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34 条记录 (耗时 0.049 秒)

    Coupler
    1.
    发明授权
    Coupler 失效
    耦合器

    公开(公告)号：US4408372A

    公开(公告)日：1983-10-11

    申请号：US198726

    申请日：1980-10-20

    申请人： Teiji Kimura ,  Shigeru Kimura

    发明人： Teiji Kimura ,  Shigeru Kimura

    IPC分类号： F16C11/06 ,  F16B17/00 ,  F16B21/07 ,  H04R1/02 ,  A44B21/00

    CPC分类号： F16B21/073 ,  Y10T24/45775

    摘要： A coupler for joining two objects comprises an insertion member attached fast to one of the objects and a reception member attached fast to the other object and used for admitting the insertion member into fast engagement therewith. The insertion member is provided with a setting portion for fast attachment to the aforementioned one object and a shaft extended from the setting portion and possessed of a radially expanded engaging portion at the leading end thereof. The reception member is provided with two generally semicylindrical shells connected to each other through a thin-walled hinge portion and adapted to form one cylindrical shape upon being closed onto each other along the matched edges thereof and a plurality of resilient engaging pieces regularly spaced in the longitudinal direction on the inner wall of each of the shells.

    摘要翻译： 用于连接两个物体的联接器包括快速附接到物体之一的插入构件和快速附接到另一物体的接收构件，并用于允许插入构件与其快速接合。 插入构件设置有用于快速附接到上述一个物体的设置部分和从设置部分延伸并且在其前端具有径向扩张的接合部分的轴。 接收构件设置有两个通常半圆柱形壳体，通过薄壁铰链部分相互连接，并且适于在沿其匹配边缘彼此闭合时形成一个圆柱形形状，并且多个弹性接合件在该 每个壳体的内壁上的纵向方向。

    N,N-substituted cyclic amine derivatives
    4.
    发明授权
    N,N-substituted cyclic amine derivatives 失效
    N，N-取代的环胺衍生物

    公开(公告)号：US06737425B1

    公开(公告)日：2004-05-18

    申请号：US09743358

    申请日：2001-01-29

    申请人： Noboru Yamamoto ,  Makoto Komatsu ,  Yuichi Suzuki ,  Koki Kawano ,  Teiji Kimura ,  Koichi Ito ,  Satoshi Nagato ,  Yoshihiko Norimine ,  Tetsuhiro Niidome ,  Tetsuyuki Teramoto ,  Yoichi Iimura ,  Shinji Hatakeyama

    发明人： Noboru Yamamoto ,  Makoto Komatsu ,  Yuichi Suzuki ,  Koki Kawano ,  Teiji Kimura ,  Koichi Ito ,  Satoshi Nagato ,  Yoshihiko Norimine ,  Tetsuhiro Niidome ,  Tetsuyuki Teramoto ,  Yoichi Iimura ,  Shinji Hatakeyama

    IPC分类号： A61K31497

    CPC分类号： C07D213/64 ,  C07D213/57 ,  C07D215/20 ,  C07D217/02 ,  C07D233/54 ,  C07D239/34 ,  C07D239/80 ,  C07D295/15 ,  C07D317/64 ,  C07D333/24 ,  C07D333/38

    摘要： The invention provides an N,N-substituted cyclic amine compound represented by the following formula (VIII): wherein A represents an aryl group etc.; E represents a group represented by the formula —CO— or a group represented by the formula —CHOH—; G represents an oxygen atom etc.; J represents an aryl group which may be substituted; R1 represents a lower alkyl group etc.; Alk represents a linear or branched lower alkylene group; n, v, w, x and y are independent of each other and each represents 0 or 1; and p represents 2 or 3, or a pharmacologically acceptable salt thereof. The compound of the present invention or a salt thereof is effective to treat a disease against which calcium antagonism is effective. The disease may include acute ischemic stroke, cerebral apoplexy, cerebral infarction, head trauma, cerebral nerve cell death, Alzheimer disease, Parkinson disease, amyotrophic lateral sclerosis, Huntington disease, cerebral circulatory metabolism disturbance, cerebral function disturbance, pain, spasm, schizophrenia, migraine, epilepsy, maniac-depressive psychosis, nerve degenerative diseases, cerebral ischemia, AIDS dementia complications, edema, anxiety disorder (generalized anxiety disorder) and diabetic neuropathy.

    摘要翻译： 本发明提供由下式（VIII）表示的N，N-取代的环胺化合物：其中A表示芳基等; E表示由式-CO-表示的基团或由式-CHOH-表示的基团; G表示氧原子等。 J表示可被取代的芳基; R 1表示低级烷基等。 Alk表示直链或支链低级亚烷基; n，v，w，x和y彼此独立，各自表示0或1; 和p表示2或3，或其药理学上可接受的盐。 本发明的化合物或其盐可有效治疗钙拮抗作用有效的疾病。 该疾病可能包括急性缺血性脑卒中，脑中风，脑梗塞，头部创伤，脑神经细胞死亡，阿尔茨海默病，帕金森病，肌萎缩性侧索硬化，亨廷顿病，脑循环代谢障碍，脑功能障碍，疼痛，痉挛，精神分裂症， 偏头痛，癫痫，疯子抑郁精神病，神经退行性疾病，脑缺血，艾滋病痴呆并发症，水肿，焦虑症（广泛性焦虑症）和糖尿病性神经病变。

    Nitrile compound
    10.
    发明授权
    Nitrile compound 失效
    腈化合物

    公开(公告)号：US06667412B1

    公开(公告)日：2003-12-23

    申请号：US09914349

    申请日：2001-08-27

    申请人： Yuichi Suzuki ,  Noboru Yamamoto ,  Koki Kawano ,  Teiji Kimura ,  Koichi Ito ,  Satoshi Nagato ,  Yoshihiko Norimine ,  Yoichi Iimura

    发明人： Yuichi Suzuki ,  Noboru Yamamoto ,  Koki Kawano ,  Teiji Kimura ,  Koichi Ito ,  Satoshi Nagato ,  Yoshihiko Norimine ,  Yoichi Iimura

    IPC分类号： C07C25536

    CPC分类号： C07D295/145 ,  C07C255/36 ,  C07C255/41 ,  C07D295/14

    摘要： The present invention provides a novel nitrile compound useful as an intermediate for the production of, for example, N,N-substituted cyclic amine derivatives or phenylacetonitrile derivatives that are useful as a medicine. Specifically it provides a nitrile carboxylic acid compound, nitrile ester compound and nitrile alcohol compound. That is, it provides a nitrile compound represented by the following formula (I): wherein R1 and R2 means substituents; m means 0 or an integer of from 1 to 6; n means 0 or an integer of from 1 to 5; and R3 means carboxyl group, a lower alkoxycarbonyl group or hydroxymethyl group.

    摘要翻译： 本发明提供了可用作制备例如可用作药物的N，N-取代的环胺衍生物或苯乙腈衍生物的中间体的新型腈化合物。 具体地说，它提供了一种腈羧酸化合物，腈酯化合物和腈醇化合物。 也就是说，它提供由下式（I）表示的腈化合物：其中R 1和R 2表示取代基; m表示0或1〜6的整数; n表示0或1至5的整数; R 3表示羧基，低级烷氧基羰基或羟甲基。