-
公开(公告)号：US09708286B2
公开(公告)日：2017-07-18
申请号：US14748925
申请日：2015-06-24
Applicant: LEO Laboratories Limited
Inventor： Gunnar Grue-Sørensen , Xifu Liang , Thomas Högberg , Kristoffer Månsson , Per Vedsø , Thomas Vifian
IPC: C07C271/34 , C07D333/38 , C07C271/36 , C07C271/38 , C07D249/06 , C07D261/18 , C07D277/32 , C07D295/21 , C07D309/08 , C07D401/04 , C07D471/04 , C07D495/04 , C07D265/36 , C07D271/08 , C07D277/587 , C07D295/205 , C07D307/00 , C07D307/94 , C07D405/06 , C07D513/04 , A61K31/365 , A61K31/381 , A61K31/404 , A61K31/415 , A61K31/416 , A61K31/4192 , A61K31/42 , A61K31/472 , A61K31/502 , A61K31/5375 , A61K31/538 , C07D209/42 , C07D217/26 , C07D231/14 , C07D231/56 , C07D237/28 , C07D249/04
CPC classification number: C07D261/18 , A61K31/365 , A61K31/381 , A61K31/404 , A61K31/415 , A61K31/416 , A61K31/4192 , A61K31/42 , A61K31/472 , A61K31/502 , A61K31/5375 , A61K31/538 , C07C271/34 , C07C271/36 , C07C271/38 , C07C2603/86 , C07D209/08 , C07D209/42 , C07D213/79 , C07D215/50 , C07D217/26 , C07D231/14 , C07D231/56 , C07D233/90 , C07D237/28 , C07D239/28 , C07D249/04 , C07D249/06 , C07D261/20 , C07D263/34 , C07D265/36 , C07D271/08 , C07D277/32 , C07D277/56 , C07D277/587 , C07D295/182 , C07D295/205 , C07D295/21 , C07D307/00 , C07D307/68 , C07D307/94 , C07D309/08 , C07D333/38 , C07D333/40 , C07D401/04 , C07D405/06 , C07D471/04 , C07D493/08 , C07D495/04 , C07D513/04
Abstract: The invention relates to compounds of general formula I wherein R is heteroaryl optionally substituted by R7; or R is heterocycloalkyl or heterocycloalkenyl, optionally substituted by R8; or R is X wherein X is —NR11R12; and pharmaceutically acceptable salts, hydrates, or solvates thereof, for use—alone or in combination with one or more other pharmaceutically active compounds—in therapy, for preventing, treating or ameliorating diseases or conditions responsive to stimulation of neutrophil oxidative burst, responsive to stimulation of keratinocyte IL-8 release or responsive to induction of necrosis.
-
公开(公告)号：US09676698B2
公开(公告)日：2017-06-13
申请号：US15178112
申请日：2016-06-09
Applicant: LEO Laboratories Limited
Inventor： Thomas Hogberg , Gunnar Grue-Sorensen , Xifu Liang , Anne Marie Horneman , Anders Klarskov Petersen
IPC: C07C49/00 , C07C67/00 , C07C69/00 , C07D319/00 , C07C67/08 , C07C67/297 , C07D319/08 , C07C49/753 , C07C59/90 , C07F7/18 , C07C67/14 , C07D317/70 , C07D493/08
CPC classification number: C07C67/08 , C07C49/753 , C07C59/90 , C07C67/14 , C07C67/297 , C07C2603/86 , C07C2603/98 , C07D317/70 , C07D319/08 , C07D493/08 , C07F7/1804 , Y02P20/55 , C07C69/533
Abstract: The present invention relates to methods of producing ingenol-3-angelate (I) from ingenol (II). Furthermore, the invention relates to intermediates useful for the synthesis of ingenol-3-angelate (I) from ingenol (II) and to methods of producing said intermediates.
-
公开(公告)号：US09404131B2
公开(公告)日：2016-08-02
申请号：US14341720
申请日：2014-07-25
Applicant: LEO Laboratories Limited
Inventor： Xifu Liang , Thomas Hogberg , Gunnar Grue-Sorensen , Thomas S. Moody , Andrew S. Rowan
CPC classification number: C12P7/62 , C12P15/00 , C12Y301/01003 , Y02P20/52
Abstract: The invention relates to methods for preparing ingenol-3-angelate from ingenol or ingenol derivatives.
Abstract translation: 本发明涉及由烯内酯或异山梨醇衍生物制备西叶醇-3-当归的方法。
-
4.发明申请PROCESS FOR THE PREPARATION OF INGENOL-3-ANGELATE FROM 20-DEOXY-INGENOL 有权从20-DEOXY-INGENOL制备INGENOL-3-ANGELATE的方法公开(公告)号：US20150329463A1
公开(公告)日：2015-11-19
申请号：US14415544
申请日：2013-07-11
Applicant: LEO Laboratories Limited
Inventor： Xifu Liang
IPC: C07C67/297 , C07C67/08
CPC classification number: C07C67/297 , C07C67/00 , C07C67/08 , C07C67/29 , C07C2103/98 , C07C2603/98 , C07C69/533
Abstract: The present invention provides a method for preparing ingenol-3-angelate.
Abstract translation: 本发明提供了一种制备美尼芬3-angelate的方法。
-
公开(公告)号：US20150175622A1
公开(公告)日：2015-06-25
申请号：US14409374
申请日：2013-06-21
Applicant: LEO LABORATORIES LIMITED
Inventor： Xifu Liang , Thomas Högberg , Bjarne Nørremark , Kristoffer Månsson , Carsten Ryttersgaard , Gunnar Grue-Sørensen
IPC: C07D495/04 , A61K31/505 , C07D261/20 , A61K31/423 , C07D213/64 , A61K31/44 , C07D231/56 , A61K31/416 , C07D233/70 , A61K31/4164 , C07D217/24 , A61K31/472 , A61K31/4365 , C07D491/048 , A61K31/4355 , C07D271/07 , A61K31/4245 , C07D239/34
CPC classification number: C07D495/04 , A61K8/49 , A61K8/4926 , A61K8/4946 , A61K8/4953 , A61K31/416 , A61K31/4164 , A61K31/42 , A61K31/423 , A61K31/4245 , A61K31/4355 , A61K31/4365 , A61K31/44 , A61K31/47 , A61K31/472 , A61K31/505 , A61K31/506 , A61K45/06 , A61Q19/08 , C07D213/64 , C07D213/84 , C07D215/22 , C07D217/24 , C07D231/56 , C07D233/70 , C07D239/34 , C07D261/20 , C07D271/06 , C07D271/07 , C07D491/00 , C07D491/048 , C07D495/00 , A61K2300/00
Abstract: The present invention relates to a compound according to formula (I) wherein R1 represents optionally substituted heteroaryl, and pharmaceutically acceptable salts, hydrates, solvates or pharmaceutically acceptable and physiologically cleavable esters thereof. The invention relates further to intermediates for the preparation of said compounds, to said compounds for use in therapy, to pharmaceutical compositions comprising said compounds, to methods of treating diseases, e.g. diseases associated with hyperplasia, neoplasia or dysplasia, with said compounds, to methods of treatment of cosmetic indications with said compounds, and to the use of said compounds in the manufacture of medicaments.
Abstract translation: 本发明涉及根据式（I）的化合物，其中R 1表示任选取代的杂芳基，及其药学上可接受的盐，水合物，溶剂合物或其药学上可接受的和生理上可切割的酯。 本发明进一步涉及用于制备所述化合物的中间体，用于治疗的所述化合物，包含所述化合物的药物组合物，治疗疾病的方法。 与所述化合物相关的与增生，瘤形成或发育不良相关的疾病，用所述化合物治疗化妆品适应症的方法，以及所述化合物在制备药物中的用途。
-
Patent Agency Ranking
公开(公告)号：US09624157B2
公开(公告)日：2017-04-18
申请号：US14415544
申请日：2013-07-11
Applicant: LEO Laboratories Limited
Inventor： Xifu Liang
IPC: C07C69/52 , C07C67/297 , C07C67/08 , C07C67/00 , C07C67/29
CPC classification number: C07C67/297 , C07C67/00 , C07C67/08 , C07C67/29 , C07C2103/98 , C07C2603/98 , C07C69/533
Abstract: The present invention provides a method for preparing ingenol-3-angelate.
-
公开(公告)号：US09422309B2
公开(公告)日：2016-08-23
申请号：US14409374
申请日：2013-06-21
Applicant: LEO LABORATORIES LIMITED
Inventor： Xifu Liang , Thomas Högberg , Bjarne Nørremark , Kristoffer Månsson , Carsten Ryttersgaard , Gunnar Grue-Sørensen
IPC: C07D495/04 , A61K31/4164 , A61K31/416 , A61K31/4245 , A61K31/4355 , A61K31/44 , A61K31/47 , A61K31/506 , C07D213/84 , C07D215/22 , C07D231/56 , C07D233/70 , C07D239/34 , C07D261/20 , C07D491/00 , C07D271/06 , C07D495/00 , C07D213/64 , A61K45/06 , A61K31/472 , A61K31/505 , A61K8/49 , A61K31/42 , A61K31/423 , A61K31/4365 , A61Q19/08 , C07D217/24 , C07D271/07 , C07D491/048
CPC classification number: C07D495/04 , A61K8/49 , A61K8/4926 , A61K8/4946 , A61K8/4953 , A61K31/416 , A61K31/4164 , A61K31/42 , A61K31/423 , A61K31/4245 , A61K31/4355 , A61K31/4365 , A61K31/44 , A61K31/47 , A61K31/472 , A61K31/505 , A61K31/506 , A61K45/06 , A61Q19/08 , C07D213/64 , C07D213/84 , C07D215/22 , C07D217/24 , C07D231/56 , C07D233/70 , C07D239/34 , C07D261/20 , C07D271/06 , C07D271/07 , C07D491/00 , C07D491/048 , C07D495/00 , A61K2300/00
Abstract: The present invention relates to a compound according to formula (I) wherein R1 represents optionally substituted heteroaryl, and pharmaceutically acceptable salts, hydrates, solvates or pharmaceutically acceptable and physiologically cleavable esters thereof. The invention relates further to intermediates for the preparation of said compounds, to said compounds for use in therapy, to pharmaceutical compositions comprising said compounds, to methods of treating diseases, e.g. diseases associated with hyperplasia, neoplasia or dysplasia, with said compounds, to methods of treatment of cosmetic indications with said compounds, and to the use of said compounds in the manufacture of medicaments.
Abstract translation: 本发明涉及根据式（I）的化合物，其中R 1表示任选取代的杂芳基，及其药学上可接受的盐，水合物，溶剂合物或其药学上可接受的和生理上可切割的酯。 本发明进一步涉及用于制备所述化合物的中间体，用于治疗的所述化合物，包含所述化合物的药物组合物，治疗疾病的方法。 与所述化合物相关的与增生，瘤形成或发育不良相关的疾病，用所述化合物治疗化妆品适应症的方法，以及所述化合物在制备药物中的用途。
-
公开(公告)号：US09416084B2
公开(公告)日：2016-08-16
申请号：US14557302
申请日：2014-12-01
Applicant: LEO Laboratories Limited
Inventor： Thomas Hogberg , Gunnar Grue-Sorensen , Xifu Liang , Anne Marie Horneman , Anders Klarskov Petersen
IPC: C07C49/753 , C07C59/90 , C07C67/08 , C07D319/08 , C07C67/297 , C07F7/18
CPC classification number: C07C67/08 , C07C49/753 , C07C59/90 , C07C67/14 , C07C67/297 , C07C2603/86 , C07C2603/98 , C07D317/70 , C07D319/08 , C07D493/08 , C07F7/1804 , Y02P20/55 , C07C69/533
Abstract: The present invention relates to methods of producing ingenol-3-angelate (I) from ingenol (II). Furthermore, the invention relates to intermediates useful for the synthesis of ingenol-3-angelate (I) from ingenol (II) and to methods of producing said intermediates.
Abstract translation: 本发明涉及从烯醇（II）生产西内醇-3-天竺葵酸（I）的方法。 此外，本发明涉及可用于合成来自烯醇（II）的内酯-3-通配物（I）的中间体以及制备所述中间体的方法。
-
公开(公告)号：US20150024443A1
公开(公告)日：2015-01-22
申请号：US14341720
申请日：2014-07-25
Applicant: LEO Laboratories Limited
Inventor： Xifu Liang , Thomas Hogberg , Gunnar Grue-Sorensen , Thomas S. Moody , Andrew S. Rowan
IPC: C12P7/62
CPC classification number: C12P7/62 , C12P15/00 , C12Y301/01003 , Y02P20/52
Abstract: The invention relates to methods for preparing ingenol-3-angelate from ingenol or ingenol derivatives.
Abstract translation: 本发明涉及由烯内酯或异山梨醇衍生物制备西叶醇-3-当归的方法。
-
公开(公告)号：US20160280627A1
公开(公告)日：2016-09-29
申请号：US15178112
申请日：2016-06-09
Applicant: LEO Laboratories Limited
Inventor： Thomas Hogberg , Gunnar Grue-Sorensen , Xifu Liang , Anne Marie Horneman , Anders Klarskov Petersen
IPC: C07C67/08 , C07C67/14 , C07D493/08 , C07F7/18 , C07D317/70 , C07C67/297 , C07D319/08
CPC classification number: C07C67/08 , C07C49/753 , C07C59/90 , C07C67/14 , C07C67/297 , C07C2603/86 , C07C2603/98 , C07D317/70 , C07D319/08 , C07D493/08 , C07F7/1804 , Y02P20/55 , C07C69/533
Abstract: The present invention relates to methods of producing ingenol-3-angelate (I) from ingenol (II). Furthermore, the invention relates to intermediates useful for the synthesis of ingenol-3-angelate (I) from ingenol (II) and to methods of producing said intermediates.
Abstract translation: 此外，本发明涉及可用于合成来自烯醇（II）的内酯-3-通配物（I）的中间体以及制备所述中间体的方法。
-
-
-
-
-
-
-
-
-
Search Results
11
records
(took 0.027 seconds)
