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公开(公告)号：US20240197924A1
公开(公告)日：2024-06-20
申请号：US18428591
申请日：2024-01-31
Applicant: RAMOT AT TEL-AVIV UNIVERSITY LTD.
Inventor： Doron Shabat , Ronit Satchi-Fainaro , Nir Hananya , Ori Green , Tal Eilon
IPC: A61K49/00 , C07D321/00 , C07F5/02 , C07F5/04 , C07F7/18 , C07F9/12 , C07F9/655 , C07H15/203 , C07H15/26 , C09B11/24 , C09B23/01 , C09B23/04 , C09B23/08 , C09K11/06
CPC classification number: A61K49/0052 , C07D321/00 , C07F5/025 , C07F5/04 , C07F7/1804 , C07F9/12 , C07F9/65512 , C07H15/203 , C07H15/26 , C09B11/24 , C09B23/0066 , C09B23/04 , C09B23/083 , C09K11/06 , C09K2211/1018
Abstract: The present invention provides dioxctane-based chemiluminescence probes, more specifically fluorophore-tethered dioxctane-based chemiluminescence probes and compositions thereof. The chemiluminescence probes disclosed are useful for both diagnostics and in vivo imaging.
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公开(公告)号：US11179482B2
公开(公告)日：2021-11-23
申请号：US16850333
申请日：2020-04-16
Applicant: RAMOT AT TEL-AVIV UNIVERSITY LTD.
Inventor： Doron Shabat , Ronit Satchi-Fainaro , Nir Hananya , Ori Green , Tal Eilon
IPC: A61K49/00 , C07F5/04 , C07D321/00 , C09K11/06 , C07F9/655 , C07H15/26 , C09B11/24 , C09B23/04 , C09B23/08 , C07F9/12 , C09B23/01 , C07F5/02 , C07H15/203 , C07F7/18
Abstract: The present invention provides dioxetane-based chemiluminescence probes, more specifically fluorophore-tethered dioxetane-based chemiluminescence probes and compositions thereof. The chemiluminescence probes disclosed are useful for both diagnostics and in vivo imaging.
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公开(公告)号：US11649475B2
公开(公告)日：2023-05-16
申请号：US17058623
申请日：2019-05-24
Applicant: NEMIS Technologies AG , Ramot at Tel-Aviv University Ltd.
Inventor： Doron Shabat , Michal Eli Roth-Konforti , Nir Hananya , Ori Green , Urs Spitz , Lukas Wick , Julian Ihssen , Raffael Vorberg , Riccardo Cribiu , Zuzana Babjakovà , Chunyan Yao
IPC: C07D321/00 , C07D407/04 , C12Q1/10 , C12Q1/04 , C12Q1/14 , C12Q1/22 , C12Q1/44 , C12Q1/54 , G01N21/76
CPC classification number: C12Q1/10 , C07D321/00 , C07D407/04 , C12Q1/04 , C12Q1/14 , C12Q1/22 , C12Q1/44 , C12Q1/54 , G01N21/76
Abstract: Dioxetane compounds represented by Formula I below, and methods of using the dioxetane compounds in the detection of presence or absence, quantification, and identification of microorganisms including bacteria, bacterial fragments (e.g., LPS, endotoxin), viruses, and fungi by means of chemiluminescence.
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公开(公告)号：US10532113B2
公开(公告)日：2020-01-14
申请号：US15124360
申请日：2015-03-13
Applicant: Ramot at Tel-Aviv University Ltd.
Inventor： Ronit Satchi-Fainaro , Doron Shabat , Rachel Blau , Yana Epshtein , Hemda Baabur-Cohen , Shiran Ferber , Orit Redy-Keisar , Einat Kisin-Finfer
IPC: A61K49/00 , A61K31/337 , A61K47/65 , A61K47/58 , A61K47/59
Abstract: Polymeric systems useful for theranostic applications are disclosed. The polymeric systems comprise a fluorescent or fluorogenic moiety and a therapeutically active agent, each attached to the same or different polymeric moiety. The polymeric systems are designed such that a fluorescent signal is generated in response to a chemical event, preferably upon contacting an analyte (e.g., an enzyme) that is over-expressed in a diseased tissue or organ. Probes useful for inclusion in such polymeric systems, processes of preparing such probes and the polymeric systems, and uses thereof in diagnostic and/or theranostic applications are also disclosed.
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5.发明授权公开(公告)号：US09341630B2
公开(公告)日：2016-05-17
申请号：US14027219
申请日：2013-09-15
Applicant: Ramot at Tel-Aviv University Ltd.
Inventor： Doron Shabat , Ronit Satchi-Fainaro
CPC classification number: C07D401/14 , A61K47/558 , A61K49/0021 , A61K49/0032 , A61K49/0052 , A61K49/0056 , C07D209/08 , C07D209/12 , C07D213/30 , C07D213/71 , C07D213/76 , C07D213/85 , C09B23/0066 , C09B23/086 , C09B23/12 , G01N33/52 , G01N33/582
Abstract: Novel fluorogenic compounds designed such that upon a chemical event, compounds capable of emitting NIR light are generated, are disclosed. The compounds comprise two or more acceptor-containing moieties and a cleavable donor-containing moiety, being in complete pi-electrons conjugation and being such that no delocalization of pi-electrons is enabled. Also disclosed are fluorescent compounds generated upon subjecting the fluorogenic compounds to a chemical event (e.g., deprotonation). Also disclosed are uses of the fluorogenic compounds as NIR probed with a Turn-ON mechanism in monitoring presence and/or level of various analytes.
Abstract translation: 新的荧光化合物被设计成使得在化学事件上产生能够发射NIR光的化合物被产生。 这些化合物包含两个或多个含受体的部分和可裂解供体的部分，其完全是π-电子共轭并且使得不能使π-电子的离域化。 还公开了在使荧光化合物经历化学事件（例如去质子化）时产生的荧光化合物。 还公开了荧光化合物作为NIR探测的用于监测各种分析物的存在和/或水平的Turn-ON机制的用途。
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Patent Agency Ranking
公开(公告)号：US20180169252A1
公开(公告)日：2018-06-21
申请号：US15737247
申请日：2016-06-16
Applicant: Ramot at Tel-Aviv University Ltd.
Inventor： Doron Shabat , Ronit Satchi-Fainaro , Samer Gnaim , Anna Scomparin
IPC: A61K47/54 , A61K31/4745 , A61K31/519 , A61K31/513 , A61K31/496 , A61K31/4184 , A61P35/00
Abstract: The present disclosure provides heteroarene-based drug derivatives having a “clickable” ketone group, as well as conjugates of said drug derivatives with targeting moieties capable of binding to extracellular antigens; and pharmaceutical compositions comprising them.
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7.发明授权Conjugates of a polymer, a bisphosphonate and an anti-angiogenesis agent and uses thereof in the treatment and monitoring of bone related diseases 有权聚合物，双膦酸盐和抗血管生成剂的结合物及其在治疗和监测骨相关疾病中的用途公开(公告)号：US09095618B2
公开(公告)日：2015-08-04
申请号：US14158881
申请日：2014-01-20
Applicant: Ramot at Tel-Aviv University Ltd.
Inventor： Ronit Satchi-Fainaro , Keren Miller , Doron Shabat , Rotem Erez
IPC: A61K31/74 , A61K47/48 , C07F9/38 , C07F9/655 , C07F9/6558 , C07K5/065 , C07K5/103 , A61K31/337 , A61K49/00 , A61K9/16
CPC classification number: A61K47/48084 , A61K9/1676 , A61K31/337 , A61K47/548 , A61K47/58 , A61K47/65 , A61K49/0017 , A61K49/0054 , A61K2800/57 , C07F9/3873 , C07F9/65517 , C07F9/65586 , C07K5/06078 , C07K5/1008
Abstract: Conjugates of polymers or copolymers having attached thereto an anti-angiogenesis agent and a bisphosphonate bone targeting agent, and processes of preparing same, are disclosed.Pharmaceutical compositions containing these conjugates and uses thereof in the treatment of bone related disorders are also disclosed.
Abstract translation: 公开了与其连接有抗血管生成剂和双膦酸盐骨靶向剂的聚合物或共聚物的缀合物及其制备方法。 还公开了含有这些缀合物的药物组合物及其在治疗骨相关疾病中的用途。
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公开(公告)号：US11931429B2
公开(公告)日：2024-03-19
申请号：US17451536
申请日：2021-10-20
Applicant: RAMOT AT TEL-AVIV UNIVERSITY LTD.
Inventor： Doron Shabat , Ronit Satchi-Fainaro , Nir Hananya , Ori Green , Tal Eilon
IPC: A61K49/00 , C07D321/00 , C07F5/02 , C07F5/04 , C07F7/18 , C07F9/12 , C07F9/655 , C07H15/203 , C07H15/26 , C09B11/24 , C09B23/01 , C09B23/04 , C09B23/08 , C09K11/06
CPC classification number: A61K49/0052 , C07D321/00 , C07F5/025 , C07F5/04 , C07F7/1804 , C07F9/12 , C07F9/65512 , C07H15/203 , C07H15/26 , C09B11/24 , C09B23/0066 , C09B23/04 , C09B23/083 , C09K11/06 , C09K2211/1018
Abstract: The present invention provides dioxetane-based chemiluminescence probes, more specifically fluorophore-tethered dioxetane-based chemiluminescence probes and compositions thereof. The chemiluminescence probes disclosed are useful for both diagnostics and in vivo imaging.
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公开(公告)号：US11241507B2
公开(公告)日：2022-02-08
申请号：US16616336
申请日：2018-05-23
Applicant: RAMOT AT TEL-AVIV UNIVERSITY LTD.
Inventor： Doron Shabat , Ori Green
IPC: A61B5/00 , A61B8/00 , A61B10/00 , A61K49/00 , C07D407/10
Abstract: The present invention provides turn-ON dioxetane-based chemiluminescence probes based on the Schapp's adamantylidene-dioxetane probe, which emit light in the near-infrared (NIR) region and are therefore useful for in vivo imaging, as well as compositions and uses thereof.
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公开(公告)号：US20200277647A1
公开(公告)日：2020-09-03
申请号：US16616356
申请日：2018-05-23
Applicant: RAMOT AT TEL-AVIV UNIVERSITY LTD.
Inventor： Doron Shabat , Michal Eli Roth-Konforti
Abstract: The present invention provides turn-ON dioxetane-based chemiluminescence probes based on the Schapp's adamantylidene-dioxetane probe, which are capable of detecting or imaging, more specifically, determining the presence, or measuring the level, of proteases, as well as compositions and uses thereof.
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