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1.发明申请Mammalian EPO mimetic CH1 deleted mimetibodies, compositions, methods and uses 有权哺乳动物EPO模拟CH1缺失的模拟物，组合物，方法和用途公开(公告)号：US20050191301A1
公开(公告)日：2005-09-01
申请号：US10609783
申请日：2003-06-30
申请人： George Heavner , David Knight , John Ghrayeb , Bernard Scallon , Thomas Nesspor , Karen Kutoloski
发明人： George Heavner , David Knight , John Ghrayeb , Bernard Scallon , Thomas Nesspor , Karen Kutoloski
IPC分类号： C12N15/09 , A61K38/00 , A61K38/22 , A61K38/55 , A61K39/395 , A61K45/00 , A61K47/42 , A61K47/48 , A61K48/00 , A61K49/00 , A61P1/00 , A61P1/02 , A61P1/16 , A61P3/00 , A61P5/00 , A61P5/02 , A61P7/00 , A61P7/02 , A61P7/06 , A61P9/00 , A61P11/00 , A61P13/12 , A61P15/00 , A61P17/00 , A61P19/00 , A61P19/02 , A61P21/00 , A61P25/00 , A61P27/02 , A61P27/16 , A61P31/00 , A61P31/20 , A61P35/00 , A61P37/00 , A61P37/06 , A61P37/08 , A61P39/02 , A61P43/00 , C07H21/04 , C07K16/00 , C07K16/28 , C07K16/42 , C07K19/00 , C12N5/10 , C12P21/08 , C12Q1/68
CPC分类号： C07K16/00 , A61K38/00 , C07K16/2863 , C07K2317/52 , C07K2317/53 , C07K2317/74 , C07K2317/75 , C07K2319/30
摘要： The present invention relates to at least one novel human EPO mimetic CH1 deleted mimetibody or specified portion or variant, including isolated nucleic acids that encode at least one EPO mimetic CH1 deleted mimetibody or specified portion or variant, CH1 deleted mimetibody or specified portion or variants, vectors, host cells, transgenic animals or plants, and methods of making and using thereof, including therapeutic compositions, methods and devices.
摘要翻译： 本发明涉及至少一种新的人EPO模拟CH1缺失的模拟体或特定部分或变体，包括编码至少一种EPO模拟CH1缺失的模拟体或特定部分或变体，CH1缺失的模拟体或特定部分或变体的分离的核酸， 载体，宿主细胞，转基因动物或植物，以及其制备和使用方法，包括治疗组合物，方法和装置。
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公开(公告)号：US20060127404A1
公开(公告)日：2006-06-15
申请号：US10953613
申请日：2004-09-29
申请人： ChiChi Huang , George Heavner , David Knight , John Ghrayeb , Bernard Scallon , Thomas Nesspor
发明人： ChiChi Huang , George Heavner , David Knight , John Ghrayeb , Bernard Scallon , Thomas Nesspor
IPC分类号： A61K39/395 , C07K16/44
CPC分类号： C04B35/632 , C07D235/18 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/12 , C07K16/00 , C07K2317/50 , C07K2317/53 , C07K2318/10
摘要： The present invention relates to at least one novel human hinge core mimetibody or specified portion or variant, including isolated nucleic acids that encode at least one hinge core mimetibody or specified portion or variant, hinge core mimetibody or specified portion or variants, vectors, host cells, transgenic animals or plants, and methods of making and using thereof, including therapeutic compositions, methods and devices.
摘要翻译： 本发明涉及至少一种新的人铰链核心模拟体或特定部分或变体，包括编码至少一个铰链核心模拟体或特定部分或变体，铰链核心模拟体或指定部分或变体，载体，宿主细胞的分离核酸 ，转基因动物或植物，及其制备和使用方法，包括治疗组合物，方法和装置。
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3.发明申请Human EPO mimetic hinge core mimetibodies, compositions, methods and uses 有权人类EPO模拟铰链核心模拟物，组合物，方法和用途公开(公告)号：US20060051844A1
公开(公告)日：2006-03-09
申请号：US10935005
申请日：2004-09-03
申请人： George Heavner , David Knight , John Ghrayeb , Bernard Scallon , Thomas Nesspor , Chichi Huang
发明人： George Heavner , David Knight , John Ghrayeb , Bernard Scallon , Thomas Nesspor , Chichi Huang
IPC分类号： C07H21/04 , C12P21/04 , C07K14/505
CPC分类号： C07K14/505 , Y10S435/972
摘要： The present invention relates to at least one novel human EPO mimetic hinge core mimetibody or specified portion or variant, including isolated nucleic acids that encode at least one EPO mimetic hinge core mimetibody or specified portion or variant, EPO mimetic hinge core mimetibody or specified portion or variants, vectors, host cells, transgenic animals or plants, and methods of making and using thereof, including therapeutic compositions, methods and devices.
摘要翻译： 本发明涉及至少一种新的人EPO模拟铰链核心模拟体或特定部分或变体，包括编码至少一个EPO模拟铰链核心模拟体或特定部分或变体的分离的核酸，EPO模拟铰链核心模拟体或特定部分或 变体，载体，宿主细胞，转基因动物或植物，以及其制备和使用方法，包括治疗组合物，方法和装置。
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4.发明申请Methods and compositions for treating renal cell carcinoma related pathologies 审中-公开用于治疗肾细胞癌相关病理的方法和组合物公开(公告)号：US20060246070A1
公开(公告)日：2006-11-02
申请号：US11241269
申请日：2005-09-30
IPC分类号： A61K39/395 , A61K38/17
CPC分类号： C07K16/241 , A61K2039/505 , C07K2317/14 , C07K2317/565
摘要： The present invention relates to methods for treating at least one renal cell carcinoma related condition or pathology, including therapeutic compositions, methods and devices, using TNF antagonists.
摘要翻译： 本发明涉及使用TNF拮抗剂治疗至少一种肾细胞癌相关病症或病理学的方法，包括治疗组合物，方法和装置。
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5.发明授权公开(公告)号：US08329170B2
公开(公告)日：2012-12-11
申请号：US13299831
申请日：2011-11-18
申请人： Jill Giles-Komar , George Heavner , David Knight , Jinquan Luo , David Peritt , Bernard Scallon , David Shealy
发明人： Jill Giles-Komar , George Heavner , David Knight , Jinquan Luo , David Peritt , Bernard Scallon , David Shealy
IPC分类号： A61K39/395
CPC分类号： C07K16/244 , A61K31/137 , A61K31/56 , A61K38/27 , A61K39/3955 , A61K45/06 , A61K51/00 , A61K2039/505 , C07K14/54 , C07K14/5434 , C07K2317/14 , C07K2317/21 , C07K2317/34 , C07K2317/55 , C07K2317/76 , C12Q1/6876
摘要： An anti-IL-12 antibody that binds to a portion of the IL-12 protein corresponding to at least one amino acid residue selected from the group consisting of residues 15, 17-21, 23, 40-43, 45-47, 54-56 and 58-62 of the amino acid sequence of the p40 subunit of IL-12, including isolated nucleic acids that encode at least one anti-IL-12 antibody, vectors, host cells, transgenic animals or plants, and methods of making and using thereof have applications in treating IL-12-related disorders, such as psoriasis.
摘要翻译： 结合IL-12蛋白的一部分对应于至少一个氨基酸残基的抗IL-12抗体，其选自残基15,17-21,23,40-43,45-47,54 -56和58-62的IL-12的p40亚基的氨基酸序列，包括编码至少一种抗IL-12抗体，载体，宿主细胞，转基因动物或植物的分离的核酸，以及制备方法 并且其用途可用于治疗诸如银屑病的IL-12相关疾病。
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6.发明申请公开(公告)号：US20120207670A1
公开(公告)日：2012-08-16
申请号：US13299831
申请日：2011-11-18
申请人： Jill Giles-Komar , George Heavner , David Knight , Jinquan Luo , David Peritt , Bernard Scallon , David Shealy
发明人： Jill Giles-Komar , George Heavner , David Knight , Jinquan Luo , David Peritt , Bernard Scallon , David Shealy
IPC分类号： A61K39/395 , A61P29/00 , A61P23/00 , A61P37/00 , A61P37/04 , A61P5/00 , A61P37/06 , A61P23/02 , A61K51/00 , A61P21/00 , A61P21/02 , A61P25/20 , A61P17/06 , A61P31/00
CPC分类号： C07K16/244 , A61K31/137 , A61K31/56 , A61K38/27 , A61K39/3955 , A61K45/06 , A61K51/00 , A61K2039/505 , C07K14/54 , C07K14/5434 , C07K2317/14 , C07K2317/21 , C07K2317/34 , C07K2317/55 , C07K2317/76 , C12Q1/6876
摘要： An anti-IL-12 antibody that binds to a portion of the IL-12 protein corresponding to at least one amino acid residue selected from the group consisting of residues 15, 17-21, 23, 40-43, 45-47, 54-56 and 58-62 of the amino acid sequence of the p40 subunit of IL-12, including isolated nucleic acids that encode at least one anti-IL-12 antibody, vectors, host cells, transgenic animals or plants, and methods of making and using thereof have applications in treating IL-12-related disorders, such as psoriasis.
摘要翻译： 结合IL-12蛋白的一部分对应于至少一个氨基酸残基的抗IL-12抗体，其选自残基15,17-21,23,40-43,45-47,54 -56和58-62的IL-12的p40亚基的氨基酸序列，包括编码至少一种抗IL-12抗体，载体，宿主细胞，转基因动物或植物的分离的核酸，以及制备方法 并且其用途可用于治疗诸如银屑病的IL-12相关疾病。
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公开(公告)号：US20090202549A1
公开(公告)日：2009-08-13
申请号：US11722312
申请日：2005-12-20
申请人： Jill Giles-Komar , George Heavner , David Knight , Jinquan Luo , David Peritt , Bernard Scallon , David Shealy
发明人： Jill Giles-Komar , George Heavner , David Knight , Jinquan Luo , David Peritt , Bernard Scallon , David Shealy
IPC分类号： A61K39/395 , G01N33/53 , C12P21/04 , C12N5/10 , C12N5/02 , C12N15/63 , C07K16/24 , C07H21/04
CPC分类号： C07K16/244 , A61K31/137 , A61K31/56 , A61K38/27 , A61K39/3955 , A61K45/06 , A61K51/00 , A61K2039/505 , C07K14/54 , C07K14/5434 , C07K2317/14 , C07K2317/21 , C07K2317/34 , C07K2317/55 , C07K2317/76 , C12Q1/6876
摘要： An anti-IL-12 antibody that binds to a portion of the IL-12 protein corresponding to at least one amino acid residue selected from the group consisting of residues 15, 17-21, 23, 40-43, 45-47, 54-56 and 58-62 of the amino acid sequence of the p40 subunit of IL-12, including isolated nucleic acids that encode at least one anti-IL-12 antibody, vectors, host cells, transgenic animals or plants, and methods of making and using thereof have applications in diagnostic and/or therapeutic compositions, methods and devices.
摘要翻译： 结合IL-12蛋白的一部分对应于至少一个氨基酸残基的抗IL-12抗体，其选自残基15,17-21,23,40-43,45-47,54 -56和58-62的IL-12的p40亚基的氨基酸序列，包括编码至少一种抗IL-12抗体，载体，宿主细胞，转基因动物或植物的分离的核酸，以及制备方法 并且其使用在诊断和/或治疗组合物，方法和装置中具有应用。
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公开(公告)号：US20070003548A1
公开(公告)日：2007-01-04
申请号：US11180219
申请日：2005-07-13
CPC分类号： C07K16/241 , A61K2039/505 , C07K2317/21 , C07K2317/56 , C07K2317/565 , C07K2317/76 , Y02A50/412
摘要： The present invention relates to at least one novel anti-TNF antibodies, including isolated nucleic acids that encode at least one anti-TNF antibody, TNF, vectors, host cells, transgenic animals or plants, and methods of making and using thereof, including therapeutic compositions, methods and devices.
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9.发明申请公开(公告)号：US20070160606A1
公开(公告)日：2007-07-12
申请号：US11240275
申请日：2005-09-30
IPC分类号： A61K39/395 , A61K38/19 , A61K38/17
CPC分类号： C07K16/241 , A61K2039/505 , C07K2317/21 , C07K2317/92
摘要： The present invention relates to at least one novel anti-TNF antibody, including isolated nucleic acids that encode at least one anti-TNF antibody, TNF, vectors, host cells, transgenic animals or plants, and methods of making and using thereof, including therapeutic compositions, methods and devices, including the treatment of renal cell carcinoma.
摘要翻译： 本发明涉及至少一种新的抗TNF抗体，包括编码至少一种抗TNF抗体，TNF，载体，宿主细胞，转基因动物或植物的分离核酸及其制备和使用方法，包括治疗 组合物，方法和装置，包括治疗肾细胞癌。
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公开(公告)号：US20050123541A1
公开(公告)日：2005-06-09
申请号：US10954900
申请日：2004-09-30
IPC分类号： C12N15/09 , A61K20060101 , A61K31/7088 , A61K35/76 , A61K38/00 , A61K39/00 , A61K39/395 , A61K45/00 , A61K48/00 , A61P20060101 , A61P35/00 , A61P37/00 , A61P43/00 , C07K20060101 , C07K16/24 , C07K16/42 , C12N20060101 , C12N5/10 , C12N15/13 , C12P21/08 , G01N20060101 , A61K31/573 , A61K31/473 , A61K31/137
CPC分类号： C07K16/241 , A61K2039/505 , C07K2317/21 , C07K2317/56 , C07K2317/565 , C07K2317/76 , Y02A50/412
摘要： The present invention relates to methods for treating carcinomas or adenocarcinomas using at least one anti-TNF antibody.
摘要翻译： 本发明涉及使用至少一种抗TNF抗体治疗癌或腺癌的方法。
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