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    Microfluidic Platform
    4.
    发明申请
    Microfluidic Platform 审中-公开
    微流控平台

    公开(公告)号：US20140166108A1

    公开(公告)日：2014-06-19

    申请号：US13877720

    申请日：2011-10-04

    申请人： Tobias Rodenfels ,  Thanh Tu Hellmich-Duong ,  Gert Blankenstein

    发明人： Tobias Rodenfels ,  Thanh Tu Hellmich-Duong ,  Gert Blankenstein

    IPC分类号： B01L3/00

    CPC分类号： B01L3/50273 ,  B01L2300/045 ,  B01L2300/046 ,  B01L2300/0816 ,  B01L2400/0481 ,  B01L2400/0655 ,  Y10T137/0318

    摘要： The invention relates to a microfluidic platform (1) having at least one means (12) for initiating a movement of a liquid (P), in particular a sample liquid, between at least two locations (100, 101) of the microfluidic platform (1).It is proposed according to the invention that the means (12) is embodied as an element of changeable volume and/or shape and is mounted on a cover-like component (11) that is movably connected to the microfluidic platform (1). By moving of the component (11) the element (12) can be brought into a position such that, by changing its volume and/or shape, it causes the liquid (P) situated at the location (100) to be moved at least partly from this location (100) to the other location (101).In this way a sample liquid (P) can be transferred from a sample application point (100) to a sample utilisation area (101) in a very simple and reliable manner.The invention further proposes a method by which a movement of a liquid between two locations can be initiated, while this can be done in particular using a microfluidic platform (1) according to the invention.

    摘要翻译： 本发明涉及一种微流体平台（1），其具有至少一个装置（12），用于在微流体平台的至少两个位置（100,101）之间启动液体（P），特别是样品液体的运动 1）。 根据本发明提出，装置（12）被实施为可变容积和/或形状的元件，并且安装在可移动地连接到微流体平台（1）的盖状部件（11）上。 通过移动部件（11），元件（12）可以进入这样的位置，使得通过改变其体积和/或形状，使得位于位置（100）处的液体（P）至少移动 部分地从该位置（100）到另一位置（101）。 以这种方式，样品液体（P）可以以非常简单和可靠的方式从样品施加点（100）转移到样品利用区域（101）。 本发明还提出了一种可以启动两个位置之间的液体的运动的方法，而这可以特别地使用根据本发明的微流体平台（1）进行。

    Method for Measuring the Scattered Light of Particles in a Medium
    6.
    发明申请
    Method for Measuring the Scattered Light of Particles in a Medium 审中-公开
    测量介质中颗粒散射光的方法

    公开(公告)号：US20150036121A1

    公开(公告)日：2015-02-05

    申请号：US14127337

    申请日：2012-07-02

    申请人： Dirk Kurowski ,  Christian Vesper ,  Gert Blankenstein

    发明人： Dirk Kurowski ,  Christian Vesper ,  Gert Blankenstein

    IPC分类号： G01N21/51 ,  G01N15/06

    CPC分类号： G01N21/51 ,  G01N15/06 ,  G01N2015/0693 ,  G01N2021/4726 ,  G01N2201/06113

    摘要： The invention relates to a method for measuring the scattered light (L2) of particles (P, PK) in a measuring medium (F), wherein a measuring container (1) is supplied with the measuring medium (F) and incident light (L1) is shone through the measuring medium (F) at least in some regions over a certain path length (1) and in a certain direction and the light (L2) scattered from the incident light (L1) is measured within a certain angle range (α).It is provided according to the invention that the incident light (L1) is guided parallel to a longitudinal axis (S) of the measuring container (1).By these measures, known methods can be improved and it is readily possible to use the invention even for very small measuring volumes of the measuring medium (F) with the associated small dimensions of the measuring container (1).

    摘要翻译： 本发明涉及一种在测量介质（F）中测量颗粒（P，PK）的散射光（L2）的方法，其中向测量容器（1）供应测量介质（F）和入射光 ）至少在某些区域中通过测量介质（F）在特定路径长度（1）和某一方向上照射，并且在一定角度范围内测量从入射光（L1）散射的光（L2） α）。 根据本发明提供入射光（L1）平行于测量容器（1）的纵向轴线（S）引导。 通过这些措施，可以改进已知的方法，并且即使对于具有测量容器（1）的相关小尺寸的测量介质（F）的非常小的测量体积也可以容易地使用本发明。

    MICROFLUIDIC FOIL STRUCTURE FOR METERING OF FLUIDS
    7.
    发明申请
    MICROFLUIDIC FOIL STRUCTURE FOR METERING OF FLUIDS 有权
    用于测量流体的微流体结构

    公开(公告)号：US20110135546A1

    公开(公告)日：2011-06-09

    申请号：US12995550

    申请日：2009-06-02

    申请人： Dirk Kurowski ,  Mario Hempel ,  Gert Blankenstein ,  Tobias Rodenfels

    发明人： Dirk Kurowski ,  Mario Hempel ,  Gert Blankenstein ,  Tobias Rodenfels

    IPC分类号： B01L3/00 ,  B32B37/00

    CPC分类号： F16K99/0001 ,  B01L3/502707 ,  B01L3/50273 ,  B01L3/502738 ,  B01L3/502746 ,  B01L2200/0689 ,  B01L2300/0887 ,  B01L2400/0406 ,  B01L2400/0442 ,  B01L2400/0638 ,  B01L2400/0688 ,  B01L2400/082 ,  B29C65/18 ,  B29C66/1122 ,  B29C66/328 ,  B29C66/53461 ,  B29C66/71 ,  B29C66/723 ,  B29C66/81419 ,  B29C66/81422 ,  B29C66/8181 ,  B29C66/8322 ,  B29L2031/756 ,  F04B43/043 ,  B29K2021/003 ,  B29K2023/00 ,  B29K2023/06 ,  B29K2023/08 ,  B29K2023/083 ,  B29K2023/12 ,  B29K2023/14 ,  B29K2023/16 ,  B29K2027/18 ,  B29K2033/08 ,  B29K2077/00

    摘要： The invention relates to a microfluidic device for metering liquids into a microfluidic network. The microfluidic channels or chambers are at least partly formed by the introduction of suitable structures into a film above the substrate carrier, so that at least some of the flow of fluid through the network takes place above the plane of the substrate. In order to form a stable channel structure or chamber structure in the film, it is envisaged that in the edge zone between the unattached and attached portions a wedge of material is formed by the viscous flow of the film material as the film is bonded to the substrate, this wedge forming a transition between the chamber wall and the substrate and raising the chamber wall above the plane of the substrate. In one method of producing a finished microfluidic structure a flat planar film is laminated onto a flat sheet-like substrate. During the lamination a mask having at least one recess or opening is pressed onto the film and onto the substrate under pressure and/or under the effect of heat. The film is thereby brought to a temperature at which there is a viscous flow of film and/or substrate medium into the region of the recess or opening, so that a wedge of material is formed and the film bulges up in the region of the recess to form a chamber. The invention further relates to methods of metering at least one liquid in a microfluidic network, in which a capillary stop is overcome by actuating the film, the film being wetted as the capillary stop is removed.

    摘要翻译： 本发明涉及用于将液体计量到微流控网络中的微流体装置。 微流体通道或室至少部分地通过将合适的结构引入到衬底载体上方的膜中而形成，使得通过网络的流体中的至少一些流动发生在衬底的平面之上。 为了在膜中形成稳定的通道结构或腔室结构，设想在未连接和附接部分之间的边缘区域中，当膜粘合到膜材料上时，由材料的粘性流形成楔形材料 衬底，该楔形件形成在室壁和衬底之间的过渡部分，并且使腔壁在衬底的平面上方升高。 在制造成品微流体结构的一种方法中，将平坦的平面薄膜层压在平板状基片上。 在层压期间，具有至少一个凹部或开口的掩模在压力和/或受热的作用下被压在膜上和衬底上。 因此，膜被带到膜和/或基底介质粘性流入凹部或开口的区域的温度，使得形成楔形材料，并且膜在凹部的区域中凸起 形成一个房间。 本发明还涉及在微流体网络中计量至少一种液体的方法，其中通过致动膜来克服毛细管塞，当毛细管停止被去除时，膜被润湿。

    METHOD AND DEVICE FOR OPTICAL EXAMINATION
    10.
    发明申请
    METHOD AND DEVICE FOR OPTICAL EXAMINATION 审中-公开
    用于光学检查的方法和装置

    公开(公告)号：US20130236985A1

    公开(公告)日：2013-09-12

    申请号：US13698111

    申请日：2011-05-26

    申请人： Gert Blankenstein ,  Dirk Kurowski

    发明人： Gert Blankenstein ,  Dirk Kurowski

    IPC分类号： G01N21/64

    CPC分类号： G01N21/6428 ,  B01L3/502715 ,  B01L2300/0654 ,  B01L2300/0816 ,  B01L2300/168 ,  B82Y15/00 ,  G01N33/54346 ,  G01N33/54366 ,  G01N33/588

    摘要： A method and a device for the optical examination of a surface region are proposed. Fluorescence measurement is used to determine the amount of a substance bound to the surface region. Light interference is shut out thanks to the surface region being covered with an optically active liquid which filters, reflects, scatters and/or absorbs light with a wavelength at least substantially corresponding to the light radiated in and/or out.

    摘要翻译： 提出了一种用于光学检测表面区域的方法和装置。 使用荧光测量来确定与表面区域结合的物质的量。 由于表面区域被光学活性液体覆盖，所以光干涉被遮挡，该光学活性液体以至少基本对应于辐射入和/或输出的光的波长进行过滤，反射，散射和/或吸收光。