公开(公告)号：US5728540A

公开(公告)日：1998-03-17

申请号：US468670

申请日：1995-06-06

Applicant: Herve Perron ,  Tomas Dobransky ,  Fran.cedilla.ois Rieger ,  Bernard Mandrand

Inventor： Herve Perron ,  Tomas Dobransky ,  Fran.cedilla.ois Rieger ,  Bernard Mandrand

IPC: G01N33/53 ,  A61K38/00 ,  C07K1/18 ,  C07K14/47 ,  C12Q1/02 ,  G01N33/50 ,  G01N33/566 ,  C12Q1/37 ,  C12N5/00 ,  C12Q1/04 ,  G01N33/567

CPC classification number: C07K14/4713 ,  G01N33/5091 ,  A61K38/00 ,  Y10S424/16 ,  Y10S435/964 ,  Y10S436/827 ,  Y10S436/828

Abstract: Gliotoxic factor in the isolated or purified state, characterized in that it possesses toxic activity with respect to human or animal astrocytic cells, having the effect of a cytomorphological disorganization of their network of intermediate filaments and/or a degradation of the proteins of said intermediate filaments and/or cell death, in particular by apoptosis.

公开(公告)号：US20110243962A1

公开(公告)日：2011-10-06

申请号：US12997486

申请日：2009-07-08

Applicant: Corinne Bernard ,  Alois Bernhardt Lang ,  Herve Perron ,  Jean-Baptiste Bertrand

Inventor： Corinne Bernard ,  Alois Bernhardt Lang ,  Herve Perron ,  Jean-Baptiste Bertrand

IPC: A61K39/42 ,  C07K16/10 ,  C07H21/04 ,  A61P37/04 ,  A61P31/12 ,  A61P25/00 ,  A61P25/18 ,  A61P17/06 ,  A61P35/00 ,  A61P3/10 ,  C12N15/63 ,  C12P21/02 ,  G01N33/566 ,  C12N5/10

CPC classification number: C07K16/1036 ,  A61K2039/505 ,  C07K2317/24 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/92

Abstract: The present invention deals with a ligand comprising each of the complementary-determining regions (CDRs) set forth in SEQ ID No. 1, SEQ ID No. 2, SEQ ID No. 3 SEQ ID No. 4, SEQ ID No. 5 and SEQ ID No. 6 or sequence having either number of substituted aminoacids within said sequences as indicated in the following, from 0 to 3 in CDR1(SEQ ID No. 1), from 0 to 2 in CDR2(SEQ ID No. 2), from 0 to 2 in CDR3(SEQ ID No. 3), from 0 to 1 in CDR4(SEQ ID No. 4), from 0 to 4 in CDR5(SEQ ID No. 5), from 0 to 2 in CDR6(SEQ ID No. 6), or aminoacids substituted with other aminoacids having equivalent chemical functions and properties, within said sequences SEQ ID No. 1 to SEQ ID No. 6.

Abstract translation: 本发明涉及包含SEQ ID No.1，SEQ ID No.2，SEQ ID No.3，SEQ ID No.4，SEQ ID No.5所示的每个互补决定区（CDR）和 SEQ ID No.6或在所述序列中具有任意数目的取代氨基酸的序列，如下所示，CDR1（SEQ ID No.1）中为0至3，CDR2（SEQ ID No.2）为0至2， 在CDR3（SEQ ID No.3）中为0至2，CDR4（SEQ ID No.4）为0至1，CDR5（SEQ ID No.5）为0至4，CDR6（SEQ ID NO：0）为0至2 SEQ ID NO：6），或在所述序列SEQ ID No.1至SEQ ID No.6内具有等同化学功能和性质的其它氨基酸取代的氨基酸。

公开(公告)号：US07771927B1

公开(公告)日：2010-08-10

申请号：US09319156

申请日：1998-07-07

Applicant: Glaucia Paranhos-Baccala ,  Florence Komurian-Pradel ,  Frederic Bedin ,  Mireille Sodoyer ,  Catherine Ott ,  Francois Mallet ,  Herve Perron ,  Bernard Mandrand

Inventor： Glaucia Paranhos-Baccala ,  Florence Komurian-Pradel ,  Frederic Bedin ,  Mireille Sodoyer ,  Catherine Ott ,  Francois Mallet ,  Herve Perron ,  Bernard Mandrand

IPC: C12Q1/70 ,  C07H21/04 ,  A61K39/21

CPC classification number: C07K14/4713 ,  C07K14/005 ,  C12N2740/10022

Abstract: The invention concerns a nucleic material, in isolated or purified state, and a nucleotide fragment comprising a nucleotide sequence selected from the group consisting in (i) the sequences SEQ ID NO: 112, SEQ ID NO:114, SEQ ID NO: 117, SEQ ID NO: 120, SEQ ID NO. 124, SEQ ID NO: 130, SEQ ID NO: 141 and SEQ ID NO: 142, (ii) the complementary sequences of sequences (i); and (iii) the sequences equivalent to sequences (ii) and (iii), in particular the sequence having for every series of 100 contiguous monomers, at least 50%, preferably 70% homology with sequences (i) and (ii) respectively. The invention also concerns their uses for detecting a retrovirus associated with multiple sclerosis and/or rheumatoid arthritis.

Abstract translation: 本发明涉及分离或纯化状态的核酸，以及包含选自（i）序列SEQ ID NO：112，SEQ ID NO：114，SEQ ID NO：117， SEQ ID NO：120，SEQ ID NO： 124，SEQ ID NO：130，SEQ ID NO：141和SEQ ID NO：142，（ii）序列（i）的互补序列; 和（iii）与序列（ii）和（iii）相当的序列，特别是具有每100个连续单体的序列的序列，分别与序列（i）和（ii）具有至少50％，优选70％的同源性。 本发明还涉及其用于检测与多发性硬化和/或类风湿性关节炎相关的逆转录病毒的用途。

公开(公告)号：US07674888B2

公开(公告)日：2010-03-09

申请号：US11581030

申请日：2006-10-16

Applicant: Herve Perron ,  Frederic Beseme ,  Frederic Bedin ,  Glaucia Paranhos-Baccala ,  Florence Komurian-Pradel ,  Colette Jolivet-Reynaud ,  Bernard Mandrand ,  Jeremy Alexander Garson ,  Philip William Tuke

Inventor： Herve Perron ,  Frederic Beseme ,  Frederic Bedin ,  Glaucia Paranhos-Baccala ,  Florence Komurian-Pradel ,  Colette Jolivet-Reynaud ,  Bernard Mandrand ,  Jeremy Alexander Garson ,  Philip William Tuke

IPC: C07H21/02

CPC classification number: C07K14/005 ,  A61K38/00 ,  C12N7/00 ,  C12N9/1241 ,  C12N2740/10022 ,  C12N2740/10051 ,  C12Q1/702

Abstract: The invention provides viral material and nucleotide fragments associated with multiple sclerosis and/or rheumatoid arthritis for use in method of diagnosis, prophylaxis, and therapy.

Abstract translation: 本发明提供了用于诊断，预防和治疗方法的与多发性硬化和/或类风湿性关节炎有关的病毒物质和核苷酸片段。

公开(公告)号：US07666420B2

公开(公告)日：2010-02-23

申请号：US10586742

申请日：2005-01-24

Applicant: Patrice Marche ,  Alexandre Rolland ,  Evelyne Jouvin-Marche ,  Herve Perron

Inventor： Patrice Marche ,  Alexandre Rolland ,  Evelyne Jouvin-Marche ,  Herve Perron

IPC: A61K39/395 ,  A61K39/42 ,  C07K16/00 ,  C07K16/08 ,  C12P21/08

CPC classification number: C07K16/28 ,  A61K2039/505 ,  C07K16/1036

Abstract: The inventive composition comprises at least one type of antibody selected in a group (i) of anti-Env-SU MSRV/HERV-W antibodies or in a group of anti-TLR4 antibodies specifically linkable with the soluble fraction of an Env protein of MSRV/HERV-W or to a TLR4 receptor of the soluble fraction of the Env protein of MSRV/HERV-W.

Abstract translation: 本发明的组合物包含选自抗-Env-SU MSRV / HERV-W抗体组（i）中的至少一种类型的抗体或与MSRV的Env蛋白的可溶性部分特异性连接的一组抗TLR4抗体 / HERV-W或MSRV / HERV-W的Env蛋白的可溶性级分的TLR4受体。

公开(公告)号：US20080176256A1

公开(公告)日：2008-07-24

申请号：US10583891

申请日：2005-01-19

Applicant: Anna Benscik-Reynier ,  Anthony William Coleman ,  Eric Da Silva ,  Marilyne Dupin ,  Edwige Leclere ,  Ambroise Martin ,  Aly Moussa ,  Herve Perron ,  Frederic Ronzon

Inventor： Anna Benscik-Reynier ,  Anthony William Coleman ,  Eric Da Silva ,  Marilyne Dupin ,  Edwige Leclere ,  Ambroise Martin ,  Aly Moussa ,  Herve Perron ,  Frederic Ronzon

IPC: G01N33/00

CPC classification number: G01N33/6896 ,  G01N2800/2828

Abstract: The invention relates to a method for detecting PrP in a biological human or animal sample that may contain PrP. The inventive method is characterised in that it uses a molecule containing at least one positive charge and/or at least one osidic bond and a ligand other than a proteinic ligand selected from macrocyclic ligands and glycosaminoglycanes.

Abstract translation: 本发明涉及用于检测可能含有PrP的生物人或动物样品中的PrP的方法。 本发明的方法的特征在于，其使用含有至少一个正电荷和/或至少一个奥斯卡的分子和除了选自大环配体和糖胺聚糖的蛋白质配体之外的配体。

公开(公告)号：US20060088820A1

公开(公告)日：2006-04-27

申请号：US11261673

申请日：2005-10-31

Applicant: Herve Perron ,  Monique Lafon

Inventor： Herve Perron ,  Monique Lafon

IPC: C12Q1/70 ,  C12Q1/68

CPC classification number: G01N33/5047 ,  G01N33/5008 ,  G01N33/5023 ,  G01N33/5091 ,  G01N33/564 ,  G01N33/56977 ,  G01N33/6893 ,  G01N2510/00

Abstract: Multiple sclerosis or a condition associated with multiple sclerosis is detected by detecting an amount of lymphocytes bearing a Vβ16, Vβ17 or Vβ7 determinant and calculating an amount of expansion or loss of these lymphocytes.

Abstract translation: 通过检测携带Vbeta16，Vbeta17或Vbeta7决定簇的淋巴细胞的量并计算这些淋巴细胞的扩增或损失量来检测多发性硬化或与多发性硬化相关的病症。

公开(公告)号：US06270953B1

公开(公告)日：2001-08-07

申请号：US09202118

申请日：1999-03-29

Applicant: Carine Malcus-Vocanson ,  Herve Perron ,  Bernard Mandrand

Inventor： Carine Malcus-Vocanson ,  Herve Perron ,  Bernard Mandrand

IPC: C12Q100

CPC classification number: G01N33/564 ,  G01N33/5014 ,  G01N33/6896

Abstract: The invention proposes a method for detecting and/or quantifying, in a biological sample, a cytotoxic factor, in particular a gliotoxic factor, with respect to adherent target cells, in particular macroglial cells, the toxicity of which causes the death by apoptosis of said cells. The method comprises providing an initial fraction of the sample, optionally enriched with the toxic factor by previous treatment, incubating the initial toxic factor with a reference culture medium comprising adherent target cells, and detecting and/or quantifying in the adherent target cells killed by apoptosis, by flow cytometry, at least one direct or indirect characteristic associated with the apoptotic adherent cells of the whole or part of the incubated medium, which, if it is present and/or is quantified, qualifies the sample as positive, i.e. as containing said toxic factor. The initial biological sample is preferably a urine specimen.

Abstract translation: 本发明提出了一种用于在生物样品中检测和/或定量细胞毒性因子，特别是胶质毒性因子的方法，所述细胞毒性因子涉及粘附的靶细胞，特别是大胶质细胞，其毒性导致所述 细胞。 该方法包括提供样品的初始级分，任选地通过先前的处理富集毒性因子，将初始毒性因子与包含贴壁靶细胞的参照培养基孵育，并在凋亡死亡的贴壁靶细胞中检测和/或定量 通过流式细胞术，与整个或部分培养的培养基的凋亡贴壁细胞相关联的至少一个直接或间接特征，如果存在和/或定量，则将样品鉴定为阳性，即含有所述 毒性因素。 初始生物样品优选为尿样。

公开(公告)号：US5876954A

公开(公告)日：1999-03-02

申请号：US389164

申请日：1995-02-15

Applicant: Herve Perron ,  Tomas Dobransky ,  Fran.cedilla.ois Rieger ,  Bernard Mandrand

Inventor： Herve Perron ,  Tomas Dobransky ,  Fran.cedilla.ois Rieger ,  Bernard Mandrand

IPC: G01N33/53 ,  A61K38/00 ,  C07K1/18 ,  C07K14/47 ,  C12Q1/02 ,  G01N33/50 ,  G01N33/566 ,  C12Q1/37 ,  C12Q1/00 ,  C12Q1/34

CPC classification number: C07K14/4713 ,  G01N33/5091 ,  A61K38/00 ,  Y10S424/16 ,  Y10S435/964 ,  Y10S436/827 ,  Y10S436/828

Abstract: Gliotoxic factor in the isolated or purified state, characterized in that it possesses toxic activity with respect to human or animal astrocytic cells, having the effect of a cytomorphological disorganization of their network of intermediate filaments and/or a degradation of the proteins of said intermediate filaments and/or cell death, in particular by apoptosis.

Abstract translation: 分离或纯化状态下的胶质毒性因子，其特征在于其对人或动物星形细胞细胞具有毒性活性，具有其中间丝的网络的细胞形态学紊乱和/或所述中间丝的蛋白质降解的作用 和/或细胞死亡，特别是凋亡。

公开(公告)号：US20090286269A1

公开(公告)日：2009-11-19

申请号：US12457535

申请日：2009-06-15

Applicant: Anna Benscik-Reynier ,  Anthony William Coleman ,  Eric Da Silva ,  Marilyne Dupin ,  Edwige Leclere ,  Ambroise Martin ,  Aly Moussa ,  Herve Perron ,  Frederic Ronzon

Inventor： Anna Benscik-Reynier ,  Anthony William Coleman ,  Eric Da Silva ,  Marilyne Dupin ,  Edwige Leclere ,  Ambroise Martin ,  Aly Moussa ,  Herve Perron ,  Frederic Ronzon

IPC: C12Q1/48 ,  G01N33/68 ,  G01N33/566

CPC classification number: G01N33/6896 ,  G01N2800/2828

Abstract: A method for detecting PrP in a biological human or animal sample that may contain said PrP. The method is characterized in that it uses a molecule containing at least one positive charge and/or at least one glycosidic bond and a ligand other than a protein ligand selected from macrocyclic ligands and glycosaminoglycans.

Abstract translation: 用于检测可能含有所述PrP的生物人或动物样品中PrP的方法。 该方法的特征在于其使用含有至少一个正电荷和/或至少一个糖苷键的分子和除了选自大环配体和糖胺聚糖的蛋白质配体之外的配体。