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    CYCLIC PEPTIDE INHIBITORS OF HEDGEHOG PROTEINS
    4.
    发明申请
    CYCLIC PEPTIDE INHIBITORS OF HEDGEHOG PROTEINS 审中-公开

    公开(公告)号：US20190241615A1

    公开(公告)日：2019-08-08

    申请号：US16311598

    申请日：2017-06-21

    申请人： Rudi Fasan ,  Andrew Owens

    发明人： Rudi Fasan ,  Andrew Owens

    IPC分类号： C07K7/08

    CPC分类号： C07K7/08 ,  C07K7/06 ,  C07K7/50

    摘要： Cyclic peptide compounds are provided that can bind to one or more homologs of Hedghehog signaling proteins and block their interaction with the Patched receptor. These compounds are useful for suppressing Hedgehog-dependent stimulation of the Hedgehog pathway in cells and in living organisms. Methods for using the cyclic peptide compounds, and compositions comprising them, for treatment of cancers and other diseases which are characterized by aberrant Hedgehog-dependent activation of the Hedgehog pathway and/or which can benefit from chemical suppression of Hedgehog-dependent signaling are also disclosed.

    Inhibitors of Akt activity
    6.
    发明申请
    Inhibitors of Akt activity 失效
    Akt活性抑制剂

    公开(公告)号：US20060030564A1

    公开(公告)日：2006-02-09

    申请号：US11234784

    申请日：2005-09-23

    申请人： Andrew Owens ,  Stanley Barnett

    发明人： Andrew Owens ,  Stanley Barnett

    IPC分类号： A61K31/503 ,  C07D487/04

    CPC分类号： C07D487/04 ,  A61K31/5025

    摘要： The present invention is directed to compounds comprising a triazolo[4,3-b]pyridazine moiety which inhibit the activity of Akt, a serine/threonine protein kinase. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for treating cancer comprising administration of the compounds of the invention.

    摘要翻译： 本发明涉及包含抑制Akt（丝氨酸/苏氨酸蛋白激酶）活性的三唑并[4,3-b]哒嗪部分的化合物。 本发明还涉及含有本发明化合物的治疗组合物和治疗癌症的方法，包括施用本发明化合物。

    Baking Pan for Shaping Cakes and Method of Using It
    7.
    发明申请
    Baking Pan for Shaping Cakes and Method of Using It 审中-公开

    公开(公告)号：US20170367352A1

    公开(公告)日：2017-12-28

    申请号：US15193869

    申请日：2016-06-27

    申请人： Andrew Owens

    发明人： Andrew Owens

    IPC分类号： A21B3/13 ,  A47J37/01

    CPC分类号： A47J37/01 ,  A21B3/132 ,  A21B3/135 ,  A21D8/06 ,  A21D13/47

    摘要： A baking pan for baking cup cakes that includes a base baking pan with baking units having a size and dimension and a top baking pan with baking units having a different size and dimension. The base baking pan and the top baking pan couple and align together and when coupled and aligned produce a first cup cake having a shape of a cup and a second cup cake having a shape of a cylinder. As such, the cup cakes are baked in two separate pieces producing a bottom cup shaped cup cake and a top cylinder shaped cup cake.