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43 条记录 (耗时 0.049 秒)

    Apparatus and method for securing ocular tissue
    1.
    发明申请
    Apparatus and method for securing ocular tissue 失效
    用于固定眼组织的装置和方法

    公开(公告)号：US20080091224A1

    公开(公告)日：2008-04-17

    申请号：US11827444

    申请日：2007-07-11

    申请人： Jack Griffis ,  Mark Cox ,  Douglas Williamson ,  Gene Zdenek ,  Peter Richardson ,  Michael Smolek ,  Barrie Soloway ,  Rex Bare ,  Andrew Scherer ,  Timothy Payne

    发明人： Jack Griffis ,  Mark Cox ,  Douglas Williamson ,  Gene Zdenek ,  Peter Richardson ,  Michael Smolek ,  Barrie Soloway ,  Rex Bare ,  Andrew Scherer ,  Timothy Payne

    IPC分类号： A61F9/007

    CPC分类号： A61F9/007 ,  A61B17/0231 ,  A61B17/30 ,  A61B2017/306 ,  A61B2017/308 ,  A61F2/14 ,  A61F9/013

    摘要： Various ocular fixation devices are disclosed. One ocular fixation device includes first and second rings, where at least one of the rings includes means for fixating ocular tissue of an eye. The means for fixating are arranged to grasp the ocular tissue of the eye and to release the ocular tissue of the eye based on rotation of at least one of the first and second rings. The ocular fixation device may also include one or more structures on which a surgical tool can be mounted on the ocular fixation device at one or more locations. For instance, a dome of the ocular fixation device could include one or more holes that are configured to receive one or more projections from the surgical tool. As another example, a base of the ocular fixation device could include one or more notches configured to receive a projection from the surgical tool.

    摘要翻译： 公开了各种眼睛固定装置。 一种眼睛固定装置包括第一和第二环，其中至少一个环包括用于固定眼睛的眼组织的装置。 用于固定的装置布置成抓住眼睛的眼组织并且基于第一和第二环中的至少一个的旋转来释放眼睛的眼组织。 眼睛固定装置还可以包括一个或多个结构，外科手术工具可以在其上一个或多个位置安装在眼睛固定装置上。 例如，眼睛固定装置的圆顶可以包括被配置为从外科手术工具接收一个或多个突起的一个或多个孔。 作为另一示例，眼睛固定装置的基底可以包括被配置为从外科手术工具接收突出物的一个或多个凹口。

    Scleral prosthesis for treating presbyopia and other eye disorders and related devices and methods
    2.
    发明申请
    Scleral prosthesis for treating presbyopia and other eye disorders and related devices and methods 有权
    用于治疗老花眼和其他眼睛疾病的巩膜假体及相关装置和方法

    公开(公告)号：US20080091266A1

    公开(公告)日：2008-04-17

    申请号：US11827382

    申请日：2007-07-11

    申请人： Jack Griffis ,  Mark Cox ,  Douglas Williamson ,  Gene Zdenek ,  Peter Richardson ,  Michael Smolek ,  Barrie Soloway ,  Rex Bare ,  Andrew Scherer ,  Timothy Payne

    发明人： Jack Griffis ,  Mark Cox ,  Douglas Williamson ,  Gene Zdenek ,  Peter Richardson ,  Michael Smolek ,  Barrie Soloway ,  Rex Bare ,  Andrew Scherer ,  Timothy Payne

    IPC分类号： A61F2/14

    CPC分类号： A61F2/147 ,  A61F2/148 ,  A61F2210/0023

    摘要： One example scleral prosthesis includes a first free end and a second free end, each wider than a middle portion of the scleral prosthesis. Multiple first portions form the first end of the scleral prosthesis. The first portions are separated along at least half of a length of the scleral prosthesis. Multiple second portions may form the second end of the scleral prosthesis, and the second portions may be separated along less than a quarter of the length of the scleral prosthesis. An implantation device can be used to facilitate implantation of a scleral prosthesis. The implantation device includes a first end portion configured to be inserted into a scleral tunnel of an eye. The implantation device also includes a second end portion configured to receive the scleral prosthesis. A rod with a tapered and rounded end can be partially inserted into the first end portion of the implantation device.

    摘要翻译： 一个例子是巩膜假体包括第一自由端和第二自由端，每个宽度大于巩膜假体的中间部分。 多个第一部分形成巩膜假体的第一端。 第一部分沿巩膜假体长度的至少一半分开。 多个第二部分可以形成巩膜假体的第二端，并且第二部分可以沿着巩膜假体的长度的小于四分之一分开。 可以使用植入装置来促进巩膜假体的植入。 植入装置包括构造成插入到眼睛的巩膜隧道中的第一端部。 植入装置还包括构造成接收巩膜假体的第二端部。 具有锥形和圆形端的杆可以部分地插入植入装置的第一端部。

    Use of adenosine receptor agonists in therapy
    5.
    发明申请
    Use of adenosine receptor agonists in therapy 失效
    腺苷受体激动剂在治疗中的应用

    公开(公告)号：US20060234975A1

    公开(公告)日：2006-10-19

    申请号：US10547454

    申请日：2004-03-05

    申请人： Peter Richardson

    发明人： Peter Richardson

    IPC分类号： A61K31/7076

    CPC分类号： A61K31/7076 ,  Y02A50/411

    摘要： Use of compounds of formula: (I) wherein R is C1-4 alkoxy and X is H or OH; for the prevention, treatment, or amelioration of cancer, inflammation, auto-immune disease, ischemia-reperfusion injury, epilepsy, sepsis, septic shock, neurode-generation (including Alzheimer's Disease), muscle fatigue or muscle cramp is described. The compounds are effective at very low doses, and so can be administered at doses at which serious side effects are not observed.

    摘要翻译： 使用式（I）的化合物，其中R是C 1-4烷氧基，X是H或OH; 描述了预防，治疗或改善癌症，炎症，自身免疫疾病，缺血再灌注损伤，癫痫，败血症，败血症休克，神经发生（包括阿尔茨海默病），肌肉疲劳或肌肉抽筋的预防，治疗或改善。 这些化合物在非常低的剂量下是有效的，因此可以在没有观察到严重副作用的剂量下给药。

    Ventilator system
    6.
    发明授权
    Ventilator system 失效
    呼吸机系统

    公开(公告)号：US5752506A

    公开(公告)日：1998-05-19

    申请号：US700840

    申请日：1996-08-21

    申请人： Peter Richardson

    发明人： Peter Richardson

    IPC分类号： A61M16/00 ,  A61M16/04 ,  A61M16/08 ,  A61H31/00

    CPC分类号： A61M16/0463 ,  A61M16/0096 ,  A61M16/0858 ,  A61M2016/0027

    摘要： A ventilation system for use in ventilating a patient includes a source of pressurized gas, a primary delivery conduit to communicate and transmit the pressurized gas, an endotracheal tube for insertion into the patient's mouth and throat, and an adapter. The adapter includes a first side aperture and a second side aperture, coupled between the primary delivery conduit and the endotracheal tube for communication pressurized gas therebetween. A pressure detector is connected to the first side aperture to detect and generate signals reflective of the pressure of gas in the adapter. An indicator associated with the pressure detector receives the signals and visually displays an indication of the detected pressure of the gas in the adapter. The second side aperture receives and communicates pulses of pressurized gas from the source of pressurized gas to the endotracheal tube. The side apertures are connected to channels that angle toward the second part. The adapter may be formed from a separate base and top joined together. A source of lung therapy material may also be included in the system.

    摘要翻译： 用于通气患者的通气系统包括加压气体源，用于连通和传送加压气体的主要输送导管，用于插入患者口腔和喉部的气管插管，以及适配器。 适配器包括第一侧孔和第二侧孔，联接在主输送导管和气管内管之间，用于在其间连通加压气体。 压力检测器连接到第一侧孔以检测并产生反映适配器中气体压力的信号。 与压力检测器相关联的指示器接收信号并且在视觉上显示检测到的适配器中气体压力的指示。 第二侧孔口将加压气体的脉冲从加压气体源传送到气管内管。 侧孔连接到与第二部分成角度的通道。 适配器可以由连接在一起的单独的基座和顶部形成。 肺部治疗材料的来源也可能包括在系统中。

    Broad-band, low frequency, high-amplitude, long time duration, oscillating airway pressure breathing apparatus and method utilizing bubbles
    9.
    发明授权
    Broad-band, low frequency, high-amplitude, long time duration, oscillating airway pressure breathing apparatus and method utilizing bubbles 有权
    宽带，低频，高振幅，长时间，振荡气道呼吸器和利用气泡的方法

    公开(公告)号：US08381723B2

    公开(公告)日：2013-02-26

    申请号：US12899323

    申请日：2010-10-06

    申请人： Robert M. DiBlasi ,  Jay C. Zignego ,  Thomas N. Hansen ,  Charles V. Smith ,  Peter Richardson

    发明人： Robert M. DiBlasi ,  Jay C. Zignego ,  Thomas N. Hansen ,  Charles V. Smith ,  Peter Richardson

    IPC分类号： A62B7/00 ,  A62B9/00

    CPC分类号： A61M16/0006 ,  A61M16/021 ,  A61M16/04 ,  A61M16/0465 ,  A61M16/06 ,  A61M16/0666 ,  A61M16/1045 ,  A61M16/202 ,  A61M16/204 ,  A61M16/205 ,  A61M16/208 ,  A61M16/209 ,  A61M2016/003 ,  A61M2202/0208 ,  A61M2202/0225 ,  A61M2202/025 ,  A61M2202/0266 ,  A61M2205/3331 ,  A61M2205/3348 ,  A61M2205/3365 ,  A61M2205/50 ,  A61M2205/70

    摘要： It has been discovered that high amplitude, low frequency, broadband spectrum pressure oscillations of sufficient time duration can help stabilize lung volumes and improve gas exchange in a patient receiving ventilation assistance by helping to recruit and stabilize alveoli. A novel device is presented which can produce pressure oscillations having high amplitudes, a low broad-band frequency spectrum and long time duration. Additionally, the device can maintain a patient's mean airway pressure at one or more controlled levels. The device can control the oscillatory amplitude, frequency range and composition, time duration, and mean airway pressure levels by adjusting certain device parameters, such as the angle and depth of the device in a fluid. A device and mechanical system for remotely adjusting and measuring the angle of the device in a fluid are also disclosed. Furthermore, a device and system are disclosed that can deliver pressure oscillations having high amplitudes, a low broad-band frequency spectrum, long time duration, and multiple mean airway inspiratory and expiratory pressure levels. The device and system also provide means for controlling respiration timing in a patient, including: breaths per minute, inspiratory time, and the ratio of inspiratory to expiratory time.

    摘要翻译： 已经发现，具有足够持续时间的高振幅，低频，宽带频谱压力振荡可以帮助稳定肺容积并通过帮助招募和稳定肺泡来改善患者接受通气辅助的气体交换。 提出了一种可以产生具有高幅度，低宽带频谱和长时间持续时间的压力振荡的新型装置。 另外，该装置可以将患者的平均气道压力维持在一个或多个受控水平。 该设备可以通过调整某些设备参数（例如流体中的设备的角度和深度）来控制振荡幅度，频率范围和组成，持续时间和平均气道压力水平。 还公开了用于远程调节和测量流体中装置的角度的装置和机械系统。 此外，公开了一种可以提供具有高幅度，低宽带频谱，长时间持续时间和多个平均气道吸气和呼气压力水平的压力振荡的装置和系统。 该装置和系统还提供用于控制患者呼吸时间的装置，包括：每分钟呼吸，吸气时间以及吸气与呼气时间的比例。

    Method of preventing adverse effects by GLP-1
    10.
    发明授权
    Method of preventing adverse effects by GLP-1 有权
    预防GLP-1不良反应的方法

    公开(公告)号：US08377869B2

    公开(公告)日：2013-02-19

    申请号：US12258340

    申请日：2008-10-24

    申请人： Peter Richardson ,  Robert A. Baughman ,  Donald Costello

    发明人： Peter Richardson ,  Robert A. Baughman ,  Donald Costello

    IPC分类号： A61K38/26 ,  A61K38/00

    CPC分类号： A61K45/06 ,  A61K31/495 ,  A61K38/26 ,  A61K38/28 ,  A61M15/00 ,  A61K2300/00

    摘要： A method for preventing or reducing adverse effects such as profuse sweating, nausea and vomiting, which normally are associated with subcutaneous and intravenous administration of glucagon-like peptide 1 (GLP-1) therapy is provided. In particular, the method comprises the rapid administration of a GLP-1 formulation into the pulmonary circulation such as by inhalation, directly into pulmonary alveolar capillaries using a dry powder drug delivery system.

    摘要翻译： 提供了通常与皮下和静脉内施用胰高血糖素样肽1（GLP-1）治疗相关的预防或减少诸如大量出汗，恶心和呕吐的不良反应的方法。 特别地，该方法包括使用干粉药物递送系统将GLP-1制剂快速施用于肺循环，例如通过吸入，直接进入肺泡毛细血管。