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公开(公告)号：US20210322991A1
公开(公告)日：2021-10-21
申请号：US17268971
申请日：2018-12-13
发明人： Diane HAMMERSTAD , Alexander GOVYADINOV , Brian J. KEEFE , Erik D. TORNIAINEN , Tyler COCHELL , Pavel KORNILOVICH
摘要： A rapid thermal cycling device can include a static microfluidic reaction chamber that can be defined between a layered substrate and a cover that can have an average space therebetween from 4 μm to 150 μm. The layered substrate can include a heating element thermally coupled to the static microfluidic reaction chamber to heat a fluid when present therein. The layered substrate, the cover, or both can include a heat diffusing material thermally coupled to the static microfluidic reaction chamber to diffuse heat out from the fluid while remaining in the static microfluidic reaction chamber.
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公开(公告)号：US20230381723A1
公开(公告)日：2023-11-30
申请号：US17826943
申请日：2022-05-27
发明人： Carson Denison , Richard W. SEAVER , Erik D. TORNIAINEN , Pavel KORNILOVICH , Alexander GOVYADINOV , Anand Samuel JEBAKUMAR , Oumnia EL FAJRI
IPC分类号： B01F33/3012 , B01F35/71
CPC分类号： B01F33/3012 , B01F35/7172 , B01F2101/2204
摘要： An example microfluidic mixer can include an inlet microfluidic channel portion and a fluid splitting channel portion including an overpass microfluidic channel to receive fluid from a first side of the inlet microfluidic channel portion and an underpass microfluidic channel to receive fluid from a second side of the inlet microfluidic channel portion, where the underpass microfluidic channel extends under the overpass microfluidic channel such that the channels overlap at their respective downstream ends. A fluid recombining channel portion is downstream of the fluid splitting portion and includes an angled recombining surface having an acute angle with respect to a direction of fluid flow, where the angled recombining surface is between the downstream ends of the overpass and underpass microfluidic channels. An outlet microfluidic channel portion is fluidly connected downstream from the fluid recombining channel portion.
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公开(公告)号：US20200368750A1
公开(公告)日：2020-11-26
申请号：US16768881
申请日：2018-10-03
摘要： A fluid thermal processing device may include a substrate, a platform projecting from the substrate, a fluid heating element supported by the platform, a temperature sensing element, distinct from the fluid heating element, supported by the platform and an enclosure supported by and cooperating with the substrate to form a fluid chamber about the platform. The fluid chamber forms a volume of uniform thickness conforming to and about the platform.
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公开(公告)号：US20240082839A1
公开(公告)日：2024-03-14
申请号：US18272792
申请日：2021-01-22
发明人： Carson DENISON , Erik D. TORNIAINEN , Richard W. SEAVER , Pavel KORNILOVICH , Alexander GOVYADINOV , Anand Samuel JEBAKUMAR
IPC分类号： B01L3/00
CPC分类号： B01L3/502746 , B01L2200/0642 , B01L2200/0684 , B01L2300/0848 , B01L2300/0874 , B01L2400/086
摘要： A microfluidic device includes a chamber having sidewalls, a floor, a ceiling, and an inlet. The microfluidic device includes pillars extending from the floor to the ceiling of the chamber. Each pillar has an orientation relative to the inlet defined by a leading surface and a trailing corner opposite the leading corner. The trailing corner has an angle less than a threshold angle that is based on a fluidic contact angle. The orientations of the pillars relative to the inlet promote fluid flow from the inlet throughout the chamber without trapping gas at the sidewalls of the chamber.
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公开(公告)号：US20200030760A1
公开(公告)日：2020-01-30
申请号：US16300975
申请日：2016-07-06
摘要： One example provides a microfluidic mixing device that includes a main fluidic channel to provide main fluidic channel flow and a number of I-shaped secondary channels extending outwardly from a portion of the main fluidic channel. A number of inertial pumps are located within the I-shaped secondary channels to create serpentine flows in the direction of the main fluidic channel flow or create vorticity-inducing counterflow in the main fluidic channel.
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公开(公告)号：US20190151846A1
公开(公告)日：2019-05-23
申请号：US16099246
申请日：2016-07-12
IPC分类号： B01L3/00
摘要： A microfluidic bead-packing method includes activating a first micropump to transfer active microbeads through an inlet microchannel from a bead suspension reservoir to an adsorbing channel; packing the microbeads in the adsorbing channel; and activating a second micropump to reverse flow through at least a portion of the inlet microchannel and to transfer a sample fluid through the inlet microchannel from a sample reservoir to the adsorbing channel such that the sample fluid interacts with the packed microbeads.
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公开(公告)号：US20230330675A1
公开(公告)日：2023-10-19
申请号：US17721724
申请日：2022-04-15
发明人： Oumnia El Fajri , Richard W. SEAVER , Erik D. TORNIAINEN , Anand Samuel JEBAKUMAR , Pavel KORNILOVICH , Alexander GOVYADINOV , Carson DENISON
IPC分类号： B01L3/00
CPC分类号： B01L3/502784 , B01L2300/0874 , B01L2300/0887 , B01L2400/0406
摘要： An example microfluidic structure can include a first microfluidic channel segment in a first elevation plane, a second microfluidic channel segment in a second elevation plane, and a transverse microfluidic channel segment connecting the first microfluidic channel segment to the second microfluidic channel segment. An interior pillar can be positioned at the transverse microfluidic channel segment. The interior pillar can have a tapered downstream edge. The tapered downstream edge can be angled in the first or second elevation plane at an acute angle. A fluid cross-sectional area can increase in the fluid flow direction along the tapered downstream edge.
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公开(公告)号：US20190299169A1
公开(公告)日：2019-10-03
申请号：US16316896
申请日：2016-10-21
发明人： Erik D. TORNIAINEN , Alexander N. GOVYADINOV , Pavel KORNILOVICH , David P. MARKEL , Richard W. SEAVER
摘要： An immiscible droplet generation system may include a chip, a microfluidic channel integrated into the chip, an input to the microfluidic channel through which the microfluidic channel is to be filled with a first fluid that is to be moved through the microfluidic channel and a droplet generator. The droplet generator is integrated into the chip to generate a droplet of a second fluid, immiscible within the first fluid, and to inject the droplet into the first fluid in the microfluidic channel.
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公开(公告)号：US20190176111A1
公开(公告)日：2019-06-13
申请号：US16300182
申请日：2016-07-08
摘要： Examples include microfluidic devices. Example microfluidic devices comprise a first microfluidic channel, a second microfluidic channel, and microfluidic output channel fluidly coupled to the first microfluidic channel and the second microfluidic channel via a fluid junction. The example device comprises a fluid actuator disposed in the microfluidic output channel to actuate to thereby pump a first fluid and a second fluid into the microfluidic output channel.
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公开(公告)号：US20190143327A1
公开(公告)日：2019-05-16
申请号：US16300115
申请日：2016-07-15
IPC分类号： B01L3/00
摘要： A microfluidic filtering system may include a first microfluidic channel, a first pump to move fluid along the first microfluidic channel in a first direction, a second microfluidic channel, a second pump to move fluid along the second microfluidic channel in a second direction opposite to the first direction and a filter channel extending between and interconnecting the first microfluidic channel and the second microfluidic channel.
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