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    Antimicrobial medical articles containing a combination of anti-infective compounds, octoxyglycerin, salicylic acid, and sesquiterpenoids
    1.
    发明申请
    Antimicrobial medical articles containing a combination of anti-infective compounds, octoxyglycerin, salicylic acid, and sesquiterpenoids 审中-公开
    包含抗感染化合物，辛氧基甘油，水杨酸和倍半萜烯的组合的抗菌药物

    公开(公告)号：US20060099237A1

    公开(公告)日：2006-05-11

    申请号：US11250241

    申请日：2005-10-14

    Applicant: Shanta Modak ,  Trupti Gaonkar

    Inventor： Shanta Modak ,  Trupti Gaonkar

    IPC: A61K33/38 ,  A61F13/00

    CPC classification number: A61L31/16 ,  A61K31/155 ,  A61K31/19 ,  A61K33/38 ,  A61K45/06 ,  A61L15/44 ,  A61L15/46 ,  A61L17/005 ,  A61L27/54 ,  A61L29/16 ,  A61L2300/216 ,  A61L2300/404 ,  A61L2300/45 ,  A61K2300/00

    Abstract: Medical articles impregnated with antimicrobial compositions containing synergistic combinations of octoxyglycerin and other anti-infective compounds are disclosed. Such medical articles may include urinary catheters, central venous catheters, tracheal catheters, arterial grafts, wound dressings, sutures, or any other medical articles derived from polymeric substrates such as biomedical polyurethane, biomedical polyvinylchloride (PVC), biomedical silicon, biodegradable polymers, polytetrafluoroethylene (PTFE), etc. or from natural products including natural rubber, silk or cotton fiber. Antimicrobial compositions comprising salicylic acid and sesquiterpenoids are also disclosed.

    Abstract translation: 公开了用含有辛氧基甘油和其它抗感染化合物的协同组合的抗微生物组合物浸渍的医疗制品。 这样的医疗制品可以包括导尿管，中心静脉导管，气管导管，动脉移植物，伤口敷料，缝合线或衍生自聚合物基底的生物医学聚氨酯，生物医学聚氯乙烯（PVC），生物医学硅，生物可降解聚合物，聚四氟乙烯 （PTFE）等，或天然橡胶，丝绸或棉纤维等天然产品。 还公开了包含水杨酸和倍半萜类化合物的抗微生物组合物。

    Combinations of antiseptic and antibiotic agents containing medical devices
    9.
    发明申请
    Combinations of antiseptic and antibiotic agents containing medical devices 审中-公开
    含有医疗器械的防腐剂和抗生素剂的组合

    公开(公告)号：US20050192547A1

    公开(公告)日：2005-09-01

    申请号：US10633204

    申请日：2003-07-30

    Applicant: Shanta Modak ,  Suhas Tambe ,  Lester Sampath

    Inventor： Shanta Modak ,  Suhas Tambe ,  Lester Sampath

    IPC: A01N47/44 ,  A61L29/16 ,  A61M25/00

    CPC classification number: A61L29/16 ,  A01N47/44 ,  A61L2300/102 ,  A61L2300/202 ,  A61L2300/206 ,  A61L2300/208 ,  A61L2300/404 ,  A61L2300/406 ,  A61L2300/45 ,  A01N59/16 ,  A01N37/44 ,  A01N25/34 ,  A01N25/10 ,  A01N2300/00

    Abstract: The present invention relates to compositions comprising a combination of one or more antiseptic and an antibiotic. It is based, at least in part, on the discovery that such combinations tend to deter the formation of antibiotic-resistant organisms. In preferred, nonlimiting embodiments of the invention, the antibiotic is minocycline and the antiseptic is a chlorhexidine compound, triclosan, or benzalkonium chloride, and in particular embodiments, a silver salt or a bismuth salt is added. Examples of specific, nonlimiting embodiments of the invention include combinations of (i) minocycline, triclosan, and a bismuth salt; (ii) minocycline, a chlorhexidine compound, and a bismuth salt; and (iii) minocycline, benzalkonium chloride, and a bismuth salt. The present invention further provides for articles, such as, but not limited to, medical articles, which have been treated with or which otherwise comprise a combination of antiseptic and antibiotic.

    Abstract translation: 本发明涉及包含一种或多种防腐剂与抗生素组合的组合物。 至少部分地基于这样的发现，即这种组合倾向于阻止抗生素抗性生物的形成。 在本发明的非限制性实施方案中，抗生素是二甲胺四环素，并且所述防腐剂是氯己定化合物，三氯生或苯扎氯铵，并且在具体实施方案中，加入银盐或铋盐。 本发明的具体的非限制性实施方案的实例包括（i）米诺环素，三氯生和铋盐的组合; （ii）米诺环素，氯己定化合物和铋盐; 和（iii）米诺环素，苯扎氯铵和铋盐。 本发明还提供了已经用抗菌素和抗生素组合处理或以其他方式组合的制品，例如但不限于医疗制品。

    Triclosan and silver compound containing medical devices
    10.
    发明授权
    Triclosan and silver compound containing medical devices 失效
    三氯生和含银化合物的医疗器械

    公开(公告)号：US06224579B1

    公开(公告)日：2001-05-01

    申请号：US09281872

    申请日：1999-03-31

    Applicant: Shanta Modak ,  Lester Sampath

    Inventor： Shanta Modak ,  Lester Sampath

    IPC: A61M532

    CPC classification number: A61L31/16 ,  A01N59/16 ,  A61L2/18 ,  A61L15/44 ,  A61L17/005 ,  A61L27/54 ,  A61L29/16 ,  A61L2300/104 ,  A61L2300/202 ,  A61L2300/21 ,  A61L2300/404 ,  A61L2300/406 ,  A61L2300/41 ,  A61L2300/45 ,  D06M11/83 ,  D06M13/432 ,  D06M16/00 ,  Y10T428/1352 ,  A01N31/16 ,  A01N31/12 ,  A01N31/08 ,  A01N25/34 ,  A01N2300/00

    Abstract: The present invention relates to polymeric medical articles comprising combinations of triclosan and silver-containing compounds. It is based, at least in part, on the discovery that these agents act synergistically, thereby permitting the use of relatively low levels of both agents. While it had been previously found that triclosan can be particularly useful when used in conjunction with chlorhexidine, it has been further discovered that medical articles having suitable antimicrobial properties may be prepared, according to the present invention, which contain triclosan without chlorhexidine. Such medical articles offer the advantage of preventing or inhibiting infection while avoiding undesirable adverse reactions to chlorhexidine by individuals that may have sensitivity to chlorhexidine.

    Abstract translation: 本发明涉及包含三氯生和含银化合物的组合的聚合物医疗制品。 至少部分地是基于发现这些试剂协同作用，从而允许使用相对较低水平的两种试剂。 虽然以前已经发现三氯生与氯己定联合使用时可能特别有用，但是已经进一步发现，根据本发明，可以制备具有合适的抗微生物性质的医药制品，其含有不含氯己定的三氯生。 这样的医疗制品具有预防或抑制感染的优点，同时避免对氯己定具有敏感性的个体对氯己定的不良不良反应。

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