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公开(公告)号：US11428618B2
公开(公告)日：2022-08-30
申请号：US16466786
申请日：2017-12-19
Applicant: Massachusetts Institute of Technology
Inventor： Rohit Nandkumar Karnik , An Chang
Abstract: Systems and methods for monitoring air particulate matter are provided herein that capture particles from the air for analysis. Particles are captured using electrostatic and/or mechanical means to deflect particles toward a substrate. Electrostatic precipitation causes charged carriers to deflect towards a charged substrate. Filtration-based means employ filters and/or fibers to capture particles from air flowing therethrough. A sensor such as a camera is used to read the captured particles. An illumination source directs light towards the substrate, causing the particles to scatter light, which the sensor can detect and derive information or imaging therefrom, which can also be used for further particle or pollution analyses. The substrate can be replenished using electrostatic techniques such as reverse electrostatic force, or mechanical means such as cleaning using a brush or replacing a tape substrate. Dynamic PM monitoring detects and makes adjustments such as those related to air volume, imaging characteristics and substrate replenishment.
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公开(公告)号：US20150246354A1
公开(公告)日：2015-09-03
申请号：US14667615
申请日：2015-03-24
Applicant: Massachusetts Institute of Technology
Inventor： Rohit Nandkumar Karnik , Seungpyo Hong , Ying Mei , Daniel Griffith Anderson , Jeffrey Michael Karp , Robert S. Langer , Suman Bose
CPC classification number: C12N5/0068 , B01L3/502715 , B01L3/502761 , B01L2200/0647 , B01L2300/0877 , B01L2300/16 , C12M23/16 , C12M47/02 , C12N5/0062 , C12N2501/58 , C12N2501/585 , C12N2533/50 , C12N2533/52 , C12N2535/10
Abstract: The present invention provides systems for cell separation based on cell rolling on surfaces along edges of regions coated with cell adhesion molecules. A variety of designs of coated regions and edges are disclosed.
Abstract translation: 本发明提供了基于在细胞粘附分子包被的区域的边缘上的表面上的细胞滚动的细胞分离系统。 公开了涂覆区域和边缘的各种设计。
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Patent Agency Ranking
公开(公告)号：US11612839B2
公开(公告)日：2023-03-28
申请号：US16341326
申请日：2017-10-18
Applicant: Massachusetts Institute of Technology
Inventor： Michael S. Bono , Sydney B. Beasley , Emily Barret Hanhauser , Chintan Vaishnav , Anastasios John Hart , Rohit Nandkumar Karnik
Abstract: Systems, devices, and methods for detecting contamination (e.g., bacteria) in fluid are provided. The systems, devices, and methods allow for filtering a fluid sample using a filter to capture and concentrate cells (e.g., bacteria) to detect electrochemical properties thereof. The cells can be exposed to a reagent that diffuses into the cells to produce a product of interest that can be used in analysis of the fluid sample. The product of interest can diffuse out of the filter into a fluid storage component for detection and analysis by an analysis component. After the sampling is completed, the filter can be detached and discarded. Other aspects of the present disclosure, including enhancements and various systems and methods for concentrating cells and analyzing the same, are also provided.
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公开(公告)号：US10011817B2
公开(公告)日：2018-07-03
申请号：US15394557
申请日：2016-12-29
Applicant: Massachusetts Institute of Technology
Inventor： Rohit Nandkumar Karnik , Seungpyo Hong , Ying Mei , Daniel Griffith Anderson , Jeffrey Michael Karp , Robert S. Langer , Suman Bose
CPC classification number: C12N5/0068 , B01L3/502715 , B01L3/502761 , B01L2200/0647 , B01L2300/0877 , B01L2300/16 , C12M23/16 , C12M47/02 , C12N5/0062 , C12N2501/58 , C12N2501/585 , C12N2533/50 , C12N2533/52 , C12N2535/10
Abstract: The present invention provides systems for cell separation based on cell rolling on surfaces along edges of regions coated with cell adhesion molecules. A variety of designs of coated regions and edges are disclosed.
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公开(公告)号：US20200047093A1
公开(公告)日：2020-02-13
申请号：US16341326
申请日：2017-10-18
Applicant: Massachusetts Institute of Technology
Inventor： Michael S. Bono , Sydney B. Beasley , Emily Barret Hanhauser , Chintan Vaishnav , Anastasios John Hart , Rohit Nandkumar Karnik
Abstract: Systems, devices, and methods for detecting contamination (e.g., bacteria) in fluid are provided. The systems, devices, and methods allow for filtering a fluid sample using a filter to capture and concentrate cells (e.g., bacteria) to detect electrochemical properties thereof. The cells can be exposed to a reagent that diffuses into the cells to produce a product of interest that can be used in analysis of the fluid sample. The product of interest can diffuse out of the filter into a fluid storage component for detection and analysis by an analysis component. After the sampling is completed, the filter can be detached and discarded. Other aspects of the present disclosure, including enhancements and various systems and methods for concentrating cells and analyzing the same, are also provided.
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公开(公告)号：US20170204367A1
公开(公告)日：2017-07-20
申请号：US15394557
申请日：2016-12-29
Applicant: Massachusetts Institute of Technology
Inventor： Rohit Nandkumar Karnik , Seungpyo Hong , Ying Mei , Daniel Griffith Anderson , Jeffrey Michael Karp , Robert S. Langer , Suman Bose
CPC classification number: C12N5/0068 , B01L3/502715 , B01L3/502761 , B01L2200/0647 , B01L2300/0877 , B01L2300/16 , C12M23/16 , C12M47/02 , C12N5/0062 , C12N2501/58 , C12N2501/585 , C12N2533/50 , C12N2533/52 , C12N2535/10
Abstract: The present invention provides systems for cell separation based on cell rolling on surfaces along edges of regions coated with cell adhesion molecules. A variety of designs of coated regions and edges are disclosed.
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公开(公告)号：US09555413B2
公开(公告)日：2017-01-31
申请号：US14667615
申请日：2015-03-24
Applicant: Massachusetts Institute of Technology
Inventor： Rohit Nandkumar Karnik , Seungpyo Hong , Ying Mei , Daniel Griffith Anderson , Jeffrey Michael Karp , Robert S. Langer , Suman Bose
CPC classification number: C12N5/0068 , B01L3/502715 , B01L3/502761 , B01L2200/0647 , B01L2300/0877 , B01L2300/16 , C12M23/16 , C12M47/02 , C12N5/0062 , C12N2501/58 , C12N2501/585 , C12N2533/50 , C12N2533/52 , C12N2535/10
Abstract: The present invention provides systems for cell separation based on cell rolling on surfaces along edges of regions coated with cell adhesion molecules. A variety of designs of coated regions and edges are disclosed.
Abstract translation: 本发明提供了基于在细胞粘附分子包被的区域的边缘上的表面上的细胞滚动的细胞分离系统。 公开了涂覆区域和边缘的各种设计。
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