公开(公告)号：US11459325B2

公开(公告)日：2022-10-04

申请号：US16961476

申请日：2019-01-30

Applicant: Takeda Pharmaceutical Company Limited

Inventor： Yuta Tanaka ,  Tomohiro Ohashi ,  Zenichi Ikeda ,  Yuta Tanaka ,  Florian Pünner ,  Takeshi Yamamoto ,  Keiko Kakegawa ,  Fumiaki Kikuchi ,  Nao Morishita ,  Takahito Kasahara ,  Masaki Seto ,  Minoru Nakamura ,  Kazuaki Takami ,  Masataka Murakami ,  Masaki Daini ,  Satoshi Mikami ,  Minoru Sasaki

IPC: C07D471/04 ,  C07D487/04 ,  C07D491/048 ,  C07D495/04 ,  C07D519/00 ,  A61P25/28

Abstract: The present invention provides a compound having a glucosylceramide lowering action (e.g., promoting glucosylceramide metabolism, inhibition of glucosylceramide synthesis, promoting glucosylceramide catabolism, etc.), which is expected to be useful as an agent for the prophylaxis or treatment of lysosome diseases (e.g., Gaucher's disease), neurodegenerative diseases (e.g., Parkinson's disease, Lewy body dementia, multiple-system atrophy) and the like.
The present invention relates to a compound represented by the formula (I): wherein each symbol is as described in the specification, or a salt thereof.

公开(公告)号：US11407748B2

公开(公告)日：2022-08-09

申请号：US16753613

申请日：2018-10-04

Applicant: Takeda Pharmaceutical Company Limited

Inventor： Shinji Nakamura ,  Satoshi Mikami ,  Tomoaki Hasui ,  Tohru Yamashita ,  Shinji Morimoto ,  Hidekazu Tokuhara ,  Norio Oyabu ,  Masami Yamada ,  Atsuko Ochida ,  Kazuaki Takami ,  Xin Liu

IPC: A61K31/519 ,  C07D471/04 ,  C07D487/04 ,  A61K9/20 ,  C07D519/00

Abstract: The present invention aims to provide a heterocyclic compound having an AMPA receptor potentiator effect, which is expected to be useful as an agent for the prophylaxis or treatment of depression, Alzheimer's disease, schizophrenia, attention deficit hyperactivity disorder (ADHD) and the like.
The present invention relates to a compound represented by the formula (I): wherein each symbol is as described in the specification, or a salt thereof.

公开(公告)号：US10975043B2

公开(公告)日：2021-04-13

申请号：US16773720

申请日：2020-01-27

Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITED

Inventor： Yoshihiro Banno ,  Masahiro Kamaura ,  Kazuaki Takami ,  Koichiro Fukuda ,  Shigekazu Sasaki

IPC: A61K31/4418 ,  A61K31/505 ,  C07D239/34 ,  C07D213/65 ,  C07D213/70 ,  C07D263/46 ,  A61K31/415 ,  A61K31/421 ,  C07D231/12 ,  C07D231/22 ,  C07D263/38 ,  A61P27/02 ,  C07K14/47 ,  C12N15/09

Abstract: Provided is a heterocyclic compound having a superior RBP4-lowering action and useful as a medicament for the prophylaxis or treatment of a disease or symptom mediated by an increase in RBP4 or retinol supplied by RBP4.
A compound represented by the formula (I): wherein each symbol is as defined in the Description, or a salt thereof has a superior RBP4-lowering action, and is useful as a medicament for the prophylaxis or treatment of a disease or symptom mediated by an increase in RBP4 or retinol supplied by RBP4.

公开(公告)号：US09975903B2

公开(公告)日：2018-05-22

申请号：US15539607

申请日：2015-12-24

Applicant: Takeda Pharmaceutical Company Limited

Inventor： Minoru Sasaki ,  Fumiaki Kikuchi ,  Zenichi Ikeda ,  Keiko Kakegawa ,  Yoichi Nishikawa ,  Shigekazu Sasaki ,  Koichiro Fukuda ,  Kazuaki Takami ,  Yoshihiro Banno ,  Masahiro Kamaura

IPC: C07D493/04 ,  C07D495/04 ,  C07D321/00 ,  C07D405/06 ,  C07D321/12 ,  C07D413/06 ,  C07D323/00 ,  C07D491/044 ,  C07D313/00 ,  C07D313/20

CPC classification number: C07D495/04 ,  A61K31/365 ,  A61K31/381 ,  A61K31/4025 ,  A61K31/422 ,  A61K31/662 ,  C07D313/00 ,  C07D313/20 ,  C07D321/00 ,  C07D321/12 ,  C07D323/00 ,  C07D405/06 ,  C07D409/12 ,  C07D413/06 ,  C07D491/044 ,  C07D493/04 ,  C07F9/655

Abstract: The present invention relates to a condensed heterocyclic compound that has an enteropeptidase inhibitory effect and is useful in the treatment or prevention of obesity, diabetes mellitus, or the like, and a medicament containing the same. Specifically, the present invention relates to a compound represented by the following formula (I) or a salt thereof, and a medicament containing the same [in the formula, each symbol is as defined in the specification].

公开(公告)号：US11560372B2

公开(公告)日：2023-01-24

申请号：US16606043

申请日：2018-04-17

Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITED

Inventor： Shinobu Sasaki ,  Masaki Seto ,  Kazuaki Takami ,  Haruhi Ando

IPC: C07D405/14 ,  A61P1/10 ,  C07D405/04 ,  C07D409/14

Abstract: The present invention aims to provide a compound that may be useful for the prophylaxis or treatment of constipation and the like. The present invention provides a compound represented by the following formula (I): wherein each symbol is as described in the specification, salt thereof.

公开(公告)号：US11236099B2

公开(公告)日：2022-02-01

申请号：US16622632

申请日：2018-06-19

Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITED

Inventor： Kazuaki Takami ,  Masaki Seto ,  Shinobu Sasaki ,  Haruhi Ando ,  Masaki Ogino ,  Tomoko Ohashi ,  Toshihiro Imaeda ,  Ikuo Fujimori ,  Yasuhiro Tsukimi ,  Masami Yamada ,  Kenichiro Shimokawa ,  Takeshi Wakabayashi ,  Masataka Murakami ,  Makoto Fushimi ,  Tomohiro Okawa ,  Jinichi Yonemori ,  Tomohiro Ohashi ,  Hideo Suzuki ,  Hironobu Maezaki ,  Ayumu Sato ,  Yasutomi Asano ,  Steve Swann

IPC: C07D491/048 ,  A61K31/4355 ,  A61P1/10

Abstract: The present invention aims to provide a compound that may be useful for the prophylaxis or treatment of constipation and the like. The present invention provides a compound represented by the following formula (I): wherein each symbol is as described in the specification, or a salt thereof.

公开(公告)号：US11186565B2

公开(公告)日：2021-11-30

申请号：US16499432

申请日：2018-03-29

Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITED

Inventor： Seiji Miwatashi ,  Yasufumi Miyamoto ,  Koji Watanabe ,  Yayoi Nakayama ,  Yuko Hitomi ,  Jumpei Aida ,  Nobuyuki Takakura ,  Hideki Furukawa ,  Naoyoshi Noguchi ,  Yasuhiro Hirata ,  Kazuaki Takami ,  Norihito Tokunaga ,  Tomohiro Okawa ,  Akito Shibuya ,  Shizuo Kasai ,  Toshitake Kobayashi ,  Tsuyoshi Maekawa

IPC: C07D401/12 ,  C07C59/72 ,  C07D211/22 ,  C07D213/64 ,  C07D401/10 ,  C07D401/14 ,  C07D413/10

Abstract: Provided is a novel aromatic ring compound which may have a GPR40 agonist activity and a GLP-1 secretagogue action. A compound represented by the formula (I): wherein each symbol is as described in the DESCRIPTION, or a salt thereof may have a GPR40 agonist activity and a GLP-1 secretagogue action, may be useful for the prophylaxis or treatment of cancer, obesity, diabetes, hypertension, hyperlipidemia, cardiac failure, diabetic complications, metabolic syndrome, sarcopenia and the like, and may afford superior efficacy.

公开(公告)号：US20190119225A1

公开(公告)日：2019-04-25

申请号：US16230634

申请日：2018-12-21

Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITED

Inventor： Yoshihiro Banno ,  Masahiro Kamaura ,  Kazuaki Takami ,  Koichiro Fukuda ,  Shigekazu Sasaki

IPC: C07D263/46 ,  C07D213/70 ,  A61P27/02 ,  C07D239/34 ,  A61K31/421 ,  C07D213/65 ,  C07D263/38 ,  A61K31/415 ,  C07D231/22 ,  C07D231/12 ,  A61K31/505 ,  A61K31/4418

Abstract: Provided is a heterocyclic compound having a superior RBP4-lowering action and useful as a medicament for the prophylaxis or treatment of a disease or symptom mediated by an increase in RBP4 or retinol supplied by RBP4.A compound represented by the formula (I): wherein each symbol is as defined in the Description, or a salt thereof has a superior RBP4-lowering action, and is useful as a medicament for the prophylaxis or treatment of a disease or symptom mediated by an increase in RBP4 or retinol supplied by RBP4.

公开(公告)号：US12162864B2

公开(公告)日：2024-12-10

申请号：US17280628

申请日：2019-09-27

Applicant: Takeda Pharmaceutical Company Limited

Inventor： Shinobu Sasaki ,  Yasutomi Asano ,  Hironobu Maezaki ,  Ayumu Sato ,  Kazuaki Takami ,  Masaki Seto ,  Haruhi Ando ,  Shuji Kitamura ,  Steve L. Swann

IPC: C07D405/14 ,  A61K9/00 ,  A61K9/20 ,  A61P1/10 ,  C07D309/14 ,  C07D407/12 ,  C07D407/14

Abstract: The present invention aims to provide a compound that may be useful for the prophylaxis or treatment of constipation and the like. The present invention provides a compound represented by the formula (I): wherein each symbol is as described in the specification, or a salt thereof.

公开(公告)号：US20220017530A1

公开(公告)日：2022-01-20

申请号：US17475733

申请日：2021-09-15

Applicant: Takeda Pharmaceutical Company Limited

Inventor： Kazuaki Takami ,  Masaki Seto ,  Shinobu Sasaki ,  Haruhi Ando ,  Masaki Ogino ,  Tomoko Ohashi ,  Toshihiro Imaeda ,  Ikuo Fujimori ,  Yasuhiro Tsukimi ,  Masami Yamada ,  Kenichiro Shimokawa ,  Takeshi Wakabayashi ,  Masataka Murakami ,  Makoto Fushimi ,  Tomohiro Okawa ,  Jinichi Yonemori ,  Tomohiro Ohashi ,  Hideo Suzuki ,  Hironobu Maezaki ,  Ayumu Sato ,  Yasutomi Asano ,  Steve Swann

IPC: C07D491/048 ,  A61P1/10 ,  A61K31/4355

Abstract: The present invention aims to provide a compound that may be useful for the prophylaxis or treatment of constipation and the like. The present invention provides a compound represented by the following formula (I): wherein each symbol is as described in the specification, or a salt thereof.