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公开(公告)号：US20160237482A1
公开(公告)日：2016-08-18
申请号：US14580137
申请日：2014-12-22
申请人： Ralf Bickel , Alexandra Dworrak , Thomas Ellinger , Eugen Ermantraut , Torsten Schulz , Thomas Ullrich
发明人： Ralf Bickel , Alexandra Dworrak , Thomas Ellinger , Eugen Ermantraut , Torsten Schulz , Thomas Ullrich
IPC分类号： C12Q1/68 , G01N33/543 , G01N33/68 , G01N21/64
CPC分类号： C12Q1/6837 , B01L3/502715 , B01L7/52 , B01L7/525 , B01L2200/027 , B01L2200/028 , B01L2300/0636 , B01L2300/0654 , B01L2300/0672 , B01L2300/0816 , B01L2300/0819 , B01L2300/0877 , B01L2300/1827 , B01L2300/1838 , B01L2400/0481 , B01L2400/0487 , C12Q1/6825 , C12Q1/6832 , G01N21/6428 , G01N33/54306 , G01N33/54366 , G01N33/58 , G01N33/6845 , G01N35/00 , G01N2021/6439 , Y10T436/143333 , C12Q2563/107 , C12Q2565/102 , C12Q2565/601 , C12Q2565/629
摘要： The invention relates to devices and methods for the detection of specific interactions between probe and target molecules. In particular, the invention relates to methods for the qualitative and/or quantitative detection of targets, including: introducing a sample containing targets into a reaction chamber formed between a first surface of the device and a second surface of a device, which is preferably located opposite to the first surface, wherein the distance between the first and the second surface is variable; and detecting the targets.
摘要翻译： 本发明涉及用于检测探针和靶分子之间特异性相互作用的装置和方法。 特别地，本发明涉及用于定性和/或定量检测靶的方法，包括：将含有靶的样品引入形成在器件的第一表面和器件的第二表面之间的反应室中，反应室优选位于 与第一表面相对，其中第一和第二表面之间的距离是可变的; 并检测目标。
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公开(公告)号：US08916348B2
公开(公告)日：2014-12-23
申请号：US11593021
申请日：2006-11-06
申请人： Ralf Bickel , Alexandra Dworrak , Thomas Ellinger , Eugen Ermantraut , Torsten Schulz , Thomas Ullrich
发明人： Ralf Bickel , Alexandra Dworrak , Thomas Ellinger , Eugen Ermantraut , Torsten Schulz , Thomas Ullrich
CPC分类号： C12Q1/6837 , B01L3/502715 , B01L7/52 , B01L7/525 , B01L2200/027 , B01L2200/028 , B01L2300/0636 , B01L2300/0654 , B01L2300/0672 , B01L2300/0816 , B01L2300/0819 , B01L2300/0877 , B01L2300/1827 , B01L2300/1838 , B01L2400/0481 , B01L2400/0487 , C12Q1/6825 , C12Q1/6832 , G01N21/6428 , G01N33/54306 , G01N33/54366 , G01N33/58 , G01N33/6845 , G01N35/00 , G01N2021/6439 , Y10T436/143333 , C12Q2563/107 , C12Q2565/102 , C12Q2565/601 , C12Q2565/629
摘要： The invention relates to devices and methods for the detection of specific interactions between probe and target molecules. In particular, the invention relates to methods for the qualitative and/or quantitative detection of targets, including: introducing a sample containing targets into a reaction chamber formed between a first surface of the device and a second surface of a device, which is preferably located opposite to the first surface, wherein the distance between the first and the second surface is variable; and detecting the targets.
摘要翻译： 本发明涉及用于检测探针和靶分子之间特异性相互作用的装置和方法。 特别地，本发明涉及用于定性和/或定量检测靶的方法，包括：将含有靶的样品引入形成在器件的第一表面和器件的第二表面之间的反应室中，反应室优选位于 与第一表面相对，其中第一和第二表面之间的距离是可变的; 并检测目标。
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公开(公告)号：US20070254372A1
公开(公告)日：2007-11-01
申请号：US11593021
申请日：2006-11-06
申请人： Ralf Bickel , Alexandra Dworrak , Thomas Ellinger , Eugen Ermantraut , Torsten Schulz , Thomas Ullrich
发明人： Ralf Bickel , Alexandra Dworrak , Thomas Ellinger , Eugen Ermantraut , Torsten Schulz , Thomas Ullrich
CPC分类号： C12Q1/6837 , B01L3/502715 , B01L7/52 , B01L7/525 , B01L2200/027 , B01L2200/028 , B01L2300/0636 , B01L2300/0654 , B01L2300/0672 , B01L2300/0816 , B01L2300/0819 , B01L2300/0877 , B01L2300/1827 , B01L2300/1838 , B01L2400/0481 , B01L2400/0487 , C12Q1/6825 , C12Q1/6832 , G01N21/6428 , G01N33/54306 , G01N33/54366 , G01N33/58 , G01N33/6845 , G01N35/00 , G01N2021/6439 , Y10T436/143333 , C12Q2563/107 , C12Q2565/102 , C12Q2565/601 , C12Q2565/629
摘要： The invention relates to devices and methods for the detection of specific interactions between probe and target molecules. In particular, the invention relates to methods for the qualitative and/or quantitative detection of targets, including: introducing a sample containing targets into a reaction chamber formed between a first surface of the device and a second surface of a device, which is preferably located opposite to the first surface, wherein the distance between the first and the second surface is variable; and detecting the targets.
摘要翻译： 本发明涉及用于检测探针和靶分子之间特异性相互作用的装置和方法。 特别地，本发明涉及用于定性和/或定量检测靶的方法，包括：将含有靶的样品引入形成在器件的第一表面和器件的第二表面之间的反应室中，反应室优选位于 与第一表面相对，其中第一和第二表面之间的距离是可变的; 并检测目标。
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公开(公告)号：US20060078929A1
公开(公告)日：2006-04-13
申请号：US11241671
申请日：2005-09-30
申请人： Ralf Bickel , Thomas Ellinger , Eugen Ermantraut , Thomas Kaiser , Torsten Schulz , Thomas Ullrich
发明人： Ralf Bickel , Thomas Ellinger , Eugen Ermantraut , Thomas Kaiser , Torsten Schulz , Thomas Ullrich
CPC分类号： B01L7/52 , B01L3/5027 , B01L2200/147 , B01L2300/0636 , B01L2300/0654 , B01L2300/0877 , G01N21/4738 , G01N21/59
摘要： The present invention relates to a device for the amplification and for the detection of nucleic acids comprising a temperature controlling and/or regulating unit; a reaction chamber containing a support with a detection area, on which a compound library is immobilized, wherein the temperature in the reaction chamber can be controlled and/or regulated by means of the temperature controlling and regulating unit; and an optical system, by means of which the time-dependent behavior of precipitate formations on the detection area is detectable. Methods of using the device are also disclosed.
摘要翻译： 本发明涉及用于扩增和检测包含温度控制和/或调节单元的核酸的装置; 包含具有检测区域的载体的反应室，其上固定有化合物文库，其中可以通过温度控制和调节单元来控制和/或调节反应室中的温度; 以及光学系统，通过该光学系统可以检测出沉积物在检测区域上的时间依赖性。 还公开了使用该装置的方法。
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公开(公告)号：US08828741B2
公开(公告)日：2014-09-09
申请号：US12092643
申请日：2006-11-06
申请人： Eugen Ermantraut , Ralf Bickel , Torsten Schulz , Thomas Ullrich
发明人： Eugen Ermantraut , Ralf Bickel , Torsten Schulz , Thomas Ullrich
IPC分类号： G01N33/537
CPC分类号： C12Q1/6837 , B01F11/0045 , B01L3/5027 , B01L3/502746 , B01L7/52 , B01L7/525 , B01L2200/027 , B01L2300/044 , B01L2300/0636 , B01L2300/0654 , B01L2300/0816 , B01L2300/0819 , B01L2300/0864 , B01L2300/0877 , B01L2300/1827 , B01L2300/1838 , B01L2400/0481 , G01N21/6452 , G01N21/6458
摘要： The present invention relates to devices and methods for the detection of analytes. In particular, the invention relates to methods for the qualitative and/or quantitative detection of analytes, comprising a microarray on a substrate, onto which probe molecules are immobilized on array elements, said microarray being disposed on a first surface of the device; and a detection chamber formed between the first surface including the microarray disposed thereon and a second surface, wherein the distance between the microarray and the second surface is variable, and wherein the second surface has a displacement structure.
摘要翻译： 本发明涉及用于检测分析物的装置和方法。 特别地，本发明涉及用于定性和/或定量检测分析物的方法，其包括在基底上的微阵列，探针分子固定在阵列元件上，所述微阵列设置在装置的第一表面上; 以及检测室，形成在包括设置在其上的微阵列的第一表面和第二表面之间，其中微阵列和第二表面之间的距离是可变的，并且其中第二表面具有位移结构。
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公开(公告)号：US08467039B2
公开(公告)日：2013-06-18
申请号：US13274175
申请日：2011-10-14
IPC分类号： G06K9/74
CPC分类号： G01N33/56966 , B01F11/0045 , B01F11/0266 , B01F13/0059 , B01L3/50273 , B01L3/502746 , B01L2200/027 , B01L2300/0636 , B01L2300/0822 , B01L2300/0825 , B01L2400/0481 , G01N21/03 , G01N35/0099 , G01N2021/0346 , G01N2035/00346
摘要： The present invention relates to devices and methods for the qualitative and/or quantitative detection of particles. In particular, the invention relates to devices for the detection of particles, comprising a reaction chamber formed within a chamber body between a first surface and a second surface, wherein the second surface is located opposite to the first surface, and one or more displacers, wherein the distance between the first surface and the second surface is variable via the one or more displacers at least in one or more parts of the surface area of the first surface and/or second surface. The invention also relates to corresponding methods for the detection of particles.
摘要翻译： 本发明涉及用于定性和/或定量检测颗粒的装置和方法。 特别地，本发明涉及用于检测颗粒的装置，其包括形成在第一表面和第二表面之间的室主体内的反应室，其中第二表面位于与第一表面相对的位置，以及一个或多个位移器， 其中所述第一表面和所述第二表面之间的距离可以经由所述一个或多个位移器在所述第一表面和/或第二表面的表面区域的至少一个或多个部分中是可变的。 本发明还涉及用于检测颗粒的相应方法。
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公开(公告)号：US20120088252A1
公开(公告)日：2012-04-12
申请号：US13274175
申请日：2011-10-14
IPC分类号： G01N21/75
CPC分类号： G01N33/56966 , B01F11/0045 , B01F11/0266 , B01F13/0059 , B01L3/50273 , B01L3/502746 , B01L2200/027 , B01L2300/0636 , B01L2300/0822 , B01L2300/0825 , B01L2400/0481 , G01N21/03 , G01N35/0099 , G01N2021/0346 , G01N2035/00346
摘要： The present invention relates to devices and methods for the qualitative and/or quantitative detection of particles. In particular, the invention relates to devices for the detection of particles, comprising a reaction chamber formed within a chamber body between a first surface and a second surface, wherein the second surface is located opposite to the first surface, and one or more displacers, wherein the distance between the first surface and the second surface is variable via the one or more displacers at least in one or more parts of the surface area of the first surface and/or second surface. The invention also relates to corresponding methods for the detection of particles.
摘要翻译： 本发明涉及用于定性和/或定量检测颗粒的装置和方法。 特别地，本发明涉及用于检测颗粒的装置，其包括形成在第一表面和第二表面之间的室主体内的反应室，其中第二表面位于与第一表面相对的位置，以及一个或多个位移器， 其中所述第一表面和所述第二表面之间的距离可经由所述一个或多个置换器在所述第一表面和/或第二表面的表面区域的至少一个或多个部分中是可变的。 本发明还涉及用于检测颗粒的相应方法。
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公开(公告)号：US20090082219A1
公开(公告)日：2009-03-26
申请号：US12092643
申请日：2006-11-06
申请人： Eugen Ermantraut , Ralf Bickel , Torsten Schulz , Thomas Ullrich
发明人： Eugen Ermantraut , Ralf Bickel , Torsten Schulz , Thomas Ullrich
CPC分类号： C12Q1/6837 , B01F11/0045 , B01L3/5027 , B01L3/502746 , B01L7/52 , B01L7/525 , B01L2200/027 , B01L2300/044 , B01L2300/0636 , B01L2300/0654 , B01L2300/0816 , B01L2300/0819 , B01L2300/0864 , B01L2300/0877 , B01L2300/1827 , B01L2300/1838 , B01L2400/0481 , G01N21/6452 , G01N21/6458
摘要： The present invention relates to devices and methods for the detection of analytes. In particular, the invention relates to methods for the qualitative and/or quantitative detection of analytes, comprising a microarray on a substrate, onto which probe molecules are immobilized on array elements, said microarray being disposed on a first surface of the device; and a detection chamber formed between the first surface including the microarray disposed thereon and a second surface, wherein the distance between the microarray and the second surface is variable, and wherein the second surface has a displacement structure.
摘要翻译： 本发明涉及用于检测分析物的装置和方法。 特别地，本发明涉及用于定性和/或定量检测分析物的方法，其包括在基底上的微阵列，探针分子固定在阵列元件上，所述微阵列设置在装置的第一表面上; 以及检测室，形成在包括设置在其上的微阵列的第一表面和第二表面之间，其中微阵列和第二表面之间的距离是可变的，并且其中第二表面具有位移结构。
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公开(公告)号：US08040494B2
公开(公告)日：2011-10-18
申请号：US12092422
申请日：2006-11-06
IPC分类号： G06K9/74
CPC分类号： G01N33/56966 , B01F11/0045 , B01F11/0266 , B01F13/0059 , B01L3/50273 , B01L3/502746 , B01L2200/027 , B01L2300/0636 , B01L2300/0822 , B01L2300/0825 , B01L2400/0481 , G01N21/03 , G01N35/0099 , G01N2021/0346 , G01N2035/00346
摘要： The present invention relates to devices and methods for the qualitative and/or quantitative detection of particles. In particular, the invention relates to devices for the detection of particles, comprising a reaction chamber formed within a chamber body between a first surface and a second surface, wherein the second surface is located opposite to the first surface, and one or more displacers, wherein the distance between the first surface and the second surface is variable via the one or more displacers at least in one or more parts of the surface area of the first surface and/or the second surface. The invention also relates to corresponding methods for the detection of particles, comprising positioning a sample supposed to comprise one or more species of particles to be detected in a reaction chamber, displacing at least a part of the sample within the reaction chamber via the one or more displacers; and detecting/determining a value indicative for the presence and/or number of one or more species of particles.
摘要翻译： 本发明涉及用于定性和/或定量检测颗粒的装置和方法。 特别地，本发明涉及用于检测颗粒的装置，其包括形成在第一表面和第二表面之间的室主体内的反应室，其中第二表面位于与第一表面相对的位置，以及一个或多个位移器， 其中所述第一表面和所述第二表面之间的距离可以经由所述一个或多个位移器在所述第一表面和/或所述第二表面的表面区域的至少一个或多个部分中是可变的。 本发明还涉及用于检测颗粒的相应方法，包括将假定包含待检测的一种或多种待检测颗粒的样品定位在反应室中，通过一个或多个反应室置换反应室内的至少一部分样品 更多的置换器 以及检测/确定指示一种或多种粒子的存在和/或数量的值。
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公开(公告)号：US20090079963A1
公开(公告)日：2009-03-26
申请号：US12092422
申请日：2006-11-06
CPC分类号： G01N33/56966 , B01F11/0045 , B01F11/0266 , B01F13/0059 , B01L3/50273 , B01L3/502746 , B01L2200/027 , B01L2300/0636 , B01L2300/0822 , B01L2300/0825 , B01L2400/0481 , G01N21/03 , G01N35/0099 , G01N2021/0346 , G01N2035/00346
摘要： The present invention relates to devices and methods for the qualitative and/or quantitative detection of particles. In particular, the invention relates to devices for the detection of particles, comprising a reaction chamber formed within a chamber body between a first surface and a second surface, wherein the second surface is located opposite to the first surface, and one or more displacers, wherein the distance between the first surface and the second surface is variable via the one or more displacers at least in one or more parts of the surface area of the first surface and/or the second surface. The invention also relates to corresponding methods for the detection of particles, comprising positioning a sample supposed to comprise one or more species of particles to be detected in a reaction chamber, displacing at least a part of the sample within the reaction chamber via the one or more displacers; and detecting/determining a value indicative for the presence and/or number of one or more species of particles.
摘要翻译： 本发明涉及用于定性和/或定量检测颗粒的装置和方法。 特别地，本发明涉及用于检测颗粒的装置，其包括形成在第一表面和第二表面之间的室主体内的反应室，其中第二表面位于与第一表面相对的位置，以及一个或多个位移器， 其中所述第一表面和所述第二表面之间的距离可以经由所述一个或多个位移器在所述第一表面和/或所述第二表面的表面区域的至少一个或多个部分中是可变的。 本发明还涉及用于检测颗粒的相应方法，包括将假定包含待检测的一种或多种待检测颗粒的样品定位在反应室中，通过一个或多个反应室置换反应室内的至少一部分样品 更多的置换器 以及检测/确定指示一种或多种粒子的存在和/或数量的值。
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