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公开(公告)号：US20150238963A1
公开(公告)日：2015-08-27
申请号：US14429280
申请日：2013-09-20
发明人： Jongyoon Han , Chao Yu Peter Chen , Chong Jin Ong , Guofeng Guan , Ali Asgar Bhagat , Lidan Wu
CPC分类号： B01L3/502753 , B01D21/00 , B01D21/0087 , B01D21/265 , B01F5/0606 , B01L3/50273 , B01L2200/0652 , B01L2300/0816 , B01L2300/0864 , B01L2300/0883 , B01L2400/0463 , B01L2400/0478 , B01L2400/0487 , B01L2400/084 , B03B5/62 , C12M47/04
摘要： A micro-fluidic device includes at least one inlet and a curvilinear microchannel having a trapezoidal cross section defined by a radially inner side, a radially outer side, a bottom side, and a top side, the cross section having a) the radially inner side and the radially outer side unequal in height, or b) the radially inner side equal in height to the radially outer side, and wherein the top side has at least two continuous straight sections, each unequal in width to the bottom side.
摘要翻译： 微流体装置包括至少一个入口和曲线微通道，其具有由径向内侧，径向外侧，底侧和顶侧限定的梯形横截面，该横截面具有a）径向内侧 并且所述径向外侧的高度不相等，或b）所述径向内侧的高度与所述径向外侧相等，并且其中所述顶侧具有至少两个连续的直线部分，每个直线部分的宽度不同于所述底侧。
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2.发明申请公开(公告)号：US20170296732A1
公开(公告)日：2017-10-19
申请号：US15511499
申请日：2015-09-17
发明人： Majid Ebrahimi Warkiani , Guofeng Guan , Kah Ping Andy Tay , Lidan Wu , Jongyoon Han , Chwee Teck Lim
摘要： A system for intra-operative blood salvage autotransfusion is provided. The system comprises at least one inlet configured to receive whole blood of a patient; at least one curvilinear microchannel in fluid flow connection with the at least one inlet, the at least one curvilinear microchannel being adapted to isolate circulating tumor cells in the whole blood, based on cell size, along at least one portion of a cross-section of the at least one curvilinear microchannel; and at least two outlets in fluid flow connection with the at least one curvilinear microchannel, at least one outlet of the at least two outlets being configured to flow the circulating tumor cells isolated from the whole blood, and at least one other outlet of the at least two outlets being configured to flow at least a portion of a remainder of the whole blood, cleansed of the isolated circulating tumor cells, for return to the patient.
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公开(公告)号：US09789485B2
公开(公告)日：2017-10-17
申请号：US14429280
申请日：2013-09-20
发明人： Jongyoon Han , Chao Yu Peter Chen , Chong Jin Ong , Guofeng Guan , Ali Asgar Bhagat , Lidan Wu
CPC分类号： B01L3/502753 , B01D21/00 , B01D21/0087 , B01D21/265 , B01F5/0606 , B01L3/50273 , B01L2200/0652 , B01L2300/0816 , B01L2300/0864 , B01L2300/0883 , B01L2400/0463 , B01L2400/0478 , B01L2400/0487 , B01L2400/084 , B03B5/62 , C12M47/04
摘要： A micro-fluidic device includes at least one inlet and a curvilinear microchannel having a trapezoidal cross section defined by a radially inner side, a radially outer side, a bottom side, and a top side, the cross section having a) the radially inner side and the radially outer side unequal in height, or b) the radially inner side equal in height to the radially outer side, and wherein the top side has at least two continuous straight sections, each unequal in width to the bottom side.
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公开(公告)号：US10806845B2
公开(公告)日：2020-10-20
申请号：US15511499
申请日：2015-09-17
发明人： Majid Ebrahimi Warkiani , Guofeng Guan , Kah Ping Andy Tay , Lidan Wu , Jongyoon Han , Chwee Teck Lim
摘要： A system for intra-operative blood salvage autotransfusion is provided. The system comprises at least one inlet configured to receive whole blood of a patient; at least one curvilinear microchannel in fluid flow connection with the at least one inlet, the at least one curvilinear microchannel being adapted to isolate circulating tumor cells in the whole blood, based on cell size, along at least one portion of a cross-section of the at least one curvilinear microchannel; and at least two outlets in fluid flow connection with the at least one curvilinear microchannel, at least one outlet of the at least two outlets being configured to flow the circulating tumor cells isolated from the whole blood, and at least one other outlet of the at least two outlets being configured to flow at least a portion of a remainder of the whole blood, cleansed of the isolated circulating tumor cells, for return to the patient.
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5.发明授权公开(公告)号：US10098581B2
公开(公告)日：2018-10-16
申请号：US15111584
申请日：2015-01-16
发明人： Joel Voldman , Hao-Wei Su , Javier Lopez Prieto , Jongyoon Han , Lidan Wu
IPC分类号： G01N15/10 , G01N15/14 , G01N15/00 , G01N15/02 , A61B5/00 , A61B5/145 , A61B5/1468 , A61B5/1486 , B01L3/00 , G01N33/487
摘要： A system includes a microfluidic device configured to isolate one or more particles from a mixture, a flow rate matching device configured to match flow rate of the microfluidic device with flow rate of an electrical measurement device configured to measure an electrical property of the isolated particles, and an electrical measurement device configured to measure an electrical property of the isolated particles.
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6.发明申请Integrated Electrical Profiling System For Measuring Leukocytes Activation From Whole Blood 审中-公开用于测量全血白细胞激活的综合电气剖面系统公开(公告)号：US20160331297A1
公开(公告)日：2016-11-17
申请号：US15111584
申请日：2015-01-16
发明人： Joel Voldman , Hao-Wei Su , Javier Lopez Prieto , Jongyoon Han , Lidan Wu
IPC分类号： A61B5/00 , G01N15/10 , B01L3/00 , G01N33/487 , A61B5/145 , A61B5/1486
CPC分类号： A61B5/412 , A61B5/14546 , A61B5/1468 , A61B5/1486 , B01L3/502715 , B01L3/502746 , B01L3/502753 , B01L3/502761 , B01L2200/0605 , B01L2200/0647 , B01L2200/0652 , B01L2300/0645 , B01L2300/0816 , B01L2300/088 , G01N15/1031 , G01N15/1404 , G01N15/1459 , G01N15/1463 , G01N15/1484 , G01N33/48735 , G01N2015/0073 , G01N2015/008 , G01N2015/1006 , G01N2015/1486 , G01N2015/149 , G01N2800/7095
摘要： A system includes a microfluidic device configured to isolate one or more particles from a mixture, a flow rate matching device configured to match flow rate of the microfluidic device with flow rate of an electrical measurement device configured to measure an electrical property of the isolated particles, and an electrical measurement device configured to measure an electrical property of the isolated particles.
摘要翻译： 一种系统包括配置成从混合物中分离一个或多个颗粒的微流体装置，配置成使微流体装置的流速与配置成测量孤立颗粒的电性能的电测量装置的流速相匹配的流速匹配装置， 以及被配置为测量所述孤立颗粒的电特性的电测量装置。
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