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    Methods and compositions to treat myocardial conditions
    4.
    发明授权
    Methods and compositions to treat myocardial conditions 有权
    治疗心肌病症的方法和组合物

    公开(公告)号：US08821473B2

    公开(公告)日：2014-09-02

    申请号：US12632612

    申请日：2009-12-07

    Applicant: Eugene T. Michal ,  Evgenia Mandrusov ,  Charles D. Claude ,  Ni Ding ,  Murthy Simhambhatla ,  Syed Faiyaz Ahmed Hossainy ,  Srinivasan Sridharan ,  Paul Consigny

    Inventor： Eugene T. Michal ,  Evgenia Mandrusov ,  Charles D. Claude ,  Ni Ding ,  Murthy Simhambhatla ,  Syed Faiyaz Ahmed Hossainy ,  Srinivasan Sridharan ,  Paul Consigny

    IPC: A61M31/00 ,  A61K31/7088 ,  A61K9/00

    CPC classification number: A61K9/0019 ,  A61K9/0024 ,  A61K31/7088

    Abstract: Methods, devices, kits and compositions to treat a myocardial infarction. In one embodiment, the method includes the prevention of remodeling of the infarct zone of the ventricle. In other embodiments, the method includes the introduction of structurally reinforcing agents. In other embodiments, agents are introduced into a ventricle to increase compliance of the ventricle. In an alternative embodiment, the prevention of remodeling includes the prevention of thinning of the ventricular infarct zone. In another embodiment, the prevention of remodeling and thinning of the infarct zone involves the cross-linking of collagen and prevention of collagen slipping. In other embodiments, the structurally reinforcing agent may be accompanied by other therapeutic agents. These agents may include but are not limited to pro-fibroblastic and angiogenic agents.

    Abstract translation: 用于治疗心肌梗塞的方法，装置，试剂盒和组合物。 在一个实施例中，该方法包括防止脑室梗死区的重塑。 在其它实施方案中，该方法包括引入结构上增强剂。 在其它实施方案中，将药剂引入心室以增加心室的依从性。 在替代实施例中，预防重塑包括防止心室梗塞区变薄。 在另一个实施方案中，预防梗塞区的重塑和变薄包括胶原蛋白的交联和预防胶原蛋白滑脱。 在其它实施方案中，结构上增强剂可以伴随其它治疗剂。 这些药剂可以包括但不限于前成纤维细胞和血管生成剂。

    Porous polymer articles and methods of making the same
    6.
    发明申请
    Porous polymer articles and methods of making the same 审中-公开
    多孔聚合物制品及其制造方法

    公开(公告)号：US20050003011A1

    公开(公告)日：2005-01-06

    申请号：US10892050

    申请日：2004-07-15

    Applicant: Srinivasan Sridharan ,  Murthy Simhambhatla

    Inventor： Srinivasan Sridharan ,  Murthy Simhambhatla

    IPC: A61L27/16 ,  A61L27/50 ,  A61L27/56 ,  A61L29/04 ,  B29C55/00 ,  B29C55/06 ,  B29D7/01 ,  B29C43/22 ,  A61K9/14

    CPC classification number: A61L27/56 ,  A61L27/16 ,  A61L27/507 ,  A61L29/041 ,  B29C55/005 ,  B29C55/065 ,  B29D7/01 ,  B29K2023/0683 ,  B29K2105/0061 ,  C08L23/06

    Abstract: A method including forming a pseudo-gel of a semi-crystalline polymer material and a solvent. The pseudo-gel is shaped into a first form and stretched. A portion of the solvent is removed to create a second form. The second form is stretched into a microstructure including nodes interconnected by fibrils. A method including forming a first form of a pseudo-gel including an ultra-high molecular weight polyethylene material and a solvent; stretching the first form; removing the solvent to form a second form; stretching the second form into a microstructure including nodes interconnected by fibrils; and annealing the stretched second form. An apparatus including a body portion formed of a dimension suitable for a medical device application and including a polyolefin polymer including a node and a fibril microstructure. An apparatus including a body portion including an ultra-high molecular weight polyolefin material including a node and a fibril microstructure.

    Abstract translation: 一种包括形成半结晶聚合物材料和溶剂的假凝胶的方法。 假凝胶成型为第一种形式并拉伸。 除去一部分溶剂以产生第二种形式。 第二种形式被拉伸成包括由原纤维相互连接的节点的微结构。 一种包括形成包含超高分子量聚乙烯材料和溶剂的第一种形式的假凝胶的方法; 拉伸第一种形式; 除去溶剂以形成第二种形式; 将第二形式拉伸成包括通过纤维互连的节点的微结构; 并退火拉伸的第二种形式。 一种装置，包括由适于医疗装置应用的尺寸形成的主体部分，并且包括包含节点和原纤维微结构的聚烯烃聚合物。 一种包括主体部分的装置，其包括包含节点和原纤维微结构的超高分子量聚烯烃材料。

    Device for treating vulnerable plaque
    8.
    发明申请
    Device for treating vulnerable plaque 有权
    治疗易损斑块的装置

    公开(公告)号：US20050222584A1

    公开(公告)日：2005-10-06

    申请号：US11140240

    申请日：2005-05-26

    Applicant: Deborah Kilpatrick ,  Robert Ainsworth ,  Murthy Simhambhatla ,  Jeong Lee

    Inventor： Deborah Kilpatrick ,  Robert Ainsworth ,  Murthy Simhambhatla ,  Jeong Lee

    IPC: A61F2/06 ,  A61F2/84 ,  A61F11/00 ,  A61M29/00

    CPC classification number: A61F2/958 ,  A61B2017/22081

    Abstract: A method of treating vulnerable plaque comprising intentionally damaging or rupturing the vulnerable plaque using a wingless balloon which is inflated from a wingless unexpanded diameter to a limited expanded diameter. This process produces significant increase in ECM synthesis at the site of the damage or rupture. As a result, the method strengthens the vulnerable plaque while minimizing or avoiding damage to the surrounding wall of the body lumen or damaging a stable plaque mistakenly believed to be a vulnerable plaque. The method of the invention is particularly useful in treating a fibroatheroma type of vulnerable plaque. In one embodiment, the balloon is self-limiting such that it expands compliantly at initial inflation pressures, and above nominal pressure it expands noncompliantly. In an alternative embodiment, the balloon is inflated using a diameter-limiting device, such as a device which limits the inflation pressure or the volume of inflation fluid in the balloon.

    Abstract translation: 一种治疗易损斑块的方法，包括使用从无翅未膨胀直径膨胀至有限扩张直径的无翼气球故意破坏或破裂易损斑块。 该过程在损伤或破裂部位产生ECM合成的显着增加。 因此，该方法可加强易损斑块，同时最大限度地减少或避免对体腔周围壁的损害或损坏被认为是易损斑块的稳定斑块。 本发明的方法特别可用于治疗纤维腺瘤型易损斑块。 在一个实施例中，气囊是自限制性的，使得其在初始充气压力下顺应地膨胀，并且在额定压力之上，其膨胀不顺利。 在替代实施例中，使用直径限制装​​置（例如限制气囊中的充气压力或膨胀流体的体积的装置）使球囊膨胀。

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