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公开(公告)号：US11543409B2
公开(公告)日：2023-01-03
申请号：US16749314
申请日：2020-01-22
Inventor： Hiroto Yanagawa
Abstract: The present disclosure provides a sensor substrate capable of detecting a trace amount of an analyte. This sensor substrate according to the present disclosure is a sensor substrate comprising a metal microstructure that generates surface plasmon when irradiated with excitation light. The metal microstructure is composed of a plurality of protrusions disposed in a planar shape. The plurality of the protrusions are disposed in such a manner that imaginary lines V each passing through a center between adjacent protrusions draw a honeycomb shape in a plan view. Each of the plurality of the protrusions has a substantially hexagonal shape in the plan view. A depth in a thickness direction of the sensor substrate of a gap present between the adjacent protrusions is larger than a radius of an imaginary circle inscribed in a hexagon forming the honeycomb shape.
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公开(公告)号：US10709224B2
公开(公告)日：2020-07-14
申请号：US15612048
申请日：2017-06-02
Inventor： Yasuaki Okumura , Hiroto Yanagawa , Yumiko Ohno , Yuichi Aoki , Mikiya Nakata , Akira Asai
Abstract: A device control system including a wearable device and a server. The wearable device includes a device that ejects a fragrance material, a biological sensor, and a computer. The computer transmits biological data to the server, receives a first control signal, and causes the device to eject a fragrance material upon receipt of the first control signal. The server includes a computer. The computer receives the biological data, estimates user's emotion from the received biological data, and in a case where it is determined that the user has positive emotion by using a result of the estimation, (i) transmits the first control signal to the wearable device and (ii) transmits, to an aroma device, a second control signal for causing the aroma device to eject a fragrance material at a predetermined timing.
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Patent Agency Ranking
公开(公告)号：US11768155B2
公开(公告)日：2023-09-26
申请号：US16747021
申请日：2020-01-20
Inventor： Hiroto Yanagawa , Masahiko Shioi , Kazuaki Nishio , Emina Ikeuchi
IPC: G01N21/64 , G01N33/543 , G01N33/68
CPC classification number: G01N21/648 , G01N33/54373 , G01N33/6857 , G01N2021/6441
Abstract: The present disclosure provides a detection device capable of detecting a low concentration of an analyte with high sensitivity. The detection apparatus according to the present disclosure comprises a metal microstructure on which a first VHH antibody having a property of binding specifically to the analyte is immobilized and which generate surface plasmon by being irradiated with excitation light, an inlet through which a second VHH antibody and a sample that may contain an analyte are introduced, wherein the second VHH antibody has a property of binding specifically to the analyte and is labeled with a fluorescent substance, a light source for irradiating the metal microstructure to which the second VHH antibody and the sample have been introduced with the excitation light, and a detection unit for detecting the analyte on the basis of fluorescence generated from the fluorescent substance by the irradiation of the excitation light.
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公开(公告)号：US11567069B2
公开(公告)日：2023-01-31
申请号：US17071578
申请日：2020-10-15
Inventor： Takashi Kanno , Hiroto Yanagawa
IPC: G01N33/543 , G01N21/64 , G01N33/553 , B82Y15/00 , G02B5/00
Abstract: One non-limiting and exemplary embodiment provides a metal microscopic structure capable of detecting a low-concentration analyte with high sensitivity. The metal microscopic structure includes a base member including multiple protrusions arrayed at predetermined intervals, and multiple projections made of a metal film covering the base member and configured to generate surface plasmons upon irradiation with light. A film thickness of the metal film positioned in a bottom portion of a gap between every adjacent two of the multiple projections is greater than a height of the multiple protrusions and is more than or equal to 90% and less than or equal to 100% of a film thickness of the metal film deposited on top portions of the multiple protrusions.
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公开(公告)号：US11435286B2
公开(公告)日：2022-09-06
申请号：US16908788
申请日：2020-06-23
Inventor： Yoshiki Sasaki , Tatsurou Kawamura , Hiroto Yanagawa
IPC: G01N21/64 , G01N33/569 , G01N33/58
Abstract: A pathogen detection apparatus includes a collector that collects a pathogen in air; a reactor that causes the pathogen collected by the collector to react with a labeled substance; a time measurer that measures time from start of reaction in the reactor; a detector that detects a quantity of labeled substance that has reacted with the pathogen; and a controller. The controller calculates a gradient value on the basis of a predetermined time period from the start of reaction measured by the time measurer and the quantity of labeled substance detected by the detector, and determines, on the basis of the gradient value, a time interval to next collection that is to be performed by the collector.
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公开(公告)号：US12006458B2
公开(公告)日：2024-06-11
申请号：US17118652
申请日：2020-12-11
Inventor： Hiroto Yanagawa
CPC classification number: C09K11/59 , C09K11/02 , G01N21/6428 , G01N21/648 , B82Y15/00 , B82Y30/00 , B82Y40/00 , G01N2021/1727 , G01N2021/258
Abstract: The present disclosure provides a complex having satisfactory dispersibility and stable luminescence characteristics. A complex of the present disclosure includes: a first substance having a property of specifically binding to a target substance; a quantum dot that contains silicon as a main component and that is negatively charged on a surface; and a linker substance that contains a compound represented by general formula (1) below and that covers the surface of the quantum dot, where the first substance has been immobilized on the surface of the quantum dot through the linker substance:
X—L—Si—(R1)(R2)(OR3) (1)
where X is a basic functional group; R1, R2, and R3 are each independently an alkyl group; and L is an alkylene group.-
公开(公告)号：US11841323B2
公开(公告)日：2023-12-12
申请号：US17077444
申请日：2020-10-22
Inventor： Hiroto Yanagawa
CPC classification number: G01N21/645 , G01N21/658 , G01N2021/6482 , G01N2201/02
Abstract: The present disclosure provides a sensor substrate that detects an analyte of a low concentration with high sensitivity and high reliability. The sensor substrate according to the present disclosure a first substrate having first microprotrusions provided on the surface thereof and covered by a metal film, an adhesive film disposed on the surface of the first substrate and having a slit, and a second substrate that is transparent, disposed on the adhesive film, and having a first through hole and a second through hole, wherein each of the first through hole and the second through hole is in communication with the slit, and the first microprotrusions overlap the slit in a plan view.
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