摘要:
A compound of the formula (I): wherein: R1 is chlorine, difluoromethyl, trifluoromethyl or cyano; and R2is a group having the formula: wherein: X is halogen, cyano, nitro or amino; Y1 is lower alkyl or lower alkoxy; and Z is halogen; or a pharmaceutically acceptable salt thereof.
摘要翻译:式(I)的化合物:其中:R1是氯,二氟甲基,三氟甲基或氰基; 并且R 2是具有下式的基团:其中:X是卤素,氰基,硝基或氨基; Y 1是低级烷基或低级烷氧基; 和Z是卤素;或其药学上可接受的盐。
摘要:
Imidazole compounds having adenosine deaminase inhibitory activity represented by the formula (I): wherein R1 is optionally substituted aryl or optionally substituted heteroaryl, R2 is lower alkyl; R3 is hydroxy or protected hydroxy; X is O or S; and -A- is lower alkylene, its prodrug, or their salt. The compounds are useful for treating and/or preventing diseases for which adenosine is effective
摘要翻译:具有由式(I)表示的腺苷脱氨酶抑制活性的咪唑化合物:其中R 1是任选取代的芳基或任选取代的杂芳基,R 2是低级烷基; R 3是羟基或被保护的羟基; X是O或S; 和-A-是低级亚烷基,其前药或其盐。 该化合物可用于治疗和/或预防腺苷有效的疾病
摘要:
Imidazole compounds having adenosine deaminase inhibitory activity represented by the formula (I) wherein R1 is aryl or heterocyclic group which is optionally substituted with substituent(s); R2 is lower alkyl; R3 is hydroxy or protected hydroxy; -A- is lower alkylene; and —X— is —O— or —S—; provided that when then R1 is aryl which is substituted with substituent(s), or heterocyclic group which is optionally substituted with substituent(s), its prodrug, or their salt. The compounds are useful for treating and/or preventing diseases for which adenosine is effective.
摘要翻译:具有由式(I)表示的腺苷脱氨酶抑制活性的咪唑化合物,其中R 1是任选被取代基取代的芳基或杂环基; R 2是低级烷基; R 3是羟基或被保护的羟基; -A-是低级亚烷基; 和-X-是-O-或-S-; 条件是当R 1是被取代基取代的芳基,或任选被取代基取代的杂环基时,其前药或其盐。 该化合物可用于治疗和/或预防腺苷有效的疾病。
摘要:
Imidazole compounds having adenosine deaminase inhibitory activity represented by the formula (I): wherein R1 is optionally substituted aryl or optionally substituted heteroaryl, R2 is lower alkyl; R3 is hydroxy or protected hydroxy; X is O or S; and -A- is lower alkylene, its prodrug, or their salt. The compounds are useful for treating and/or preventing diseases for which adenosine is effective.
摘要翻译:具有由式(I)表示的腺苷脱氨酶抑制活性的咪唑化合物:其中R 1是任选取代的芳基或任选取代的杂芳基,R 2是低级烷基; R 3是羟基或被保护的羟基; X是O或S; 和-A-是低级亚烷基,其前药或其盐。 该化合物可用于治疗和/或预防腺苷有效的疾病。
摘要:
Pieces of working information on workloads, positions of the workloads, pieces of environmental information on cooling facilities, and positions of the cooling facilities are stored as arrangement information. The pieces of working information on the workloads are estimated, and allocation of tentative workloads is deduced for fear the pieces of working information may exceed the performances of a group of information processing devices. Tentative power consumptions and arrangement information resulting from the allocation of the tentative workloads, and tentative power consumptions and arrangement information necessary for the allocation of the tentative workloads are calculated. Tentative cooling powers required to control the cooling facilities are calculated. Allocation of the tentative workloads minimizing the sum total of the tentative power consumptions of the information processing devices and the tentative cooling powers of the cooling facilities is searched. Based on the searched allocation, the workloads are allocated to the information processing devices.
摘要:
A data processor for a display device that includes a plurality of pixels, each of which includes red, first green, blue, and second green sub-pixels, may include an input gamma processor for processing image data including red, green, and blue grayscale data into linearized image data by applying a gamma function to the image data, a first sub-pixel rendering unit for rendering the linearized image data according to layout of a plurality of sub-pixels included in the plurality of pixels using a 3×1 rendering filter to output linearized second sub-pixel data, and an output gamma processor for processing the linearized second sub-pixel data into non-linearized second sub-pixel data by applying an inverse gamma function to the linearized second sub-pixel data.
摘要:
Total power consumption of information-processing devices and power supply/cooling facilities is reduced to realize energy saving operation of information-processing system. The information-processing system includes information-processing devices, power supply facilities, cooling facilities and an operations management device. The operations management device is connected to the devices and the facilities and includes layout information constituted of locations and operating information of the devices and locations and environmental information of the facilities. Also, the operations management device obtains the power consumption of the devices, the power supply loss of the power supply facilities and the cooling power of the cooling facilities by using the layout information, and then allocates the workloads to the devices so as to reduce the total sum of power consumption, supply loss and cooling power.
摘要:
There are provided a multi-layer piezoelectric element that is driven stably for a long period of time without developing cracks in a junction between a metallized layer and a lead member or a stacked body, and an injection device and a fuel injection system provided with the same. A multi-layer piezoelectric element includes a stacked body in which piezoelectric layers and internal electrodes are laminated; a metallized layer disposed on a side surface of the stacked body, the metalized layer being electrically connected to the internal electrodes; and an external electrode member disposed on the metallized layer, with an electrically-conductive adhesive layer interposed therebetween, wherein the electrically-conductive adhesive layer has a plurality of voids configured not to open on a surface thereof which surface is in contact with the metallized layer.
摘要:
Arrangements reducing power consumption of an air conditioner and a storage device. A control method with a management server apparatus for a plurality of storage devices and an air conditioner includes calculating plural combinations of allocating the work amount to the plurality of storage devices, calculating the heating value of each storage device included in the plurality of storage devices for each of the plural combinations, calculating the quantity of heat conducted to the air conditioner, based on the heating value and positional information of the plurality of storage devices and the air conditioner, calculating the power consumption to cool the quantity of heat conducted to the air conditioner, selecting a combination included in the plural combinations based on the power consumption of the air conditioner, and issuing a move of the data stored in a first storage device to a second storage device, based on the selected combination.
摘要:
There is provided an image processing apparatus having an image segmentation unit that divides image formation into image areas in a first direction, a random number memory that stores random numbers, a reference position determination unit that determines a reference position so as to vary in a second direction perpendicular to the first direction, a pixel determination unit that determines a pixel as a target to be subjected to correction processing of pixel insertion into or pixel reduction from each of the image areas, for the each of the image areas, according to the stored random numbers and the determined reference position, among pixels in the each of the image areas, and an image width change unit that performs the correction processing on the determined pixel to change an image width of the image information in the first direction.