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公开(公告)号：US10011817B2
公开(公告)日：2018-07-03
申请号：US15394557
申请日：2016-12-29
Applicant: Massachusetts Institute of Technology
Inventor： Rohit Nandkumar Karnik , Seungpyo Hong , Ying Mei , Daniel Griffith Anderson , Jeffrey Michael Karp , Robert S. Langer , Suman Bose
CPC classification number: C12N5/0068 , B01L3/502715 , B01L3/502761 , B01L2200/0647 , B01L2300/0877 , B01L2300/16 , C12M23/16 , C12M47/02 , C12N5/0062 , C12N2501/58 , C12N2501/585 , C12N2533/50 , C12N2533/52 , C12N2535/10
Abstract: The present invention provides systems for cell separation based on cell rolling on surfaces along edges of regions coated with cell adhesion molecules. A variety of designs of coated regions and edges are disclosed.
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公开(公告)号：US09901879B2
公开(公告)日：2018-02-27
申请号：US14530292
申请日：2014-10-31
Inventor： Rohit N. Karnik , Suman Bose , Michael S. H. Boutilier , Nicolas G. Hadjiconstantinou , Tarun Kumar Jain , Sean C. O'Hern , Tahar Laoui , Muataz A. Atieh , Doojoon Jang
IPC: B01D29/00 , B01D29/46 , B01D39/00 , B01D39/14 , B05D5/00 , B05D5/12 , B01D65/00 , B01D53/22 , B01D71/02 , C23C16/455 , B01D65/10 , B01D67/00
CPC classification number: B01D65/003 , B01D53/22 , B01D65/108 , B01D67/0006 , B01D71/021 , B01D71/024 , B01D71/025 , B01D2053/221 , B01D2256/245 , B01D2257/304 , B01D2257/504 , B01D2257/702 , B01D2323/283 , C23C16/45555 , Y02C10/10
Abstract: Two-dimensional material based filters, their method of manufacture, and their use are disclosed. In one embodiment, a membrane may include an active layer including a plurality of defects and a deposited material associated with the plurality of defects may reduce flow therethrough. Additionally, a majority of the active layer may be free from the material. In another embodiment, a membrane may include a porous substrate and an atomic layer deposited material disposed on a surface of the porous substrate. The atomic layer deposited material may be less hydrophilic than the porous substrate and an atomically thin active layer may be disposed on the atomic layer deposited material.
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公开(公告)号：US10668435B2
公开(公告)日：2020-06-02
申请号：US15878361
申请日：2018-01-23
Inventor： Rohit N. Karnik , Suman Bose , Michael S. H. Boutilier , Nicolas G. Hadjiconstantinou , Tarun Kumar Jain , Sean C. O'Hern , Tahar Laoui , Muataz A. Atieh , Doojoon Jang
Abstract: Two-dimensional material based filters, their method of manufacture, and their use are disclosed. In one embodiment, a membrane may include an active layer including a plurality of defects and a deposited material associated with the plurality of defects may reduce flow therethrough. Additionally, a majority of the active layer may be free from the material. In another embodiment, a membrane may include a porous substrate and an atomic layer deposited material disposed on a surface of the porous substrate. The atomic layer deposited material may be less hydrophilic than the porous substrate and an atomically thin active layer may be disposed on the atomic layer deposited material.
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公开(公告)号：US20150246354A1
公开(公告)日：2015-09-03
申请号：US14667615
申请日：2015-03-24
Applicant: Massachusetts Institute of Technology
Inventor： Rohit Nandkumar Karnik , Seungpyo Hong , Ying Mei , Daniel Griffith Anderson , Jeffrey Michael Karp , Robert S. Langer , Suman Bose
CPC classification number: C12N5/0068 , B01L3/502715 , B01L3/502761 , B01L2200/0647 , B01L2300/0877 , B01L2300/16 , C12M23/16 , C12M47/02 , C12N5/0062 , C12N2501/58 , C12N2501/585 , C12N2533/50 , C12N2533/52 , C12N2535/10
Abstract: The present invention provides systems for cell separation based on cell rolling on surfaces along edges of regions coated with cell adhesion molecules. A variety of designs of coated regions and edges are disclosed.
Abstract translation: 本发明提供了基于在细胞粘附分子包被的区域的边缘上的表面上的细胞滚动的细胞分离系统。 公开了涂覆区域和边缘的各种设计。
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公开(公告)号：US20170204367A1
公开(公告)日：2017-07-20
申请号：US15394557
申请日：2016-12-29
Applicant: Massachusetts Institute of Technology
Inventor： Rohit Nandkumar Karnik , Seungpyo Hong , Ying Mei , Daniel Griffith Anderson , Jeffrey Michael Karp , Robert S. Langer , Suman Bose
CPC classification number: C12N5/0068 , B01L3/502715 , B01L3/502761 , B01L2200/0647 , B01L2300/0877 , B01L2300/16 , C12M23/16 , C12M47/02 , C12N5/0062 , C12N2501/58 , C12N2501/585 , C12N2533/50 , C12N2533/52 , C12N2535/10
Abstract: The present invention provides systems for cell separation based on cell rolling on surfaces along edges of regions coated with cell adhesion molecules. A variety of designs of coated regions and edges are disclosed.
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Patent Agency Ranking
公开(公告)号：US09555413B2
公开(公告)日：2017-01-31
申请号：US14667615
申请日：2015-03-24
Applicant: Massachusetts Institute of Technology
Inventor： Rohit Nandkumar Karnik , Seungpyo Hong , Ying Mei , Daniel Griffith Anderson , Jeffrey Michael Karp , Robert S. Langer , Suman Bose
CPC classification number: C12N5/0068 , B01L3/502715 , B01L3/502761 , B01L2200/0647 , B01L2300/0877 , B01L2300/16 , C12M23/16 , C12M47/02 , C12N5/0062 , C12N2501/58 , C12N2501/585 , C12N2533/50 , C12N2533/52 , C12N2535/10
Abstract: The present invention provides systems for cell separation based on cell rolling on surfaces along edges of regions coated with cell adhesion molecules. A variety of designs of coated regions and edges are disclosed.
Abstract translation: 本发明提供了基于在细胞粘附分子包被的区域的边缘上的表面上的细胞滚动的细胞分离系统。 公开了涂覆区域和边缘的各种设计。
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公开(公告)号：US20150122727A1
公开(公告)日：2015-05-07
申请号：US14530292
申请日：2014-10-31
Inventor： ROHIT N. KARNIK , Suman Bose , Michael S.H. Boutilier , Nicolas G. Hadjiconstantinou , Tarun Kumar Jain , Sean C. O'Hern , Tahar Laoui , Muataz A. Atieh , Doojoon Jang
IPC: B01D65/00 , B01D71/02 , C23C16/455 , B01D53/22
CPC classification number: B01D65/003 , B01D53/22 , B01D65/108 , B01D67/0006 , B01D71/021 , B01D71/024 , B01D71/025 , B01D2053/221 , B01D2256/245 , B01D2257/304 , B01D2257/504 , B01D2257/702 , B01D2323/283 , C23C16/45555 , Y02C10/10
Abstract: Two-dimensional material based filters, their method of manufacture, and their use are disclosed. In one embodiment, a membrane may include an active layer including a plurality of defects and a deposited material associated with the plurality of defects may reduce flow therethrough. Additionally, a majority of the active layer may be free from the material. In another embodiment, a membrane may include a porous substrate and an atomic layer deposited material disposed on a surface of the porous substrate. The atomic layer deposited material may be less hydrophilic than the porous substrate and an atomically thin active layer may be disposed on the atomic layer deposited material.
Abstract translation: 公开了基于二维材料的过滤器，其制造方法及其用途。 在一个实施例中，膜可以包括包括多个缺陷的活性层，并且与多个缺陷相关联的沉积材料可以减少通过其中的流动。 此外，活性层的大部分可以不含该材料。 在另一个实施例中，膜可以包括多孔基底和设置在多孔基底的表面上的原子层沉积材料。 原子层沉积材料可能比多孔基底亲水性差，并且可以在原子层沉积材料上设置原子薄的有源层。
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公开(公告)号：US11717791B2
公开(公告)日：2023-08-08
申请号：US16860054
申请日：2020-04-27
Inventor： Rohit N. Karnik , Suman Bose , Michael S. H. Boutilier , Nicolas G. Hadjiconstantinou , Tarun Kumar Jain , Sean C. O'Hern , Tahar Laoui , Muataz A. Atieh , Doojoon Jang
CPC classification number: B01D65/003 , B01D53/22 , B01D65/108 , B01D67/0006 , B01D71/021 , B01D71/024 , B01D71/025 , C23C16/45555 , B01D69/12 , B01D2053/221 , B01D2256/245 , B01D2257/304 , B01D2257/504 , B01D2257/702 , B01D2323/283 , Y02C20/40
Abstract: Two-dimensional material based filters, their method of manufacture, and their use are disclosed. In one embodiment, a membrane may include an active layer including a plurality of defects and a deposited material associated with the plurality of defects may reduce flow therethrough. Additionally, a majority of the active layer may be free from the material. In another embodiment, a membrane may include a porous substrate and an atomic layer deposited material disposed on a surface of the porous substrate. The atomic layer deposited material may be less hydrophilic than the porous substrate and an atomically thin active layer may be disposed on the atomic layer deposited material.
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公开(公告)号：US20200316528A1
公开(公告)日：2020-10-08
申请号：US16860054
申请日：2020-04-27
Inventor： Rohit N. Karnik , Suman Bose , Michael S.H. Boutilier , Nicolas G. Hadjiconstantinou , Tarun Kumar Jain , Sean C. O'Hern , Tahar Laoui , Muataz A. Atieh , Doojoon Jang
Abstract: Two-dimensional material based filters, their method of manufacture, and their use are disclosed. In one embodiment, a membrane may include an active layer including a plurality of defects and a deposited material associated with the plurality of defects may reduce flow therethrough. Additionally, a majority of the active layer may be free from the material. In another embodiment, a membrane may include a porous substrate and an atomic layer deposited material disposed on a surface of the porous substrate. The atomic layer deposited material may be less hydrophilic than the porous substrate and an atomically thin active layer may be disposed on the atomic layer deposited material.
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公开(公告)号：US20180353650A1
公开(公告)日：2018-12-13
申请号：US16007922
申请日：2018-06-13
Inventor： Suman Bose , Volkan Yesilyurt , Lisa Rae Volpatti , Robert S. Langer , Daniel G. Anderson
CPC classification number: A61L27/3834 , A61K9/0024 , A61L27/16 , A61L27/34 , A61L27/38 , A61L27/52 , A61L29/041 , A61L31/048 , C08F20/18 , C08F2438/01 , C08L33/26 , C08L2203/02
Abstract: Macrodevices containing a micro-fabricated body having at least one or multiple compartments and a porous membrane, methods of making and using thereof, are described. The one or multiple compartments encapsulate one or more cells that secrete a therapeutic agent in cell-based therapy. The porous membrane provides immunoprotection the encapsulated cells. Further, the surface of the macrodevices is chemically modified using polymers and/or small molecules, reducing fibrosis of the macrodevices, thereby allowing in vivo delivery of the secreted therapeutic agents for extended periods of time.
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