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1.发明授权Peptides and compounds that bind selectins including endothelial leukocyte adhesion molecule 1 失效结合选丝素的肽和化合物，包括内皮细胞粘附分子1
公开(公告)号：US5643873A
公开(公告)日：1997-07-01
申请号：US241054
申请日：1994-05-11
申请人： Ronald W. Barrett , Steven E. Cwirla , William J. Dower , Kerry J. Koller , Jung Lee , Christine L. Martens , Beatrice Ruhland-Fritsch
发明人： Ronald W. Barrett , Steven E. Cwirla , William J. Dower , Kerry J. Koller , Jung Lee , Christine L. Martens , Beatrice Ruhland-Fritsch
CPC分类号： A61K49/0056 , A61K47/48238 , A61K51/08 , C07K1/047 , C07K14/001 , C07K7/06 , C07K7/08 , A61K2123/00 , A61K38/00
摘要： Disclosed are peptides and peptide mimetics that bind selectins, including endothelial leukocyte adhesion molecule 1 (ELAM-1). Such peptides and peptide mimetics are useful in methods for blocking adhesion of leukocytes to the selectins for the purpose of inhibiting inflammation as well as in diagnostic methods employing labeled peptides and peptide mimetics that bind selectins for the purpose of determining the site of inflammation in mammals which inflammation is mediated by the presence of one or more selectins.
摘要翻译： 公开了结合选择素的肽和肽模拟物，包括内皮细胞粘附分子1（ELAM-1）。 这样的肽和肽模拟物可用于阻止白细胞粘附到选择素上用于抑制炎症的方法以及使用结合选择素的标记肽和肽模拟物的诊断方法，以确定哺乳动物的炎症位点 炎症由一种或多种选择素的存在介导。
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2.发明授权Peptides and compounds that bind selectins including endothelium leukocyte adhesion molecule 1 失效结合选择素的肽和化合物，包括内皮细胞粘附分子1
公开(公告)号：US5786322A
公开(公告)日：1998-07-28
申请号：US485508
申请日：1995-06-07
申请人： Ronald W. Barrett , Steven E. Cwirla , William J. Dower , Kerry J. Koller , Jung Lee , Christine L. Martens , Beatrice Ruhland-Fritsch
发明人： Ronald W. Barrett , Steven E. Cwirla , William J. Dower , Kerry J. Koller , Jung Lee , Christine L. Martens , Beatrice Ruhland-Fritsch
IPC分类号： A61K38/00 , A61K47/48 , A61K49/00 , A61K51/08 , C07K1/04 , C07K7/06 , C07K7/08 , C07K14/00 , C07K5/00 , C07K7/00 , C07K16/00
CPC分类号： A61K49/0056 , A61K47/48238 , A61K51/08 , C07K1/047 , C07K14/001 , C07K7/06 , C07K7/08 , A61K2123/00 , A61K38/00
摘要： Disclosed are peptides and peptide mimetics that bind selectins, including endothelial leukocyte adhesion molecule 1 (ELAM-1). Such peptides and peptide mimetics are useful in methods for blocking adhesion of leukocytes to the selectins for the purpose of inhibiting inflammation as well as in diagnostic methods employing labeled peptides and peptide mimetics that bind selectins for the purpose of determining the site of inflammation in mammals which inflammation is mediated by the presence of one or more selectins.
摘要翻译： 公开了结合选择蛋白的肽和肽模拟物，包括内皮细胞粘附分子1（ELAM-1）。 这样的肽和肽模拟物可用于阻止白细胞粘附到选择素上用于抑制炎症的方法以及使用结合选择素的标记肽和肽模拟物的诊断方法，以确定哺乳动物的炎症位点 炎症由一种或多种选择素的存在介导。
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3.发明授权Peptides and compounds that bind selectins including endothelium leukocyte adhesion molecule 1 (ELAM-1) 失效结合选择素的肽和化合物，包括内皮细胞粘附分子1（ELAM-1）
公开(公告)号：US5728802A
公开(公告)日：1998-03-17
申请号：US439817
申请日：1995-05-12
申请人： Ronald W. Barrett , Steven E. Cwirla , William J. Dower , Kerry J. Koller , Jung Lee , Christine L. Martens , Beatrice Ruhland
发明人： Ronald W. Barrett , Steven E. Cwirla , William J. Dower , Kerry J. Koller , Jung Lee , Christine L. Martens , Beatrice Ruhland
CPC分类号： A61K51/08 , A61K47/48238 , A61K49/0056 , C07K1/047 , C07K14/001 , C07K7/06 , C07K7/08 , A61K2123/00 , A61K38/00
摘要： Disclosed are peptides and peptide mimetics that bind selectins, including endothelial leukocyte adhesion molecule 1 (ELAM-1). Such peptides and peptide mimetics are useful in methods for blocking adhesion of leukocytes to the selectins for the purpose of inhibiting inflammation as well as in diagnostic methods employing labeled peptides and peptide mimetics that bind selectins for the purpose of determining the site of inflammation in mammals which inflammation is mediated by the presence of one or more selectins.
摘要翻译： 公开了结合选择素的肽和肽模拟物，包括内皮细胞粘附分子1（ELAM-1）。 这样的肽和肽模拟物可用于阻止白细胞粘附到选择素上用于抑制炎症的方法以及使用结合选择素的标记肽和肽模拟物的诊断方法，以确定哺乳动物的炎症位点 炎症由一种或多种选择素的存在介导。
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公开(公告)号：US5648458A
公开(公告)日：1997-07-15
申请号：US390156
申请日：1995-02-16
摘要： The peptide HITWDQLWNVMN (SEQ ID NO: 4) and related peptides and peptidomimetics bind to endothelial leukocyte adhesion molecule 1 and block the binding of leukocytes to this important receptor and so can be used to ameliorate the detrimental effects of certain disease conditions.
摘要翻译： 肽HITWDQLWNVMN（SEQ ID NO：4）和相关肽和肽模拟物结合内皮细胞粘附分子1并阻断白细胞与这种重要受体的结合，因此可用于改善某些疾病状况的不利影响。
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公开(公告)号：US20090214489A1
公开(公告)日：2009-08-27
申请号：US12103377
申请日：2008-04-15
申请人： William J. Dower , Ronald W. Barrett , Steven E. Cwirla , David J. Duffin , Christian M. Gates , Sherril S. Haselden , Larry C. Mattheakis , Peter J. Schatz , Christopher R. Wagstrom , Nicholas C. Wrighton
发明人： William J. Dower , Ronald W. Barrett , Steven E. Cwirla , David J. Duffin , Christian M. Gates , Sherril S. Haselden , Larry C. Mattheakis , Peter J. Schatz , Christopher R. Wagstrom , Nicholas C. Wrighton
CPC分类号： C07K7/08 , A61K38/00 , C07K7/64 , C07K14/521 , C07K14/524
摘要： Described are peptides and peptide mimetics that bind to and activate the thrombopoietin receptor. Such peptides and peptide mimetics are useful in methods for treating hematological disorders and particularly, thrombocytopenia resulting from chemotherapy, radiation therapy, or bone marrow transfusions as well as in diagnostic methods employing labeled peptides and peptide mimetics.
摘要翻译： 描述了结合并激活血小板生成素受体的肽和肽模拟物。 这样的肽和肽模拟物可用于治疗血液学疾病，特别是由化疗，放射治疗或骨髓输注引起的血小板减少症以及使用标记肽和肽模拟物的诊断方法。
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公开(公告)号：US06506362B1
公开(公告)日：2003-01-14
申请号：US09832230
申请日：2001-04-10
申请人： William J. Dower , Ronald W. Barrett , Steven E. Cwirla , Christian M. Gates , Peter J. Schatz , Palaniappan Balasubramanian , Christopher R. Wagstrom , Richard Wayne Hendren , Randolph B. Deprince , Surekha Podduturi , Qun Yin
发明人： William J. Dower , Ronald W. Barrett , Steven E. Cwirla , Christian M. Gates , Peter J. Schatz , Palaniappan Balasubramanian , Christopher R. Wagstrom , Richard Wayne Hendren , Randolph B. Deprince , Surekha Podduturi , Qun Yin
IPC分类号： A61K3819
CPC分类号： C07K14/524
摘要： Described are peptides and peptide mimetics that bind to and activate the thrombopoietin receptor. Such peptides and peptide mimetics are useful in methods for treating hematological disorders and particularly, thrombocytopenia resulting from chemotherapy, radiation therapy, or bone marrow transfusions as well as in diagnostic methods employing labeled peptides and peptide mimetics.
摘要翻译： 描述了结合并激活血小板生成素受体的肽和肽模拟物。 这样的肽和肽模拟物可用于治疗血液学疾病，特别是由化疗，放射治疗或骨髓输注引起的血小板减少症以及使用标记肽和肽模拟物的诊断方法。
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公开(公告)号：US5723286A
公开(公告)日：1998-03-03
申请号：US541108
申请日：1990-06-20
IPC分类号： C12N1/21 , C07K1/04 , C07K5/083 , C07K5/087 , C07K5/103 , C07K5/107 , C07K14/435 , C07K14/675 , C12N7/00 , C12N15/09 , C12N15/10 , C12N15/62 , C12N15/70 , C12Q1/70 , C12R1/19 , C40B30/04 , C40B40/02 , G01N33/68 , C12N15/64 , C12Q1/60
CPC分类号： C40B30/04 , C07K1/047 , C07K14/435 , C07K14/675 , C07K5/0806 , C07K5/0812 , C07K5/1008 , C07K5/1016 , C12N15/1037 , C12N15/62 , C12N15/70 , C12Q1/70 , C40B40/02 , G01N33/6845 , G01N33/6878 , C07K2319/00
摘要： Peptides which bind to selected receptor molecules are identified by screening libraries which encode a random or controlled collection of amino acids. Peptides encoded by the libraries are expressed as fusion proteins of bacteriophage coat proteins, and bacteriophage particles are then screened against the receptors of interest. Peptides having a wide variety of uses, such as therapeutic or diagnostic reagents, may thus be identified without any prior information on the structure of the expected ligand or receptor molecule.
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公开(公告)号：US08227422B2
公开(公告)日：2012-07-24
申请号：US11610226
申请日：2006-12-13
申请人： William J. Dower , Ronald W. Barrett , Steven E. Cwirla , David J. Duffin , Christian M. Gates , Sherril S. Haselden , Larry C. Mattheakis , Peter J. Schatz , Christopher R. Wagstrom , Nicholas C. Wrighton
发明人： William J. Dower , Ronald W. Barrett , Steven E. Cwirla , David J. Duffin , Christian M. Gates , Sherril S. Haselden , Larry C. Mattheakis , Peter J. Schatz , Christopher R. Wagstrom , Nicholas C. Wrighton
IPC分类号： C07K7/50
CPC分类号： C07K7/08 , A61K38/00 , C07K7/64 , C07K14/521 , C07K14/524
摘要： Described are peptides and peptide mimetics that bind to and activate the thrombopoietin receptor. Such peptides and peptide mimetics are useful in methods for treating hematological disorders and particularly, thrombocytopenia resulting from chemotherapy, radiation therapy, or bone marrow transfusions as well as in diagnostic methods employing labeled peptides and peptide mimetics.
摘要翻译： 描述了结合并激活血小板生成素受体的肽和肽模拟物。 这样的肽和肽模拟物可用于治疗血液学疾病，特别是由化疗，放射治疗或骨髓输注引起的血小板减少症以及使用标记肽和肽模拟物的诊断方法。
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公开(公告)号：US07229757B2
公开(公告)日：2007-06-12
申请号：US10105029
申请日：2002-03-21
IPC分类号： C12Q1/68
CPC分类号： C40B40/02 , C12N15/1037 , G01N33/6845
摘要： Icosahedral phage and collections thereof that display various compounds are provided. In some instances, the icosahedral phage include nucleic acid tags that serve to record a characteristic of the compound or compounds that are attached to the phage. A number of different methods for using the icosahedral phage to screen a library of compounds for a desired biological activity are also provided, especially assays for compounds that are substrates for receptor-mediated transport processes such as endocytosis and transcytosis.
摘要翻译： 提供显示各种化合物的二十面体噬菌体及其收集物。 在一些情况下，二十面体噬菌体包括用于记录附着于噬菌体的化合物或化合物的特征的核酸标签。 还提供了许多用于使用二十面体噬菌体筛选化合物文库以获得所需生物学活性的不同方法，特别是用于受体介导的转运过程例如内吞作用和转胞吞作用的底物的化合物的测定。
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公开(公告)号：US06251864B1
公开(公告)日：2001-06-26
申请号：US09516704
申请日：2000-03-01
申请人： William J. Dower , Ronald W. Barrett , Steven E. Cwirla , Christian M. Gates , Peter J. Schatz , Palaniappan Balasubramanian , Christopher R. Wagstrom , Richard Wayne Hendren , Randolph B. Deprince , Surekha Podduturi , Qun Yin
发明人： William J. Dower , Ronald W. Barrett , Steven E. Cwirla , Christian M. Gates , Peter J. Schatz , Palaniappan Balasubramanian , Christopher R. Wagstrom , Richard Wayne Hendren , Randolph B. Deprince , Surekha Podduturi , Qun Yin
IPC分类号： A61K3800
CPC分类号： C07K14/524
摘要： Described are peptides and peptide mimetics that bind to and activate the thrombopoietin receptor. Such peptides and peptide mimetics are useful in methods for treating hematological disorders and particularly, thrombocytopenia resulting from chemotherapy, radiation therapy, or bone marrow transfusions as well as in diagnostic methods employing labeled peptides and peptide mimetics.
摘要翻译： 描述了结合并激活血小板生成素受体的肽和肽模拟物。 这样的肽和肽模拟物可用于治疗血液学疾病，特别是由化疗，放射治疗或骨髓输注引起的血小板减少症以及使用标记肽和肽模拟物的诊断方法。
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