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1.发明授权Insulins with an acyl moiety comprising repeating units of alkylene glycol containing amino acids 有权具有酰基部分的胰岛素包含含氨基酸的亚烷基二醇的重复单元公开(公告)号：US08962794B2
公开(公告)日：2015-02-24
申请号：US12673337
申请日：2008-08-15
摘要： Acylated insulins wherein an acyl moiety is attached to the parent insulin and wherein said acyl moiety comprises repeating units of alkylene glycol containing amino acids and wherein there is only one lysine residue (K & Lys) in the parent insulin have satisfactory properties when administered pulmonary.
摘要翻译： 其中酰基部分连接到母体胰岛素上的酰化胰岛素，其中所述酰基部分包含含有氨基酸的亚烷基二醇的重复单元，并且当给予肺部时，母体胰岛素中仅有一个赖氨酸残基（K＆Lys）具有令人满意的性质。
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公开(公告)号：US08691759B2
公开(公告)日：2014-04-08
申请号：US12922117
申请日：2009-03-13
申请人： Peter Madsen , Thomas Boerglum Kjeldsen , Thomas Hoeg-Jensen , Palle Jakobsen , Tina Moeller Tagmose , Janos Tibor Kodra , Patrick William Garibay
发明人： Peter Madsen , Thomas Boerglum Kjeldsen , Thomas Hoeg-Jensen , Palle Jakobsen , Tina Moeller Tagmose , Janos Tibor Kodra , Patrick William Garibay
摘要： Novel acylated insulin analogues exhibiting resistance towards proteases can, effectively, be administered pulmonary or orally. The insulin analogues contain B25H and A14E or A14H.
摘要翻译： 对蛋白酶具有抗性的新型酰化胰岛素类似物可以有效地被肺或口服给药。 胰岛素类似物含有B25H和A14E或A14H。
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3.发明申请Insulin Derivatives Conjugated with Structurally Well Defined Branched Polymers 审中-公开与结构定义良好的支化聚合物共轭的胰岛素衍生物公开(公告)号：US20090036353A1
公开(公告)日：2009-02-05
申请号：US11814184
申请日：2006-01-26
申请人： Carsten Behrens , Jesper Lau , Janos Tibor Kodra , Mikael Kofod-Hansen , Thomas Hoeg-Jensen , Peter Madsen , Svend Havelund
发明人： Carsten Behrens , Jesper Lau , Janos Tibor Kodra , Mikael Kofod-Hansen , Thomas Hoeg-Jensen , Peter Madsen , Svend Havelund
CPC分类号： B82Y5/00 , A61K47/59 , A61K47/595 , A61K47/60 , A61K47/641 , A61K47/6949
摘要： Insulin conjugated with structurally well defined, bifurcated and trifurcated polymers can be use by pulmonary delivery for systemic absorption through the lungs to reduce or eliminate the need for administering other insulins by injection.
摘要翻译： 与结构良好定义的分叉和三化聚合物结合的胰岛素可以通过肺部递送用于通过肺的全身吸收，以减少或消除通过注射施用其它胰岛素的需要。
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公开(公告)号：US08722620B2
公开(公告)日：2014-05-13
申请号：US12280851
申请日：2007-02-27
申请人： Charlotte Harkjaer Fynbo , Ib Jonassen , Thomas Børglum Kjeldsen , Peter Madsen , Patrick William Garibay , Janos Tibor Kodra , Thomas Hoeg-Jensen , Tina Møller Tagmose
发明人： Charlotte Harkjaer Fynbo , Ib Jonassen , Thomas Børglum Kjeldsen , Peter Madsen , Patrick William Garibay , Janos Tibor Kodra , Thomas Hoeg-Jensen , Tina Møller Tagmose
摘要： The present invention is related to insulin derivatives having a side chain attached to an ε-amino group of a Lys residue present in the A-chain or to an ε-amino group of a Lys residue in the B-chain.
摘要翻译： 本发明涉及具有连接在A链中存在的Lys残基的侧链或B链中的Lys残基的' - 氨基的侧链的胰岛素衍生物。
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公开(公告)号：US20090137454A1
公开(公告)日：2009-05-28
申请号：US12280851
申请日：2007-02-27
申请人： Charlotte Harkjaer Fynbo , Ib Jonassen , Thomas Borglum Kjeldsen , Peter Madsen , Patrick William Garibay , Janos Tibor Kodra , Thomas Hoeg-Jensen , Tina Moller Tagmose
发明人： Charlotte Harkjaer Fynbo , Ib Jonassen , Thomas Borglum Kjeldsen , Peter Madsen , Patrick William Garibay , Janos Tibor Kodra , Thomas Hoeg-Jensen , Tina Moller Tagmose
摘要： The present invention is related to insulin derivatives having a side chain attached to an ε-amino group of a Lys residue present in the A-chain or to an ε-amino group of a Lys residue in the B-chain.
摘要翻译： 本发明涉及具有连接于存在于A链中的Lys残基的ε-氨基侧链或B链中Lys残基的ε-氨基的侧链的胰岛素衍生物。
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公开(公告)号：US06762318B2
公开(公告)日：2004-07-13
申请号：US10308528
申请日：2002-12-03
申请人： Janos Tibor Kodra , Peter Madsen , Jesper Lau , Anker Steen Jorgensen , Inge Thoger Christensen
发明人： Janos Tibor Kodra , Peter Madsen , Jesper Lau , Anker Steen Jorgensen , Inge Thoger Christensen
IPC分类号： C07C22900
CPC分类号： A61K45/06 , A61K31/195 , A61K31/198 , A61K31/41 , A61K31/4439 , A61K2300/00
摘要： Novel compounds that act to antagonize the action of the glucagon peptide hormone on the glucagon receptor. More particularly, it relates to glucagon antagonists or inverse agonists.
摘要翻译： 用于拮抗胰高血糖素肽激素对胰高血糖素受体的作用的新型化合物。 更具体地，涉及胰高血糖素拮抗剂或反向激动剂。
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公开(公告)号：US20090143592A1
公开(公告)日：2009-06-04
申请号：US11949075
申请日：2007-12-03
申请人： Jesper Lau , Peter Madsen , Christian Sams , Carsten Behrens , Josef Vagner , Inge Thoger Christensen , Behrend Frederik Lundt , Ulla Grove Sidelmann , Henning Thogersen , Anthony L. Ling , Michael Bruno Plewe , Larry Kenneth Truesdale , Anker Steen Jogensen , Janos Tibor Kodra , Shenghua Shi
发明人： Jesper Lau , Peter Madsen , Christian Sams , Carsten Behrens , Josef Vagner , Inge Thoger Christensen , Behrend Frederik Lundt , Ulla Grove Sidelmann , Henning Thogersen , Anthony L. Ling , Michael Bruno Plewe , Larry Kenneth Truesdale , Anker Steen Jogensen , Janos Tibor Kodra , Shenghua Shi
IPC分类号： C07D211/88 , C07D257/06 , C07D333/24 , C07C57/62
CPC分类号： C07D209/48 , C07B2200/07 , C07C237/36 , C07C237/42 , C07C243/38 , C07C271/56 , C07C271/58 , C07C275/24 , C07C275/26 , C07C275/28 , C07C275/30 , C07C275/34 , C07C275/36 , C07C275/38 , C07C275/42 , C07C275/60 , C07C275/62 , C07C311/47 , C07C317/22 , C07C317/32 , C07C317/42 , C07C323/21 , C07C323/44 , C07C2601/02 , C07C2601/08 , C07C2601/14 , C07C2602/08 , C07C2602/10 , C07C2602/42 , C07C2603/18 , C07C2603/68 , C07C2603/94 , C07D209/08 , C07D211/58 , C07D213/75 , C07D215/38 , C07D231/40 , C07D235/30 , C07D257/06 , C07D277/72 , C07D295/13 , C07D295/135 , C07D307/68 , C07D317/66 , C07D319/18 , C07D319/20 , C07D333/20 , C07D333/38 , C07D333/60 , C07D333/68 , C07D333/70 , C07D409/12 , C07D417/12 , C07D487/04
摘要： A novel class of compounds, which act to antagonize the action of the glucagon hormone on the glucagon receptor. Owing to their antagonizing effect of the glucagon receptor the compounds may be suitable for the treatment and/or prevention of any glucagon-mediated conditions and diseases such as hyperglycemia, Type 1 diabetes, Type 2 diabetes and obesity.
摘要翻译： 一类新颖的化合物，其作用是拮抗胰高血糖素激素对胰高血糖素受体的作用。 由于它们对胰高血糖素受体的拮抗作用，所述化合物可适用于治疗和/或预防任何胰高血糖素介导的病症和疾病如高血糖症，1型糖尿病，2型糖尿病和肥胖症。
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公开(公告)号：US06927214B1
公开(公告)日：2005-08-09
申请号：US09483504
申请日：2000-01-14
申请人： Min Teng , Larry Kenneth Truesdale , Dilip Bhumralkar , Dan Kiel , Michael D. Johnson , Christine Thomas , Anker Steen Jorgensen , Peter Madsen , Preben Houlberg Olesen , Liselotte Bjerre Knudsen , Ingrid Vivika Petterson , Johannes Cornelis de Jong , Carsten Behrens , Janos Tibor Kodra , Jesper Lau
发明人： Min Teng , Larry Kenneth Truesdale , Dilip Bhumralkar , Dan Kiel , Michael D. Johnson , Christine Thomas , Anker Steen Jorgensen , Peter Madsen , Preben Houlberg Olesen , Liselotte Bjerre Knudsen , Ingrid Vivika Petterson , Johannes Cornelis de Jong , Carsten Behrens , Janos Tibor Kodra , Jesper Lau
IPC分类号： C07D215/20 , C07D215/36 , C07D241/44 , C07D401/12 , C07D403/04 , C07D403/12 , C07D405/04 , C07D405/12 , C07D417/12 , C07D491/10 , C07D495/04 , A61K31/33 , A61K31/495 , C07D239/00 , C07D241/36
CPC分类号： C07D491/10 , C07D215/20 , C07D215/36 , C07D241/44 , C07D401/12 , C07D403/04 , C07D403/12 , C07D405/04 , C07D405/12 , C07D417/12 , C07D495/04
摘要： Novel non-peptide GLP-1 agonists, pharmaceutical compositions comprising them, use of the non-peptide GLP-1 agonists for the preparation of pharmaceutical compositions and methods for the treatment and/or prevention of disorders and diseases wherein an activation of the human GLP-1 receptor is beneficial, especially metabolic disorders such as IGT, Type 1 diabetes, Type 2 diabetes and obesity.
摘要翻译： 新型非肽GLP-1激动剂，包含它们的药物组合物，使用非肽GLP-1激动剂来制备用于治疗和/或预防疾病和疾病的药物组合物和方法，其中人GLP -1受体是有益的，特别是代谢疾病如IGT，1型糖尿病，2型糖尿病和肥胖。
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公开(公告)号：US06881746B2
公开(公告)日：2005-04-19
申请号：US10448529
申请日：2003-05-30
申请人： Jesper Lau , Inge Thoger Christensen , Peter Madsen , Paw Bloch , Carsten Behrens , Janos Tibor Kodra , Poul Enrico Nielsen
发明人： Jesper Lau , Inge Thoger Christensen , Peter Madsen , Paw Bloch , Carsten Behrens , Janos Tibor Kodra , Poul Enrico Nielsen
IPC分类号： A61K31/195 , A61K31/198 , A61K31/41 , A61K31/4439 , A61K45/06 , A61K31/425 , A61P3/00 , C07D277/04
CPC分类号： A61K45/06 , A61K31/195 , A61K31/198 , A61K31/41 , A61K31/4439 , A61K2300/00
摘要： Novel compounds that act to antagonize the action of the glucagon peptide hormone on the glucagon receptor. More particularly, it relates to glucagon antagonists or inverse agonists.
摘要翻译： 用于拮抗胰高血糖素肽激素对胰高血糖素受体的作用的新型化合物。 更具体地，涉及胰高血糖素拮抗剂或反向激动剂。
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公开(公告)号：US06875760B2
公开(公告)日：2005-04-05
申请号：US10233851
申请日：2002-08-30
申请人： Jesper Lau , Peter Madsen , Christian Sams , Carsten Behrens , Inge Thøger Christensen , Behrend Frederik Lundt , Ulla Grove Sidelmann , Henning Thøgersen , Anthony L. Ling , Michael Bruno Plewe , Larry Kenneth Truesdale , Anker Steen Jøgensen , Janos Tibor Kodra , Shenghua Shi
发明人： Jesper Lau , Peter Madsen , Christian Sams , Carsten Behrens , Inge Thøger Christensen , Behrend Frederik Lundt , Ulla Grove Sidelmann , Henning Thøgersen , Anthony L. Ling , Michael Bruno Plewe , Larry Kenneth Truesdale , Anker Steen Jøgensen , Janos Tibor Kodra , Shenghua Shi
IPC分类号： C07C237/36 , C07C237/42 , C07C243/38 , C07C271/56 , C07C271/58 , C07C275/24 , C07C275/26 , C07C275/28 , C07C275/30 , C07C275/34 , C07C275/36 , C07C275/38 , C07C275/42 , C07C275/60 , C07C275/62 , C07C311/47 , C07C317/22 , C07C317/32 , C07C317/42 , C07C323/21 , C07C323/44 , C07D209/08 , C07D209/48 , C07D211/58 , C07D213/75 , C07D215/38 , C07D231/40 , C07D235/30 , C07D257/06 , C07D277/72 , C07D295/13 , C07D295/135 , C07D307/68 , C07D317/66 , C07D319/18 , C07D319/20 , C07D333/20 , C07D333/38 , C07D333/60 , C07D333/68 , C07D333/70 , C07D409/12 , C07D417/12 , C07D487/04 , A61K31/33 , A61K31/695 , C07D257/00
CPC分类号： C07D209/48 , C07B2200/07 , C07C237/36 , C07C237/42 , C07C243/38 , C07C271/56 , C07C271/58 , C07C275/24 , C07C275/26 , C07C275/28 , C07C275/30 , C07C275/34 , C07C275/36 , C07C275/38 , C07C275/42 , C07C275/60 , C07C275/62 , C07C311/47 , C07C317/22 , C07C317/32 , C07C317/42 , C07C323/21 , C07C323/44 , C07C2601/02 , C07C2601/08 , C07C2601/14 , C07C2602/08 , C07C2602/10 , C07C2602/42 , C07C2603/18 , C07C2603/68 , C07C2603/94 , C07D209/08 , C07D211/58 , C07D213/75 , C07D215/38 , C07D231/40 , C07D235/30 , C07D257/06 , C07D277/72 , C07D295/13 , C07D295/135 , C07D307/68 , C07D317/66 , C07D319/18 , C07D319/20 , C07D333/20 , C07D333/38 , C07D333/60 , C07D333/68 , C07D333/70 , C07D409/12 , C07D417/12 , C07D487/04
摘要： A novel class of compounds, which act to antagonize the action of the glucagon hormone on the glucagon receptor. Owing to their antagonizing effect of the glucagon receptor the compounds may be suitable for the treatment and/or prevention of any glucagon-mediated conditions and diseases such as hyperglycemia, Type 1 diabetes, Type 2 diabetes and obesity.
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