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公开(公告)号：US20050260710A1
公开(公告)日：2005-11-24
申请号：US11092988
申请日：2005-03-30
申请人： Kazuo Suzuki , Masahiro Furutani , Kenji Yamamoto , Naohito Ohno , Kei Takahashi , Yasuaki Aratani , Akiko Togi
发明人： Kazuo Suzuki , Masahiro Furutani , Kenji Yamamoto , Naohito Ohno , Kei Takahashi , Yasuaki Aratani , Akiko Togi
CPC分类号： C07K16/00 , A61K2039/505 , C07K2317/52 , C07K2317/622 , C07K2319/00
摘要： The purpose of the present invention is to provide methods for producing recombinant polyclonal immunoglobulins using recombinant DNA techniques, which provides constant supply of immunoglobulin preparations with minimum risk of infection. A method of the present invention comprises the following steps: (1) isolating a plurality of types of genes from cDNAs derived from tissues or cells expressing immunoglobulins, said genes encoding a plurality of types of polypeptides respectively, and said polypeptides containing a plurality of types of immunoglobulin variable regions respectively, and preparing mixture of the genes; (2) preparing a plurality of types of recombinant vectors into which a plurality of types of genes are introduced respectively by contacting said mixture of the genes with vectors, and preparing mixture of the recombinant vectors; (3) preparing a plurality of types of transformants into which a plurality of types of recombinant vectors are introduced respectively by contacting said mixture of the recombinant vectors with host cells, and preparing mixture of the transformants; and (4) culturing said mixture of the transformants, and obtaining mixture of polypeptides from the transformants culture, wherein said polypeptides contain a plurality of types of immunoglobulin variable regions respectively.
摘要翻译： 本发明的目的是提供使用重组DNA技术制备重组多克隆免疫球蛋白的方法，其提供具有最小感染风险的免疫球蛋白制剂的恒定供应。 本发明的方法包括以下步骤：（1）从衍生自表达免疫球蛋白的组织或细胞的cDNA分离多种类型的基因，所述基因分别编码多种类型的多肽，所述多肽含有多种类型 的免疫球蛋白可变区，并制备基因的混合物; （2）通过将所述基因混合物与载体接触，制备多种类型的重组载体，其中分别导入多种类型的基因，并制备重组载体的混合物; （3）通过使重组载体的混合物与宿主细胞接触，制备分别引入多种类型的重组载体的多种类型的转化体，并制备转化体的混合物; （4）培养所述转化体的所述混合物，并从所述转化体培养物获得多肽的混合物，其中所述多肽分别含有多种类型的免疫球蛋白可变区。
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2.发明授权公开(公告)号：US07925484B2
公开(公告)日：2011-04-12
申请号：US10695247
申请日：2003-10-27
申请人： Wayne Dawson , Kazuo Suzuki , Kenji Yamamoto
发明人： Wayne Dawson , Kazuo Suzuki , Kenji Yamamoto
IPC分类号： G06G7/48
CPC分类号： G06F19/16
摘要： This invention is an algorithm for estimating the topology of a protein by determination of the free energy from a global entropy evaluation model combined with local correction methods.
摘要翻译： 本发明是通过从局部校正方法结合的全局熵评估模型中确定自由能来估计蛋白质拓扑的算法。
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3.发明申请公开(公告)号：US20050090991A1
公开(公告)日：2005-04-28
申请号：US10695247
申请日：2003-10-27
申请人： Wayne Dawson , Kazuo Suzuki , Kenji Yamamoto
发明人： Wayne Dawson , Kazuo Suzuki , Kenji Yamamoto
CPC分类号： G06F19/16
摘要： This invention is an algorithm for estimating the topology of a protein by determination of the free energy from a global entropy evaluation model combined with local correction methods.
摘要翻译： 本发明是通过从局部校正方法结合的全局熵评估模型中确定自由能来估计蛋白质拓扑的算法。
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公开(公告)号：US11901568B2
公开(公告)日：2024-02-13
申请号：US17653400
申请日：2022-03-03
申请人： Ryo Shimizu , Kumiko Nomura , Tomohiro Takeshita , Shu Miyasaka , Kenji Yamamoto
发明人： Ryo Shimizu , Kumiko Nomura , Tomohiro Takeshita , Shu Miyasaka , Kenji Yamamoto
CPC分类号： H01M4/926 , H01M4/8842 , C22C5/04
摘要： To provide an electrocatalyst for fuel cells, which is configured to ensure both the initial performance and durability of fuel cells. An electrocatalyst for fuel cells, wherein the electrocatalyst comprises a carbon support including a mesopore and a catalyst alloy supported on the carbon support, and the catalyst alloy is a catalyst alloy of platinum and a transition metal; wherein the mesopore includes at least one throat; wherein an average effective diameter of the at least one throat is 1.8 nm or more and less than 3.2 nm; and wherein a transition metal ratio of the catalyst alloy supported on a deeper-side region than the at least one throat, is lower than the transition metal ratio of the catalyst alloy supported on a nearer-side region than the at least one throat.
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公开(公告)号：US10050257B2
公开(公告)日：2018-08-14
申请号：US13995916
申请日：2011-12-12
摘要： An aluminum alloy foil for an electrode current collectors has a high post-drying strength after application of an active material while keeping a high electrical conductivity. The aluminum alloy foil includes 0.1 to 1.0 mass % of Fe, 0.01 to 0.5% of Si, and 0.01 to 0.2 mass % of Cu, and the rest includes Al and unavoidable impurities. The aluminum alloy foil after final cold rolling has a tensile strength of 220 MPa or higher, a 0.2% yield strength of 180 MPa or higher, and an electrical conductivity of 58% IACS or higher. The aluminum alloy foil has a tensile strength of 190 MPa or higher and a 0.2% yield strength of 160 MPa or higher after the aluminum alloy foil is heat treated at any of 120° C. for 24 hours, 140° C. for 3 hours, and 160° C. for 15 minutes.
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公开(公告)号：US10016798B2
公开(公告)日：2018-07-10
申请号：US14424582
申请日：2012-08-31
申请人： Kenji Yamamoto
发明人： Kenji Yamamoto
CPC分类号： B21B35/147 , F16D3/10 , F16D3/16 , F16D3/185 , F16D3/845 , F16D2300/06 , F16J15/525
摘要： In a gear spindle, outer cylinder gear sections (11) are each integrally formed on an inner peripheral surface of a spindle outer cylinder and inner cylinder gear sections (14) are each integrally formed on an outer peripheral surface of a spindle inner cylinder (13). An oil seal (27) that seals in the lubricating oil (20) for each of the aforementioned gear sections includes, a seal body (29) having a channel-shaped cross section and interposed in the peripheral gap between the inner peripheral surface of the spindle outer cylinder and the outer peripheral surface of the spindle inner cylinder (13), and a seal mounting member (30) that includes a band, a spring, or the like that tightens and fixes the seal body to the outer peripheral surface of the spindle inner cylinder (13) to allow expansion of the seal body in the axial direction in the aforementioned peripheral gap.
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公开(公告)号：US09902093B2
公开(公告)日：2018-02-27
申请号：US14009522
申请日：2012-04-03
申请人： Takaharu Kashi , Kenji Yamamoto
发明人： Takaharu Kashi , Kenji Yamamoto
CPC分类号： B29C33/68 , B21D37/01 , C23C14/0641 , C23C14/5886
摘要： A press-forming mold has a protective film for preventing seizing during press-forming formed on at least a forming surface that comes into contact with a formed body. The protective film is formed by PVD. An arbitrary selection section extracted from the surface of the protective film is divided into a plurality of individual sections; and, when the gradient of the surface at the nth division point is represented by (dZn/dXn), taking N to represent the number of divisions, the root-mean-square RΔq calculated by the following numerical expression is no greater than 0.032. R Δ q = 1 N ∑ n = 1 N ( d Z n d X n ) 2 It is thereby possible to improve the seizing resistance of a press-forming mold having a protective film formed by PVD.
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公开(公告)号：US09546408B2
公开(公告)日：2017-01-17
申请号：US14005853
申请日：2012-03-13
申请人： Akihiro Sakamoto , Kazuo Okamura , Kenji Yamamoto , Tomohiko Omura , Yuji Arai
发明人： Akihiro Sakamoto , Kazuo Okamura , Kenji Yamamoto , Tomohiko Omura , Yuji Arai
IPC分类号： C21D1/18 , C21D1/19 , C21D6/00 , C21D9/08 , C22C38/00 , C22C38/02 , C22C38/04 , C22C38/06 , C22C38/22 , C22C38/24 , C22C38/26 , C22C38/42 , C22C38/44 , C22C38/46 , C22C38/48 , C22C38/18 , C22C38/40 , C22C1/02
CPC分类号： C21D1/18 , C21D1/19 , C21D6/002 , C21D9/08 , C21D2221/00 , C22C1/02 , C22C38/001 , C22C38/02 , C22C38/04 , C22C38/06 , C22C38/18 , C22C38/22 , C22C38/24 , C22C38/26 , C22C38/40 , C22C38/42 , C22C38/44 , C22C38/46 , C22C38/48
摘要： A method for quenching a steel pipe by water cooling from an outer surface thereof, where pipe end portions are not subjected to water cooling, and at least part of a main body other than the pipe end portions is subjected to water cooling. A region(s) that is not subjected to direct water cooling over an entire circumference thereof can be along an axial direction at least in part of the main body other than the pipe end portions. The start and stop of water cooling can be intermittent at least in part of the quenching. During the water cooling of the pipe outer surface, an intensified water cooling can be performed in a temperature range in which the pipe outer surface temperature is higher than Ms point. Thereafter, the cooling can be switched to moderate cooling so that the outer surface is cooled down to Ms point or lower.
摘要翻译： 通过水管从其外表面进行水冷淬火的方法，其中管端部不进行水冷，至少部分管端部以外的主体进行水冷。 在其整个圆周上不经受直接水冷却的区域可以沿除了管端部以外的主体的至少一部分的轴向方向。 水冷却的开始和停止至少部分地可以是间歇性的淬火。 在管外表面的水冷却期间，可以在管外表面温度高于Ms点的温度范围内进行增强的水冷。 此后，可以将冷却切换到适度的冷却，使得外表面冷却至Ms点或更低。
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公开(公告)号：US09297061B2
公开(公告)日：2016-03-29
申请号：US12449303
申请日：2008-02-15
申请人： Takashi Kuchiyama , Kenji Yamamoto
发明人： Takashi Kuchiyama , Kenji Yamamoto
CPC分类号： C23C14/086 , C03C17/3441 , C03C2217/944 , C03C2218/365
摘要： In a transparent electroconductive film including a transparent substrate and a transparent electroconductive oxide layer disposed on the transparent substrate, when the transparent electroconductive oxide layer is composed of zinc oxide, the surface resistivity of the transparent electroconductive oxide layer increases with time and thus it has been difficult to obtain a transparent electroconductive film stable against an environmental variation. Consequently, hard carbon films are provided on the surfaces of a transparent electroconductive oxide layer including at least one layer and containing zinc oxide as a main component in “the order of transparent substrate-hard carbon film-transparent electroconductive oxide layer-hard carbon film” or “the order of hard carbon film-transparent substrate-transparent electroconductive oxide layer-hard carbon film”. Alternatively, an organosilicon compound covering layer is provided on a surface of the transparent electroconductive oxide layer. Thereby, the water contact angle can be 75 degrees or more, and an increase in the resistivity of the transparent electroconductive oxide layer can be suppressed.
摘要翻译： 在透明导电膜包括透明基板和透明导电氧化物层的透明导电膜上，当透明导电氧化物层由氧化锌组成时，透明导电氧化物层的表面电阻率随着时间的推移而增加， 难以获得对环境变化稳定的透明导电膜。 因此，在“透明基板 - 硬质碳膜透明导电氧化物层 - 硬质碳膜”的顺序，在包含至少一层并含有氧化锌作为主要成分的透明导电氧化物层的表面上设置硬质碳膜， 或“硬碳膜透明基板透明导电氧化物层 - 硬质碳膜的顺序”。 或者，在透明导电氧化物层的表面上设置有机硅化合物覆盖层。 因此，水接触角可以为75度以上，并且可以抑制透明导电氧化物层的电阻率的增加。
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10.发明授权Arc evaporation source having fast film-forming speed, coating film manufacturing method and film formation apparatus using the arc evaporation source 有权电弧蒸发源具有快速的成膜速度，涂膜制造方法和使用电弧蒸发源的成膜装置公开(公告)号：US09266180B2
公开(公告)日：2016-02-23
申请号：US13805259
申请日：2011-06-15
CPC分类号： B23K9/00 , C23C14/325 , H01J37/32055 , H01J37/3402
摘要： An arc evaporation source having fast film-forming speed includes: at least one circumference magnet surrounding the circumference of a target, wherein the magnetization direction of the magnet runs orthogonal to the target surface; a non-ring shaped first permanent magnet on the target's rear surface side has a polarity in the same direction as the circumference magnet, and is arranged so that its magnetization direction runs orthogonal to the target's surface; a non-ring shaped second permanent magnet arranged either on the rear surface side of the first permanent magnet or between the first permanent magnet and the target, so as to leave a gap from the first permanent magnet, has a polarity in the same direction as the circumference magnet, and is arranged so that its magnetization direction runs orthogonal to the surface of the target; and a magnetic body between the first permanent magnet and the second permanent magnet.
摘要翻译： 具有快速成膜速度的电弧蒸发源包括：围绕靶周围的至少一个圆周磁体，其中磁体的磁化方向正交于目标表面; 目标的背面侧的非环状的第一永久磁铁具有与周边磁体相同方向的极性，并且被配置为使其磁化方向与目标表面正交; 布置在第一永磁体的后表面侧或第一永磁体与靶之间以便与第一永久磁铁隔开间隙的非环形的第二永久磁铁的极性与 圆周磁体，并且被布置成使得其磁化方向垂直于靶的表面; 以及在第一永磁体和第二永磁体之间的磁体。
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