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127 条记录 (耗时 0.029 秒)

    Preparation of 3-arylacrylic acids and their derivatives
    2.
    发明授权
    Preparation of 3-arylacrylic acids and their derivatives 失效
    3-芳基丙烯酸及其衍生物的制备

    公开(公告)号：US5359122A

    公开(公告)日：1994-10-25

    申请号：US193872

    申请日：1994-02-08

    申请人： Michael Huellmann ,  Josef Gnad ,  Rainer Becker

    发明人： Michael Huellmann ,  Josef Gnad ,  Rainer Becker

    IPC分类号： C07C57/44 ,  C07C59/64 ,  C07C67/46 ,  C07C69/734

    CPC分类号： C07C59/64 ,  C07C57/44 ,  C07C67/46

    摘要： The preparation of 3-arylacrylic acids and their derivatives I ##STR1## where Ar is aryl which can additionally have substituents which do not react with ketene and are stable under the conditions of the reaction described below, andR.sup.1 is hydrogen, an alkali metal, an alkaline earth metal, ammonium or C.sub.1 -C.sub.20 -alkyl,comprises a first stage in which a dialkyl acetal of an aromatic aldehyde of the formula II ##STR2## where R.sup.2 is C.sub.1 -C.sub.4 -alkyl, is reacted with ketene of the formula CH.sub.2 .dbd.C.dbd.O in the presence of catalytic amounts of a protic or Lewis acid to give a 3-arylpropionic acid derivative of the formula III ##STR3## and a second stage in which this intermediate III is reacted in the presence of acid or base and, in the case where R.sup.1 is C.sub.1 -C.sub.20 -alkyl, additionally with a C.sub.1 -C.sub.20 -alkanol to give the final product I.

    摘要翻译： 3-芳基丙烯酸及其衍生物的制备I（I）其中Ar是可以另外具有不与乙烯酮反应并且在下述反应条件下稳定的取代基的芳基，R 1是氢， 碱金属，碱土金属，铵或C 1 -C 20烷基，包括其中R 2为C 1 -C 4 - 烷基的式II的芳族醛的二烷基缩醛反应的第一阶段 在催化量的质子或路易斯酸存在下，式CH 2 = C = O的烯酮，得到式III的3-芳基丙酸衍生物（III），其中该中间体III为 在酸或碱的存在下反应，在R1为C1-C20烷基的情况下，另外加入C1-C20链烷醇，得到最终产物I.

    Preparation of muscone, intermediates for this preparation and preparation of said intermediates
    6.
    发明授权
    Preparation of muscone, intermediates for this preparation and preparation of said intermediates 失效
    麦芽糖的制备，本制剂的中间体和制备中间体

    公开(公告)号：US5081311A

    公开(公告)日：1992-01-14

    申请号：US524929

    申请日：1990-05-18

    申请人： Michael Huellmann ,  Thomas Kuekenhoehner ,  Karl Brenner ,  Rainer Becker ,  Matthias Irgang ,  Charles Schommer

    发明人： Michael Huellmann ,  Thomas Kuekenhoehner ,  Karl Brenner ,  Rainer Becker ,  Matthias Irgang ,  Charles Schommer

    IPC分类号： B01J21/06 ,  B01J23/04 ,  B01J23/10 ,  B01J23/12 ,  C07B61/00 ,  C07C45/30 ,  C07C45/61 ,  C07C45/62 ,  C07C45/66 ,  C07C45/68 ,  C07C45/72 ,  C07C49/203 ,  C07C49/385

    CPC分类号： C07C45/68 ,  C07C45/30 ,  C07C45/62 ,  C07C45/66 ,  C07C45/72

    摘要： Muscone of the formula I ##STR1## is prepared by a process in which an open-chain 2,15-diketone of the general formula IICH.sub.3 --CO--X--CO--CH.sub.3 (II)where X is one of the radicals--(--CH.sub.2 --).sub.12 -- (a)--CH.dbd.CH--(--CH.sub.2 --).sub.8 --CH.dbd.CH-- (b)--CH.sub.2 --CH.dbd.CH--(--CH.sub.2 --).sub.6 --CH.dbd.CH--CH.sub.2 --(c)--CH.sub.2 --CH.sub.2 --CH.dbd.CH--(--CH.sub.2 --).sub.4 --CH.dbd.CH--CH.sub.2 --CH.sub.2 -- (d) or--CH.sub.2 --CH.sub.2 CH.sub.2 --CH.dbd.CH--(--CH.sub.2 --).sub.2 --CH.dbd.CH--CH.sub.2 --CH.sub.2 --CH.sub.2 -- (e)is brought into contact, at from 300.degree. to 400.degree. C. in the presence of from 5 to 15% by weight, based on the amount of catalyst, of water, in the gas phase, with a fixed-bed catalyst containing TiO.sub.2, CeO.sub.2 or the ThO.sub.2 as the catalytically active compound and the unsaturated cyclic ketone formed by intramolecular aldol condensation is subjected to catalytic hydrogenation. Furthermore, the open-chain unsaturated ketones of the formulae IIb, IIc and IId and advantageous processes for their preparation and their use as intermediates for a simple industrial synthesis of muscone are claimed.

    摘要翻译： 通式Ⅰ（I）的肌醇通过以下方法制备，其中通式II CH3-CO-X-CO-CH3（Ⅱ）的开链2,15-二酮其中X是 基团 - （ - CH2-）12-（a）-CH = CH - （ - CH2-）8-CH = CH-（b）-CH2-CH = CH-（ - CH2-）6-CH = CH-CH2 - （c）-CH 2 -CH 2 -CH = CH - （ - CH 2 - ）4 -CH = CH-CH 2 -CH 2 - （d）或-CH 2 -CH 2 CH 2 -CH = CH - （ - CH 2 - ）2 -CH = CH-CH 2 -CH 2 -CH 2 - （e）在300-400℃下，以5-15重量％的量存在下，基于催化剂的量，在气体中 使用含有TiO 2，CeO 2或ThO 2作为催化活性化合物的固定床催化剂和通过分子内醛醇缩合形成的不饱和环酮进行催化氢化。 此外，要求具有式IIb，IIc和IId的开链不饱和酮及其制备的有利方法及其作为简单的工业合成肌肉的中间体的用途。

    Preparation of alkylated dodechydronaphto[2,1-b]furans
    7.
    发明授权
    Preparation of alkylated dodechydronaphto[2,1-b]furans 失效
    制备烷基化的dodechydronaphto [2,1-b]呋喃

    公开(公告)号：US4918205A

    公开(公告)日：1990-04-17

    申请号：US250077

    申请日：1988-09-28

    申请人： Walter Gramlich ,  Eckhard Hickmann ,  Rainer Becker ,  Gerald Lauterbach

    发明人： Walter Gramlich ,  Eckhard Hickmann ,  Rainer Becker ,  Gerald Lauterbach

    IPC分类号： C07B61/00 ,  B01J31/02 ,  B01J31/24 ,  C07D307/92 ,  C11B9/00

    CPC分类号： C07D307/92 ,  C11B9/0076

    摘要： Alkylated dodecahydronaphtho[2,1-b]furans of the general formula I ##STR1## where R.sup.1 and R.sup.2 are identical and each is hydrogen or methyl are prepared by reacting alkylated 2-hydroxydecahydronaphthalene-1-ethanol of the formula II ##STR2## where R.sup.1 and R.sup.2 are as defined above, with a sulfonyl chloride in the presence of basic catalysts by performing the cyclization in the presence of concentrated aqueous alkali metal hydroxides and a phase transfer catalyst, preferably a tetra-substituted ammonium or phosphonium salt, the sulfonyl chloride used preferably comprising a sulfonyl chloride of the general formula IIIR.sub.3 -SO.sub.2 Clwhere R.sup.3 is C.sub.1 -C.sub.3 -alkyl or phenyl which may be substituted in the para position by methyl, chlorine, bromine or nitro.

    摘要翻译： 通式Ⅰ的烷基化十​​二氢萘并[2,1-b]呋喃，其中R 1和R 2相同，各自为氢或甲基，是通过使式II的烷基化的2-羟基十氢化萘-1-乙醇 在碱性催化剂的存在下，通过在浓碱碱金属氢氧化物和相转移催化剂，优选四取代的铵或相互转移的催化剂存在下进行环化，其中R 1和R 2如上定义，与磺酰氯反应， 所用的磺酰氯优选包含通式IIIR 3 -SO 2 Cl的磺酰氯，其中R 3是C 1 -C 3 - 烷基或可以在对位被甲基，氯，溴或硝基取代的苯基。

    Preparation of N-(2-hydroxyethyl)-piperazine
    8.
    发明授权
    Preparation of N-(2-hydroxyethyl)-piperazine 失效
    制备N-（2-羟乙基） - 哌嗪

    公开(公告)号：US5455352A

    公开(公告)日：1995-10-03

    申请号：US282073

    申请日：1994-07-28

    申请人： Michael Huellmann ,  Rainer Becker ,  Emil Scharf

    发明人： Michael Huellmann ,  Rainer Becker ,  Emil Scharf

    IPC分类号： B01J23/74 ,  B01J23/88 ,  C07B61/00 ,  C07D295/08 ,  C07D295/088

    CPC分类号： C07D295/088 ,  Y02P20/582

    摘要： Preparation of N-(2-hydroxyethyl)-piperazine by reacting triethanolamine with ammonia in the presence of hydrogen at from 100.degree. to 500.degree. C. and from 10 to 500 bar over a heterogeneous catalyst in which the catalytically active material contains from 20 to 85% by weight of ZrO.sub.2 or Al.sub.2 O.sub.3 or mixtures thereof, from 1 to 30% by weight of at least one copper oxide, calculated as CuO, and from 1 to 60% by weight of at least one oxide of cobalt, nickel or molybdenum, calculated as CoO, NiO and MoO.sub.3, respectively.

    摘要翻译： 通过使三乙醇胺与氨在100〜500℃的氢气和10〜500巴的存在下，在非均相催化剂上制备N-（2-羟乙基） - 哌嗪，其中催化活性物质含有20〜 85重量％的ZrO 2或Al 2 O 3或其混合物，1至30重量％的以CuO计算的至少一种氧化铜和1至60重量％的至少一种钴，镍或钼的氧化物， 分别计算为CoO，NiO和MoO3。

    Preparation of 1,1,3,4,4,6-hexamethyl-1,2,3,4-tetra-hydronaphthalene
    9.
    发明授权
    Preparation of 1,1,3,4,4,6-hexamethyl-1,2,3,4-tetra-hydronaphthalene 失效
    制备1,1,3,4,4,6-六甲基-1,2,3,4-四氢化萘

    公开(公告)号：US5068479A

    公开(公告)日：1991-11-26

    申请号：US668484

    申请日：1991-03-13

    申请人： Michael Huellmann ,  Herbert Mayr ,  Rainer Becker

    发明人： Michael Huellmann ,  Herbert Mayr ,  Rainer Becker

    IPC分类号： B01J31/26 ,  C07B61/00 ,  C07C2/72 ,  C07C13/48

    CPC分类号： C07C2/72 ,  C07C2102/10

    摘要： A process for preparing 1,1,3,4,4,6-hexamethyl-1,2,3,4-tetrahydronaphthalene of the formula I ##STR1## comprises reacting p-cymene of the formula II ##STR2## with a hexene of the formula IIIa, IIIb and/or IIIc ##STR3## in the presence of a catalytic amount of aluminum halide and a catalytic amount of a triphenylmethyl compound of the formula IV ##STR4## wherein R.sup.1, R.sup.2 and R.sup.3 are each, independently of one another, hydrogen, C.sub.1 -C.sub.4 -alkyl, nitro or halogen and X is hydrogen or halogen.

    摘要翻译： 制备式I（I）的1,1,3,4,4,6-六甲基-1,2,3,4-四氢化萘的方法包括使式II的对甲基异丙苯（IMAGE）（ II）与式IIIa，IIIb和/或IIIc（IIIa）（IIIb）（IIIc）的己烯在催化量的卤化铝和催化量的三苯基甲基 式IV的化合物其中R 1，R 2和R 3各自独立地为氢，C 1 -C 4 - 烷基，硝基或卤素，X为氢或卤素。