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49 条记录 (耗时 0.064 秒)

    Effective Monitoring System or Anthrax, Smallpox, or Other Pathogens
    1.
    发明申请
    Effective Monitoring System or Anthrax, Smallpox, or Other Pathogens 审中-公开
    有效的监测系统或炭疽病，天花或其他病原体

    公开(公告)号：US20090162891A1

    公开(公告)日：2009-06-25

    申请号：US11963813

    申请日：2007-12-22

    申请人： Peter S. Lu ,  Thomas M. Sherlock ,  Joseph Byerly

    发明人： Peter S. Lu ,  Thomas M. Sherlock ,  Joseph Byerly

    IPC分类号： C12Q1/04 ,  C12M1/00 ,  C12M1/34

    CPC分类号： G01N33/56911 ,  C12M23/32 ,  C12M41/36 ,  C12Q1/04 ,  G01N2001/021 ,  G01N2001/028 ,  G01N2333/32 ,  Y02A50/451 ,  Y02A50/52 ,  Y10S435/808

    摘要： A device and method for detecting anthrax or other pathogens are disclosed. Individual self-contained monitoring devices of a monitoring system can be portable or stationary (e.g. installed in air ducts or plumbing of buildings) and can be part of a network of devices. Monitoring devices may be used for the detection of a variety of airborne or surface pathogens, including but not limited to anthrax, smallpox, and Salmonella. Bioamplification-coupled proteomics assays provide rapid and reliable detection of pathogens, with self-checking capabilities reducing or eliminating false positives and false negatives. Sample preservation capability allows pathogen samples to be preserved after detection for further testing. The device of the invention can be remotely operated by minimally trained technicians or security personnel. The pathogen monitoring device of the invention provides a more compact, accurate, rapid, and cost-effective alternative to other anthrax detectors, and an effective weapon against bioterrorism.

    摘要翻译： 公开了一种用于检测炭疽病或其他病原体的装置和方法。 监控系统的各个独立的监控设备可以是便携式的或静态的（例如安装在空气管道或建筑物的管道中），并且可以是设备网络的一部分。 监测装置可用于检测各种空气传播或表面病原体，包括但不限于炭疽，天花和沙门氏菌。 生物扩增耦合蛋白质组学检测提供了快速可靠的病原体检测，具有自我检查功能，减少或消除假阳性和假阴性。 样品保存能力允许在检测后保留病原体样品进行进一步测试。 本发明的装置可由受过训练的技术人员或安全人员进行远程操作。 本发明的病原体监测装置为其他炭疽检测器提供了更紧凑，准确，快速和成本有效的替代方案，也是提供了抗生物恐怖主义的有效武器。

    Effective monitoring system for anthrax smallpox, or other pathogens
    3.
    发明授权
    Effective monitoring system for anthrax smallpox, or other pathogens 有权
    有效的监测系统为炭疽病或其他病原体

    公开(公告)号：US07312071B2

    公开(公告)日：2007-12-25

    申请号：US10313354

    申请日：2002-12-06

    申请人： Peter S. Lu ,  Thomas M. Sherlock ,  Joseph Byerly

    发明人： Peter S. Lu ,  Thomas M. Sherlock ,  Joseph Byerly

    IPC分类号： C12M1/34

    CPC分类号： G01N33/56911 ,  C12M23/32 ,  C12M41/36 ,  C12Q1/04 ,  G01N2001/021 ,  G01N2001/028 ,  G01N2333/32 ,  Y02A50/451 ,  Y02A50/52 ,  Y10S435/808

    摘要： A device and method for detecting anthrax or other pathogens are disclosed. Individual self-contained monitoring devices of a monitoring system can be portable or stationary (e.g. installed in air ducts or plumbing of buildings) and can be part of a network of devices. Monitoring devices may be used for the detection of a variety of airborne or surface pathogens, including but not limited to anthrax, smallpox, and Salmonella. Bioamplification-coupled proteomics assays provide rapid and reliable detection of pathogens, with self-checking capabilities reducing or eliminating false positives and false negatives. Sample preservation capability allows pathogen samples to be preserved after detection for further testing. The device of the invention can be remotely operated by minimally trained technicians or security personnel. The pathogen monitoring device of the invention provides a more compact, accurate, rapid, and cost-effective alternative to other anthrax detectors, and an effective weapon against bioterrorism.

    摘要翻译： 公开了一种用于检测炭疽病或其他病原体的装置和方法。 监控系统的各个独立的监控设备可以是便携式的或静态的（例如安装在空气管道或建筑物的管道中），并且可以是设备网络的一部分。 监测装置可用于检测各种空气传播或表面病原体，包括但不限于炭疽，天花和沙门氏菌。 生物扩增耦合蛋白质组学检测提供了快速可靠的病原体检测，具有自我检查功能，减少或消除假阳性和假阴性。 样品保存能力允许在检测后保留病原体样品进行进一步测试。 本发明的装置可由受过训练的技术人员或安全人员进行远程操作。 本发明的病原体监测装置为其他炭疽检测器提供了更紧凑，准确，快速和成本有效的替代方案，也是提供了抗生物恐怖主义的有效武器。

    Assays For Detecting Inhibitors Of Binding Between COX-2 And PDZ Proteins
    6.
    发明申请
    Assays For Detecting Inhibitors Of Binding Between COX-2 And PDZ Proteins 审中-公开
    检测COX-2和PDZ蛋白结合抑制剂的检测方法

    公开(公告)号：US20100152294A1

    公开(公告)日：2010-06-17

    申请号：US12538665

    申请日：2009-08-10

    申请人： Michael P. Belmares ,  Jonathan David Garman ,  Peter S. Lu

    发明人： Michael P. Belmares ,  Jonathan David Garman ,  Peter S. Lu

    IPC分类号： A61K31/192 ,  G01N33/567 ,  C12N5/079 ,  G01N33/566 ,  A61P35/00

    CPC分类号： G01N33/6896 ,  C12Q1/26 ,  G01N33/88 ,  G01N2500/00

    摘要： The invention provides an assay for determining whether a test agent is a COX modulator. In general terms, the assay includes: determining whether a test agent modulates binding of a PDZ-containing polypeptide to a COX PL-containing polypeptide. The PDZ-containing polypeptide may contain the PDZ domain of PDZ domain of MAGI1, TIP-1, MAST2, PSD95, or SHANK. The assays may be done in a cell-free environment or in a cellular environment, particularly using a neuronal cell. The invention finds use in a variety of therapeutic applications, including for identifying agents for use in treating cancer, pain, inflammation and neuronal conditions caused by acute insult, e.g., stroke.

    摘要翻译： 本发明提供了一种用于确定测试试剂是否是COX调节剂的测定法。 一般来说，测定包括：测定测试试剂是否调节含PDZ的多肽与含COX PL的多肽的结合。 含PDZ的多肽可以含有MAGI1，TIP-1，MAST2，PSD95或SHANK的PDZ结构域的PDZ结构域。 测定可以在无细胞环境或细胞环境中进行，特别是使用神经元细胞。 本发明可用于各种治疗应用，包括用于鉴定用于治疗由急性损伤（例如中风）引起的癌症，疼痛，炎症和神经元病症的药剂。

    METHODS AND COMPOSITIONS FOR DIAGNOSIS AND TREATMENT OF INFLUENZA
    8.
    发明申请
    METHODS AND COMPOSITIONS FOR DIAGNOSIS AND TREATMENT OF INFLUENZA 审中-公开
    用于诊断和治疗流感病毒的方法和组合物

    公开(公告)号：US20100112547A1

    公开(公告)日：2010-05-06

    申请号：US12539535

    申请日：2009-08-11

    申请人： Peter S. Lu ,  Michael Belmares ,  Dave Garman

    发明人： Peter S. Lu ,  Michael Belmares ,  Dave Garman

    IPC分类号： C12Q1/70

    CPC分类号： A61K38/07 ,  A61K38/08 ,  C07K5/1008 ,  C07K5/1013 ,  C07K5/1019 ,  C07K5/1021 ,  C07K7/06 ,  C12N2760/16111 ,  G01N33/56983 ,  G01N2333/11 ,  G01N2500/02

    摘要： The invention provides method and compositions for determining the presence and amount of an influenza virus in a sample including high risk strains of Influenza A. Also provided are methods for determining whether a subject is infected with a influenza virus, as well as, the type and strain of the influenza virus. The methods involve contacting a sample from the subject with a PDZ polypeptides (PDZ) and/or PDZ ligands (PL) and determining whether binding interactions occur between PDZ and PL. Assays for identifying anti-viral agents are also provided, as well as, methods for using the compositions to alter PDZ binding to PL in influenza infected cells.

    摘要翻译： 本发明提供用于确定样品中流感病毒的存在和量的方法和组合物，其包括流感A的高风险菌株。还提供了确定受试者是否感染流感病毒的方法以及类型和 流感病毒株。 所述方法包括使来自受试者的样品与PDZ多肽（PDZ）和/或PDZ配体（PL）接触并确定在PDZ和PL之间是否发生结合相互作用。 还提供了用于鉴定抗病毒剂的测定法，以及使用该组合物改变流感病毒感染细胞中PDZ与PL结合的方法。

    Assays for detecting inhibitors of binding between COX-2 and PDZ proteins
    9.
    发明授权
    Assays for detecting inhibitors of binding between COX-2 and PDZ proteins 失效
    用于检测COX-2和PDZ蛋白之间结合抑制剂的试验

    公开(公告)号：US07588911B2

    公开(公告)日：2009-09-15

    申请号：US11426282

    申请日：2006-06-23

    申请人： Michael P. Belmares ,  Jonathan David Garman ,  Peter S. Lu

    发明人： Michael P. Belmares ,  Jonathan David Garman ,  Peter S. Lu

    IPC分类号： C12Q1/26

    CPC分类号： G01N33/6896 ,  C12Q1/26 ,  G01N33/88 ,  G01N2500/00

    摘要： The invention provides an assay for determining whether a test agent is a COX modulator. In general terms, the assay includes: determining whether a test agent modulates binding of a PDZ-containing polypeptide to a COX PL-containing polypeptide. The PDZ-containing polypeptide may contain the PDZ domain of PDZ domain of MAGI1, TIP-1, MAST2, PSD95, or SHANK. The assays may be done in a cell-free environment or in a cellular environment, particularly using a neuronal cell. The invention finds use in a variety of therapeutic applications, including for identifying agents for use in treating cancer, pain, inflammation and neuronal conditions caused by acute insult, e.g., stroke.

    摘要翻译： 本发明提供了一种用于确定测试试剂是否是COX调节剂的测定法。 一般来说，测定包括：测定测试试剂是否调节含PDZ的多肽与含COX PL的多肽的结合。 含PDZ的多肽可以含有MAGI1，TIP-1，MAST2，PSD95或SHANK的PDZ结构域的PDZ结构域。 测定可以在无细胞环境或细胞环境中进行，特别是使用神经元细胞。 本发明可用于各种治疗应用，包括用于鉴定用于治疗由急性损伤（例如中风）引起的癌症，疼痛，炎症和神经元病症的药剂。