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公开(公告)号：US11161736B2
公开(公告)日：2021-11-02
申请号：US16078896
申请日：2017-03-02
Applicant: National University of Singapore , Massachusetts Institute of Technology , Shanghai Jiao Tong University
Inventor： Wang Xi , Chwee Teck Lim , Fang Kong , Xiaobo Gong
IPC: B29C41/14 , B81C1/00 , A61L27/60 , A61L27/18 , A61L27/50 , B29C41/42 , C08L15/00 , C08L75/04 , C08L79/08 , C08L83/04 , C12M3/06 , A61F2/10 , B29L31/00
Abstract: The present invention relates to a flexible polymer-based microtube having an inner diameter of about 4 μm to about 1000 μm and a variable outer diameter, wherein the cross-sectional shape of the microtube can be, for instance, circular, rectangular, square, triangular, elliptical, star or irregular. The present invention also relates to a method of making the flexible microtube and devices incorporating the flexible microtube.
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2.发明申请公开(公告)号：US20170296732A1
公开(公告)日：2017-10-19
申请号：US15511499
申请日：2015-09-17
Inventor： Majid Ebrahimi Warkiani , Guofeng Guan , Kah Ping Andy Tay , Lidan Wu , Jongyoon Han , Chwee Teck Lim
Abstract: A system for intra-operative blood salvage autotransfusion is provided. The system comprises at least one inlet configured to receive whole blood of a patient; at least one curvilinear microchannel in fluid flow connection with the at least one inlet, the at least one curvilinear microchannel being adapted to isolate circulating tumor cells in the whole blood, based on cell size, along at least one portion of a cross-section of the at least one curvilinear microchannel; and at least two outlets in fluid flow connection with the at least one curvilinear microchannel, at least one outlet of the at least two outlets being configured to flow the circulating tumor cells isolated from the whole blood, and at least one other outlet of the at least two outlets being configured to flow at least a portion of a remainder of the whole blood, cleansed of the isolated circulating tumor cells, for return to the patient.
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公开(公告)号：US20140087456A1
公开(公告)日：2014-03-27
申请号：US14030343
申请日：2013-09-18
Applicant: National University Of Singapore
Inventor： Chwee Teck Lim , Swee Jin Tan , Ali Asgar S. Bhagat
IPC: G01N33/49
CPC classification number: G01N33/491 , B01L3/502753 , B01L2200/0668 , B01L2300/0816 , B01L2300/0864 , B01L2400/0478 , B01L2400/086 , C12M47/04 , G01N33/5005 , G01N33/5091 , G01N33/57407 , G01N2800/52
Abstract: A micro-fluidic device operable to isolate target cells from a biological fluid comprises: an inlet operable to receive the biological fluid, the biological fluid comprising target cells and other components; a waste outlet operable to receive at least the other components of the biological fluid; a plurality of parallel arrays of cell isolation wells coupling the inlet with the waste outlet, each parallel array of cell isolation wells supporting a flow of the biological fluid from the inlet to the waste outlet in response to a pressure differential thereacross, each array of cell isolation wells comprising a plurality isolation wells, each isolation well being dimensioned to mechanically trap the target cells therein whilst permitting flow of other components of the biological fluid; and at least one pressure maintenance structure operable to assist in maintaining a predetermined pressure differential across each of the plurality of parallel arrays of cell isolation wells.
Abstract translation: 可操作以从生物流体分离靶细胞的微流体装置包括：可操作以接收生物流体的入口，所述生物流体包含靶细胞和其它组分; 废物出口，其可操作以至少接收所述生物流体的其它组分; 将入口与废物出口连接的多个平行阵列的细胞隔离井，每个平行的细胞隔离孔阵列响应于其间的压力差，支持生物流体从入口到废物出口的流动，每个细胞阵列 分离井包括多个分离井，每个分离井的尺寸被设计成在其中机械捕获靶细胞，同时允许生物流体的其它组分的流动; 以及至少一个压力维持结构，其可操作以帮助维持多个平行的细胞隔离井中的每一个的预定压差。
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4.发明公开公开(公告)号：US20230210698A1
公开(公告)日：2023-07-06
申请号：US17928127
申请日：2021-05-05
Applicant: National University of Singapore
Inventor： Yuji Gao , Thanh Dat Nguyen , Ji Long Kenan Long , S. Y. John Ho , Chwee Teck Lim
CPC classification number: A61F13/00051 , A61M1/90
Abstract: A layered dressing includes: a permeable wound contact layer for placing in contact with a wound; a breathable barrier layer; a biosensor sensing array configured to detect one or more markers in wound fluid; and a fluid collection layer disposed between the wound contact layer and breathable barrier layer and configured to deliver wound fluid by capillary action from a wound in contact with the wound contact layer to the biosensor sensing array.
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公开(公告)号：US10234451B2
公开(公告)日：2019-03-19
申请号：US14846371
申请日：2015-09-04
Applicant: National University of Singapore
Inventor： Ramesh Ramji , Fook Chiong Cheong , Chwee Teck Lim
IPC: C12M3/06 , G01N33/543 , G01N33/569 , C12M1/12 , C12M1/00 , C12M1/34
Abstract: The disclosure relates to a method and device for detecting and quantifying biological molecules such as cell surface or intracellular ligands/receptors in a dynamic system with high sensitivity and specificity; the method of using such platform optionally in combination with an optical detection system and kits comprising the optical platform.
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Patent Agency Ranking
公开(公告)号：US11525796B2
公开(公告)日：2022-12-13
申请号：US16487983
申请日：2018-02-19
Applicant: National University of Singapore
Inventor： Joo Chuan Yeo , Wang Xi , Longteng Yu , Chwee Teck Lim
Abstract: A soft, flexible microtube sensor and associated method of sensing force are described. A liquid metallic alloy is sealed within a microtube as thin as a strand of human hair to form the physical force sensing mechanism. The sensor is hardly distinguishable with the naked eye, and can be used for the continuous biomonitoring of physiological signals, such as unobtrusive pulse monitoring. Also described is a method of fabricating the microtube sensor and wearable devices incorporating one or more microtube sensors.
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公开(公告)号：US20190161736A1
公开(公告)日：2019-05-30
申请号：US16096249
申请日：2016-04-29
Applicant: National University of Singapore
Inventor： Bee Luan Khoo , Chwee Teck Lim , Gianluca Grenci
Abstract: The disclosure relates to the enrichment and expansion of rare cells in blood such as circulating tumor cells (CTCs), cancer stem cells [CSCs] and other rare circulating cells. The microwells promote interactions between patient-derived CTCs and blood cells, allowing expansion of CTCs without the need for pre-enrichment or additional growth supplements. The cultured cells can be selected for propagation from single cells and have utility in drug screening, diagnostics and prognostics. The disclosure also includes a system comprising a cell enrichment device for enriching CTCs and CSCs and a device adapted to co-operate with the cell enrichment device to allow the testing of one or more agents, for example therapeutic or diagnostic agents.
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公开(公告)号：US20180067000A1
公开(公告)日：2018-03-08
申请号：US15559617
申请日：2016-03-23
Applicant: NATIONAL UNIVERSITY OF SINGAPORE
Inventor： . Kenry , Joo Chuan Yeo , Chwee Teck Lim
Abstract: A resistive microfluidic pressure sensor is provided which comprises a first layer comprising a microfluidic channel with a carbon-based conductive liquid and a second layer comprising at least two electrodes, the at least two electrodes being adapted to measure resistance of the carbon-based conductive liquid upon deformation of the microfluidic channel as a result of a change in force applied on a surface of the sensor.
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公开(公告)号：US10806845B2
公开(公告)日：2020-10-20
申请号：US15511499
申请日：2015-09-17
Inventor： Majid Ebrahimi Warkiani , Guofeng Guan , Kah Ping Andy Tay , Lidan Wu , Jongyoon Han , Chwee Teck Lim
Abstract: A system for intra-operative blood salvage autotransfusion is provided. The system comprises at least one inlet configured to receive whole blood of a patient; at least one curvilinear microchannel in fluid flow connection with the at least one inlet, the at least one curvilinear microchannel being adapted to isolate circulating tumor cells in the whole blood, based on cell size, along at least one portion of a cross-section of the at least one curvilinear microchannel; and at least two outlets in fluid flow connection with the at least one curvilinear microchannel, at least one outlet of the at least two outlets being configured to flow the circulating tumor cells isolated from the whole blood, and at least one other outlet of the at least two outlets being configured to flow at least a portion of a remainder of the whole blood, cleansed of the isolated circulating tumor cells, for return to the patient.
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公开(公告)号：US20200025699A1
公开(公告)日：2020-01-23
申请号：US16487983
申请日：2018-02-19
Applicant: National University of Singapore
Inventor： Joo Chuan Yeo , Wang Xi , Longteng Yu , Chwee Teck Lim
Abstract: A soft, flexible microtube sensor and associated method of sensing force are described. A liquid metallic alloy is sealed within a microtube as thin as a strand of human hair to form the physical force sensing mechanism. The sensor is hardly distinguishable with the naked eye, and can be used for the continuous biomonitoring of physiological signals, such as unobtrusive pulse monitoring. Also described is a method of fabricating the microtube sensor and wearable devices incorporating one or more microtube sensors.
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