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公开(公告)号：US12264173B2
公开(公告)日：2025-04-01
申请号：US18354362
申请日：2023-07-18
Applicant: GILEAD SCIENCES, INC.
Inventor： Gregory F. Chin , Byoung-Kwon Chun , Michael O. Clarke , Bindu Goyal , Hon C. Hui , Petr Jansa , Richard L. Mackman , Dustin S. Siegel , Hai Yang
IPC: A61P31/14 , A61K31/661 , A61K31/675 , A61P31/12 , C07F9/6561
Abstract: The present disclosure provides compounds for treating a variety of diseases, such as respiratory syncytial virus (RSV), HRV, hMPV, Ebola, Zika, West Nile, Dengue, and HCV.
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公开(公告)号：US12030903B2
公开(公告)日：2024-07-09
申请号：US17178115
申请日：2021-02-17
Applicant: Gilead Sciences, Inc.
Inventor： Daniel H. Byun , Gregory F. Chin , Michael O. Clarke , Bindu Goyal , Petr Jansa , Richard L. Mackman , Michael R. Mish , Dustin S. Siegel
IPC: C07F9/6561 , A61K45/06
CPC classification number: C07F9/6561 , A61K45/06
Abstract: The present disclosure describes 4′-fluoromethyl nucleosides for treating viral infections, including Dengue.
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公开(公告)号：US20240024341A1
公开(公告)日：2024-01-25
申请号：US18202751
申请日：2023-05-26
Applicant: Gilead Sciences, Inc.
Inventor： Scott Ellis , Davin S. Rautiola , Dustin S. Siegel , Maria M. Toteva , Adelle A. Vandersteen
IPC: A61K31/685 , A61P31/14 , A61K9/00 , A61K9/19 , A61K31/675 , A61K47/40
CPC classification number: A61K31/685 , A61P31/14 , A61K9/0019 , A61K9/0078 , A61K9/19 , A61K31/675 , A61K47/40
Abstract: The present disclosure provides pharmaceutical formulations of the compound of Formula I, Formula Ia, or Formula Ib, or a pharmaceutically acceptable salt thereof, and an aqueous vehicle. The pharmaceutical formulations of the disclosure are useful in treatment and prevention of viral infections in subjects in need thereof and are for administration by inhalation.
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公开(公告)号：US12054507B2
公开(公告)日：2024-08-06
申请号：US17178156
申请日：2021-02-17
Applicant: Gilead Sciences, Inc.
Inventor： Byoung-Kwon Chun , Edward Doerffler , Dustin S. Siegel , Andrew C. Stevens , Tiago Vieira
IPC: A01N43/00 , A01N43/46 , A61K31/55 , A61P31/14 , A61P31/16 , C07D487/04 , C07F9/6561
CPC classification number: C07F9/6561 , A61P31/14 , A61P31/16 , C07D487/04
Abstract: The present disclosure provides a compound of Formula I:
which is useful in treating a variety of diseases, such as diseases caused by respiratory syncytial virus (RSV), HRV, hMPV, ebola, Zika, West Nile, Dengue, HCV and/or HBV infections.-
公开(公告)号：US20240199676A1
公开(公告)日：2024-06-20
申请号：US18174474
申请日：2023-02-24
Applicant: Gilead Sciences, Inc.
Inventor： Byoung-Kwon Chun , Michael O. Clarke , Deeba Ensan , Richard L. Mackman , Devan Naduthambi , Dustin S. Siegel
IPC: C07H7/06 , A61K31/706 , A61P31/14
CPC classification number: C07H7/06 , A61K31/706 , A61P31/14
Abstract: Antiviral compounds and methods of using the same, singly or in combination with additional agents, and pharmaceutical compositions of said compounds for the treatment of viral infections are disclosed.
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Patent Agency Ranking
公开(公告)号：US20240043427A1
公开(公告)日：2024-02-08
申请号：US17997594
申请日：2021-04-29
Applicant: Gilead Sciences, Inc.
Inventor： Mark J. Bartlett , Gregory F. Chin , Michael O. Clarke , Jennifer L. Cosman , Deeba Ensan , Bindu Goyal , Stephen Ho , Hon C. Hui , Richard L. Mackman , Michael R. Mish , Scott D. Schroeder , Nathan D. Shapiro , Dustin S. Siegel , Doris T. Tang , Hai Yang
IPC: C07D487/04 , C07D519/00 , A61K45/06 , C07K16/28
CPC classification number: C07D487/04 , C07D519/00 , C07K16/2827 , C07K16/2818 , A61K45/06
Abstract: The present disclosure provides pyrimidine dione compounds, and pharmaceutical compositions thereof, for treating cancer, including solid tumors. The compounds can be used alone or in combination with other anti-cancer agents.
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公开(公告)号：US20230382940A1
公开(公告)日：2023-11-30
申请号：US18176864
申请日：2023-03-01
Applicant: Gilead Sciences, Inc.
Inventor： Byoung-Kwon Chun , Michael O. Clarke , Deeba Ensan , Rao V. Kalla , Richard L. Mackman , Devan Naduthambi , Dustin S. Siegel
Abstract: Antiviral compounds and methods of using the same, singly or in combination with additional agents, and pharmaceutical compositions of said compounds for the treatment of viral infections are disclosed.
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公开(公告)号：US11701372B2
公开(公告)日：2023-07-18
申请号：US17222125
申请日：2021-04-05
Applicant: Gilead Sciences, Inc.
Inventor： Scott Ellis , Davin S. Rautiola , Dustin S. Siegel , Maria M. Toteva , Adelle A. Vandersteen
IPC: A61K31/685 , A61P31/14 , A61K9/00 , A61K9/19 , A61K31/675 , A61K47/40
CPC classification number: A61K31/685 , A61K9/0019 , A61K9/0078 , A61K9/19 , A61K31/675 , A61K47/40 , A61P31/14
Abstract: The present disclosure provides pharmaceutical formulations of the compound of Formula I, Formula Ia, or Formula Ib, or a pharmaceutically acceptable salt thereof, and an aqueous vehicle. The pharmaceutical formulations of the disclosure are useful in treatment and prevention of viral infections in subjects in need thereof and are for administration by inhalation.
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公开(公告)号：US20210330685A1
公开(公告)日：2021-10-28
申请号：US17222125
申请日：2021-04-05
Applicant: Gilead Sciences, Inc.
Inventor： Scott Ellis , Davin S. Rautiola , Dustin S. Siegel , Maria M. Toteva , Adelle A. Vandersteen
IPC: A61K31/685 , A61K9/00 , A61K47/40 , A61K31/675 , A61K9/19 , A61P31/14
Abstract: The present disclosure provides pharmaceutical formulations of the compound of Formula I, Formula Ia, or Formula Ib, or a pharmaceutically acceptable salt thereof, and an aqueous vehicle. The pharmaceutical formulations of the disclosure are useful in treatment and prevention of viral infections in subjects in need thereof and are for administration by inhalation.
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公开(公告)号：US20250109157A1
公开(公告)日：2025-04-03
申请号：US18899540
申请日：2024-09-27
Applicant: Gilead Sciences, Inc.
Inventor： Richard L. Mackman , Dustin S. Siegel
IPC: C07F9/6561 , A61K31/685 , A61K31/688 , A61K45/06
Abstract: Compounds of Formula I and methods of using said compounds, singly or in combination with additional agents, and salts or pharmaceutical compositions of said compounds for the treatment of viral infections are disclosed.
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