-
1.发明授权
公开(公告)号：US5665331A
公开(公告)日：1997-09-09
申请号：US370998
申请日：1995-01-10
CPC分类号： B82Y5/00 , A61K49/0485 , A61K9/145 , Y10S977/745 , Y10S977/881 , Y10S977/915 , Y10S977/927 , Y10S977/928
摘要： This invention describes the coprecipitation of nanoparticulate pharmaceutical agent dispersion via a process that comprises the dissolution of the said pharmaceutical agent in combination with a crystal growth modifier (CGM) in an alkaline solution and then neutralizing the said solution with an acid in the presence of suitable surface-modifying surface-active agent or agents to form a fine particle dispersion of the said pharmaceutical agent, followed by steps of diafiltration clean-up of the dispersion and then concentration of it to a desired level. This process of dispersion preparation leads to microcrystalline particles of Z-average diameters smaller than 400 nm as measured by photon correlation spectroscopy. Various modification of precipitation schemes are described, many of which are suitable for large-scale manufacture of these agent dispersions. It has been discovered that coprecipitation with CGM leads to smaller particle size compared to a case where precipitation is carried out using the pharmaceutical agent alone. Thus, this dispersion of instant invention is expected to have greater bioavailability. The CGM compound is a compound that has at least about 75% of its chemical structure identical to that of the pharmaceutical agent.
摘要翻译： 本发明描述了纳米颗粒药剂分散体的共沉淀，该方法包括在碱性溶液中将所述药剂与晶体生长调节剂（CGM）组合溶解，然后在适当的存在下用酸中和所述溶液 表面改性表面活性剂或试剂以形成所述药剂的细颗粒分散体，然后将分散体进行渗滤清洗，然后将其浓缩至期望水平。 这种分散制备过程导致通过光子相关光谱测量的Z平均直径小于400nm的微晶颗粒。 描述了各种改性的沉淀方案，其中许多适用于这些试剂分散体的大规模制造。 已经发现，与仅使用药剂进行沉淀的情况相比，CGM的共沉淀导致较小的粒度。 因此，本发明的这种分散体预期具有更大的生物利用度。 CGM化合物是其化学结构的至少约75％与药剂相同的化合物。
-
2.发明授权Use of acid processed ossein gelatin and chain-extended acid processed ossein gelatin as peptizers in the preparation of photographic elements 失效使用酸处理的骨胶原明胶和链延长的酸处理的骨胶原明胶作为摄影元件的制备中的胶溶剂
公开(公告)号：US5536630A
公开(公告)日：1996-07-16
申请号：US312204
申请日：1994-09-26
申请人： Pranab Bagchi , Melvin D. Sterman , Jacob I. Cohen
发明人： Pranab Bagchi , Melvin D. Sterman , Jacob I. Cohen
CPC分类号： G03C1/047 , C08H1/06 , C09H7/00 , G03C2001/0471
摘要： The invention provides a method of nucleating silver halide particles wherein said nucleation is carried out in the presence of acid processed ossein (APO) gelatin or chain-extended acid processed ossein (CE-APO) gelatin and the composition formed therefrom.
摘要翻译： 本发明提供了一种成核卤化银颗粒的方法，其中所述成核在酸处理的骨胶原（APO）明胶或链延长的酸处理的骨胶质素（CE-APO）明胶及其形成的组合物存在下进行。
-
公开(公告)号：US5393650A
公开(公告)日：1995-02-28
申请号：US265997
申请日：1994-06-27
申请人： Pranab Bagchi , Melvin M. Kestner
发明人： Pranab Bagchi , Melvin M. Kestner
摘要： This invention describes the use of surfactants of the following types:Type A--Surfactant comprising 6 to 22 carbon atom hydrophobic tail with one or more attached hydrophilic chains comprising at least 8 oxyethylene and/or glycidyl ether groups that may or may not be terminated with a negative charge such as a sulfate group.Type B--Block oligomeric surfactants comprising hydrophobic polyoxypropylene blocks (A) and hydrophilic polyoxyethylene blocks (B) joined in the manner of A--B--A, B--A--B, A--B, (A--B.sub.n .tbd.G.tbd.(B--A).sub.n, or (B--A).sub.n .tbd.G(A--B).sub.n, where G is a connective organic moiety and n is between 1 and 3.Type C--Sugar surfactants, comprising between one to three 6 to 22 carbon atom hydrophobic tail with one or more attached hydrophilic mono or oligosaccharidic chains that may or may not be terminated by a negatively charged group such as a sulfate group.in combination with gelatin-grafted-polymer particles to obtain aggregation and defect free photographic multilayer coatings that are considerably low in pressure sensitivity.
摘要翻译： 本发明描述了以下类型的表面活性剂的用途：A型表面活性剂，其包含6至22个碳原子的疏水尾部，其具有一个或多个附着的亲水链，其包含至少8个氧化乙烯和/或缩水甘油醚基团，其可以或可以不以 负电荷如硫酸根组。 包含以ABA，BAB，AB，（A-Bn 3BOND G 3BOND（BA）n或（BA）n 3BOND G）的方式连接的疏水性聚氧丙烯嵌段（A）和亲水性聚氧乙烯嵌段（B）的B型低聚表面活性剂 （AB）n，其中G是连接性有机部分，n在1和3之间。C型糖表面活性剂，包含1至3个6至22个碳原子的疏水尾部与一个或多个连接的亲水单糖或寡糖链， 或者可能不被带负电荷的基团如硫酸根基团终止，与明胶接枝聚合物颗粒组合以获得相当低的压敏度的聚集和无缺陷的照相多层涂层。
-
公开(公告)号：US5252425A
公开(公告)日：1993-10-12
申请号：US746544
申请日：1991-08-19
申请人： Pranab Bagchi
发明人： Pranab Bagchi
CPC分类号： G03F3/10 , B41M5/345 , Y10S430/163
摘要： This invention relates to a full-color hard copy imaging system and a process, where a multiply photosensitive donor sheet, comprising clear polymeric or an opaque paper base, coated sequentially with a first layer of patches of a cyan, a magenta, and a yellow dye, that are thermally diffusible, with a second layer also coated sequentially with patches of a red light sensitive, a green light sensitive or a blue light sensitive, negative or a positive working photoresist layer, in such a manner that each of the colored dye patches are in registry with their complementary color sensitive photoresist patches, is exposed with white light sequentially, three times in registry on the three primary light sensitive patches, through a multicolor image (a positive transparency or a photographic negative), to produce crosslinks, image wise, in the exposed areas in the case of the negative resist system, or to uncrosslink the resist structure image wise in the exposed areas for a positive working resist system. In the second step, the first color patch is laminated on to a receiver sheet that is composed of a clear plastic layer in which the chromogenic dyes are soluble, with or without a white reflective backing and the first color image is transferred to the receiver sheet by thermal evaporation. The image is formed due to the hindrance of diffusion of dye in the crosslinked regions of the resist layer in the donor sheet. In subsequent consecutive steps the two remaining color images are transferred, by similar thermal process in registry on to the receiver sheet, thereby forming a full-color image of the original image.
摘要翻译： 本发明涉及一种全色硬拷贝成像系统和一种方法，其中包括透明聚合物或不透明纸基的多次感光供体片，其顺序地涂覆有青色，品红色和黄色的第一层贴片 染料，其具有热扩散性，第二层依次涂覆有红色光敏感，绿色光敏感或蓝色光敏感，负性或正性光致抗蚀剂层的贴片，使得每种着色染料 贴片与其互补的色彩敏感的光刻胶贴片注册，通过多色图像（正透明度或照相底片）依次曝光三次在三个主要光敏贴片上注册，以产生交联，图像 在阴性抗蚀剂体系的情况下的暴露区域中，或者在曝光区域中将抗蚀剂结构图像未交叉显影以进行正面工作 抗蚀系统 在第二步骤中，将第一色块层压到由可见发色染料的透明塑料层组成的接收片上，具有或不具有白色反射背衬，并将第一彩色图像转印到接收片 通过热蒸发。 由于染料在供体片中的抗蚀剂层的交联区域中扩散的阻碍而形成图像。 在随后的连续步骤中，通过类似的热处理将两个剩余的彩色图像转印到接收片上，从而形成原始图像的全色图像。
-
公开(公告)号：US5248558A
公开(公告)日：1993-09-28
申请号：US718489
申请日：1991-06-20
申请人： Pranab Bagchi , William L. Gardner
发明人： Pranab Bagchi , William L. Gardner
CPC分类号： G03C1/95 , G03C1/047 , G03C1/053 , Y10T428/2989 , Y10T428/2991 , Y10T428/2998
摘要： It has been shown by Photon Correlation Spectroscopy than when additional hardener is added to below saturation gel-grafted polymer particles, the gel layer shrinks due to hardening, as there is no free gel left in solution. In films, such case-hardened gelatin-grafted soft polymer particles can act as highly elastic stress absorbing fillers. This is because the dry case-hardened shell is expected to form a thin hard shell around the soft polymer particles. It is shown that gelatin-grafted soft polymer particles and case-hardened gelatin-grafted soft polymer particles, incorporated in the emulsion layers of pressure sensitive photographic products, produce coatings with highly reduced pressure sensitivity without any developability or delamination concerns. In this invention the case-hardened gelatin-grafted polymer particles are preferred over the simple gelatin-grafted material. The core polymer particle can have diameters anywhere between 10 to 10.sup.8 nm with a monolayer of gelatin shell that is chemically bonded to its surface and the gelatin shell is further cross-linked with each other to hydrated thicknesses of between 5 to 20 nm.
摘要翻译： 通过光子相关光谱显示，当将额外的固化剂加入到饱和的凝胶接枝聚合物颗粒中时，凝胶层由于硬化而收缩，因为溶液中不存在游离凝胶。 在膜中，这种表面硬化的明胶接枝的软聚合物颗粒可以用作高弹性应力吸收填料。 这是因为干燥壳体硬化壳体预期在软聚合物颗粒周围形成薄的硬壳。 显示出掺入压敏照相产品的乳剂层中的明胶接枝的软聚合物颗粒和表面硬化的明胶接枝的软聚合物颗粒产生具有高度降低的压力敏感性的涂层，而没有任何显影性或分层问题。 在本发明中，表面硬化的明胶接枝聚合物颗粒优于简单的明胶接枝材料。 核心聚合物颗粒的直径可以在10至108nm之间，单层明胶壳化学键合到其表面，明胶壳体进一步交联，水合厚度在5至20nm之间。
-
公开(公告)号：US5158863A
公开(公告)日：1992-10-27
申请号：US649515
申请日：1991-02-01
申请人： Pranab Bagchi , James T. Beck , Lia A. Crede
发明人： Pranab Bagchi , James T. Beck , Lia A. Crede
IPC分类号： G03C1/005
CPC分类号： G03C1/005 , Y10S516/04
摘要： The invention is performed by providing a first flow of water and surfactant, a second flow comprising solvent, base and photographic material, and mixing said first and second streams and either simultaneously or immediately following thereof neutralizing said streams to prevent hydrolysis of a hydrolyzable surfactant and/or premature precipitation of particles before neutralization. The streams then may be immediately treated for formation into photographic materials. In a preferred method the first and second stream may be brought together immediately prior to a mixer with addition of acid directly into the mixer to neutralize the dispersion of fine particles.
摘要翻译： 本发明通过提供水和表面活性剂的第一流，包含溶剂，碱和照相材料的第二流，并混合所述第一和第二料流，并同时或紧随其后中和所述料流以防止可水解表面活性剂的水解， /或中和前颗粒的过早沉淀。 然后可以将物流立即处理以形成照相材料。 在优选的方法中，可以在混合器之前立即将第一和第二物流直接加入到混合器中以中和细颗粒的分散体。
-
公开(公告)号：US4990431A
公开(公告)日：1991-02-05
申请号：US297005
申请日：1989-01-17
申请人： Pranab Bagchi , James T. Beck , Lia A. Crede
发明人： Pranab Bagchi , James T. Beck , Lia A. Crede
CPC分类号： G03C1/005
摘要： The invention is performed by providing a first flow of water and surfactant, a second flow comprising solvent, base and photographic material, and mixing said first and second streams and either simultaneously or immediately following thereof neutralizing said streams to prevent hydrolysis of a hydrolyzable surfactant and/or premature precipitation of particles before neutralization. The streams then may be immediately treated for formation into photographic materials. In a preferred method the first and second stream may be brought together immediately prior to a mixer with addition of acid directly into the mixer to neutralize the dispersion of fine particles.
摘要翻译： 本发明通过提供水和表面活性剂的第一流，包含溶剂，碱和照相材料的第二流，并混合所述第一和第二料流，并同时或紧随其后中和所述料流以防止可水解表面活性剂的水解， /或中和前颗粒的过早沉淀。 然后可以将物流立即处理以形成照相材料。 在优选的方法中，可以在混合器之前立即将第一和第二物流直接加入到混合器中以中和细颗粒的分散体。
-
公开(公告)号：US5896155A
公开(公告)日：1999-04-20
申请号：US808590
申请日：1997-02-28
CPC分类号： B41J2/005 , B41J2202/16 , B41J2202/21
摘要： A liquid ink, drop on demand page-width printhead comprises a semiconductor substrate, a plurality of drop-emitter nozzles fabricated on the substrate; an ink supply manifold coupled to the nozzles; pressure means for subjecting ink in the manifold to a pressure above ambient pressure causing a meniscus to form in each nozzle; a means for applying heat to the perimeter of the meniscus in predetermined selectively addressed nozzles; a means for controlling the volume of poised drops in the selectively addressed nozzles; and a means for transferrring the poised drops onto the recording media.
摘要翻译： 液体墨水，按需印刷页宽打印头包括半导体基板，在基板上制造的多个液滴发射器喷嘴; 联接到喷嘴的供墨歧管; 用于使歧管中的墨水经受高于环境压力的压力，从而在每个喷嘴中形成弯液面; 用于在预定的选择性寻址的喷嘴中向弯液面的周边施加热量的装置; 用于控制选择性寻址的喷嘴中的稳定液滴体积的装置; 以及用于将准备好的液滴转移到记录介质上的装置。
-
公开(公告)号：US5741633A
公开(公告)日：1998-04-21
申请号：US478631
申请日：1995-06-07
申请人： Mark Anthony Whitson , John Derek Lewis , Tienteh Chen , Thomas Joseph Dannhauser , Pranab Bagchi
发明人： Mark Anthony Whitson , John Derek Lewis , Tienteh Chen , Thomas Joseph Dannhauser , Pranab Bagchi
IPC分类号： G03C1/015 , G03C1/005 , G03C1/035 , G03C1/04 , G03C1/047 , G03C1/30 , G03C1/42 , G03C1/43 , G03C7/388 , G03C1/91
CPC分类号： G03C1/047 , G03C1/005 , G03C1/30 , G03C7/388 , G03C7/3882 , G03C2001/0471 , Y10S430/151
摘要： The invention describes silver halide packet emulsion grains or crystals that are conventionally precipitated using gelatin of a given isoelectric pH, surrounded by a layer of gelatin-grafted-polymer particles wherein the grafted gelatin has a different isoelectric pH and the said gelatin-grafted-polymer particles are optionally chemically bonded to the gelatin surrounding the silver halide microcrystals. Such packet emulsions can form the basis for a mixed-packet color photographic system.
-
10.发明授权
公开(公告)号：US5716642A
公开(公告)日：1998-02-10
申请号：US370928
申请日：1995-01-10
CPC分类号： B82Y5/00 , A61K49/0428 , A61K9/146 , Y10S977/746 , Y10S977/881 , Y10S977/90 , Y10S977/915
摘要： This invention describes the preparation of nanoparticulate pharmaceutical agent dispersion via a process that comprises the dissolution of the said pharmaceutical agent in an alkaline solution and then neutralizing the said solution with an acid in the presence of suitable surface-modifying, surface-active agents to form a fine particle dispersion of the said pharmaceutical agent. A combination of surface active surface modifying agents comprising a nonionic surface active substance and an anionic surface active material having a chemical structure which is at least on a molecular basis 75% similar to the pharmaceutical agent is used. This process is preferably followed by steps of diafiltration clean-up of the dispersion and then concentration of it to a desired level. This process of dispersion preparation leads to microcrystalline particles of Z-average diameters smaller than 400 nm as measured by photon correlation spectroscopy. Various modifications of precipitation schemes are described, many of which are suitable for large-scale manufacture of these agent dispersions.
摘要翻译： 本发明描述了纳米颗粒药剂分散体的制备方法，该方法包括将所述药剂溶解在碱性溶液中，然后在合适的表面改性表面活性剂存在下用酸中和所述溶液形成 所述药剂的细颗粒分散体。 使用包含非离子表面活性物质的表面活性表面改性剂和具有与药剂相似至少分子量为75％的化学结构的阴离子表面活性物质的组合。 该方法优选的是通过渗滤清洁分散体的步骤，然后将其浓缩至期望的水平。 这种分散制备过程导致通过光子相关光谱测量的Z平均直径小于400nm的微晶颗粒。 描述了沉淀方案的各种改进，其中许多适用于这些试剂分散体的大规模生产。
-
-
-
-
-
-
-
-
-
搜索结果
49 条记录 (耗时 0.048 秒)
