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公开(公告)号：US20150036121A1
公开(公告)日：2015-02-05
申请号：US14127337
申请日：2012-07-02
CPC分类号： G01N21/51 , G01N15/06 , G01N2015/0693 , G01N2021/4726 , G01N2201/06113
摘要： The invention relates to a method for measuring the scattered light (L2) of particles (P, PK) in a measuring medium (F), wherein a measuring container (1) is supplied with the measuring medium (F) and incident light (L1) is shone through the measuring medium (F) at least in some regions over a certain path length (1) and in a certain direction and the light (L2) scattered from the incident light (L1) is measured within a certain angle range (α).It is provided according to the invention that the incident light (L1) is guided parallel to a longitudinal axis (S) of the measuring container (1).By these measures, known methods can be improved and it is readily possible to use the invention even for very small measuring volumes of the measuring medium (F) with the associated small dimensions of the measuring container (1).
摘要翻译： 本发明涉及一种在测量介质（F）中测量颗粒（P，PK）的散射光（L2）的方法，其中向测量容器（1）供应测量介质（F）和入射光 ）至少在某些区域中通过测量介质（F）在特定路径长度（1）和某一方向上照射，并且在一定角度范围内测量从入射光（L1）散射的光（L2） α）。 根据本发明提供入射光（L1）平行于测量容器（1）的纵向轴线（S）引导。 通过这些措施，可以改进已知的方法，并且即使对于具有测量容器（1）的相关小尺寸的测量介质（F）的非常小的测量体积也可以容易地使用本发明。
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公开(公告)号：US20110135546A1
公开(公告)日：2011-06-09
申请号：US12995550
申请日：2009-06-02
CPC分类号： F16K99/0001 , B01L3/502707 , B01L3/50273 , B01L3/502738 , B01L3/502746 , B01L2200/0689 , B01L2300/0887 , B01L2400/0406 , B01L2400/0442 , B01L2400/0638 , B01L2400/0688 , B01L2400/082 , B29C65/18 , B29C66/1122 , B29C66/328 , B29C66/53461 , B29C66/71 , B29C66/723 , B29C66/81419 , B29C66/81422 , B29C66/8181 , B29C66/8322 , B29L2031/756 , F04B43/043 , B29K2021/003 , B29K2023/00 , B29K2023/06 , B29K2023/08 , B29K2023/083 , B29K2023/12 , B29K2023/14 , B29K2023/16 , B29K2027/18 , B29K2033/08 , B29K2077/00
摘要： The invention relates to a microfluidic device for metering liquids into a microfluidic network. The microfluidic channels or chambers are at least partly formed by the introduction of suitable structures into a film above the substrate carrier, so that at least some of the flow of fluid through the network takes place above the plane of the substrate. In order to form a stable channel structure or chamber structure in the film, it is envisaged that in the edge zone between the unattached and attached portions a wedge of material is formed by the viscous flow of the film material as the film is bonded to the substrate, this wedge forming a transition between the chamber wall and the substrate and raising the chamber wall above the plane of the substrate. In one method of producing a finished microfluidic structure a flat planar film is laminated onto a flat sheet-like substrate. During the lamination a mask having at least one recess or opening is pressed onto the film and onto the substrate under pressure and/or under the effect of heat. The film is thereby brought to a temperature at which there is a viscous flow of film and/or substrate medium into the region of the recess or opening, so that a wedge of material is formed and the film bulges up in the region of the recess to form a chamber. The invention further relates to methods of metering at least one liquid in a microfluidic network, in which a capillary stop is overcome by actuating the film, the film being wetted as the capillary stop is removed.
摘要翻译： 本发明涉及用于将液体计量到微流控网络中的微流体装置。 微流体通道或室至少部分地通过将合适的结构引入到衬底载体上方的膜中而形成，使得通过网络的流体中的至少一些流动发生在衬底的平面之上。 为了在膜中形成稳定的通道结构或腔室结构，设想在未连接和附接部分之间的边缘区域中，当膜粘合到膜材料上时，由材料的粘性流形成楔形材料 衬底，该楔形件形成在室壁和衬底之间的过渡部分，并且使腔壁在衬底的平面上方升高。 在制造成品微流体结构的一种方法中，将平坦的平面薄膜层压在平板状基片上。 在层压期间，具有至少一个凹部或开口的掩模在压力和/或受热的作用下被压在膜上和衬底上。 因此，膜被带到膜和/或基底介质粘性流入凹部或开口的区域的温度，使得形成楔形材料，并且膜在凹部的区域中凸起 形成一个房间。 本发明还涉及在微流体网络中计量至少一种液体的方法，其中通过致动膜来克服毛细管塞，当毛细管停止被去除时，膜被润湿。
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3.发明授权公开(公告)号：US08580072B2
公开(公告)日：2013-11-12
申请号：US12519293
申请日：2007-12-07
CPC分类号： B81C1/00119 , B01L3/502707 , B01L3/50273 , B01L3/502738 , B01L2200/0636 , B01L2200/12 , B01L2300/0681 , B01L2300/0867 , B01L2300/0887 , B01L2300/123 , B01L2400/0406 , B01L2400/0481 , B01L2400/0655 , B01L2400/0688 , B81B2201/058 , Y10T137/8593 , Y10T156/10
摘要： A device for the intake or manipulation of a fluid, in particular, a liquid, and a method for the production of a device of this type in which a flat, non-preformed covering film is laminated onto a carrier, a three-dimensionally shaped or convex chamber wall being formed solely by means of the laminating process. The chamber wall which forms a boundary of a chamber for the fluid is partially deformable. The device is simple to produce and can be used universally.
摘要翻译： 用于吸入或操纵流体，特别是液体的装置，以及用于制造这种类型的装置的方法，其中平坦的未预成型的覆盖膜层压在载体上，三维形状 或凸室壁仅通过层压工艺形成。 形成用于流体的室的边界的室壁是部分可变形的。 该设备生产简单，可以普遍使用。
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公开(公告)号：US20130236985A1
公开(公告)日：2013-09-12
申请号：US13698111
申请日：2011-05-26
申请人： Gert Blankenstein , Dirk Kurowski
发明人： Gert Blankenstein , Dirk Kurowski
IPC分类号： G01N21/64
CPC分类号： G01N21/6428 , B01L3/502715 , B01L2300/0654 , B01L2300/0816 , B01L2300/168 , B82Y15/00 , G01N33/54346 , G01N33/54366 , G01N33/588
摘要： A method and a device for the optical examination of a surface region are proposed. Fluorescence measurement is used to determine the amount of a substance bound to the surface region. Light interference is shut out thanks to the surface region being covered with an optically active liquid which filters, reflects, scatters and/or absorbs light with a wavelength at least substantially corresponding to the light radiated in and/or out.
摘要翻译： 提出了一种用于光学检测表面区域的方法和装置。 使用荧光测量来确定与表面区域结合的物质的量。 由于表面区域被光学活性液体覆盖，所以光干涉被遮挡，该光学活性液体以至少基本对应于辐射入和/或输出的光的波长进行过滤，反射，散射和/或吸收光。
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公开(公告)号：US20130206253A1
公开(公告)日：2013-08-15
申请号：US13810468
申请日：2011-07-05
申请人： Dirk Kurowski , Gert Blankenstein , Dirk Osterloh , Marc Prenger , Ying Yu
发明人： Dirk Kurowski , Gert Blankenstein , Dirk Osterloh , Marc Prenger , Ying Yu
CPC分类号： B01L3/00 , B01L3/502707 , B01L2200/025 , B01L2200/12 , B01L2300/044 , B01L2300/0887 , B23P19/00 , Y10T29/49826 , Y10T29/49865 , Y10T137/7036
摘要： A microfluidic device and a method of producing it are proposed, in which a film covers a chamber in a carrier. The film is locally re-tightened in the region of the chamber after the film has been secured to the carrier. In this way it is possible to prevent undesirable bulging of the film into the chamber.
摘要翻译： 提出一种微流体装置及其制造方法，其中膜覆盖载体中的室。 在胶片已经固定到载体上之后，膜在室的区域中被局部地再次拧紧。 以这种方式，可以防止膜进入腔室的不希望的膨胀。
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公开(公告)号：US20130112612A1
公开(公告)日：2013-05-09
申请号：US13640393
申请日：2011-04-01
IPC分类号： G01N1/28
CPC分类号： G01N1/28 , B01L3/502715 , B01L3/502723 , B01L3/50273 , B01L3/502746 , B01L3/502753 , B01L2200/027 , B01L2300/0681 , B01L2300/0851 , B01L2300/087 , B01L2300/0887 , B01L2400/0406 , B29C65/548 , G01N33/491 , G01N33/492
摘要： The invention relates to a device for sample separation, particularly for blood separation, in which the sample liquid is introduced into a feed device. The sample flows vertically through a separating device such as a filter or a membrane, so that sample particles are retained and separated off.The sample liquid thus separated, particularly blood plasma, is received by an inlet chamber underneath the separating device and conveyed by means of a channel in the lateral direction out of the inlet chamber.Particularly advantageously, the channel extends into the inlet chamber, the channel being formed by a recess in the base of the inlet chamber.
摘要翻译： 本发明涉及用于样品分离的装置，特别是用于血液分离的装置，其中将样品液体引入进料装置。 样品垂直通过诸如过滤器或膜的分离装置，使样品颗粒保持和分离。 由此分离的样品液体，特别是血浆，被分离装置下方的入口室接收，并且通过横向方向的通道从入口室输送。 特别有利的是，通道延伸到入口室中，通道由入口室的底部中的凹部形成。
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公开(公告)号：US20100126927A1
公开(公告)日：2010-05-27
申请号：US12519293
申请日：2007-12-07
CPC分类号： B81C1/00119 , B01L3/502707 , B01L3/50273 , B01L3/502738 , B01L2200/0636 , B01L2200/12 , B01L2300/0681 , B01L2300/0867 , B01L2300/0887 , B01L2300/123 , B01L2400/0406 , B01L2400/0481 , B01L2400/0655 , B01L2400/0688 , B81B2201/058 , Y10T137/8593 , Y10T156/10
摘要： A device for the intake or manipulation of a fluid, in particular, a liquid, and a method for the production of a device of this type in which a flat, non-preformed covering film is laminated onto a carrier, a three-dimensionally shaped or convex chamber wall being formed solely by means of the laminating process. The chamber wall which forms a boundary of a chamber for the fluid is partially deformable. The device is simple to produce and can be used universally.
摘要翻译： 用于吸入或操纵流体，特别是液体的装置，以及用于制造这种类型的装置的方法，其中平坦的未预成型的覆盖膜层压在载体上，三维形状 或凸室壁仅通过层压工艺形成。 形成用于流体的室的边界的室壁是部分可变形的。 该设备生产简单，可以普遍使用。
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8.发明授权公开(公告)号：US09383293B2
公开(公告)日：2016-07-05
申请号：US13640393
申请日：2011-04-01
CPC分类号： G01N1/28 , B01L3/502715 , B01L3/502723 , B01L3/50273 , B01L3/502746 , B01L3/502753 , B01L2200/027 , B01L2300/0681 , B01L2300/0851 , B01L2300/087 , B01L2300/0887 , B01L2400/0406 , B29C65/548 , G01N33/491 , G01N33/492
摘要： The invention relates to a device for sample separation, particularly for blood separation, in which the sample liquid is introduced into a feed device. The sample flows vertically through a separating device such as a filter or a membrane, so that sample particles are retained and separated off.The sample liquid thus separated, particularly blood plasma, is received by an inlet chamber underneath the separating device and conveyed by means of a channel in the lateral direction out of the inlet chamber.Particularly advantageously, the channel extends into the inlet chamber, the channel being formed by a recess in the base of the inlet chamber.
摘要翻译： 本发明涉及用于样品分离的装置，特别是用于血液分离的装置，其中将样品液体引入进料装置。 样品垂直通过诸如过滤器或膜的分离装置，使样品颗粒保持和分离。 由此分离的样品液体，特别是血浆，被分离装置下方的入口室接收，并且通过横向方向的通道从入口室输送。 特别有利的是，通道延伸到入口室中，通道由入口室的底部中的凹部形成。
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9.发明申请METHOD FOR FILLING A BLISTER PACKAGING WITH LIQUID, AND BLISTER PACKAGING WITH A CAVITY FOR FILLING WITH LIQUID 审中-公开用液体填充泡罩包装的方法，以及用于用液体填充的袋子的包装公开(公告)号：US20140000223A1
公开(公告)日：2014-01-02
申请号：US13883903
申请日：2011-11-03
申请人： Dirk Osterloh , Dirk Kurowski , Tobia Rodenfels , Gert Blankenstein , Tobias Eichmann , Thanh Tu Hellmich-Duong
发明人： Dirk Osterloh , Dirk Kurowski , Tobia Rodenfels , Gert Blankenstein , Tobias Eichmann , Thanh Tu Hellmich-Duong
IPC分类号： B65B55/24
摘要： A method for filling a cavity, of a packaging, particularly a blister packaging, with a liquid and a packaging suitable for this purpose are proposed. The cavity is completely filled with the liquid by an acceleration force or by continuous throughflow.
摘要翻译： 提出了一种用于用液体填充包装，特别是泡罩包装的空腔的方法，适用于此目的的包装。 通过加速力或连续通流将空腔完全充满液体。
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公开(公告)号：US08580209B2
公开(公告)日：2013-11-12
申请号：US12995550
申请日：2009-06-02
CPC分类号： F16K99/0001 , B01L3/502707 , B01L3/50273 , B01L3/502738 , B01L3/502746 , B01L2200/0689 , B01L2300/0887 , B01L2400/0406 , B01L2400/0442 , B01L2400/0638 , B01L2400/0688 , B01L2400/082 , B29C65/18 , B29C66/1122 , B29C66/328 , B29C66/53461 , B29C66/71 , B29C66/723 , B29C66/81419 , B29C66/81422 , B29C66/8181 , B29C66/8322 , B29L2031/756 , F04B43/043 , B29K2021/003 , B29K2023/00 , B29K2023/06 , B29K2023/08 , B29K2023/083 , B29K2023/12 , B29K2023/14 , B29K2023/16 , B29K2027/18 , B29K2033/08 , B29K2077/00
摘要： A microfluidic device meters liquids into a network of channels or chambers partly formed by a film partly attached to and above a substrate, the network permitting flow of fluid above the substrate. To form a channel or chamber, the edge zone between unattached and attached portions of the film forms a wedge of material by viscous flow of film material as the film is laminated to the substrate, this wedge forming a transition between the chamber wall and the substrate, raising the wall above the plane of the substrate. Film is laminated with a mask having an opening, the mask pressed onto the film under pressure and/or with heat. The film is brought to a temperature to produce a viscous flow of film and/or substrate medium into the region of the opening, forming a wedge of material as the film bulges up at the opening to form a chamber.
摘要翻译： 微流体装置将液体计量到由部分地连接到基底上方的膜的部分形成的通道或室的网络中，所述网络允许流体在基底上方流动。 为了形成通道或腔室，薄膜的未连接部分和附着部分之间的边缘区域通过薄膜材料的粘性流动形成楔形材料，该薄膜层压到基底上，该楔形物形成在室壁和基底之间的过渡 ，将基板的平面上方的壁提升。 膜与具有开口的掩模层压，将掩模在压力和/或加热下压在膜上。 使膜达到温度，以便在开口的区域中产生粘性的膜和/或基底介质流，当膜在开口处向上凸起以形成室时形成楔形材料。
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