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公开(公告)号：US20150153333A1
公开(公告)日：2015-06-04
申请号：US14414905
申请日：2013-07-23
Applicant: MYCARTIS NV
Inventor： Raphael Tornay , Nicolas Demierre , Stephan Gamper , Philippe Renaud
CPC classification number: G01N33/5306 , B01L3/502707 , B01L3/502761 , B01L3/545 , B01L2200/0647 , B01L2200/10 , B01L2200/12 , B01L2300/0803 , B01L2300/0819 , B01L2300/0893 , C23F1/02 , G01N33/54373
Abstract: The method according to the invention consists in providing a wafer having a bottom layer, a top first sacrificial layer and an insulating layer, structuring the first sacrificial layer to form a three dimensional structure onto which a first structural layer is deposited to define a corresponding three dimensional structure on the bottom surface of the first structural layer. The method consists also in forming a second three dimensional structure on the upper surface of the first structural layer.
Abstract translation: 根据本发明的方法在于提供具有底层，顶部第一牺牲层和绝缘层的晶片，构造第一牺牲层以形成三维结构，在其上沉积第一结构层以限定对应的三 在第一结构层的底表面上的尺寸结构。 该方法还包括在第一结构层的上表面上形成第二三维结构。
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公开(公告)号：US10001478B2
公开(公告)日：2018-06-19
申请号：US14904764
申请日：2014-08-14
Applicant: MYCARTIS NV
Inventor： Raphael Tornay , Patrick Van Den Bogaard , Nicolas Demierre , Didier Falconnet
IPC: G01N21/75 , G01N33/543 , B01L3/00
CPC classification number: G01N33/54386 , B01J2219/00536 , B01J2219/00556 , B01J2219/0056 , B01J2219/00612 , B01J2219/00637 , B01J2219/00693 , B01J2219/00725 , B01J2219/0074 , B01L3/502761 , B01L2200/0647 , B01L2300/021 , B01L2300/0636 , B01L2300/0819 , B01L2300/0832
Abstract: The present invention relates to a microcarrier comprising at least a detection surface for performing an assay, said detection surface comprising a first area being functionalized with a first functional group for detecting at least a chemical and/or biological interaction, said first area being designed for providing a first signal. The microcarrier is characterized in that the detection surface further comprises a second area being designed for providing a second signal different from the first signal, said second signal being emitted during the assay. Thus, information about the presence of the at least a chemical and/or biological interaction is provided by a comparison of the first signal and the second signal.
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公开(公告)号：US20150141281A1
公开(公告)日：2015-05-21
申请号：US14413314
申请日：2013-07-10
Applicant: MYCARTIS NV
Inventor： Raphael Tornay , Nicolas Demierre , Jose De Gil , Robin Muller , Didier Falconnet
IPC: G01N33/543
CPC classification number: G01N33/54313 , B01L3/502761 , B01L2200/0668 , B01L2400/086 , G01N33/54366 , G01N33/54373 , Y10T436/2575
Abstract: The present invention relates to a method for performing a chemical and/or a biological assay comprising the following successive steps of: a) providing an assay device with a microchannel having an inlet and an outlet and further comprising restricting means designed to restrict the movement toward the outlet of microparticles introduced in the microchannel while letting a fluid to flow through the restricting means, b) introducing microparticles in the microchannel via the inlet, c) restricting the movement of said microparticles in the microchannel toward the outlet using restricting means, d) flowing a fluid sample through the microchannel, e) performing a biological and/or chemical read-out on each microparticle, the method further comprising the steps of: f) moving the microparticles in the microchannel, and g) repeating successively the steps d) and e).
Abstract translation: 本发明涉及一种用于进行化学和/或生物测定的方法，包括以下连续步骤：a）提供具有入口和出口的微通道的测定装置，并且还包括限制装置， 在使流体流过所述限制装置的同时引入微通道的出口，b）通过所述入口将微粒引入所述微通道中，c）使用限制装置限制所述微通道中所述微粒向所述出口的移动; d） 流体样品通过微通道，e）对每个微粒进行生物和/或化学读出，所述方法还包括以下步骤：f）移动微通道中的微粒，并且g）连续重复步骤d） 和e）。
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公开(公告)号：US09400275B2
公开(公告)日：2016-07-26
申请号：US14414905
申请日：2013-07-23
Applicant: MYCARTIS NV
Inventor： Raphael Tornay , Nicolas Demierre , Stephan Gamper , Philippe Renaud
IPC: G01N33/53 , B01L3/00 , G01N33/543 , C23F1/02
CPC classification number: G01N33/5306 , B01L3/502707 , B01L3/502761 , B01L3/545 , B01L2200/0647 , B01L2200/10 , B01L2200/12 , B01L2300/0803 , B01L2300/0819 , B01L2300/0893 , C23F1/02 , G01N33/54373
Abstract: The method according to the invention consists in providing a wafer having a bottom layer, a top first sacrificial layer and an insulating layer, structuring the first sacrificial layer to form a three dimensional structure onto which a first structural layer is deposited to define a corresponding three dimensional structure on the bottom surface of the first structural layer. The method consists also in forming a second three dimensional structure on the upper surface of the first structural layer.
Abstract translation: 根据本发明的方法在于提供具有底层，顶部第一牺牲层和绝缘层的晶片，构造第一牺牲层以形成三维结构，在其上沉积第一结构层以限定对应的三 在第一结构层的底表面上的尺寸结构。 该方法还包括在第一结构层的上表面上形成第二三维结构。
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公开(公告)号：US09625455B2
公开(公告)日：2017-04-18
申请号：US14413314
申请日：2013-07-10
Applicant: MYCARTIS NV
Inventor： Raphael Tornay , Nicolas Demierre , Jose De Gil , Robin Muller , Didier Falconnet
IPC: G01N33/543 , B01L3/00
CPC classification number: G01N33/54313 , B01L3/502761 , B01L2200/0668 , B01L2400/086 , G01N33/54366 , G01N33/54373 , Y10T436/2575
Abstract: A method for performing a chemical and/or a biological assay including the following successive steps of: a) providing an assay device with a microchannel having an inlet and an outlet and restricting means for restricting movement toward the outlet of microparticles introduced in the microchannel while letting a fluid to flow through the restricting means, b) introducing microparticles in the microchannel via the inlet, c) restricting the movement of said microparticles in the microchannel toward the outlet using the restricting means, d) flowing a fluid sample through the microchannel, and e) performing a biological and/or chemical read-out on each microparticle. The method also includes the steps of: f) moving the microparticles in the microchannel, and g) repeating successively the steps d) and e).
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Patent Agency Ranking
公开(公告)号：US09333501B2
公开(公告)日：2016-05-10
申请号：US14414513
申请日：2013-07-22
Applicant: MYCARTIS NV
Inventor： Nicolas Demierre , Stephan Gamper , Raphael Tornay , Philippe Renaud
CPC classification number: B01L3/502707 , B01L3/502761 , B01L3/545 , B01L2200/0647 , B01L2200/10 , B01L2200/12 , B01L2300/0803 , B01L2300/0819 , B01L2300/0893 , B01L2300/16 , G01N15/1456
Abstract: The present invention relates to a method for producing microcarriers, the method comprising the steps of providing a wafer having a bottom layer, a top layer and an insulating layer, structuring the top layer to define at least one three-dimensional structure on the top surface of the top layer, etching away the top layer to delineate lateral walls of bodies of the microcarriers, applying a continuous polymer layer over the top surface of the bodies of the microcarriers, removing the bottom layer and the insulating layer, structuring the bottom surfaces of the bodies of the microcarriers to define at least one three-dimensional structure on the bottom surface of each body, and removing the polymer layer to release the microcarriers.
Abstract translation: 本发明涉及一种生产微载体的方法，该方法包括以下步骤：提供具有底层，顶层和绝缘层的晶片，构成顶层以在顶表面上限定至少一个三维结构 顶层，蚀刻顶层以描绘微载体的主体的侧壁，在微载体的主体的顶表面上施加连续的聚合物层，去除底层和绝缘层，构成底层的底表面 微载体的主体在每个主体的底表面上限定至少一个三维结构，并且移除聚合物层以释放微载体。
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公开(公告)号：US20150190803A1
公开(公告)日：2015-07-09
申请号：US14414513
申请日：2013-07-22
Applicant: MYCARTIS NV
Inventor： Nicolas Demierre , Stephan Gamper , Raphael Tornay , Philippe Renaud
IPC: B01L3/00
CPC classification number: B01L3/502707 , B01L3/502761 , B01L3/545 , B01L2200/0647 , B01L2200/10 , B01L2200/12 , B01L2300/0803 , B01L2300/0819 , B01L2300/0893 , B01L2300/16 , G01N15/1456
Abstract: The present invention relates to a method for producing microcarriers, the method comprising the steps of providing a wafer having a bottom layer, a top layer and an insulating layer, structuring the top layer to define at least one three-dimensional structure on the top surface of the top layer, etching away the top layer to delineate lateral walls of bodies of the microcarriers, applying a continuous polymer layer over the top surface of the bodies of the microcarriers, removing the bottom layer and the insulating layer, structuring the bottom surfaces of the bodies of the microcarriers to define at least one three-dimensional structure on the bottom surface of each body, and removing the polymer layer to release the microcarriers.
Abstract translation: 本发明涉及一种生产微载体的方法，该方法包括以下步骤：提供具有底层，顶层和绝缘层的晶片，构成顶层以在顶表面上限定至少一个三维结构 顶层，蚀刻顶层以描绘微载体的主体的侧壁，在微载体的主体的顶表面上施加连续的聚合物层，去除底层和绝缘层，构成底层的底表面 微载体的主体在每个主体的底表面上限定至少一个三维结构，并且移除聚合物层以释放微载体。
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公开(公告)号：US20150162141A1
公开(公告)日：2015-06-11
申请号：US14414174
申请日：2013-07-22
Applicant: MYCARTIS NV
Inventor： Raphael Tornay , Nicolas Demierre , Stephan Gamper , Philippe Renaud
IPC: H01G13/06
CPC classification number: H01G13/06 , B01J2219/005 , B01J2219/00502 , B01J2219/00536 , B01J2219/00556 , B01J2219/00637 , B01L3/502707 , B01L3/502761 , B01L3/508 , B01L3/54 , B01L3/545 , B01L2200/0647 , B01L2200/10 , B01L2200/12 , B01L2300/0803 , B01L2300/0819 , B01L2300/0851 , B01L2300/0893 , B81B2201/058 , B81B2201/06 , B81C99/008 , G01N33/54313
Abstract: The present invention relates to a method for producing microcarriers comprising the following steps: (a) providing a wafer having a sandwich structure comprising a bottom layer, a top layer and an insulating layer located between said bottom and top layers, (b) etching away the top layer to delineate lateral walls of bodies of the microcarriers, (c) depositing a first active layer at least on a top surface of the bodies, (d) applying a continuous polymer layer over the first active layer, (e) etching away the bottom layer and the insulating layer, (f) removing the polymer layer to release the microcarriers.
Abstract translation: 本发明涉及一种生产微载体的方法，包括以下步骤：（a）提供具有夹层结构的晶片，该夹层结构包括位于所述底层和顶层之间的底层，顶层和绝缘层，（b）蚀刻掉 描绘微载体的主体的侧壁的顶层，（c）至少在主体的顶表面上沉积第一有源层，（d）在第一有源层上施加连续聚合物层，（e）蚀刻掉 底层和绝缘层，（f）去除聚合物层以释放微载体。
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公开(公告)号：US09682377B2
公开(公告)日：2017-06-20
申请号：US14413518
申请日：2013-07-02
Applicant: MYCARTIS NV
Inventor： Laurent Coulot , Nicolas Demierre , Raphael Tornay
CPC classification number: B01L3/502761 , B01L3/502715 , B01L3/50273 , B01L9/527 , B01L2200/027 , B01L2200/0647 , B01L2300/0858 , Y10T436/2575
Abstract: The present invention relates to a method for injecting microparticles into a microfluidic channel by means of injecting means, said microfluidic channel opening out on a sidewall of an inlet well, the method comprising the steps of: a) positioning the injecting means tip above said sidewall and at a predetermined distance (d) therefrom, and b) injecting the microparticles into said inlet well so that they come into contact with said sidewall during injection, the sidewall being tilted so that at least a portion of the microparticles included in the injected liquid sample slides on the sidewall and enters the microfluidic channel.
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公开(公告)号：US09349545B2
公开(公告)日：2016-05-24
申请号：US14414174
申请日：2013-07-22
Applicant: MYCARTIS NV
Inventor： Raphael Tornay , Nicolas Demierre , Stephan Gamper , Philippe Renaud
IPC: H01G13/06 , B01L3/00 , B81C99/00 , G01N33/543
CPC classification number: H01G13/06 , B01J2219/005 , B01J2219/00502 , B01J2219/00536 , B01J2219/00556 , B01J2219/00637 , B01L3/502707 , B01L3/502761 , B01L3/508 , B01L3/54 , B01L3/545 , B01L2200/0647 , B01L2200/10 , B01L2200/12 , B01L2300/0803 , B01L2300/0819 , B01L2300/0851 , B01L2300/0893 , B81B2201/058 , B81B2201/06 , B81C99/008 , G01N33/54313
Abstract: The present invention relates to a method for producing microcarriers comprising the following steps: (a) providing a wafer having a sandwich structure comprising a bottom layer, a top layer and an insulating layer located between said bottom and top layers, (b) etching away the top layer to delineate lateral walls of bodies of the microcarriers, (c) depositing a first active layer at least on a top surface of the bodies, (d) applying a continuous polymer layer over the first active layer, (e) etching away the bottom layer and the insulating layer, (f) removing the polymer layer to release the microcarriers.
Abstract translation: 本发明涉及一种生产微载体的方法，包括以下步骤：（a）提供具有夹层结构的晶片，该夹层结构包括位于所述底层和顶层之间的底层，顶层和绝缘层，（b）蚀刻掉 描绘微载体的主体的侧壁的顶层，（c）至少在主体的顶表面上沉积第一有源层，（d）在第一有源层上施加连续聚合物层，（e）蚀刻掉 底层和绝缘层，（f）去除聚合物层以释放微载体。
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