公开(公告)号：US20240226904A1

公开(公告)日：2024-07-11

申请号：US18405433

申请日：2024-01-05

Applicant: MESO SCALE TECHNOLOGIES, LLC.

Inventor： Gary I. KRIVOY ,  Cecilia ZIMMERMAN ,  Jules VANDERSARL ,  Sandor KOVACS ,  Aaron H. LEIMKUEHLER ,  Leo TABAKIN ,  Jon WILLOUGHBY ,  Manish KOCHAR ,  Charles M. CLINTON

IPC: B01L9/00

CPC classification number: B01L9/523 ,  B01L2300/0654 ,  B01L2300/0663 ,  B01L2300/0829 ,  B01L2300/168 ,  B01L2300/1844 ,  B01L2300/1894

Abstract: Apparatuses, systems, method, reagents, and kits for conducting assays as well as process for their preparation are described. The apparatuses, systems, method, reagents, and kits may be employed in conducting automated analysis in a multi-well plate assay format.

公开(公告)号：US20220244188A1

公开(公告)日：2022-08-04

申请号：US17603771

申请日：2020-04-22

Applicant: Gary I. KRIVOY ,  Cecilia ZIMMERMAN ,  Jules VANDERDARL ,  Sandor KOVACS ,  Aaron LEIMKUEHLER ,  Leo TABAKIN ,  Jon WILLOUGHBY ,  Manish KOCHAR ,  Charles M. CLINTON ,  Meso Scale Technologies, LLC.

Inventor： Gary I. KRIVOY ,  Cecilia ZIMMERMAN ,  Jules VANDERSARL ,  Sandor KOVACS ,  Aaron LEIMKUEHLER ,  Leo TABAKIN ,  Jon WILLOUGHBY ,  Manish KOCHAR ,  Charles M. CLINTON

IPC: G01N21/76 ,  G01N35/02 ,  G01N35/00

Abstract: Apparatuses, systems, method, reagents, and kits for conducting assays as well as process for their preparation ar described. They are particularly well suited for conducting automated analysis in a multi-well plate assay format. Also disclosed are systems, devices, and methods provided herein for using a CCD camera based system to generate measurements having reduced crosstalk between measurements of multiple spatially separated subjects. CCD camera based systems as provided herein use improved reference level clamping circuits configured to fully reset reference levels during CCD readout, thereby reducing a level of crosstalk between measurements.

公开(公告)号：US20240382969A1

公开(公告)日：2024-11-21

申请号：US18671149

申请日：2024-05-22

Applicant: Meso Scale Technologies, LLC.

Inventor： Eli N. GLEZER ,  Bandele JEFFREY-COKER ,  Kenneth PAGE ,  Sandor KOVACS ,  Sudeep KUMAR ,  Kristian ROTH

IPC: B01L3/00 ,  F16K11/074

Abstract: Assay cartridges are described that have a plurality of chambers and a fluidic network that includes fluidic conduits and a multi-port valve designed to selectively connect the valve inlet and one valve outlet through a fluidic connector in the valve as the remaining valve outlets are scaled.

公开(公告)号：US20210016288A1

公开(公告)日：2021-01-21

申请号：US16929757

申请日：2020-07-15

Applicant: Meso Scale Technologies, LLC.

Inventor： Gary I. KRIVOY ,  Cecilia ZIMMERMAN ,  Jules VANDERSARL ,  Sandor KOVACS ,  Aaron H. LEIMKUEHLER ,  Leo TABAKIN ,  Jon WILLOUGHBY ,  Manish KOCHAR ,  Charles M. Clinton

IPC: B01L9/00

Abstract: Apparatuses, systems, method, reagents, and kits for conducting assays as well as process for their preparation are described. The apparatuses, systems, method, reagents, and kits may be employed in conducting automated analysis in a multi-well plate assay format.

公开(公告)号：US20250012822A1

公开(公告)日：2025-01-09

申请号：US18894461

申请日：2024-09-24

Applicant: MESO SCALE TECHNOLOGIES, LLC.

Inventor： Eli N. GLEZER ,  Carl EDENS ,  Bandele JEFFREY-COKER ,  Sandor KOVACS ,  Christopher FRYE

IPC: G01N35/00 ,  B01F31/22 ,  B01F101/23 ,  B06B1/16 ,  G01N33/543 ,  G01N35/10

Abstract: The present invention relates to a system for performing assays on a solid phase to measure the level of analyte in a sample. Such a system may perform immunoassays using electrochemiluminescence (ECL) including a counterbalanced orbital shaking apparatus for assay consumables.

公开(公告)号：US20230258679A1

公开(公告)日：2023-08-17

申请号：US18003983

申请日：2021-06-30

Applicant: MESO SCALE TECHNOLOGIES, LLC.

Inventor： Pei-Ming WU ,  Sandor KOVACS

IPC: G01N35/10 ,  H04R3/00 ,  H04R1/04

CPC classification number: G01N35/1011 ,  H04R3/00 ,  H04R1/04 ,  G01N2035/1013

Abstract: Devices and methods for proximity detection based on sound are provided. According to an embodiment, an acoustic probe includes a sound generator and an acoustic sensor, and at least one of the sound generator or the acoustic sensor is disposed within the dispense chamber portion. According to an embodiment, the liquid dispenser includes a sound generator and an acoustic sensor, and further includes one or more side conduits, where at least one of the sound generator or the acoustic sensor is disposed within a cavity of a respective one of the one or more side conduits, wherein the cavity and a connector of each of the one or more side conduits are free from resonance within a frequency range of the sound sensed by the acoustic sensor.

公开(公告)号：US20220097072A1

公开(公告)日：2022-03-31

申请号：US17492207

申请日：2021-10-01

Applicant: Meso Scale Technologies, LLC.

Inventor： Eli N. GLEZER ,  Bandele JEFFREY-COKER ,  Kenneth PAGE ,  Sandor KOVACS ,  Sudeep KUMAR ,  Kristian ROTH

IPC: B01L3/00 ,  F16K11/074

Abstract: Assay cartridges are described that have a plurality of chambers and a fluidic network that includes fluidic conduits and a multi-port valve designed to selectively connect the valve inlet and one valve outlet through a fluidic connector in the valve as the remaining valve outlets are sealed.

公开(公告)号：US20240293822A1

公开(公告)日：2024-09-05

申请号：US18436879

申请日：2024-02-08

Applicant: MESO SCALE TECHNOLOGIES, LLC.

Inventor： Eli N. GLEZER ,  Stephen HIGGINS ,  Sandor KOVACS ,  Sudeep KUMAR ,  Kenneth PAGE ,  Kristian ROTH ,  George SIGAL

IPC: B01L7/00 ,  B01L3/00 ,  C12Q1/686

CPC classification number: B01L7/525 ,  B01L3/5027 ,  B01L2200/027 ,  B01L2200/0605 ,  B01L2200/0621 ,  B01L2200/0631 ,  B01L2200/10 ,  B01L2200/146 ,  B01L2200/16 ,  B01L2300/0645 ,  B01L2300/0816 ,  B01L2300/0864 ,  B01L2300/0867 ,  B01L2300/087 ,  B01L2300/0883 ,  B01L2400/0487 ,  B01L2400/0688 ,  B01L2400/0694 ,  C12Q1/686

Abstract: Assay cartridges are described that have purification, reaction, and detection zones and other fluidic components which can include sample chambers, waste chambers, conduits, vents, reagent chambers, reconstitution chambers and the like. The assay cartridges are used to conduct multiplexed nucleic acid measurements. Also described are kits including such cartridges, methods of using the same, and a reader configured to analyze an assay conducted using an assay cartridge.

公开(公告)号：US20240280786A1

公开(公告)日：2024-08-22

申请号：US18596909

申请日：2024-03-06

Applicant: MESO SCALE TECHNOLOGIES, LLC.

Inventor： Ian D. CHAMBERLIN ,  Charles M. CLINTON ,  Eli N. GLEZER ,  Bandele JEFFREY-COKER ,  Manish KOCHAR ,  Sandor KOVACS ,  D.T. LE ,  Aaron LEIMKUEHLER ,  George SIGAL ,  Leo TABAKIN ,  Jon WILLOUGHBY

IPC: G02B7/36 ,  G01N21/25 ,  G01N21/64 ,  G01N35/02

CPC classification number: G02B7/36 ,  G01N21/253 ,  G01N21/6452 ,  G01N35/028

Abstract: Apparatuses, systems, method, reagents, and kits for conducting assays as well as process for their preparation are described. They are particularly well suited for conducting automated analysis in a multi-well plate assay format.

公开(公告)号：US20220019053A1

公开(公告)日：2022-01-20

申请号：US17492187

申请日：2021-10-01

Applicant: Meso Scale Technologies, LLC.

Inventor： Ian CHAMBERLIN ,  Charles M. CLINTON ,  Eli N. GLEZER ,  Bandele JEFFREY-COKER ,  Manish KOCHAR ,  Sandor KOVACS ,  D.T. Le ,  Aaron LEIMKUEHLER ,  George SIGAL ,  Leo TABAKIN ,  Jon WILLOUGHBY

IPC: G02B7/36 ,  G01N21/25 ,  G01N21/64 ,  G01N35/02

Abstract: Apparatuses, systems, method, reagents, and kits for conducting assays as well as process for their preparation are described. They are particularly well suited for conducting automated analysis in a multi-well plate assay format.