公开(公告)号：US20240043427A1

公开(公告)日：2024-02-08

申请号：US17997594

申请日：2021-04-29

Applicant: Gilead Sciences, Inc.

Inventor： Mark J. Bartlett ,  Gregory F. Chin ,  Michael O. Clarke ,  Jennifer L. Cosman ,  Deeba Ensan ,  Bindu Goyal ,  Stephen Ho ,  Hon C. Hui ,  Richard L. Mackman ,  Michael R. Mish ,  Scott D. Schroeder ,  Nathan D. Shapiro ,  Dustin S. Siegel ,  Doris T. Tang ,  Hai Yang

IPC: C07D487/04 ,  C07D519/00 ,  A61K45/06 ,  C07K16/28

CPC classification number: C07D487/04 ,  C07D519/00 ,  C07K16/2827 ,  C07K16/2818 ,  A61K45/06

Abstract: The present disclosure provides pyrimidine dione compounds, and pharmaceutical compositions thereof, for treating cancer, including solid tumors. The compounds can be used alone or in combination with other anti-cancer agents.

公开(公告)号：US11767337B2

公开(公告)日：2023-09-26

申请号：US17178463

申请日：2021-02-18

Applicant: Gilead Sciences, Inc.

Inventor： Gregory F. Chin ,  Byoung-Kwon Chun ,  Michael O. Clarke ,  Bindu Goyal ,  Hon C. Hui ,  Petr Jansa ,  Richard L. Mackman ,  Dustin S. Siegel ,  Hai Yang

IPC: C07F9/6561 ,  A61P31/14

CPC classification number: C07F9/6561 ,  A61P31/14

Abstract: The present disclosure provides compounds for treating a variety of diseases, such as respiratory syncytial virus (RSV), HRV, hMPV, Ebola, Zika, West Nile, Dengue, and HCV.

公开(公告)号：US20230295201A1

公开(公告)日：2023-09-21

申请号：US18171950

申请日：2023-02-21

Applicant: Gilead Sciences, Inc.

Inventor： Daniel H. Byun ,  Gregory F. Chin ,  Byoung-kwon Chun ,  Michael O. Clarke ,  Bindu Goyal ,  Hon C. Hui ,  Petr Jansa ,  Richard L. Mackman ,  Michael R. Mish ,  Dustin S. Siegel ,  David Sperandio ,  Hai Yang ,  Lijun Zhang

IPC: C07F9/6561 ,  A61K31/706

CPC classification number: C07F9/6561 ,  A61K31/706

Abstract: The present disclosure provides compounds for treating a variety of diseases, such as respiratory syncytial virus (RSV), HRV, hMPV, ebola, Zika, West Nile, Dengue, and HCV.

公开(公告)号：US12110294B2

公开(公告)日：2024-10-08

申请号：US17243911

申请日：2021-04-29

Applicant: Gilead Sciences, Inc.

Inventor： Mark J. Bartlett ,  Gregory F. Chin ,  Michael O. Clarke ,  Jennifer L. Cosman ,  Deeba Ensan ,  Bindu Goyal ,  Stephen Ho ,  Hon C. Hui ,  Richard L. Mackman ,  Michael R. Mish ,  Scott D. Schroeder ,  Nathan D. Shapiro ,  Dustin S. Siegel ,  Doris T. Tang ,  Hai Yang

IPC: C07D487/04 ,  A61K45/06 ,  C07D519/00 ,  C07K16/28

CPC classification number: C07D487/04 ,  A61K45/06 ,  C07D519/00 ,  C07K16/2818 ,  C07K16/2827

Abstract: The present disclosure provides pyrimidine dione compounds of Formula I






and pharmaceutical compositions thereof, for treating cancer, including solid tumors either-used alone or in combination with other anti-cancer agents.

公开(公告)号：US20230039553A1

公开(公告)日：2023-02-09

申请号：US17243911

申请日：2021-04-29

Applicant: Gilead Sciences, Inc.

Inventor： Mark J. Bartlett ,  Gregory F. Chin ,  Michael O. Clarke ,  Jennifer L. Cosman ,  Deeba Ensan ,  Bindu Goyal ,  Stephen Ho ,  Hon C. Hui ,  Richard L. Mackman ,  Michael R. Mish ,  Scott D. Schroeder ,  Nathan D. Shapiro ,  Dustin S. Siegel ,  Doris T. Tang ,  Hai Yang

IPC: C07D487/04 ,  C07D519/00 ,  A61K45/06 ,  C07K16/28

Abstract: The present disclosure provides pyrimidine dione compounds, and pharmaceutical compositions thereof, for treating cancer, including solid tumors. The compounds can be used alone or in combination with other anti-cancer agents.

公开(公告)号：US20210292348A1

公开(公告)日：2021-09-23

申请号：US17178115

申请日：2021-02-17

Applicant: Gilead Sciences, Inc.

Inventor： Daniel H. Byun ,  Gregory F. Chin ,  Michael O. Clarke ,  Bindu Goyal ,  Petr Jansa ,  Richard L. Mackman ,  Michael R. Mish ,  Dustin S. Siegel

IPC: C07F9/6561 ,  A61K45/06

Abstract: The present disclosure describes 4′-fluoromethyl nucleosides for treating viral infections, including Dengue.

公开(公告)号：US20210284670A1

公开(公告)日：2021-09-16

申请号：US17178463

申请日：2021-02-18

Applicant: Gilead Sciences, Inc.

Inventor： Gregory F. Chin ,  Byoung-Kwon Chun ,  Michael O. Clarke ,  Bindu Goyal ,  Hon C. Hui ,  Petr Jansa ,  Richard L. Mackman ,  Dustin S. Siegel ,  Hai Yang

IPC: C07F9/6561 ,  A61P31/14

Abstract: The present disclosure provides compounds for treating a variety of diseases, such as respiratory syncytial virus (RSV), HRV, hMPV, Ebola, Zika, West Nile, Dengue, and HCV.

公开(公告)号：US12264173B2

公开(公告)日：2025-04-01

申请号：US18354362

申请日：2023-07-18

Applicant: GILEAD SCIENCES, INC.

Inventor： Gregory F. Chin ,  Byoung-Kwon Chun ,  Michael O. Clarke ,  Bindu Goyal ,  Hon C. Hui ,  Petr Jansa ,  Richard L. Mackman ,  Dustin S. Siegel ,  Hai Yang

IPC: A61P31/14 ,  A61K31/661 ,  A61K31/675 ,  A61P31/12 ,  C07F9/6561

Abstract: The present disclosure provides compounds for treating a variety of diseases, such as respiratory syncytial virus (RSV), HRV, hMPV, Ebola, Zika, West Nile, Dengue, and HCV.

公开(公告)号：US12091420B2

公开(公告)日：2024-09-17

申请号：US18376159

申请日：2023-10-03

Applicant: Gilead Sciences, Inc.

Inventor： Stephen E. Ammann ,  Xinpei Cai ,  Eda Y. Canales ,  Weng K. Chang ,  Gregory F. Chin ,  Henok H. Kinfe ,  Jessica L. Mckinley ,  Michael R. Mish ,  Devan Naduthambi ,  Jason K. Perry ,  Kevin X. Rodriguez ,  Scott D. Schroeder ,  Christopher J. Swank ,  Joshua J. Van Veldhuizen

IPC: C07D495/04 ,  C07D401/04 ,  C07D519/00

CPC classification number: C07D495/04 ,  C07D401/04 ,  C07D519/00

Abstract: The present disclosure relates to compounds of Formula I:




and pharmaceutically acceptable salts thereof, pharmaceutical compositions thereof, useful in the treatment of treating viral infections, for example, coronaviridae infections.

公开(公告)号：US20240239807A1

公开(公告)日：2024-07-18

申请号：US18365919

申请日：2023-08-04

Applicant: Gilead Sciences, Inc.

Inventor： Stephen E. Ammann ,  Xinpei Cai ,  Eda Y. Canales ,  Weng K. Chang ,  Gregory F. Chin ,  Henok H. Kinfe ,  Scott E. Lazerwith ,  Jessica L. McKinley ,  Michael R. Mish ,  Devan Naduthambi ,  Jason K. Perry ,  Kevin X. Rodriguez ,  Scott D. Schroeder ,  Christopher J. Swank ,  Joshua J. Van Veldhuizen

IPC: C07D495/04 ,  A61P31/14 ,  C07D401/04 ,  C07D401/14 ,  C07D405/14 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04 ,  C07D487/04 ,  C07D487/10 ,  C07D491/107 ,  C07D491/113 ,  C07D498/04 ,  C07D513/04 ,  C07D519/00

CPC classification number: C07D495/04 ,  A61P31/14 ,  C07D401/04 ,  C07D401/14 ,  C07D405/14 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04 ,  C07D487/04 ,  C07D487/10 ,  C07D491/107 ,  C07D491/113 ,  C07D498/04 ,  C07D513/04 ,  C07D519/00

Abstract: The present disclosure relates to compounds of Formula I:




and pharmaceutically acceptable salts thereof, pharmaceutical compositions thereof, useful in the treatment of treating viral infections, for example, coronaviridae infections.