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公开(公告)号：US11530304B2
公开(公告)日：2022-12-20
申请号：US15433566
申请日：2017-02-15
Applicant: MODERN MEADOW, INC.
Inventor： Brendan Patrick Purcell , David Thomas Williamson , Lixin Dai , Darryl Miles Cassingham , Stephen M. Spinella , Katherine Amy Congdon
IPC: B32B5/26 , D06N3/00 , D06N7/00 , C08J3/24 , D01F4/00 , D06M15/15 , B32B5/02 , B32B7/12 , B32B9/02 , B32B15/02 , B32B15/14 , B32B23/10 , B32B27/12 , B32B29/02 , B32B1/08 , B32B3/26 , D04H1/4382 , C14C13/00 , D04H13/00 , D06P3/32 , C07K14/78 , C14C9/00 , C14C9/02 , D01C3/00 , D04H1/00 , D06M15/05 , D06M23/16 , D06M101/06
Abstract: A biofabricated material comprising a network of crosslinked collagen fibrils produced from recombinant collagen that contains substantially no 3-hydroxyproline residues is disclosed. This material is composed of collagen which is also a major component of natural leather and is produced by a process of fibrillation of collagen molecules into fibrils, crosslinking the fibrils and lubricating the crosslinked fibrils. Unlike natural leathers, this biofabricated material exhibits non-anisotropic (not directionally dependent) physical properties, for example, a sheet of biofabricated material can have substantially the same elasticity or tensile strength when stretched or stressed in different directions. Unlike natural leather, it has a uniform texture that facilitates uniform uptake of dyes and coatings. Aesthetically, it produces a uniform and consistent grain for ease of manufacturability. It can have substantially identical grain, texture and other aesthetic properties on both sides distinct from natural leather where the grain increases from one side (e.g., distal surface) to the other (proximal inner layers).
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公开(公告)号：US11542374B2
公开(公告)日：2023-01-03
申请号：US15433877
申请日：2017-02-15
Applicant: MODERN MEADOW, INC.
Inventor： Brendan Patrick Purcell , David Thomas Williamson , Suzanne Lee , Amy Congdon
IPC: B32B5/26 , D06M15/15 , D06N3/00 , D06N7/00 , D04H13/00 , C08J3/24 , D01F4/00 , B32B5/02 , B32B7/12 , B32B9/02 , B32B15/02 , B32B15/14 , B32B23/10 , B32B27/12 , B32B29/02 , B32B1/08 , B32B3/26 , D04H1/4382 , C14C13/00 , D06P3/32 , C07K14/78 , C14C9/00 , C14C9/02 , D01C3/00 , D04H1/00 , D06M15/05 , D06M23/16 , D06M101/06
Abstract: The invention is directed to a composite material comprising a biofabricated material and a secondary component. The secondary component may be a porous material, such as a sheet of paper, cellulose, or fabric that has been coated or otherwise contacted with the biofabricated material. The biofabricated material comprises a uniform network of crosslinked collagen fibrils and provides strength, elasticity and an aesthetic appearance to the composite material.
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公开(公告)号：US11286354B2
公开(公告)日：2022-03-29
申请号：US15433632
申请日：2017-02-15
Applicant: MODERN MEADOW, INC.
Inventor： Brendan Patrick Purcell , David Thomas Williamson , Francoise Suzanne Marga , Susan J. Schofer , Darryl Miles Cassingham
IPC: C08J3/24 , D01F4/00 , B32B5/26 , D06M15/15 , D06N3/00 , D06N7/00 , B32B5/02 , B32B7/12 , B32B9/02 , B32B15/02 , B32B15/14 , B32B23/10 , B32B27/12 , B32B29/02 , B32B1/08 , B32B3/26 , D04H1/4382 , C14C13/00 , D04H13/00 , D06P3/32 , C07K14/78 , C14C9/00 , C14C9/02 , D01C3/00 , D04H1/00 , D06M15/05 , D06M23/16 , D06M101/06
Abstract: Described herein is a method for producing a biofabricated material from collagen or collagen-like proteins. The collagen or collagen-like proteins are isolated from animal sources or produced by recombinant DNA techniques or by chemical synthesis. The collagen or collagen-like proteins are fibrillated, crosslinked, dehydrated and lubricated thus forming the biofabricated material having a substantially uniform network of collagen fibrils.
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公开(公告)号：US11001679B2
公开(公告)日：2021-05-11
申请号：US16358299
申请日：2019-03-19
Applicant: MODERN MEADOW, INC.
Inventor： Brendan Patrick Purcell , David Thomas Williamson , Lixin Dai , Darryl Miles Cassingham , Stephen M. Spinella
IPC: D06M15/15 , C08J3/24 , D01F4/00 , B32B5/26 , D06N3/00 , D06N7/00 , B32B5/02 , B32B7/12 , B32B9/02 , B32B15/02 , B32B15/14 , B32B23/10 , B32B27/12 , B32B29/02 , B32B1/08 , B32B3/26 , C14C13/00 , D04H13/00 , D06P3/32 , C07K14/78 , C14C9/00 , C14C9/02 , D04H1/4382 , D01C3/00 , D04H1/00 , D06M15/05 , D06M23/16 , D06M101/06
Abstract: A biofabricated material containing a network of crosslinked collagen fibrils is disclosed. This material is composed of collagen which is also a major component of natural leather and is produced by a process of fibrillation of collagen molecules into fibrils, crosslinking the fibrils and lubricating the crosslinked fibrils. Unlike natural leathers, this biofabricated material exhibits non-anisotropic (not directionally dependent) physical properties, for example, a sheet of biofabricated material can have substantially the same elasticity or tensile strength when stretched or stressed in different directions. Unlike natural leather, it has a uniform texture that facilitates uniform uptake of dyes and coatings. Aesthetically, it produces a uniform and consistent grain for ease of manufacturability. It can have substantially identical grain, texture and other aesthetic properties on both sides distinct from natural leather where the grain increases from one side (e.g., distal surface) to the other (proximal inner layers).
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公开(公告)号：US10370505B2
公开(公告)日：2019-08-06
申请号：US15433693
申请日：2017-02-15
Applicant: MODERN MEADOW, INC.
Inventor： Brendan Patrick Purcell , David Thomas Williamson , Suzanne Lee , Amy Congdon
IPC: C08J3/24 , C14C13/00 , D04H13/00 , D06P3/32 , C07K14/78 , C14C9/00 , C14C9/02 , D04H1/4382 , D01C3/00 , D06N3/00 , D04H1/00 , D06M15/05 , D01F4/00 , B32B5/26 , D06M15/15 , D06N7/00 , B32B5/02 , B32B7/12 , B32B9/02 , B32B15/02 , B32B15/14 , B32B23/10 , B32B27/12 , B32B29/02 , B32B1/08 , B32B3/26 , D06M101/06 , D06M23/16
Abstract: The invention is directed to a composite material comprising a biofabricated material and a secondary component. The secondary component may be a porous material, such as a sheet of paper, cellulose, or fabric that has been coated or otherwise contacted with the biofabricated material. The biofabricated material comprises a uniform network of crosslinked collagen fibrils and provides strength, elasticity and an aesthetic appearance to the composite material.
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Patent Agency Ranking
公开(公告)号：US09752122B2
公开(公告)日：2017-09-05
申请号：US14486850
申请日：2014-09-15
Applicant: Modern Meadow, Inc.
Inventor： Francoise Suzanne Marga , Brendan Patrick Purcell , Gabor Forgacs , Andras Forgacs
CPC classification number: C12N5/0658 , A23L13/00 , A23P10/20 , A23V2002/00 , C12N2500/92 , C12N2531/00 , A23V2200/264
Abstract: Edible microcarriers, including microcarrier beads, microspheres and microsponges, appropriate for use in a bioreactor to culture cells that may be used to form a comestible engineered meat product. For example, the edible microcarriers described herein may include porous microcarriers that may be used to grow cells (e.g., smooth muscle cells) and may be included with the cells in the final engineered meat product, without requiring modification or removal of the cells from the microcarriers. In a particular example, the edible microcarriers may be formed of cross-linked pectin, such as pectin-thiopropionylamide (PTP), and RGD-containing polypeptide, such as thiolated cardosin A. Methods of forming edible microcarriers, methods of using the edible microcarriers to make engineered meat, and engineered meat including the edible microcarriers are also described herein.
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公开(公告)号：US11913166B2
公开(公告)日：2024-02-27
申请号：US15761209
申请日：2016-09-21
Applicant: MODERN MEADOW, INC.
Inventor： Brendan Patrick Purcell , Gabor Forgacs
CPC classification number: D06N3/0006 , C12N5/0068 , C14C3/06 , D06N3/00 , D06N3/0011 , C12N2533/50
Abstract: Engineered, reinforced leather materials (engineered leathers) including a composite of a fibrous matrix that has been tanned to allow crosslinking of the fibrous matrix to the collagen formed by cultured cells (e.g., fibroblasts). These engineered leathers may be referred to as fiber-reinforced biological tissue composites. Also described herein are methods of making such fiber-reinforced biological tissue composites.
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公开(公告)号：US11525042B2
公开(公告)日：2022-12-13
申请号：US15433676
申请日：2017-02-15
Applicant: MODERN MEADOW, INC.
Inventor： Brendan Patrick Purcell , David Thomas Williamson , Suzanne Lee , Amy Congdon
IPC: C08J3/24 , B32B5/26 , D06N3/00 , D06N7/00 , B32B5/02 , B32B7/12 , B32B9/02 , B32B1/08 , B32B3/26 , D04H1/4382 , D06P3/32 , D01F4/00 , D06M15/15 , B32B15/02 , B32B15/14 , B32B23/10 , B32B27/12 , B32B29/02 , C14C13/00 , D04H13/00 , C07K14/78 , C14C9/00 , C14C9/02 , D01C3/00 , D04H1/00 , D06M15/05 , D06M23/16 , D06M101/06
Abstract: The invention is directed to a composite material comprising a biofabricated material and a secondary component. The secondary component may be a porous material, such as a sheet of paper, cellulose, or fabric that has been coated or otherwise contacted with the biofabricated material. The biofabricated material comprises a uniform network of crosslinked collagen fibrilsand provides strength, elasticity and an aesthetic appearance to the composite material.
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公开(公告)号：US10519285B2
公开(公告)日：2019-12-31
申请号：US15433675
申请日：2017-02-15
Applicant: MODERN MEADOW, INC.
Inventor： Brendan Patrick Purcell , David Thomas Williamson , Suzanne Lee , Amy Congdon
IPC: C08J3/24 , C14C13/00 , D04H13/00 , D06P3/32 , C07K14/78 , C14C9/02 , C14C9/00 , D04H1/4382 , D01C3/00 , D06N3/00 , D04H1/00 , D06M15/05 , D01F4/00 , B32B5/26 , D06M15/15 , D06N7/00 , B32B5/02 , B32B7/12 , B32B9/02 , B32B1/08 , B32B3/26 , B32B15/02 , B32B15/14 , B32B23/10 , B32B27/12 , B32B29/02 , D06M101/06 , D06M23/16
Abstract: The invention is directed to a method for producing a composite material comprising a biofabricated material and a secondary component. The secondary component may be a porous material, such as a sheet of paper, cellulose, or fabric that has been coated or otherwise contacted with the biofabricated material. The biofabricated material comprises a uniform network of crosslinked collagen fibrils and provides strength, elasticity and an aesthetic appearance to the composite material.
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公开(公告)号：US10301440B2
公开(公告)日：2019-05-28
申请号：US15433777
申请日：2017-02-15
Applicant: MODERN MEADOW, INC.
Inventor： Brendan Patrick Purcell , David Thomas Williamson , Lixin Dai , Darryl Miles Cassingham , Stephen M. Spinella
IPC: D06M15/15 , C08J3/24 , C14C13/00 , D04H13/00 , D06P3/32 , C07K14/78 , C14C9/00 , C14C9/02 , D04H1/4382 , D01C3/00 , D06N3/00 , D04H1/00 , D06M15/05 , D01F4/00 , B32B5/26 , D06N7/00 , B32B5/02 , B32B7/12 , B32B9/02 , B32B15/02 , B32B15/14 , B32B23/10 , B32B27/12 , B32B29/02 , B32B1/08 , B32B3/26 , D06M101/06 , D06M23/16
Abstract: A biofabricated material containing a network of crosslinked collagen fibrils is disclosed. This material is composed of collagen which is also a major component of natural leather and is produced by a process of fibrillation of collagen molecules into fibrils, crosslinking the fibrils and lubricating the crosslinked fibrils. Unlike natural leathers, this biofabricated material exhibits non-anisotropic (not directionally dependent) physical properties, for example, a sheet of biofabricated material can have substantially the same elasticity or tensile strength when stretched or stressed in different directions. Unlike natural leather, it has a uniform texture that facilitates uniform uptake of dyes and coatings. Aesthetically, it produces a uniform and consistent grain for ease of manufacturability. It can have substantially identical grain, texture and other aesthetic properties on both sides distinct from natural leather where the grain increases from one side (e.g., distal surface) to the other (proximal inner layers).
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