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公开(公告)号：US20240401138A1
公开(公告)日：2024-12-05
申请号：US18751175
申请日：2024-06-21
Applicant: Natera, Inc.
Inventor： Matthew Rabinowitz , Matthew Micah Hill , Bernhard Zimmermann , Johan Baner , George Gemelos , Milena Banjevic , Allison Ryan , Styrmir Sigurjonsson , Zachary Demko
IPC: C12Q1/6883 , C12Q1/6809 , C12Q1/6811 , C12Q1/6844 , C12Q1/6848 , C12Q1/6851 , C12Q1/6855 , C12Q1/6869 , C12Q1/6874
Abstract: The invention provides methods for simultaneously amplifying multiple nucleic acid regions of interest in one reaction volume as well as methods for selecting a library of primers for use in such amplification methods. The invention also provides library of primers with desirable characteristics, such as minimal formation of amplified primer dimers or other non-target amplicons.
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公开(公告)号：US20240336970A1
公开(公告)日：2024-10-10
申请号：US18751153
申请日：2024-06-21
Applicant: Natera, Inc.
Inventor： Matthew Rabinowitz , Matthew Micah Hill , Bernhard Zimmermann , Johan Baner , George Gemelos , Milena Banjevic , Allison Ryan , Styrmir Sigurjonsson , Zachary Demko
IPC: C12Q1/6883 , C12Q1/6809 , C12Q1/6811 , C12Q1/6844 , C12Q1/6848 , C12Q1/6851 , C12Q1/6855 , C12Q1/6869 , C12Q1/6874
CPC classification number: C12Q1/6883 , C12Q1/6809 , C12Q1/6811 , C12Q1/6844 , C12Q1/6848 , C12Q1/6851 , C12Q1/6855 , C12Q1/6869 , C12Q1/6874 , C12Q2600/156
Abstract: The invention provides methods for simultaneously amplifying multiple nucleic acid regions of interest in one reaction volume as well as methods for selecting a library of primers for use in such amplification methods. The invention also provides library of primers with desirable characteristics, such as minimal formation of amplified primer dimers or other non-target amplicons.
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公开(公告)号：US11946101B2
公开(公告)日：2024-04-02
申请号：US17845169
申请日：2022-06-21
Applicant: Natera, Inc.
Inventor： Huseyin Eser Kirkizlar , Raheleh Salari , Styrmir Sigurjonsson , Bernhard Zimmermann , Allison Ryan , Naresh Vankayalapati
IPC: C07H21/04 , C12Q1/6853 , C12Q1/6858 , C12Q1/6869 , C12Q1/6886 , G16B20/00 , G16B20/10 , G16H10/40
CPC classification number: C12Q1/6858 , C12Q1/6853 , C12Q1/6869 , C12Q1/6886 , G16B20/00 , G16B20/10 , G16H10/40 , C12Q2539/10 , C12Q2600/106 , C12Q2600/156 , Y02A90/10
Abstract: The invention provides improved methods, compositions, and kits for detecting ploidy of chromosome regions, e.g. for detecting cancer or a chromosomal abnormality in a gestating fetus. The methods can utilize a set of more than 200 SNPs that are found within haploblocks and can include analyzing a series of target chromosomal regions related to cancer or a chromosomal abnormality in a gestating fetus. Finally the method may use knowledge about chromosome crossover locations or a best fit algorithm for the analysis. The compositions may comprise more than 200 primers located within haplotype blocks known to show CNV.
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公开(公告)号：US11591649B2
公开(公告)日：2023-02-28
申请号：US16796748
申请日：2020-02-20
Applicant: Natera, Inc.
Inventor： Matthew Rabinowitz , Matthew Hill , Bernhard Zimmermann , Johan Baner , George Gemelos , Milena Banjevic , Allison Ryan , Styrmir Sigurjonsson , Zachary Demko
IPC: C12Q1/6869 , G16B10/00 , C12Q1/6876 , C12Q1/6844
Abstract: Methods for non-invasive prenatal paternity testing are disclosed herein. The method uses genetic measurements made on plasma taken from a pregnant mother, along with genetic measurements of the alleged father, and genetic measurements of the mother, to determine whether or not the alleged father is the biological father of the fetus. This is accomplished by way of an informatics based method that can compare the genetic fingerprint of the fetal DNA found in maternal plasma to the genetic fingerprint of the alleged father.
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公开(公告)号：US11408031B2
公开(公告)日：2022-08-09
申请号：US16012667
申请日：2018-06-19
Applicant: Natera, Inc.
Inventor： Allison Ryan , Styrmir Sigurjonsson , Milena Banjevic , George Gemelos , Matthew Hill , Johan Baner , Matthew Rabinowitz , Zachary Demko , Bernhard Zimmerman
IPC: C12Q1/68 , C12Q1/6869 , C12Q1/6876 , C12Q1/6844 , G16B10/00
Abstract: Methods for non-invasive prenatal paternity testing are disclosed herein. The method uses genetic measurements made on plasma taken from a pregnant mother, along with genetic measurements of the alleged father, and genetic measurements of the mother, to determine whether or not the alleged father is the biological father of the fetus. This is accomplished by way of an informatics based method that can compare the genetic fingerprint of the fetal DNA found in maternal plasma to the genetic fingerprint of the alleged father.
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Patent Agency Ranking
公开(公告)号：US10522242B2
公开(公告)日：2019-12-31
申请号：US15343003
申请日：2016-11-03
Applicant: Natera, Inc.
Inventor： Matthew Rabinowitz , Allison Ryan , George Gemelos , Milena Banjevic , Zachary Demko
IPC: G01N33/50 , G16B30/00 , G16B20/00 , C12Q1/6827 , C12Q1/6874 , C12Q1/6876 , C12Q1/6883 , G06N7/00
Abstract: Disclosed herein are methods for determining the copy number of a chromosome in a fetus in the context of non-invasive prenatal diagnosis. In an embodiment, the measured genetic data from a sample of genetic material that contains both fetal DNA and maternal DNA is analyzed, along with the genetic data from the biological parents of the fetus, and the copy number of the chromosome of interest is determined. In an embodiment, the maternal serum is measured using a single-nucleotide polymorphism (SNP) microarray, along with parental genomic data, and the determination of the chromosome copy number is used to make clinical decisions pertaining to the fetus.
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公开(公告)号：US20160369346A1
公开(公告)日：2016-12-22
申请号：US15252795
申请日：2016-08-31
Applicant: Natera, Inc.
Inventor： Matthew Rabinowitz , Allison Ryan , George Gemelos , Milena Banjevic , Zachary Demko
CPC classification number: G16B30/00 , C12Q1/6827 , C12Q1/6874 , C12Q1/6876 , C12Q1/6883 , C12Q2600/156 , C12Q2600/16 , G06N7/005 , G16B20/00 , C12Q2537/16 , C12Q2537/165
Abstract: Disclosed herein are methods for determining the copy number of a chromosome in a fetus in the context of non-invasive prenatal diagnosis. In an embodiment, the measured genetic data from a sample of genetic material that contains both fetal DNA and maternal DNA is analyzed, along with the genetic data from the biological parents of the fetus, and the copy number of the chromosome of interest is determined. In an embodiment, the maternal serum is measured using a single-nucleotide polymorphism (SNP) microarray, along with parental genomic data, and the determination of the chromosome copy number is used to make clinical decisions pertaining to the fetus.
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公开(公告)号：US20160171152A1
公开(公告)日：2016-06-16
申请号：US14983128
申请日：2015-12-29
Applicant: Natera, Inc.
Inventor： Matthew Rabinowitz , Allison Ryan , George Gemelos , Milena Banjevic , Zachary Demko
CPC classification number: G06F19/22 , C12Q1/6827 , C12Q1/6874 , C12Q1/6876 , C12Q1/6883 , C12Q2600/156 , C12Q2600/16 , G06F19/18 , G06N7/005 , C12Q2537/16 , C12Q2537/165
Abstract: Disclosed herein are methods for determining the copy number of a chromosome in a fetus in the context of non-invasive prenatal diagnosis. In an embodiment, the measured genetic data from a sample of genetic material that contains both fetal DNA and maternal DNA is analyzed, along with the genetic data from the biological parents of the fetus, and the copy number of the chromosome of interest is determined. In an embodiment, the maternal serum is measured using a single-nucleotide polymorphism (SNP) microarray, along with parental genomic data, and the determination of the chromosome copy number is used to make clinical decisions pertaining to the fetus.
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公开(公告)号：US20160024564A1
公开(公告)日：2016-01-28
申请号：US14866223
申请日：2015-09-25
Applicant: Natera, Inc.
Inventor： Matthew Rabinowitz , Allison Ryan , George Gemelos , Milena Banjevic , Zachary Demko
IPC: C12Q1/68
CPC classification number: G06F19/22 , C12Q1/6827 , C12Q1/6874 , C12Q1/6876 , C12Q1/6883 , C12Q2600/156 , C12Q2600/16 , G06F19/18 , G06N7/005 , C12Q2537/16 , C12Q2537/165
Abstract: Disclosed herein are methods for determining the copy number of a chromosome in a fetus in the context of non-invasive prenatal diagnosis. In an embodiment, the measured genetic data from a sample of genetic material that contains both fetal DNA and maternal DNA is analyzed, along with the genetic data from the biological parents of the fetus, and the copy number of the chromosome of interest is determined. In an embodiment, the maternal serum is measured using a single-nucleotide polymorphism (SNP) microarray, along with parental genomic data, and the determination of the chromosome copy number is used to make clinical decisions pertaining to the fetus.
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公开(公告)号：US09228234B2
公开(公告)日：2016-01-05
申请号：US14080656
申请日：2013-11-14
Applicant: Natera, Inc.
Inventor： Matthew Rabinowitz , Allison Ryan , George Gemelos , Milena Banjevic , Zachary Demko
CPC classification number: G06F19/22 , C12Q1/6827 , C12Q1/6874 , C12Q1/6876 , C12Q1/6883 , C12Q2600/156 , C12Q2600/16 , G06F19/18 , G06N7/005 , C12Q2537/16 , C12Q2537/165
Abstract: Disclosed herein are methods for determining the copy number of a chromosome in a fetus in the context of non-invasive prenatal diagnosis. In an embodiment, the measured genetic data from a sample of genetic material that contains both fetal DNA and maternal DNA is analyzed, along with the genetic data from the biological parents of the fetus, and the copy number of the chromosome of interest is determined. In an embodiment, the maternal serum is measured using a single-nucleotide polymorphism (SNP) microarray, along with parental genomic data, and the determination of the chromosome copy number is used to make clinical decisions pertaining to the fetus.
Abstract translation: 本文公开了用于在非侵入性产前诊断的上下文中确定胎儿中染色体的拷贝数的方法。 在一个实施方案中，分析来自含有胎儿DNA和母体DNA的遗传物质的样品的测量的遗传数据以及来自胎儿的生物亲本的遗传数据，并确定感兴趣的染色体的拷贝数。 在一个实施方案中，使用单核苷酸多态性（SNP）微阵列以及亲本基因组数据测量母体血清，并且使用染色体拷贝数的确定来进行与胎儿有关的临床决定。
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