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1.发明授权公开(公告)号：US11226348B2
公开(公告)日：2022-01-18
申请号：US15843867
申请日：2017-12-15
Applicant: Roche Diagnostics Operations, Inc.
Inventor： Urs Vollenweider , Gottlieb Schacher , Goran Savatic , Marco Maetzler , Christoph Ludwig , Christian Loewenstein , Yves Laloux , Rik Harbers , Matthias Edelmann , Andreas Drechsler
IPC: G01N35/04
Abstract: A storage module for a laboratory automation system, a method of operating a laboratory automation system, and a laboratory automation system are presented. Items used by laboratory stations are stored centrally in a storage module and can be transported to the laboratory stations using a laboratory sample distribution system.
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公开(公告)号：US11150256B2
公开(公告)日：2021-10-19
申请号：US16105121
申请日：2018-08-20
Applicant: Roche Diagnostics Operations, Inc.
Inventor： Friedrich Ackermann , Andreas Calatzis , Rik Harbers , Roland Hutter , Jean-Pierre Bolliger , Theresa Kitcoff , Patrick Sascha Labud
Abstract: A reagent management system is disclosed comprising a reagent container section for receiving reagent containers and a reagent reconstitution device for reconstituting dry, or lyophilized, reagents or concentrated reagents in reagent containers in order to carry out in-vitro diagnostic tests with the reconstituted reagents. A controller is programmed to instruct the reagent reconstitution device to automatically reconstitute an initial volume of a selected reagent type in reagent containers. The initial volume is calculated based on an open container stability time (OCS) of the reconstituted reagent type for each reagent container and on a number of tests to be carried out within the OCS of the reconstituted reagent type. A reagent container for use by the reagent management system and methods of automatically reconstituting a dry, or lyophilized reagent, or a concentrated liquid reagent in a reagent container to carry out an in-vitro diagnostic test with the reagent are disclosed.
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3.发明申请公开(公告)号：US20170176478A1
公开(公告)日：2017-06-22
申请号：US15376704
申请日：2016-12-13
Applicant: Roche Diagnostics Operations, Inc.
Inventor： Rik Harbers , Marcel Thomann
CPC classification number: G01N35/00693 , G01N21/253 , G01N21/274 , G01N21/31 , G01N21/474 , G01N21/55 , G01N35/026 , G01N2201/127
Abstract: A method for calibration and/or error detection in an optical measurement device for biological samples having at least a first and a second measurement channel is described. The method comprises calculating an updated reference factor for the second measurement channel based on the first and second detection signals, comparing the updated reference factor with at least one current reference factors and depending on the result of the comparison, storing the updated reference factor as a current reference factor for use in a later measurement in the second measurement channel or keeping the current reference factors for use in a later measurement in the second measurement channel.
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公开(公告)号：US09322765B2
公开(公告)日：2016-04-26
申请号：US14303644
申请日：2014-06-13
Applicant: Roche Diagnostics Operations, Inc.
Inventor： Rik Harbers , Philipp Nicolas Zeller
CPC classification number: G01N21/01 , G01J1/08 , G01J3/0286 , G01J3/10 , G01N21/17 , H05B33/0821
Abstract: An optical system comprising a light source comprising a plurality of light emitting elements (LEEs) is presented. The light source is mounted on the same substrate or chip board so that the LEEs are in thermal contact with each other such as to enable thermic conduction and heat transfer between the LEEs. The system is switchable between light source modes in which different light emitting elements or a different number of light emitting elements is switched in an on mode and in a down mode respectively. In all light source modes, one or more light emitting elements, such as those with longer expected lifetime, remain in the on mode, while one or more light emitting elements, such as those with shorter expected lifetime, may be switched in the down mode.
Abstract translation: 提出了一种包括包括多个发光元件（LEE）的光源的光学系统。 光源安装在相同的基板或芯片板上，使得LEE彼此热接触，以便能够在LEE之间进行热传导和热传递。 该系统可以在其中不同的发光元件或不同数量的发光元件分别在接通模式和下降模式下切换的光源模式之间切换。 在所有光源模式中，一个或多个发光元件，例如具有较长预期寿命的发光元件保持在导通模式，而一个或多个发光元件，例如具有较短预期寿命的发光元件可以在下模式 。
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公开(公告)号：US20130130400A1
公开(公告)日：2013-05-23
申请号：US13737523
申请日：2013-01-09
Applicant: ROCHE DIAGNOSTICS OPERATIONS, INC.
Inventor： Rik Harbers , Kurt Schildknecht
IPC: G01N21/75
CPC classification number: G01N21/75 , G01J3/28 , G01J3/42 , G01N21/255
Abstract: An optical device for determining the presence and/or concentration of analytes in a sample is presented. The optical device comprises a detector and a detection unit comprising optical path components. The detection unit has wavelength-dependent responsivity. The optical device further comprises a light source for emitting light of different respective usable wavelength ranges. The light is guidable through the optical path to the detector to generate baseline signals and response signals relative to the baseline signal indicative of the presence and/or concentration of analytes in the optical path. The intensity of the light reaching the detector is adjusted inverse to the wavelength-dependent responsivity with respect to at least two respective usable wavelength ranges so that a reduction of the ratio between the maximum baseline signal at one of the selected usable wavelength ranges and the minimum baseline signal at another of the selected usable wavelength ranges is obtained.
Abstract translation: 提出了用于确定样品中分析物的存在和/或浓度的光学装置。 光学装置包括检测器和包括光路部件的检测单元。 检测单元具有波长依赖的响应性。 光学装置还包括用于发射不同的各个可用波长范围的光的光源。 光通过到检测器的光路是可引导的，以相对于指示光路中分析物的存在和/或浓度的基线信号产生基线信号和响应信号。 到达检测器的光的强度相对于至少两个相应的可用波长范围与波长相关的响应度相反地调整，使得在所选择的可用波长范围之一的最大基线信号与最小基准信号之间的比率的减小 获得在所选择的可用波长范围中的另一个的基线信号。
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Patent Agency Ranking
公开(公告)号：US20220003788A1
公开(公告)日：2022-01-06
申请号：US17304467
申请日：2021-06-22
Applicant: Roche Diagnostics Operations, Inc.
Inventor： Jean-Pierre Bolliger , Rik Harbers , Rolf Knobel
Abstract: A method of determining a level of interference with a photometric in-vitro diagnostic assay and an in-vitro diagnostic analyzer for carrying out the method are described. The method comprises treating an aliquot of a sample with at least one reagent to obtain a sample/reagent mixture and subjecting the sample/reagent mixture to a photometric measurement in order to obtain a result of the in-vitro diagnostic assay, and during the same photometric measurement determining a preliminary level of interference by semi-quantitatively determining one or more interfering substances in the same sample/reaction mixture. The method further comprises triggering a separate photometric measurement of another aliquot of the same sample either undiluted or diluted with a liquid other than a reagent in order to determine an effective level of interference by quantitatively determining the one or more interfering substances, only upon determining a preliminary level of interference above a predetermined threshold.
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公开(公告)号：US11204361B2
公开(公告)日：2021-12-21
申请号：US15875215
申请日：2018-01-19
Applicant: Roche Diagnostics Operations, Inc.
Inventor： Armin Birrer , Andreas Drechsler , Rik Harbers
Abstract: A laboratory automation system for processing sample containers containing laboratory samples and/or for processing the samples is presented. The laboratory automation system comprises a digital camera configured to take an image of the sample container together with a calibration element. The image comprises image data related to the sample container and image data related to the calibration element. The laboratory automation system also comprises an image processing device configured to determine geometrical properties of the sample container depending on the image data related to the sample container and the image data related to the calibration element.
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公开(公告)号：US20180252651A1
公开(公告)日：2018-09-06
申请号：US15909295
申请日：2018-03-01
Applicant: Roche Diagnostics Operations, Inc.
Inventor： Rik Harbers , Kurt Schildknecht
CPC classification number: G01N21/75 , G01J3/28 , G01J3/42 , G01N21/255
Abstract: An optical device for determining the presence and/or concentration of analytes in a sample is presented. The optical device comprises a detector and a detection unit comprising optical path components. The detection unit has wavelength-dependent responsivity. The optical device further comprises a light source for emitting light of different respective usable wavelength ranges. The light is guidable through the optical path to the detector to generate baseline signals and response signals relative to the baseline signal indicative of the presence and/or concentration of analytes in the optical path. The intensity of the light reaching the detector is adjusted inverse to the wavelength-dependent responsivity with respect to at least two respective usable wavelength ranges so that a reduction of the ratio between the maximum baseline signal at one of the selected usable wavelength ranges and the minimum baseline signal at another of the selected usable wavelength ranges is obtained.
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公开(公告)号：US20180224476A1
公开(公告)日：2018-08-09
申请号：US15875215
申请日：2018-01-19
Applicant: Roche Diagnostics Operations, Inc.
Inventor： Armin Birrer , Andreas Drechsler , Rik Harbers
CPC classification number: G01N35/10 , B65G54/02 , G01N21/51 , G01N35/00732 , G01N35/04 , G01N2035/00801 , G01N2035/00821 , G01N2035/0401 , G01N2035/0406 , G01N2035/0493 , G06T7/0012 , G06T7/60
Abstract: A laboratory automation system for processing sample containers containing laboratory samples and/or for processing the samples is presented. The laboratory automation system comprises a digital camera configured to take an image of the sample container together with a calibration element. The image comprises image data related to the sample container and image data related to the calibration element. The laboratory automation system also comprises an image processing device configured to determine geometrical properties of the sample container depending on the image data related to the sample container and the image data related to the calibration element.
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公开(公告)号：US20140291557A1
公开(公告)日：2014-10-02
申请号：US14303644
申请日：2014-06-13
Applicant: Roche Diagnostics Operations, Inc.
Inventor： Rik Harbers , Philipp Nicolas Zeller
CPC classification number: G01N21/01 , G01J1/08 , G01J3/0286 , G01J3/10 , G01N21/17 , H05B33/0821
Abstract: An optical system comprising a light source comprising a plurality of light emitting elements (LEEs) is presented. The light source is mounted on the same substrate or chip board so that the LEEs are in thermal contact with each other such as to enable thermic conduction and heat transfer between the LEEs. The system is switchable between light source modes in which different light emitting elements or a different number of light emitting elements is switched in an on mode and in a down mode respectively. In all light source modes, one or more light emitting elements, such as those with longer expected lifetime, remain in the on mode, while one or more light emitting elements, such as those with shorter expected lifetime, may be switched in the down mode.
Abstract translation: 提出了一种包括包括多个发光元件（LEE）的光源的光学系统。 光源安装在相同的基板或芯片板上，使得LEE彼此热接触，以便能够在LEE之间进行热传导和热传递。 该系统可以在其中不同的发光元件或不同数量的发光元件分别在接通模式和下降模式下切换的光源模式之间切换。 在所有光源模式中，一个或多个发光元件，例如具有较长预期寿命的发光元件保持在导通模式，而一个或多个发光元件，例如具有较短预期寿命的发光元件可以在下模式 。
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