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1.发明授权Process for the preparation of small molecule inhibitors of MDM2 and intermediates used therein 失效制备MDM2的小分子抑制剂的方法及其中使用的中间体公开(公告)号：US08742121B2
公开(公告)日：2014-06-03
申请号：US13614751
申请日：2012-09-13
Applicant: Shaomeng Wang , Ke Ding , Guoping Wang
Inventor： Shaomeng Wang , Ke Ding , Guoping Wang
IPC: C07D401/02 , C07D487/10 , C07D209/04
CPC classification number: C07D209/54 , C07D487/10 , C07D491/10
Abstract: The invention relates to small molecules which function as inhibitors of the interaction between p53 and MDM2. The invention also relates to the use of these compounds for inhibiting cell growth, inducing cell death, inducing cell cycle arrest and/or sensitizing cells to additional agent(s).
Abstract translation: 本发明涉及作为p53和MDM2相互作用抑制剂的小分子。 本发明还涉及这些化合物用于抑制细胞生长，诱导细胞死亡，诱导细胞周期停滞和/或使细胞对附加试剂敏感的用途。
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公开(公告)号：US08088931B2
公开(公告)日：2012-01-03
申请号：US12822829
申请日：2010-06-24
Applicant: Shaomeng Wang , Ke Ding , Yipin Lu , Zaneta Nikolovska-Coleska , Su Qiu , Guoping Wang , Dongguang Qin , Sanjeev Kumar
Inventor： Shaomeng Wang , Ke Ding , Yipin Lu , Zaneta Nikolovska-Coleska , Su Qiu , Guoping Wang , Dongguang Qin , Sanjeev Kumar
IPC: C07D207/00
CPC classification number: C07D209/54 , C07D487/10 , C07D491/10
Abstract: The invention relates to small molecules which function as inhibitors of the interaction between p53 and MDM2. The invention also relates to the use of these compounds for inhibiting cell growth, inducing cell death, inducing cell cycle arrest and/or sensitizing cells to additional agent(s).
Abstract translation: 本发明涉及作为p53和MDM2相互作用抑制剂的小分子。 本发明还涉及这些化合物用于抑制细胞生长，诱导细胞死亡，诱导细胞周期停滞和/或使细胞对附加试剂敏感的用途。
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公开(公告)号：US07759383B2
公开(公告)日：2010-07-20
申请号：US11360485
申请日：2006-02-22
Applicant: Shaomeng Wang , Ke Ding , Yipin Lu , Zaneta Nikolovska-Coleska , Su Qiu , Guoping Wang , Dongguang Qin , Sanjeev Kumar
Inventor： Shaomeng Wang , Ke Ding , Yipin Lu , Zaneta Nikolovska-Coleska , Su Qiu , Guoping Wang , Dongguang Qin , Sanjeev Kumar
IPC: A61K31/40 , C07D487/10
CPC classification number: C07D209/54 , C07D487/10 , C07D491/10
Abstract: The invention relates to small molecules which function as inhibitors of the interaction between p53 and MDM2. The invention also relates to the use of these compounds for inhibiting cell growth, inducing cell death, inducing cell cycle arrest and/or sensitizing cells to additional agent(s).
Abstract translation: 本发明涉及作为p53和MDM2相互作用抑制剂的小分子。 本发明还涉及这些化合物用于抑制细胞生长，诱导细胞死亡，诱导细胞周期停滞和/或使细胞对附加试剂敏感的用途。
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公开(公告)号：US20120101092A1
公开(公告)日：2012-04-26
申请号：US13336047
申请日：2011-12-23
Applicant: Shaomeng Wang , Ke Ding , Yipin Lu , Zaneta Nikolovska-Coleska , Su Qiu , Guoping Wang , Dongguang Qin , Sanjeev Kumar
Inventor： Shaomeng Wang , Ke Ding , Yipin Lu , Zaneta Nikolovska-Coleska , Su Qiu , Guoping Wang , Dongguang Qin , Sanjeev Kumar
IPC: A61K31/5377 , A61K31/407 , C07D413/00 , A61P35/00 , C07D487/04 , A61K31/4985 , C12N5/09 , C07D487/10 , A61K31/437
CPC classification number: C07D209/54 , C07D487/10 , C07D491/10
Abstract: The invention relates to small molecules which function as inhibitors of the interaction between p53 and MDM2. The invention also relates to the use of these compounds for inhibiting cell growth, inducing cell death, inducing cell cycle arrest and/or sensitizing cells to additional agent(s).
Abstract translation: 本发明涉及作为p53和MDM2相互作用抑制剂的小分子。 本发明还涉及这些化合物用于抑制细胞生长，诱导细胞死亡，诱导细胞周期停滞和/或使细胞对附加试剂敏感的用途。
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公开(公告)号：US20100273799A1
公开(公告)日：2010-10-28
申请号：US12822829
申请日：2010-06-24
Applicant: Shaomeng Wang , Ke Ding , Yipin Lu , Zaneta Nikolovska-Coleska , Su Qiu , Guoping Wang , Dongguang Qin , Sanjeev Kumar
Inventor： Shaomeng Wang , Ke Ding , Yipin Lu , Zaneta Nikolovska-Coleska , Su Qiu , Guoping Wang , Dongguang Qin , Sanjeev Kumar
IPC: A61K31/5377 , A61K31/407 , A61P35/00 , C07D487/10 , C07D401/14 , A61K31/496 , C07D413/14 , C12N5/02
CPC classification number: C07D209/54 , C07D487/10 , C07D491/10
Abstract: The invention relates to small molecules which function as inhibitors of the interaction between p53 and MDM2. The invention also relates to the use of these compounds for inhibiting cell growth, inducing cell death, inducing cell cycle arrest and/or sensitizing cells to additional agent(s).
Abstract translation: 本发明涉及作为p53和MDM2相互作用抑制剂的小分子。 本发明还涉及这些化合物用于抑制细胞生长，诱导细胞死亡，诱导细胞周期停滞和/或使细胞对附加试剂敏感的用途。
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Patent Agency Ranking
公开(公告)号：US20060211757A1
公开(公告)日：2006-09-21
申请号：US11360485
申请日：2006-02-22
Applicant: Shaomeng Wang , Ke Ding , Yipin Lu , Zaneta Nikolovska-Coleska , Su Qiu , Guoping Wang , Dongguang Qin , Sanjeev Kumar
Inventor： Shaomeng Wang , Ke Ding , Yipin Lu , Zaneta Nikolovska-Coleska , Su Qiu , Guoping Wang , Dongguang Qin , Sanjeev Kumar
IPC: A61K31/407 , C07D209/54
CPC classification number: C07D209/54 , C07D487/10 , C07D491/10
Abstract: The invention relates to small molecules which function as inhibitors of the interaction between p53 and MDM2. The invention also relates to the use of these compounds for inhibiting cell growth, inducing cell death, inducing cell cycle arrest and/or sensitizing cells to additional agent(s).
Abstract translation: 本发明涉及作为p53和MDM2相互作用抑制剂的小分子。 本发明还涉及这些化合物用于抑制细胞生长，诱导细胞死亡，诱导细胞周期停滞和/或使细胞对另外的药剂敏化的用途。
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公开(公告)号：US08901117B2
公开(公告)日：2014-12-02
申请号：US13336047
申请日：2011-12-23
Applicant: Shaomeng Wang , Ke Ding , Yipin Lu , Zaneta Nikolovska-Coleska , Su Qiu , Guoping Wang , Dongguang Qin , Sanjeev Kumar
Inventor： Shaomeng Wang , Ke Ding , Yipin Lu , Zaneta Nikolovska-Coleska , Su Qiu , Guoping Wang , Dongguang Qin , Sanjeev Kumar
IPC: A61K31/5377 , A61K31/407 , A61K31/437 , A61K31/4985 , C07D209/54 , C07D491/10 , C07D487/10
CPC classification number: C07D209/54 , C07D487/10 , C07D491/10
Abstract: The invention relates to small molecules which function as inhibitors of the interaction between p53 and MDM2. The invention also relates to the use of these compounds for inhibiting cell growth, inducing cell death, inducing cell cycle arrest and/or sensitizing cells to additional agent(s).
Abstract translation: 本发明涉及作为p53和MDM2相互作用抑制剂的小分子。 本发明还涉及这些化合物用于抑制细胞生长，诱导细胞死亡，诱导细胞周期停滞和/或使细胞对附加试剂敏感的用途。
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8.发明申请PROCESS FOR THE PREPARATION OF SMALL MOLECULE INHIBITORS OF MDM2 AND INTERMEDIATES USED THEREIN 失效制备MDM2小分子抑制剂及其使用的中间体的方法公开(公告)号：US20130030173A1
公开(公告)日：2013-01-31
申请号：US13614751
申请日：2012-09-13
Applicant: Shaomeng Wang , Ke Ding , Guoping Wang
Inventor： Shaomeng Wang , Ke Ding , Guoping Wang
IPC: C07D487/10
CPC classification number: C07D209/54 , C07D487/10 , C07D491/10
Abstract: The invention relates to small molecules which function as inhibitors of the interaction between p53 and MDM2. The invention also relates to the use of these compounds for inhibiting cell growth, inducing cell death, inducing cell cycle arrest and/or sensitizing cells to additional agent(s).
Abstract translation: 本发明涉及作为p53和MDM2相互作用抑制剂的小分子。 本发明还涉及这些化合物用于抑制细胞生长，诱导细胞死亡，诱导细胞周期停滞和/或使细胞对另外的药剂敏化的用途。
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9.发明授权Small molecule inhibitors of anti-apoptotic BCL-2 family members and the uses thereof 有权抗细胞凋亡BCL-2家族成员的小分子抑制剂及其用途公开(公告)号：US08557812B2
公开(公告)日：2013-10-15
申请号：US11209998
申请日：2005-08-22
Applicant: Shaomeng Wang , Guoping Wang , Guozhi Tang , Renxiao Wang , Zaneta Nikolovska-Coleska , Dajun Yang , Liang Xu
Inventor： Shaomeng Wang , Guoping Wang , Guozhi Tang , Renxiao Wang , Zaneta Nikolovska-Coleska , Dajun Yang , Liang Xu
IPC: C07D401/02 , A61K31/47
CPC classification number: C07C205/38 , C07C39/10 , C07C39/15 , C07C39/17 , C07C39/367 , C07C43/23 , C07C43/295 , C07C49/747 , C07C49/82 , C07C49/83 , C07C49/84 , C07C65/105 , C07C235/60 , C07C235/64 , C07C311/29 , C07C311/46 , C07C317/22 , C07C317/40 , C07C317/44 , C07C2601/14 , C07C2603/74 , C07D211/16 , C07D213/70 , C07D215/227 , C07D215/233 , C07D217/06 , C07D263/56 , C07D277/64 , C07D307/84 , C07D321/12 , C07D333/60 , C07D333/76 , C07D401/12 , C07D405/12
Abstract: The invention relates to small molecules which function as inhibitors of anti-apoptotic Bcl-2 family member proteins (e.g., Bcl-2 and Bcl-xL). The invention also relates to the use of these compounds for inducing apoptotic cell death and sensitizing cells to the induction of apoptotic cell death.
Abstract translation: 本发明涉及作为抗凋亡Bcl-2家族成员蛋白（例如Bcl-2和Bcl-xL）的抑制剂的小分子。 本发明还涉及这些化合物用于诱导凋亡细胞死亡和使细胞对诱导凋亡性细胞死亡致敏的用途。
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公开(公告)号：US20060084647A1
公开(公告)日：2006-04-20
申请号：US11209998
申请日：2005-08-22
Applicant: Shaomeng Wang , Guoping Wang , Guozhi Tang , Renxiao Wang , Zaneta Nikolovska-Coleska , Dajun Yang , Liang Xu
Inventor： Shaomeng Wang , Guoping Wang , Guozhi Tang , Renxiao Wang , Zaneta Nikolovska-Coleska , Dajun Yang , Liang Xu
IPC: A61K31/5377 , A61K31/506 , A61K31/4709 , A61K31/47 , A61K31/445 , A61K31/165 , C07D413/02 , C07D401/02 , C07C317/32
CPC classification number: C07C205/38 , C07C39/10 , C07C39/15 , C07C39/17 , C07C39/367 , C07C43/23 , C07C43/295 , C07C49/747 , C07C49/82 , C07C49/83 , C07C49/84 , C07C65/105 , C07C235/60 , C07C235/64 , C07C311/29 , C07C311/46 , C07C317/22 , C07C317/40 , C07C317/44 , C07C2601/14 , C07C2603/74 , C07D211/16 , C07D213/70 , C07D215/227 , C07D215/233 , C07D217/06 , C07D263/56 , C07D277/64 , C07D307/84 , C07D321/12 , C07D333/60 , C07D333/76 , C07D401/12 , C07D405/12
Abstract: The invention relates to small molecules which function as inhibitors of anti-apoptotic Bcl-2 family member proteins (e.g., Bcl-2 and Bcl-xL). The invention also relates to the use of these compounds for inducing apoptotic cell death and sensitizing cells to the induction of apoptotic cell death.
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