)号：US06251582B1
公开(公告)日：2001-06-26
申请号：US09116498
申请日：1998-07-16
IPC分类号： C12Q170
CPC分类号： G01N33/74 , G01N33/56988 , G01N2333/726
摘要： The present invention provides two new HIV/SIV translocation promoting agents, Bonzo and BOB. The present invention also provides the amino acid and DNA sequences of human, African green monkey, and pigtail macaque of the receptor protein Bonzo. Mammalian cells transfected with Bonzo and/or BOB and human CD4 as well as antibodies to the receptor Bonzo are also included. Furthermore, a method of identifying other such translocation promoting agents is also disclosed. Diagnostic and therapeutic uses of the translocation promoting agents of the present invention are also provided.
摘要翻译： 本发明提供两种新的HIV / SIV易位促进剂Bonzo和BOB。 本发明还提供了受体蛋白质Bonzo的人，非洲绿猴和猪尾猕猴的氨基酸和DNA序列。 还包括用Bonzo和/或BOB和人CD4转染的哺乳动物细胞以及受体Bonzo的抗体。 此外，还公开了鉴定其他这种易位促进剂的方法。 还提供了本发明的易位促进剂的诊断和治疗用途。
-
公开(公告)号：US07776597B2
公开(公告)日：2010-08-17
申请号：US11911378
申请日：2006-04-14
申请人： Hongkui Deng , Mingxiao Ding , Yan Shi , Wei Jiang , Lingling Hou , Fuchou Tang
发明人： Hongkui Deng , Mingxiao Ding , Yan Shi , Wei Jiang , Lingling Hou , Fuchou Tang
CPC分类号： C12N5/0676 , A61K35/12 , C12N2500/25 , C12N2500/38 , C12N2500/44 , C12N2501/115 , C12N2501/16 , C12N2501/385 , C12N2506/02 , C12N2533/52 , C12N2533/90
摘要： The present invention provided a simple three-step approach based on the combinational induction with activin A, all-trans retinoic acid and, optionally, other maturation factors which are able to induce embryonic stem cells to differentiate into insulin-producing cells. A kit used to induce embryonic stem cells to differentiate into insulin-producing cells was also provided.
摘要翻译： 本发明提供了基于与激活素A，全反式视黄酸和任选地能够诱导胚胎干细胞分化成胰岛素生成细胞的其它成熟因子的组合诱导的简单的三步法。 还提供了用于诱导胚胎干细胞分化成胰岛素生成细胞的试剂盒。
-
7.发明授权Modulation of primary stem cell differentiation using an insulin-like growth factor binding protein 失效使用胰岛素样生长因子结合蛋白调节原代干细胞分化公开(公告)号：US06841386B2
公开(公告)日：2005-01-11
申请号：US09962026
申请日：2001-09-24
申请人： Morey Kraus , Hongkui Deng , Liqin Liu
发明人： Morey Kraus , Hongkui Deng , Liqin Liu
CPC分类号： C12N5/0647 , C12N2501/105
摘要： The present invention features methods of modulating primary stem cell differentiation in culture by altering the endogenous activity of an insulin-like growth factor.
摘要翻译： 本发明的特征在于通过改变胰岛素样生长因子的内源性活性来调节培养中的原代干细胞分化的方法。
-
8.发明申请METHODS FOR OBTAINING HEPATOCYTES, HEPATIC ENDODERM CELLS AND HEPATIC PROGENITOR CELLS BY INDUCED DIFFERENTIATION 审中-公开通过诱导分化获得肝细胞癌，肝细胞和HEPICAL PROGENITOR细胞的方法公开(公告)号：US20120190059A1
公开(公告)日：2012-07-26
申请号：US13386373
申请日：2010-07-23
申请人： Hongkui Deng , Mingxiao Ding , Dongxin Zhao , Song Chen , Zhihua Song
发明人： Hongkui Deng , Mingxiao Ding , Dongxin Zhao , Song Chen , Zhihua Song
IPC分类号： C12N5/0735 , C12N5/071 , C12Q1/02
CPC分类号： C12N5/0672 , C12N5/067 , C12N2500/25 , C12N2501/115 , C12N2501/117 , C12N2501/12 , C12N2501/155 , C12N2501/16 , C12N2501/237 , C12N2501/39 , C12N2506/02 , C12N2506/45
摘要： The present invention discloses a method for inducing the differentiation of embryonic stem cells (ESC) or induced pluripotent stem cells (iPS cells) into hepatocytes, a method for inducing the differentiation of embryonic stem cells or induced pluripotent stem cells into hepatic endoderm cells, and a method for inducing the differentiation of embryonic stem cells (ESC) or induced pluripotent stem cells into hepatic progenitor cells. The present invention also provides the hepatocytes, hepatic endoderm cells and hepatic progenitor cells obtained by above methods, and the uses of these cells.
摘要翻译： 本发明公开了诱导胚胎干细胞（ESC）或诱导的多能干细胞（iPS细胞）分化为肝细胞的方法，诱导胚胎干细胞或诱导多能干细胞分化为肝内胚层细胞的方法，以及 诱导胚胎干细胞（ESC）或诱导多能干细胞分化为肝祖细胞的方法。 本发明还提供通过上述方法获得的肝细胞，肝内胚层细胞和肝祖细胞，以及这些细胞的用途。
-
公开(公告)号：US20080286867A1
公开(公告)日：2008-11-20
申请号：US11911378
申请日：2006-04-14
申请人： Hongkui Deng , Mingxiao Ding , Yan Shi , Wei Jiang , Lingling Hou , Fuchou Tang
发明人： Hongkui Deng , Mingxiao Ding , Yan Shi , Wei Jiang , Lingling Hou , Fuchou Tang
IPC分类号： C12N5/06
CPC分类号： C12N5/0676 , A61K35/12 , C12N2500/25 , C12N2500/38 , C12N2500/44 , C12N2501/115 , C12N2501/16 , C12N2501/385 , C12N2506/02 , C12N2533/52 , C12N2533/90
摘要： The present invention provided a simple three-step approach based on the combinational induction with activin A, all-trans retinoic acid and, optionally, other maturation factors which are able to induce embryonic stem cells to differentiate into insulin-producing cells. A kit used to induce embryonic stem cells to differentiate into insulin-producing cells was also provided.
摘要翻译： 本发明提供了基于与激活素A，全反式视黄酸和任选地能够诱导胚胎干细胞分化成胰岛素生成细胞的其它成熟因子的组合诱导的简单的三步法。 还提供了用于诱导胚胎干细胞分化成胰岛素生成细胞的试剂盒。
-
-
-
-
-
-
-
-
搜索结果
9 条记录 (耗时 0.033 秒)
