公开(公告)号：US20070293937A1

公开(公告)日：2007-12-20

申请号：US11809779

申请日：2007-06-01

申请人： David Biggs ,  David Grewe ,  Neal Fearnot ,  Patrick Ruane ,  Anthony Ragheb

发明人： David Biggs ,  David Grewe ,  Neal Fearnot ,  Patrick Ruane ,  Anthony Ragheb

IPC分类号： A61F2/06 ,  A61K38/00 ,  A61P9/00

CPC分类号： A61L27/34 ,  A61L27/54 ,  A61L29/085 ,  A61L29/16 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/434 ,  A61L2300/608

摘要： An endoluminal medical device comprises a drug release system that releases a cathepsin inhibitor at a predetermined location within a lumen of a patient. The endoluminal devices and methods of treatment of disease can treat illnesses such as aneurysms and aortic dissections.

摘要翻译： 腔内医疗装置包括药物释放系统，其在组织蛋白酶抑制剂在患者的内腔内的预定位置释放。 腔内装置和治疗疾病的方法可以治疗诸如动脉瘤和主动脉夹层的疾病。

公开(公告)号：US20070150047A1

公开(公告)日：2007-06-28

申请号：US11599859

申请日：2006-11-15

申请人： Patrick Ruane ,  Waleska Perez-Segarra ,  Anthony Ragheb ,  Neal Fearnot ,  William Voorhees ,  Brian Bates ,  Thomas Osborne

发明人： Patrick Ruane ,  Waleska Perez-Segarra ,  Anthony Ragheb ,  Neal Fearnot ,  William Voorhees ,  Brian Bates ,  Thomas Osborne

IPC分类号： A61F2/06

CPC分类号： A61F2/82 ,  A61F2250/0068 ,  A61K51/1282 ,  A61L27/306 ,  A61L27/54 ,  A61L29/085 ,  A61L29/106 ,  A61L29/16 ,  A61L31/088 ,  A61L31/10 ,  A61L31/146 ,  A61L31/16 ,  A61L33/022 ,  A61L2300/602 ,  A61L2300/608 ,  A61L2420/08 ,  A61N5/1002

摘要： Methods of making coated implantable medical devices are provided. The methods include positioning a first layer comprising a bioactive on at least a portion of a structure, and positioning at least one porous layer over the first layer. The at least one porous layer has a thickness adequate to provide a controlled release of the bioactive.

摘要翻译： 提供涂覆的可植入医疗装置的方法。 所述方法包括将包含生物活性的第一层定位在结构的至少一部分上，并将至少一个多孔层定位在第一层之上。 至少一个多孔层具有足以提供生物活性的受控释放的厚度。

公开(公告)号：US20070050010A1

公开(公告)日：2007-03-01

申请号：US11515395

申请日：2006-09-01

申请人： Brian Bates ,  Anthony Ragheb ,  Neal Fearnot ,  William Voorhees ,  Thomas Kozma ,  David Grewe ,  Darin Schaeffer

发明人： Brian Bates ,  Anthony Ragheb ,  Neal Fearnot ,  William Voorhees ,  Thomas Kozma ,  David Grewe ,  Darin Schaeffer

IPC分类号： A61F2/86 ,  A61F2/06

CPC分类号： A61F2/91 ,  A61F2/24 ,  A61F2/82 ,  A61F2/885 ,  A61F2250/0068 ,  A61K51/1282 ,  A61L27/306 ,  A61L27/54 ,  A61L29/085 ,  A61L29/106 ,  A61L29/16 ,  A61L31/088 ,  A61L31/10 ,  A61L31/16 ,  A61L33/022 ,  A61L2300/256 ,  A61L2300/416 ,  A61L2300/602 ,  A61L2300/606 ,  A61L2300/608 ,  A61N5/1002 ,  C08L65/04

摘要： A coated implantable medical device 10 includes a structure 12 adapted for introduction into the vascular system, esophagus, trachea, colon, biliary tract, or urinary tract; at least one coating layer 16 posited on one surface of the structure; and at least one layer 18 of a bioactive material posited on at least a portion of the coating layer 16, wherein the coating layer 16 provides for the controlled release of the bioactive material from the coating layer. In addition, at least one porous layer 20 can be posited over the bioactive material layer 18, wherein the porous layer includes a polymer and provides for the controlled release of the bioactive material therethrough. Preferably, the structure 12 is a coronary stent. The porous layer 20 includes a polymer applied preferably by vapor or plasma deposition and provides for a controlled release of the bioactive material. It is particularly preferred that the polymer is a polyamide, parylene or a parylene derivative, which is deposited without solvents, heat or catalysts, and merely by condensation of a monomer vapor.

摘要翻译： 涂覆的可植入医疗装置10包括适于引入到血管系统，食道，气管，结肠，胆道或尿道中的结构12; 至少一个涂层16位于该结构的一个表面上; 和至少一层生物活性物质的层18位于涂层16的至少一部分上，其中涂层16提供生物活性材料从涂层的受控释放。 此外，至少一个多孔层20可以放置在生物活性材料层18上方，其中多孔层包括聚合物并提供生物活性材料通过其控制释放。 优选地，结构12是冠状动脉支架。 多孔层20包括优选通过蒸气或等离子体沉积施加的聚合物，并提供生物活性材料的受控释放。 特别优选的是，聚合物是聚酰胺，聚对二甲苯或聚对二甲苯衍生物，它们不经溶剂，热或催化剂沉积，并且仅通过单体蒸气的冷凝而沉积。

公开(公告)号：US20070168012A1

公开(公告)日：2007-07-19

申请号：US11604539

申请日：2006-11-27

申请人： Anthony Ragheb ,  Brian Bates ,  Neal Fearnot ,  Thomas Kozma ,  William Voorhees

发明人： Anthony Ragheb ,  Brian Bates ,  Neal Fearnot ,  Thomas Kozma ,  William Voorhees

IPC分类号： A61F2/06

CPC分类号： A61K51/1282 ,  A61F2/24 ,  A61F2/82 ,  A61F2250/0068 ,  A61L27/306 ,  A61L27/54 ,  A61L29/085 ,  A61L29/106 ,  A61L29/16 ,  A61L31/088 ,  A61L31/10 ,  A61L31/16 ,  A61L33/022 ,  A61L2300/256 ,  A61L2300/416 ,  A61L2300/602 ,  A61L2300/606 ,  A61L2300/608 ,  A61L2420/08 ,  A61N5/1002 ,  C08L65/04

摘要： Methods of making coated implantable medical devices are provided. The methods include positioning a first layer comprising a bioactive on at least a portion of a structure, and positioning at least one porous layer over the first layer. The at least one porous layer has a thickness adequate to provide a controlled release of the bioactive.

摘要翻译： 提供涂覆的可植入医疗装置的方法。 所述方法包括将包含生物活性的第一层定位在结构的至少一部分上，并将至少一个多孔层定位在第一层之上。 至少一个多孔层具有足以提供生物活性的受控释放的厚度。

公开(公告)号：US20050278021A1

公开(公告)日：2005-12-15

申请号：US11141574

申请日：2005-05-31

申请人： Brian Bates ,  Anthony Ragheb ,  Joseph Stewart ,  William Bourdeau ,  Brian Choules ,  James Purdy ,  Neal Fearnot

发明人： Brian Bates ,  Anthony Ragheb ,  Joseph Stewart ,  William Bourdeau ,  Brian Choules ,  James Purdy ,  Neal Fearnot

IPC分类号： A61F2/00 ,  A61F2/82 ,  A61L27/54 ,  A61L29/16 ,  A61L31/16 ,  A61F2/06

CPC分类号： A61M25/10 ,  A61F2/82 ,  A61F2/844 ,  A61F2/86 ,  A61F2/958 ,  A61F2210/0014 ,  A61F2210/0076 ,  A61F2240/001 ,  A61F2250/0025 ,  A61F2250/0026 ,  A61F2250/0067 ,  A61F2250/0081 ,  A61F2250/0098 ,  A61F2310/00011 ,  A61L27/54 ,  A61L29/08 ,  A61L29/085 ,  A61L29/16 ,  A61L29/18 ,  A61L31/14 ,  A61L31/16 ,  A61L2300/416 ,  A61L2300/606 ,  A61L2400/18 ,  A61L2420/02 ,  A61L2420/06 ,  A61M25/1029 ,  A61M25/104 ,  A61M2025/1031 ,  A61M2025/105 ,  A61M2250/00

摘要： A coated medical device (10) including a structure (12) adapted for introduction into a passage or vessel of a patient. The structure is formed of preferably a non-porous base material (14) having a bioactive material layer (18) disposed thereon. The medical device is preferably an implantable stent or balloon (26) of which the bioactive material layer is deposited thereon. The stent can be positioned around the balloon and another layer of the bioactive material posited over the entire structure and extending beyond the ends of the positioned stent. The ends of the balloon extend beyond the ends of the stent and include the bioactive material thereon for delivering the bioactive material to the cells of a vessel wall coming in contact therewith. The balloon further includes a layer of hydrophilic material (58) positioned between the base and bioactive material layers of the balloon.

摘要翻译： 一种涂覆的医疗装置（10），包括适于引入患者的通道或容器中的结构（12）。 该结构优选由其上设置有生物活性材料层（18）的无孔基材（14）形成。 该医疗装置优选为其上沉积有生物活性物质层的可植入支架或球囊（26）。 支架可以围绕气囊定位，另一层生物活性材料放置在整个结构上并延伸超过定位的支架的端部。 气囊的端部延伸超过支架的端部并且包括其上的生物活性材料，用于将生物活性材料输送到与其接触的血管壁的细胞。 气囊还包括位于气囊的基部和生物活性材料层之间的一层亲水材料（58）。

公开(公告)号：US20060195176A1

公开(公告)日：2006-08-31

申请号：US11410354

申请日：2006-04-25

申请人： Brian Bates ,  Anthony Ragheb ,  Neal Fearnot ,  Thomas Kozma ,  William Voorhees

发明人： Brian Bates ,  Anthony Ragheb ,  Neal Fearnot ,  Thomas Kozma ,  William Voorhees

IPC分类号： A61F2/82

CPC分类号： A61L33/022 ,  A61F2/0077 ,  A61F2/02 ,  A61F2/06 ,  A61F2/24 ,  A61F2/82 ,  A61F2/91 ,  A61F2210/0076 ,  A61F2250/0067 ,  A61F2250/0068 ,  A61K51/1282 ,  A61L27/306 ,  A61L27/54 ,  A61L29/085 ,  A61L29/106 ,  A61L29/16 ,  A61L31/088 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/256 ,  A61L2300/416 ,  A61L2300/602 ,  A61L2300/606 ,  A61L2300/608 ,  A61L2420/08 ,  A61N5/1002 ,  C08L65/04

摘要： Bioactive-coated medical devices are provided, including coated vascular stents. The medical device coating can include a coating layer posited over at least a portion of the medical device surface, and can include a butyl methacrylate polymer or an ethylene-vinyl acetate copolymer in combination with a bioactive material that can function as both an immunosuppressive agent and an antiproliferative agent. Optionally, multilayer coatings can further include an adhesion promoting layer comprising parylene positioned between the coating layer and the medical device surface, a porous layer comprising butyl methacrylate positioned over at least a portion of the coating layer, or both. The coating layer preferably comprises between about 0.5 and 2.0 μg/mm2 of the bioactive material on the outer surface of the medical device. The bioactive material can be absorbed into the coating layer, which can have a thickness of between about 0.5 μm to about 5 μm.

摘要翻译： 提供生物活性涂层医疗器械，包括涂层血管支架。 医疗器械涂层可以包括位于医疗器械表面的至少一部分上的涂层，并且可以包括甲基丙烯酸丁酯聚合物或乙烯 - 乙酸乙烯酯共聚物与可以用作免疫抑制剂和生物活性物质的生物活性材料 抗增生剂。 任选地，多层涂层还可以包括粘合促进层，其包括定位在涂层和医疗器件表面之间的聚对二甲苯，包含位于涂层的至少一部分上的甲基丙烯酸丁酯的多孔层，或两者。 涂层优选包含在医疗装置的外表面上的生物活性材料的约0.5和2.0杯/平方毫米之间。 生物活性材料可以被吸收到涂层中，其可以具有在约0.5μm至约5μm之间的厚度。

公开(公告)号：US20070203520A1

公开(公告)日：2007-08-30

申请号：US11654278

申请日：2007-01-16

申请人： Dennis Griffin ,  Arne Molgaard-Nielsen ,  Anthony Ragheb ,  Raymond Leonard ,  Neal Fearnot ,  William Voorhees ,  Thomas Kozma ,  Brian Bates ,  Thomas Osborne

发明人： Dennis Griffin ,  Arne Molgaard-Nielsen ,  Anthony Ragheb ,  Raymond Leonard ,  Neal Fearnot ,  William Voorhees ,  Thomas Kozma ,  Brian Bates ,  Thomas Osborne

IPC分类号： A61M29/00

CPC分类号： A61F2/01 ,  A61F2002/016 ,  A61F2230/005 ,  A61F2230/0086 ,  A61F2250/0067

摘要： Endovascular filter (10) including a plurality of struts (14) with distal ends (18) adapted to anchor the filter to the vessel wall after deployment, such as by having barbs (20), the filter being adapted to be retrieved if desired. Strut distal ends (18) are coated with an antiproliferative agent (40) that inhibits the ingrowth of tissue around the filter, thereby permitting the filter to be retrieved and removed atraumatically after a prolonged period of time, thus extending the useful life of the retrievable filter. Optionally, the proximal end (22) of the filter may also be so coated, or the entire filter.

摘要翻译： 包括具有远端（18）的多个支柱（14）的血管内过滤器（10），其适于在部署之后将过滤器锚定到血管壁，例如通过具有倒钩（20），如果需要，该过滤器适于被检索。 支架远端（18）涂覆有抗增殖剂（40），其抑制过滤器周围的组织的向内生长，从而允许过滤器在延长的时间段后无损伤地取出和去除，从而延长可回收的使用寿命 过滤。 可选地，过滤器的近端（22）也可以如此涂覆，或整个过滤器。

公开(公告)号：US20240058094A1

公开(公告)日：2024-02-22

申请号：US18234440

申请日：2023-08-16

申请人： Ram H. Paul, Jr. ,  Sean D. Chambers ,  David Gross ,  Neal Fearnot ,  Jesse Roll ,  Joshua F. Krieger ,  Carl A. Cook

发明人： Ram H. Paul, Jr. ,  Sean D. Chambers ,  David Gross ,  Neal Fearnot ,  Jesse Roll ,  Joshua F. Krieger ,  Carl A. Cook

IPC分类号： A61B90/00 ,  A61B5/055 ,  A61L31/02 ,  A61L31/14

CPC分类号： A61B90/39 ,  A61B5/055 ,  A61L31/022 ,  A61L31/14 ,  A61B2090/3954 ,  A61M2025/09075

摘要： The disclosure relates to methods of imaging a portion of a body vessel using magnetic resonance imaging (MRI), methods of performing interventional medical treatment under MRI, interventional medical devices, such as wire guides, useful in performing treatment under MRI, and methods of making interventional medical devices. A method of imaging a portion of a body vessel of a patient using MRI includes advancing through a body vessel an end of a wire guide comprising a continuous metal core member and a continuous jacket disposed over the entire core member through a body vessel and scanning the portion of the patient that is positioned within an MRI scanner and that includes a portion of the body vessel within which the end of the wire guide is disposed. A secondary medical device, such as a catheter, can be disposed over the wire guide and manipulated in the method.

公开(公告)号：US20080097585A1

公开(公告)日：2008-04-24

申请号：US11772438

申请日：2007-07-02

申请人： Richard Sisken ,  Michael Hiles ,  Neal Fearnot ,  Alan Leewood

发明人： Richard Sisken ,  Michael Hiles ,  Neal Fearnot ,  Alan Leewood

IPC分类号： A61F2/06

CPC分类号： A61F2/2412 ,  A61F2/2475

摘要： Medical device valve repair systems that include a stabilization member are provided. The stabilization member includes an engaging channel to contact the engaging surface of a valve holding valve leaflets in a position such that a tissue repair device may form a coaptation between the valve leaflets.

摘要翻译： 提供包括稳定构件的医疗装置阀门维修系统。 稳定构件包括接合通道，以将阀保持瓣膜小叶的接合表面接触在一个位置，使得组织修复装置可以在瓣膜单元之间形成接合。

公开(公告)号：US20230248241A1

公开(公告)日：2023-08-10

申请号：US18106601

申请日：2023-02-07

申请人： Eric D. Anttila ,  Grant M. Baker ,  Eric Brandner ,  Sean D. Chambers ,  Neal Fearnot ,  David C. Gross ,  Joshua F. Krieger ,  Ram H. Paul, JR. ,  Andrew J. Robison ,  Jesse Roll

发明人： Eric D. Anttila ,  Grant M. Baker ,  Eric Brandner ,  Sean D. Chambers ,  Neal Fearnot ,  David C. Gross ,  Joshua F. Krieger ,  Ram H. Paul, JR. ,  Andrew J. Robison ,  Jesse Roll

IPC分类号： A61B5/00 ,  A61B90/00 ,  A61B5/055 ,  A61B10/02

CPC分类号： A61B5/0036 ,  A61B5/055 ,  A61B10/0233 ,  A61B90/39 ,  A61B2090/3954

摘要： Example medical systems for performing treatment under magnetic resonance imaging and related devices, kits, and methods are described. An example medical system includes a first medical device, a second medical device, and a marker. The first medical device is formed of a first material. The first material has a first magnetic susceptibility. The second medical device is formed of a second material. The second material has a second magnetic susceptibility. The marker is disposed on the second medical device and is formed of a third material. The third material has a third magnetic susceptibility that is different than the first magnetic susceptibility and the second magnetic susceptibility.