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公开(公告)号：US20100093689A1
公开(公告)日：2010-04-15
申请号：US12619702
申请日：2009-11-17
申请人： James C. Sutton , Zulan Pi , Rejean Ruel , Alexandre L'Heureux , Carl Thibeault , Patrick Y.S. Lam
发明人： James C. Sutton , Zulan Pi , Rejean Ruel , Alexandre L'Heureux , Carl Thibeault , Patrick Y.S. Lam
IPC分类号： A61K31/4439 , C07D417/12 , C07D417/14 , C07D413/12 , C07D487/04 , C07D513/04 , A61K31/4545 , A61K31/496 , A61K31/444 , A61K31/4985 , A61K31/437
CPC分类号： C07D213/74 , C07D213/75 , C07D213/80 , C07D277/42 , C07D277/56 , C07D401/12 , C07D401/14 , C07D405/14 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D487/04 , C07D513/04
摘要： The present invention provides novel heteroaryl compounds and analogues thereof, which are selective inhibitors of the human P2Y1 receptor. The invention also provides for various pharmaceutical compositions of the same and methods for treating diseases responsive to modulation of P2Y1 receptor activity.
摘要翻译： 本发明提供了新的杂芳基化合物及其类似物，它们是人P2Y1受体的选择性抑制剂。 本发明还提供了相同的各种药物组合物以及治疗对P2Y1受体活性调节作用的疾病的方法。
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公开(公告)号：US08273772B2
公开(公告)日：2012-09-25
申请号：US12619702
申请日：2009-11-17
申请人： James C. Sutton , Zulan Pi , Rejean Ruel , Alexandre L'Heureux , Carl Thibeault , Patrick Y. S. Lam
发明人： James C. Sutton , Zulan Pi , Rejean Ruel , Alexandre L'Heureux , Carl Thibeault , Patrick Y. S. Lam
IPC分类号： A61K31/4436 , C07D417/12
CPC分类号： C07D213/74 , C07D213/75 , C07D213/80 , C07D277/42 , C07D277/56 , C07D401/12 , C07D401/14 , C07D405/14 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D487/04 , C07D513/04
摘要： The present invention provides novel heteroaryl compounds and analogues thereof, which are selective inhibitors of the human P2Y1 receptor. The invention also provides for various pharmaceutical compositions of the same and methods for treating diseases responsive to modulation of P2Y1 receptor activity.
摘要翻译： 本发明提供了新的杂芳基化合物及其类似物，它们是人P2Y1受体的选择性抑制剂。 本发明还提供了相同的各种药物组合物以及治疗对P2Y1受体活性调节作用的疾病的方法。
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公开(公告)号：US20060173002A1
公开(公告)日：2006-08-03
申请号：US11333050
申请日：2006-01-17
申请人： James Sutton , Zulan Pi , Rejean Ruel , Alexandre L'Heureux , Carl Thibeault , Patrick Lam
发明人： James Sutton , Zulan Pi , Rejean Ruel , Alexandre L'Heureux , Carl Thibeault , Patrick Lam
IPC分类号： A61K31/498 , A61K31/4745 , A61K31/43 , A61K31/428
CPC分类号： C07D213/74 , C07D213/75 , C07D213/80 , C07D277/42 , C07D277/56 , C07D401/12 , C07D401/14 , C07D405/14 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D487/04 , C07D513/04
摘要： The present invention provides novel heteroaryl compounds and analogues thereof, which are selective inhibitors of the human P2Y1 receptor. The invention also provides for various pharmaceutical compositions of the same and methods for treating diseases responsive to modulation of P2Y1 receptor activity.
摘要翻译： 本发明提供了新的杂芳基化合物及其类似物，它们是人P2Y 1受体的选择性抑制剂。 本发明还提供了相同的各种药物组合物以及治疗对P2Y受体活性的调节作用的疾病的方法。
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公开(公告)号：US07645778B2
公开(公告)日：2010-01-12
申请号：US11333050
申请日：2006-01-17
申请人： James C. Sutton , Zulan Pi , Rejean Ruel , Alexandre L'Heureux , Carl Thibault , Patrick Y. S. Lam
发明人： James C. Sutton , Zulan Pi , Rejean Ruel , Alexandre L'Heureux , Carl Thibault , Patrick Y. S. Lam
IPC分类号： A61K31/4436 , C07D417/12
CPC分类号： C07D213/74 , C07D213/75 , C07D213/80 , C07D277/42 , C07D277/56 , C07D401/12 , C07D401/14 , C07D405/14 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D487/04 , C07D513/04
摘要： The present invention provides novel heteroaryl compounds and analogues thereof, which are selective inhibitors of the human P2Y1 receptor. The invention also provides for various pharmaceutical compositions of the same and methods for treating diseases responsive to modulation of P2Y1 receptor activity.
摘要翻译： 本发明提供了新的杂芳基化合物及其类似物，它们是人P2Y1受体的选择性抑制剂。 本发明还提供了相同的各种药物组合物以及治疗对P2Y1受体活性调节作用的疾病的方法。
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5.发明授权Urea antagonists of P2Y1receptor useful in the treatment of thrombotic conditions 有权P2Y1受体的尿素拮抗剂可用于治疗血栓形成公开(公告)号：US07674828B2
公开(公告)日：2010-03-09
申请号：US12117005
申请日：2008-05-08
申请人： Hannguang J. Chao , Huji Tuerdi , Timothy F. Herpin , Jacques Y. Roberge , Yalei Liu , Michael R. Lawrence , Robert P. Rehfuss , Charles G. Clark , Jennifer X. Qiao , Timur Gungor , Patrick Y. S. Lam , Tammy C. Wang , Rejean Ruel , Alexandre L'Heureux , Carl Thibeault , Gilles Bouthillier , Dora M. Schnur
发明人： Hannguang J. Chao , Huji Tuerdi , Timothy F. Herpin , Jacques Y. Roberge , Yalei Liu , Michael R. Lawrence , Robert P. Rehfuss , Charles G. Clark , Jennifer X. Qiao , Timur Gungor , Patrick Y. S. Lam , Tammy C. Wang , Rejean Ruel , Alexandre L'Heureux , Carl Thibeault , Gilles Bouthillier , Dora M. Schnur
IPC分类号： A61K31/155 , C07C275/28
CPC分类号： C07D409/14 , C07C275/30 , C07C275/32 , C07D213/40 , C07D213/75 , C07D213/89 , C07D231/40 , C07D231/50 , C07D237/22 , C07D333/36 , C07D401/12 , C07D401/14 , C07D405/12 , C07D405/14 , C07D409/12 , C07D413/12 , C07D417/12 , C07F7/1804
摘要： The present invention provides novel pyridyl or phenyl ureas and analogues thereof, which are selective inhibitors of the human P2Y1 receptor. The invention also provides for various pharmaceutical compositions of the same and methods for treating diseases responsive to modulation of P2Y1 receptor activity.
摘要翻译： 本发明提供了作为人P2Y1受体的选择性抑制剂的新颖的吡啶基或苯基脲及其类似物。 本发明还提供了相同的各种药物组合物以及治疗对P2Y1受体活性调节作用的疾病的方法。
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6.发明授权Urea antagonists of P2Y1 receptor useful in the treatment of thrombotic conditions 有权P2Y1受体的尿素拮抗剂可用于治疗血栓形成公开(公告)号：US07388021B2
公开(公告)日：2008-06-17
申请号：US11126915
申请日：2005-05-10
申请人： Hannguang J. Chao , Huji Tuerdi , Timothy F. Herpin , Jacques Yves Roberge , Yalei Liu , R. Michael Lawrence , Robert P. Rehfuss , Charles G. Clark , Jennifer X. Qiao , Timur Gungor , Patrick Y. S. Lam , Tammy Wang , Rejean Ruel , Alexandre L'Heureux , Carl Thibeault , Gilles Bouthillier , Dora M. Schnur
发明人： Hannguang J. Chao , Huji Tuerdi , Timothy F. Herpin , Jacques Yves Roberge , Yalei Liu , R. Michael Lawrence , Robert P. Rehfuss , Charles G. Clark , Jennifer X. Qiao , Timur Gungor , Patrick Y. S. Lam , Tammy Wang , Rejean Ruel , Alexandre L'Heureux , Carl Thibeault , Gilles Bouthillier , Dora M. Schnur
IPC分类号： A61K31/4412 , A61K31/444 , C07D213/60 , C07D213/72
CPC分类号： C07D409/14 , C07C275/30 , C07C275/32 , C07D213/40 , C07D213/75 , C07D213/89 , C07D231/40 , C07D231/50 , C07D237/22 , C07D333/36 , C07D401/12 , C07D401/14 , C07D405/12 , C07D405/14 , C07D409/12 , C07D413/12 , C07D417/12 , C07F7/1804
摘要： The present invention provides novel pyridyl or phenyl ureas and analogues thereof, which are selective inhibitors of the human P2Y1 receptor. The invention also provides for various pharmaceutical compositions of the same and methods for treating diseases responsive to modulation of P2Y1 receptor activity.
摘要翻译： 本发明提供了新的吡啶基或苯基脲及其类似物，它们是人P2Y 1受体的选择性抑制剂。 本发明还提供了相同的各种药物组合物以及治疗对P2Y受体活性的调节作用的疾病的方法。
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7.发明申请UREA ANTAGONISTS OF P2Y1 RECEPTOR USEFUL IN THE TREATMENT OF THROMBOTIC CONDITIONS 有权P2Y1受体的尿素拮抗剂用于治疗血栓病症公开(公告)号：US20080280905A1
公开(公告)日：2008-11-13
申请号：US12117005
申请日：2008-05-08
申请人： Hannguang J. Chao , Huji Tuerdi , Timothy F. Herpin , Jaques Yves Roberge , Yalei Liu , R. Michael Lawrence , Robert P. Rehfuss , Charles G. Clark , Jennifer X. Qiao , Timur Gungor , Patrick Y. S. Lam , Tammy Wang , Rejean Ruel , Alexandre L'Heureux , Carl Thibeault , Gilles Bouthillier , Dora M. Schnur
发明人： Hannguang J. Chao , Huji Tuerdi , Timothy F. Herpin , Jaques Yves Roberge , Yalei Liu , R. Michael Lawrence , Robert P. Rehfuss , Charles G. Clark , Jennifer X. Qiao , Timur Gungor , Patrick Y. S. Lam , Tammy Wang , Rejean Ruel , Alexandre L'Heureux , Carl Thibeault , Gilles Bouthillier , Dora M. Schnur
IPC分类号： A61K31/5377 , C07D213/72 , C07D413/12 , A61K31/4412 , A61K31/4439 , A61K31/4709 , A61P7/00 , A61P9/00 , A61K31/4725 , A61K31/444 , A61K31/4545 , A61K31/496 , C07D401/12
CPC分类号： C07D409/14 , C07C275/30 , C07C275/32 , C07D213/40 , C07D213/75 , C07D213/89 , C07D231/40 , C07D231/50 , C07D237/22 , C07D333/36 , C07D401/12 , C07D401/14 , C07D405/12 , C07D405/14 , C07D409/12 , C07D413/12 , C07D417/12 , C07F7/1804
摘要： The present invention provides novel pyridyl or phenyl ureas and analogues thereof, which are selective inhibitors of the human P2Y1 receptor. The invention also provides for various pharmaceutical compositions of the same and methods for treating diseases responsive to modulation of P2Y1 receptor activity.
摘要翻译： 本发明提供了新的吡啶基或苯基脲及其类似物，它们是人P2Y 1受体的选择性抑制剂。 本发明还提供了相同的各种药物组合物以及治疗对P2Y受体活性的调节作用的疾病的方法。
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8.发明申请Urea antagonists of P2Y1 receptor useful in the treatment of thrombotic conditions 有权P2Y1受体的尿素拮抗剂可用于治疗血栓形成公开(公告)号：US20050267119A1
公开(公告)日：2005-12-01
申请号：US11126915
申请日：2005-05-11
申请人： Hannguang Chao , Huji Tuerdi , Timothy Herpin , Jacques Roberge , Yalei Liu , R. Lawrence , Robert Rehfuss , Charles Clark , Jennifer Qiao , Timur Gungor , Patrick Lam , Tammy Wang , Rejean Ruel , Alexandre L'Heureux , Carl Thibeault , Gilles Bouthillier , Dora Schnur
发明人： Hannguang Chao , Huji Tuerdi , Timothy Herpin , Jacques Roberge , Yalei Liu , R. Lawrence , Robert Rehfuss , Charles Clark , Jennifer Qiao , Timur Gungor , Patrick Lam , Tammy Wang , Rejean Ruel , Alexandre L'Heureux , Carl Thibeault , Gilles Bouthillier , Dora Schnur
IPC分类号： A61K31/4439 , A61K31/444 , A61K31/501 , C07C275/30 , C07C275/32 , C07D213/40 , C07D213/75 , C07D213/89 , C07D231/40 , C07D231/50 , C07D237/22 , C07D333/36 , C07D401/12 , C07D401/14 , C07D405/12 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/12 , C07D417/12 , C07F7/18 , C07D43/02 , C07D41/02
CPC分类号： C07D409/14 , C07C275/30 , C07C275/32 , C07D213/40 , C07D213/75 , C07D213/89 , C07D231/40 , C07D231/50 , C07D237/22 , C07D333/36 , C07D401/12 , C07D401/14 , C07D405/12 , C07D405/14 , C07D409/12 , C07D413/12 , C07D417/12 , C07F7/1804
摘要： The present invention provides novel pyridyl or phenyl ureas and analogues thereof, which are selective inhibitors of the human P2Y1 receptor. The invention also provides for various pharmaceutical compositions of the same and methods for treating diseases responsive to modulation of P2Y1 receptor activity.
摘要翻译： 本发明提供了新的吡啶基或苯基脲及其类似物，它们是人P2Y 1受体的选择性抑制剂。 本发明还提供了相同的各种药物组合物以及治疗对P2Y受体活性的调节作用的疾病的方法。
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公开(公告)号：US20060058304A1
公开(公告)日：2006-03-16
申请号：US11214267
申请日：2005-08-29
申请人： Rajeev Bhide , Rejean Ruel , Carl Thibault , Alexandre L'Heureux
发明人： Rajeev Bhide , Rejean Ruel , Carl Thibault , Alexandre L'Heureux
IPC分类号： A61K31/53 , C07D487/04
CPC分类号： C07D487/04 , A61K31/53 , A61K45/06 , A61K2300/00
摘要： The present invention provides compounds of formula I, and pharmaceutically acceptable salts thereof. The formula I compounds inhibit the tyrosine kinase activity of growth factor receptors such as VEGFR-2 and FGFR-1, thereby making them useful as anti-cancer agents. The formula I compounds are also useful for the treatment of other diseases associated with signal transduction pathways operating through growth factor receptors.
摘要翻译： 本发明提供式I化合物，
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公开(公告)号：US06969717B2
公开(公告)日：2005-11-29
申请号：US10622593
申请日：2003-07-18
IPC分类号： A61K31/53 , A61K31/5377 , A61K31/541 , A61K31/662 , A61K45/00 , A61K45/06 , A61P1/04 , A61P1/16 , A61P3/04 , A61P3/10 , A61P7/06 , A61P9/00 , A61P9/06 , A61P9/08 , A61P9/10 , A61P11/00 , A61P11/06 , A61P13/08 , A61P13/10 , A61P13/12 , A61P15/00 , A61P17/00 , A61P17/02 , A61P17/06 , A61P19/00 , A61P19/02 , A61P19/10 , A61P21/04 , A61P25/00 , A61P25/02 , A61P25/16 , A61P25/28 , A61P27/02 , A61P27/16 , A61P29/00 , A61P31/10 , A61P31/12 , A61P31/18 , A61P31/22 , A61P35/00 , A61P35/02 , A61P35/04 , A61P37/00 , A61P37/02 , A61P37/04 , A61P37/06 , A61P43/00 , C07D487/02 , C07D487/04 , C07F9/6561 , C07D484/04
CPC分类号： C07D487/04 , A61K31/53 , A61K45/06 , A61K2300/00
摘要： The present invention provides compounds of formula I, and pharmaceutically acceptable salts thereof. The formula I compounds inhibit the tyrosine kinase activity of growth factor receptors such as VEGFR-2 and FGFR-1, thereby making them useful as anti-cancer agents. The formula I compounds are also useful for the treatment of other diseases associated with signal transduction pathways operating through growth factor receptors.
摘要翻译： 本发明提供式I化合物及其药学上可接受的盐。 式I化合物抑制生长因子受体如VEGFR-2和FGFR-1的酪氨酸激酶活性，从而使其成为抗癌剂。 式I化合物还可用于治疗与通过生长因子受体操作的信号转导途径相关的其它疾病。
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