公开(公告)号：US20090136959A1

公开(公告)日：2009-05-28

申请号：US12288775

申请日：2008-10-23

申请人： Sean A. McCarthy ,  Christopher C. Fraser ,  John D. Sharp ,  Thomas M. Barnes ,  Susan J. Kirst ,  Paul S. Myers ,  Nicholas Wrighton ,  Andrew D.J. Goodearl ,  Douglas A. Holtzman ,  Mehran Khodadoust

发明人： Sean A. McCarthy ,  Christopher C. Fraser ,  John D. Sharp ,  Thomas M. Barnes ,  Susan J. Kirst ,  Paul S. Myers ,  Nicholas Wrighton ,  Andrew D.J. Goodearl ,  Douglas A. Holtzman ,  Mehran Khodadoust

IPC分类号： C12Q1/68 ,  C12N15/11 ,  C12N15/00 ,  C12N5/06 ,  C07K14/00 ,  G01N33/00 ,  C07K1/00 ,  C07K16/18 ,  C12P21/04 ,  G01N33/53

CPC分类号： C07K14/47

摘要： The invention provides isolated nucleic acids encoding a variety of proteins having diagnostic, preventive, therapeutic, and other uses. These nucleic and proteins are useful for diagnosis, prevention, and therapy of a number of human and other animal disorders. The invention also provides antisense nucleic acid molecules, expression vectors containing the nucleic acid molecules of the invention, host cells into which the expression vectors have been introduced, and non-human transgenic animals in which a nucleic acid molecule of the invention has been introduced or disrupted. The invention still further provides isolated polypeptides, fusion polypeptides, antigenic peptides and antibodies. Diagnostic, screening, and therapeutic methods using compositions of the invention are also provided. The nucleic acids and polypeptides of the present invention are useful as modulating agents in regulating a variety of cellular processes.

摘要翻译： 本发明提供编码具有诊断，预防，治疗和其它用途的各种蛋白质的分离的核酸。 这些核酸和蛋白质可用于诊断，预防和治疗许多人类和其他动物疾病。 本发明还提供反义核酸分子，含有本发明的核酸分子的表达载体，已经引入了表达载体的宿主细胞和其中引入了本发明的核酸分子的非人转基因动物，或 中断了 本发明还进一步提供分离的多肽，融合多肽，抗原肽和抗体。 还提供了使用本发明组合物的诊断，筛选和治疗方法。 本发明的核酸和多肽可用作调节各种细胞过程的调节剂。

公开(公告)号：US20100062487A1

公开(公告)日：2010-03-11

申请号：US12387959

申请日：2009-05-08

申请人： Christopher C. Fraser ,  Thomas M. Barnes ,  John D. Sharp ,  Susan J. Kirst ,  Paul S. Myers ,  Kevin R. Leiby ,  Douglas A. Holtzman ,  Sean A. McCarthy ,  Nicholas Wrighton ,  Charles R. Mackay ,  Andrew D.J. Goodearl

发明人： Christopher C. Fraser ,  Thomas M. Barnes ,  John D. Sharp ,  Susan J. Kirst ,  Paul S. Myers ,  Kevin R. Leiby ,  Douglas A. Holtzman ,  Sean A. McCarthy ,  Nicholas Wrighton ,  Charles R. Mackay ,  Andrew D.J. Goodearl

IPC分类号： C12P21/02 ,  C07H21/04 ,  C12N5/00 ,  C12N1/00 ,  C07K14/00 ,  C07K16/00 ,  G01N33/53

CPC分类号： C07K14/47 ,  A01K2217/05 ,  A61K38/00 ,  C07K14/705 ,  C07K2319/00 ,  Y02A50/411 ,  Y10T436/143333

摘要： The invention provides isolated nucleic acids encoding a variety of proteins having diagnostic, preventive, therapeutic, and other uses. These nucleic and proteins are useful for diagnosis, prevention, and therapy of a number of human and other animal disorders. The invention also provides antisense nucleic acid molecules, expression vectors containing the nucleic acid molecules of the invention, host cells into which the expression vectors have been introduced, and non-human transgenic animals in which a nucleic acid molecule of the invention has been introduced or disrupted. The invention still further provides isolated polypeptides, fusion polypeptides, antigenic peptides and antibodies. Diagnostic, screening, and therapeutic methods using compositions of the invention are also provided. The nucleic acids and polypeptides of the present invention are useful as modulating agents in regulating a variety of cellular processes.

摘要翻译： 本发明提供编码具有诊断，预防，治疗和其它用途的各种蛋白质的分离的核酸。 这些核酸和蛋白质可用于诊断，预防和治疗许多人类和其他动物疾病。 本发明还提供反义核酸分子，含有本发明的核酸分子的表达载体，已经引入了表达载体的宿主细胞和其中引入了本发明的核酸分子的非人转基因动物，或 中断了 本发明还进一步提供分离的多肽，融合多肽，抗原肽和抗体。 还提供了使用本发明组合物的诊断，筛选和治疗方法。 本发明的核酸和多肽可用作调节各种细胞过程的调节剂。

公开(公告)号：US20120045777A1

公开(公告)日：2012-02-23

申请号：US13169686

申请日：2011-06-27

申请人： Christopher C. Fraser ,  Thomas M. Barnes ,  John D. Sharp ,  Susan J. Kirst ,  Paul S. Myers ,  Kevin R. Leiby ,  Douglas A. Holtzman ,  Sean A. McCarthy ,  Nicholas Wrighton ,  Charles R. Mackay ,  Andrew D.J. Goodearl

发明人： Christopher C. Fraser ,  Thomas M. Barnes ,  John D. Sharp ,  Susan J. Kirst ,  Paul S. Myers ,  Kevin R. Leiby ,  Douglas A. Holtzman ,  Sean A. McCarthy ,  Nicholas Wrighton ,  Charles R. Mackay ,  Andrew D.J. Goodearl

IPC分类号： G01N33/53 ,  C12Q1/37 ,  C12P21/02 ,  C12N9/99 ,  C12N9/64 ,  C12N15/57 ,  C12N5/00 ,  C12N15/63 ,  G01N33/50 ,  C07K14/00 ,  C07K16/18 ,  C07H21/04 ,  G01N33/573 ,  C12N5/10

CPC分类号： C07K14/47 ,  A01K2217/05 ,  A61K38/00 ,  C07K14/705 ,  C07K2319/00 ,  Y02A50/411 ,  Y10T436/143333

摘要： The invention provides isolated nucleic acids encoding a variety of proteins having diagnostic, preventive, therapeutic, and other uses. These nucleic and proteins are useful for diagnosis, prevention, and therapy of a number of human and other animal disorders. The invention also provides antisense nucleic acid molecules, expression vectors containing the nucleic acid molecules of the invention, host cells into which the expression vectors have been introduced, and non-human transgenic animals in which a nucleic acid molecule of the invention has been introduced or disrupted. The invention still further provides isolated polypeptides, fusion polypeptides, antigenic peptides and antibodies. Diagnostic, screening, and therapeutic methods using compositions of the invention are also provided. The nucleic acids and polypeptides of the present invention are useful as modulating agents in regulating a variety of cellular processes.

摘要翻译： 本发明提供编码具有诊断，预防，治疗和其它用途的各种蛋白质的分离的核酸。 这些核酸和蛋白质可用于诊断，预防和治疗许多人类和其他动物疾病。 本发明还提供反义核酸分子，含有本发明的核酸分子的表达载体，已经引入了表达载体的宿主细胞和其中引入了本发明的核酸分子的非人转基因动物，或 中断了 本发明还进一步提供分离的多肽，融合多肽，抗原肽和抗体。 还提供了使用本发明组合物的诊断，筛选和治疗方法。 本发明的核酸和多肽可用作调节各种细胞过程的调节剂。

公开(公告)号：US5882893A

公开(公告)日：1999-03-16

申请号：US985090

申请日：1997-12-04

申请人： Andrew D.J. Goodearl

发明人： Andrew D.J. Goodearl

IPC分类号： C07K14/705 ,  C12N15/12

CPC分类号： C07K14/70571 ,  A01K2217/05 ,  C07K2319/00

摘要： The invention provides isolated nucleic acids molecules, designated muscarinic acetylcholine receptor 6 ("mACHR-6") nucleic acid molecules, which encode polypeptides involved in the modulation of acetylcholine responses in acetylcholine responsive cells. The invention also provides antisense nucleic acid molecules, expression vectors containing mACHR-6 nucleic acid molecules, host cells into which the expression vectors have been introduced, and non-human transgenic animals in which an mACHR-6 gene has been introduced or disrupted. The invention still further provides isolated mACHR-6 polypeptides, fusion polypeptides, antigenic peptides, and anti-mACHR-6 antibodies. Diagnostic, screening, and therapeutic methods utilizing compositions of the invention are also provided.

摘要翻译： 本发明提供分离的核酸分子，命名为毒蕈碱性乙酰胆碱受体6（“mACHR-6”）核酸分子，其编码涉及乙酰胆碱反应性细胞中乙酰胆碱反应调节的多肽。 本发明还提供反义核酸分子，含有mACHR-6核酸分子的表达载体，其中引入了表达载体的宿主细胞和其中引入或破坏了mACHR-6基因的非人转基因动物。 本发明还进一步提供了分离的mACHR-6多肽，融合多肽，抗原肽和抗mACHR-6抗体。 还提供了利用本发明组合物的诊断，筛选和治疗方法。

公开(公告)号：US20090226450A1

公开(公告)日：2009-09-10

申请号：US12386856

申请日：2009-04-23

申请人： Martin R. Hodge ,  Clare M. Lloyd ,  Nadine S. Weich ,  Jose M. Lora ,  David White ,  Maria A. Glucksmann ,  Keith E. Robison ,  Inmaculada Silos-Santiago ,  Andrew D.J. Goodearl ,  Rory A.J. Curtis

发明人： Martin R. Hodge ,  Clare M. Lloyd ,  Nadine S. Weich ,  Jose M. Lora ,  David White ,  Maria A. Glucksmann ,  Keith E. Robison ,  Inmaculada Silos-Santiago ,  Andrew D.J. Goodearl ,  Rory A.J. Curtis

IPC分类号： A61K39/395 ,  C12N15/11 ,  C12N5/00 ,  C07K14/00 ,  C07K16/18 ,  C12P21/02 ,  G01N33/566 ,  G01N33/53 ,  C12Q1/68 ,  A61K38/02 ,  A61K38/16 ,  A61K31/7088

CPC分类号： C07K14/47 ,  C07K16/286 ,  G01N33/6893 ,  G01N33/74 ,  G01N2333/726 ,  G01N2500/04 ,  G01N2800/122 ,  G01N2800/24

摘要： The invention provides isolated nucleic acids molecules, designated 15571, 2465, 14266, 2882, 52871, 8203 or 16852 nucleic acid molecules. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 15571, 2465, 14266, 2882, 52871, 8203 or 16852 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a 15571, 2465, 14266, 2882, 52871, 8203 or 16852 gene has been introduced or disrupted. The invention still further provides isolated 15571, 2465, 14266, 2882, 52871, 8203 or 16852 proteins, fusion proteins, antigenic peptides and anti-15571, 2465, 14266, 2882, 52871, 8203 or 16852 antibodies. Diagnostic and therapeutic methods utilizing compositions of the invention are also provided.

摘要翻译： 本发明提供分离的核酸分子，命名为15571,2465,14266,2882,52871,8203或16852核酸分子。 本发明还提供反义核酸分子，含有15571,2465,14266,2882,52871,8203或16852核酸分子的重组表达载体，已经引入表达载体的宿主细胞，以及非人类转基因动物，其中15571， 2465,14266,2882,52871,8203或16852基因已被引入或破坏。 本发明还进一步提供了分离的15571,2465,14266,2882,52871,8203或16852蛋白，融合蛋白，抗原肽和抗15571,2465,14266,2882,52871,8203或16852抗体。 还提供了利用本发明组合物的诊断和治疗方法。

公开(公告)号：US20110171205A1

公开(公告)日：2011-07-14

申请号：US13012890

申请日：2011-01-25

申请人： Martin R. Hodge ,  Clare M. Lloyd ,  Nadine S. Weich ,  Jose M. Lora ,  David White ,  Maria A. Glucksmann ,  Keith E. Robison ,  Inmaculada Silos-Santiago ,  Andrew D.J. Goodearl ,  Rory A.J. Curtis

发明人： Martin R. Hodge ,  Clare M. Lloyd ,  Nadine S. Weich ,  Jose M. Lora ,  David White ,  Maria A. Glucksmann ,  Keith E. Robison ,  Inmaculada Silos-Santiago ,  Andrew D.J. Goodearl ,  Rory A.J. Curtis

IPC分类号： A61K39/395 ,  C07H21/04 ,  C12N5/00 ,  C07K14/00 ,  C07K16/18 ,  C12P21/02 ,  C12Q1/68 ,  G01N33/53 ,  A61K38/17 ,  A61K31/7088 ,  C12N15/11 ,  C12N1/21 ,  A61P25/00 ,  A61P19/02 ,  A61P25/28 ,  A61P25/16 ,  A61P25/18 ,  A61P9/00 ,  A61P9/04 ,  A61P35/00 ,  A61P3/10 ,  A61P15/02

CPC分类号： C07K14/47 ,  C07K16/286 ,  G01N33/6893 ,  G01N33/74 ,  G01N2333/726 ,  G01N2500/04 ,  G01N2800/122 ,  G01N2800/24

摘要： The invention provides isolated nucleic acids molecules, designated 15571, 2465, 14266, 2882, 52871, 8203 or 16852 nucleic acid molecules. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 15571, 2465, 14266, 2882, 52871, 8203 or 16852 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a 15571, 2465, 14266, 2882, 52871, 8203 or 16852 gene has been introduced or disrupted. The invention still further provides isolated 15571, 2465, 14266, 2882, 52871, 8203 or 16852 proteins, fusion proteins, antigenic peptides and anti-15571, 2465, 14266, 2882, 52871, 8203 or 16852 antibodies. Diagnostic and therapeutic methods utilizing compositions of the invention are also provided.

摘要翻译： 本发明提供分离的核酸分子，命名为15571,2465,14266,2882,52871,8203或16852核酸分子。 本发明还提供反义核酸分子，含有15571,2465,14266,2882,52871,8203或16852核酸分子的重组表达载体，已经引入表达载体的宿主细胞，以及非人类转基因动物，其中15571， 2465,14266,2882,52871,8203或16852基因已被引入或破坏。 本发明还进一步提供了分离的15571,2465,14266,2882,52871,8203或16852蛋白，融合蛋白，抗原肽和抗15571,2465,14266,2882,52871,8203或16852抗体。 还提供了利用本发明组合物的诊断和治疗方法。