公开(公告)号：US06426072B1

公开(公告)日：2002-07-30

申请号：US09643597

申请日：2000-08-21

申请人： Tongtong Wang ,  Liqun Fan ,  Michael D. Kalos ,  Chaitanya S. Bangur ,  Nancy A. Hosken ,  Gary R. Fanger ,  Samuel X. Li ,  Aijun Wang ,  Yasir A. W. Skeiky ,  Robert A. Henderson ,  Patricia D. McNeill

发明人： Tongtong Wang ,  Liqun Fan ,  Michael D. Kalos ,  Chaitanya S. Bangur ,  Nancy A. Hosken ,  Gary R. Fanger ,  Samuel X. Li ,  Aijun Wang ,  Yasir A. W. Skeiky ,  Robert A. Henderson ,  Patricia D. McNeill

IPC分类号： A61K3900

CPC分类号： C07K16/3023

摘要： Compositions and methods for the therapy and diagnosis of cancer, such as lung cancer, are disclosed. Compositions may comprise one or more lung tumor proteins, immunogenic portions thereof, or polynucleotides that encode such portions. Alternatively, a therapeutic composition may comprise an antigen presenting cell that expresses a lung tumor protein, or a T cell that is specific for cells expressing such a protein. Such compositions may be used, for example, for the prevention and treatment of diseases such as lung cancer. Diagnostic methods based on detecting a lung tumor protein, or mRNA encoding such a protein, in a sample are also provided.

公开(公告)号：US07049063B2

公开(公告)日：2006-05-23

申请号：US09735705

申请日：2000-12-12

申请人： Tongtong Wang ,  Liqun Fan ,  Michael D. Kalos ,  Chaitanya S. Bangur ,  Nancy A. Hosken ,  Gary R. Fanger ,  Samuel X. Li ,  Aijun Wang ,  Yasir A. W. Skeiky ,  Robert A. Henderson ,  Patricia D. McNeill ,  Neil Fanger

发明人： Tongtong Wang ,  Liqun Fan ,  Michael D. Kalos ,  Chaitanya S. Bangur ,  Nancy A. Hosken ,  Gary R. Fanger ,  Samuel X. Li ,  Aijun Wang ,  Yasir A. W. Skeiky ,  Robert A. Henderson ,  Patricia D. McNeill ,  Neil Fanger

IPC分类号： C12Q1/68 ,  C07H21/02 ,  C07H21/04

CPC分类号： C07K16/3023 ,  A61K38/00 ,  A61K39/00 ,  A61K2039/5154 ,  A61K2039/53 ,  A61K2039/6068 ,  C07K14/47 ,  C07K2317/21 ,  C07K2319/00 ,  C12Q1/6809 ,  C12Q1/6886 ,  C12Q2600/158

摘要： Compositions and methods for the therapy and diagnosis of cancer, particularly lung cancer, are disclosed. Illustrative compositions comprise one or more lung tumor polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases, particularly lung cancer.

摘要翻译： 公开了用于治疗和诊断癌症，特别是肺癌的组合物和方法。 说明性组合物包含一种或多种肺肿瘤多肽，其免疫原性部分，编码这种多肽的多核苷酸，表达此类多肽的抗原呈递细胞，以及对表达该多肽的细胞特异的T细胞。 所公开的组合物可用于例如疾病，特别是肺癌的诊断，预防和/或治疗。

公开(公告)号：US06737514B1

公开(公告)日：2004-05-18

申请号：US09630940

申请日：2000-08-02

申请人： Tongtong Wang ,  Liqun Fan ,  Michael D. Kalos ,  Chaitanya S. Bangur ,  Nancy A. Hosken ,  Gary R. Fanger ,  Samuel X. Li ,  Aijun Wang ,  Yasir A. W. Skeiky ,  Robert A. Henderson ,  Patricia D. McNeill

发明人： Tongtong Wang ,  Liqun Fan ,  Michael D. Kalos ,  Chaitanya S. Bangur ,  Nancy A. Hosken ,  Gary R. Fanger ,  Samuel X. Li ,  Aijun Wang ,  Yasir A. W. Skeiky ,  Robert A. Henderson ,  Patricia D. McNeill

IPC分类号： C07K1600

CPC分类号： C07K14/47 ,  A61K38/00 ,  A61K39/00 ,  A61K2039/5154 ,  C07K16/3023 ,  C07K2319/00

摘要： Compositions and methods for the therapy and diagnosis of cancer, such as lung cancer, are disclosed. Compositions may comprise one or more lung tumor proteins, immunogenic portions thereof, or polynucleotides that encode such portions. Alternatively, a therapeutic composition may comprise an antigen presenting cell that expresses a lung tumor protein, or a T cell that is specific for cells expressing such a protein. Such compositions may be used, for example, for the prevention and treatment of diseases such as lung cancer. Diagnostic methods based on detecting a lung tumor protein, or mRNA encoding such a protein, in a sample are also provided.

摘要翻译： 公开了用于治疗和诊断癌症的组合物和方法，例如肺癌。 组合物可以包含一种或多种肺肿瘤蛋白，其免疫原性部分，或编码这些部分的多核苷酸。 或者，治疗组合物可以包含表达肺肿瘤蛋白的抗原呈递细胞，或表达这种蛋白质的细胞特异的T细胞。 这样的组合物可以用于例如预防和治疗诸如肺癌的疾病。 还提供了基于检测样品中的肺肿瘤蛋白或编码这种蛋白质的mRNA的诊断方法。

公开(公告)号：US06531315B1

公开(公告)日：2003-03-11

申请号：US09606421

申请日：2000-06-28

申请人： Tongtong Wang ,  Liqun Fan ,  Michael D. Kalos ,  Chaitanya S. Bangur ,  Nancy A. Hosken ,  Gary R. Fanger ,  Samuel X. Li ,  Aijun Wang ,  Yasir A. W. Skeiky

发明人： Tongtong Wang ,  Liqun Fan ,  Michael D. Kalos ,  Chaitanya S. Bangur ,  Nancy A. Hosken ,  Gary R. Fanger ,  Samuel X. Li ,  Aijun Wang ,  Yasir A. W. Skeiky

IPC分类号： C12N508

CPC分类号： C07K14/47 ,  A61K38/00 ,  A61K39/00 ,  A61K2039/5154 ,  C07K2319/00 ,  C12Q1/6809

摘要： Compositions and methods for the therapy and diagnosis of cancer, such as lung cancer, are disclosed. Compositions may comprise one or more lung tumor proteins, immunogenic portions thereof, or polynucleotides that encode such portions. Alternatively, a therapeutic composition may comprise an antigen presenting cell that expresses a lung tumor protein, or a T cell that is specific for cells expressing such a protein. Such compositions may be used, for example, for the prevention and treatment of diseases such as lung cancer. Diagnostic methods based on detecting a lung tumor protein, or mRNA encoding such a protein, in a sample are also provided.

公开(公告)号：US06518256B1

公开(公告)日：2003-02-11

申请号：US09542615

申请日：2000-04-04

申请人： Tongtong Wang ,  Liqun Fan ,  Michael D. Kalos ,  Chaitanya S. Bangur ,  Nancy A. Hosken ,  Gary R. Fanger

发明人： Tongtong Wang ,  Liqun Fan ,  Michael D. Kalos ,  Chaitanya S. Bangur ,  Nancy A. Hosken ,  Gary R. Fanger

IPC分类号： A01N4304

CPC分类号： C07K14/47 ,  A61K38/00 ,  A61K39/00 ,  A61K2039/5154 ,  C07K2319/00 ,  C12Q1/6809 ,  C12Q1/6886 ,  C12Q2600/158

摘要： Compounds and methods for the treatment and diagnosis of lung cancer are provided. The inventive compounds include polypeptides containing at least a portion of a lung tumor protein. Vaccines and pharmaceutical compositions for immunotherapy of lung cancer comprising such polypeptides, or DNA molecules encoding such polypeptides, are also provided, together with DNA molecules for preparing the inventive polypeptides.

公开(公告)号：US06800746B2

公开(公告)日：2004-10-05

申请号：US09759143

申请日：2001-01-12

申请人： Jiangchun Xu ,  Davin C. Dillon ,  Jennifer L. Mitcham ,  Susan L. Harlocker ,  Yuqiu Jiang ,  Michael D. Kalos ,  Gary R. Fanger ,  Marc W. Retter ,  John A. Stolk ,  Craig H. Day ,  Thomas S. Vedvick ,  Darrick Carter ,  Samuel X. Li ,  Aijun Wang ,  Yasir A. W. Skeiky ,  William T. Hepler ,  Robert A. Henderson

发明人： Jiangchun Xu ,  Davin C. Dillon ,  Jennifer L. Mitcham ,  Susan L. Harlocker ,  Yuqiu Jiang ,  Michael D. Kalos ,  Gary R. Fanger ,  Marc W. Retter ,  John A. Stolk ,  Craig H. Day ,  Thomas S. Vedvick ,  Darrick Carter ,  Samuel X. Li ,  Aijun Wang ,  Yasir A. W. Skeiky ,  William T. Hepler ,  Robert A. Henderson

IPC分类号： C12Q168

CPC分类号： C07K14/005 ,  A61K38/00 ,  A61K39/00 ,  A61K2035/124 ,  A61K2039/5156 ,  A61K2039/53 ,  C07K14/47 ,  C07K14/4748 ,  C07K14/705 ,  C07K2319/00 ,  C12N9/6424 ,  C12N2760/16022

摘要： Compositions and methods for the therapy and diagnosis of cancer, particularly prostate cancer, are disclosed. Illustrative compositions comprise one or more prostate-specific polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases, particularly prostate cancer.

公开(公告)号：US06512094B1

公开(公告)日：2003-01-28

申请号：US09593793

申请日：2000-06-13

申请人： Jiangchun Xu ,  Davin C. Dillon ,  Jennifer L. Mitcham ,  Susan L. Harlocker ,  Yuqiu Jiang ,  Michael D. Kalos ,  Gary R. Fanger ,  Marc W. Retter ,  John A. Stolk ,  Craig H. Day ,  Thomas S. Vedvick ,  Darrick Carter ,  Samuel X. Li ,  Aijun Wang ,  Yasir A. W. Skeiky ,  William T. Hepler ,  Robert A. Henderson

发明人： Jiangchun Xu ,  Davin C. Dillon ,  Jennifer L. Mitcham ,  Susan L. Harlocker ,  Yuqiu Jiang ,  Michael D. Kalos ,  Gary R. Fanger ,  Marc W. Retter ,  John A. Stolk ,  Craig H. Day ,  Thomas S. Vedvick ,  Darrick Carter ,  Samuel X. Li ,  Aijun Wang ,  Yasir A. W. Skeiky ,  William T. Hepler ,  Robert A. Henderson

IPC分类号： C07K100

摘要： Compositions and methods for the therapy and diagnosis of cancer, such as prostate cancer, are disclosed. Compositions may comprise one or more prostate-specific proteins, immunogenic portions thereof, or polynucleotides that encode such portions. Alternatively, a therapeutic composition may comprise an antigen presenting cell that expresses a prostate-specific protein, or a T cell that is specific for cells expressing such a protein. Such compositions may be used, for example, for the prevention and treatment of diseases such as prostate cancer. Diagnostic methods based on detecting a prostate-specific protein, or mRNA encoding such a protein, in a sample are also provided.

公开(公告)号：US06620922B1

公开(公告)日：2003-09-16

申请号：US09636215

申请日：2000-08-09

申请人： Jiangchun Xu ,  Davin C. Dillon ,  Jennifer L. Mitcham ,  Susan L. Harlocker ,  Yuqiu Jiang ,  Michael D. Kalos ,  Gary R. Fanger ,  Marc W. Retter ,  John A. Stolk ,  Craig H. Day ,  Thomas S. Vedvick ,  Darrick Carter ,  Samuel X. Li ,  Aijun Wang ,  Yasir A. W. Skeiky ,  William T. Hepler ,  Robert A. Henderson

发明人： Jiangchun Xu ,  Davin C. Dillon ,  Jennifer L. Mitcham ,  Susan L. Harlocker ,  Yuqiu Jiang ,  Michael D. Kalos ,  Gary R. Fanger ,  Marc W. Retter ,  John A. Stolk ,  Craig H. Day ,  Thomas S. Vedvick ,  Darrick Carter ,  Samuel X. Li ,  Aijun Wang ,  Yasir A. W. Skeiky ,  William T. Hepler ,  Robert A. Henderson

IPC分类号： C07H2104

CPC分类号： C07K14/005 ,  A61K38/00 ,  A61K39/00 ,  A61K2039/5156 ,  A61K2039/53 ,  C07K14/4748 ,  C07K14/705 ,  C07K2319/00 ,  C12N9/6424 ,  C12N2760/16222

摘要： Compositions and methods for the therapy and diagnosis of cancer, such as prostate cancer, are disclosed. Compositions may comprise one or more prostate-specific proteins, immunogenic portions thereof, or polynucleotides that encode such portions. Alternatively, a therapeutic composition may comprise an antigen presenting cell that expresses a prostate-specific protein, or a T cell that is specific for cells expressing such a protein. Such compositions may be used, for example, for the prevention and treatment of diseases such as prostate cancer. Diagnostic methods based on detecting a prostate-specific protein, or mRNA encoding such a protein, in a sample are also provided.

公开(公告)号：US07033827B2

公开(公告)日：2006-04-25

申请号：US10144678

申请日：2002-05-09

申请人： Jiangchun Xu ,  Davin C. Dillon ,  Jennifer L. Mitcham ,  Susan L. Harlocker ,  Yuqiu Jiang ,  Robert A. Henderson ,  Michael D. Kalos ,  Gary R. Fanger ,  Marc W. Retter ,  John A. Stolk ,  Craig H. Day ,  Thomas S. Vedvick ,  Darrick Carter ,  Samuel X. Li ,  Aijun Wang ,  Yasir A. W. Skeiky ,  William T. Hepler ,  John Hural ,  Patricia D. McNeill ,  Raymond L. Houghton ,  Carlota Vinals y de Bassols ,  Teresa M. Foy ,  Yoshihiro Watanabe ,  Madeleine Joy Meagher ,  Ta Deng

发明人： Jiangchun Xu ,  Davin C. Dillon ,  Jennifer L. Mitcham ,  Susan L. Harlocker ,  Yuqiu Jiang ,  Robert A. Henderson ,  Michael D. Kalos ,  Gary R. Fanger ,  Marc W. Retter ,  John A. Stolk ,  Craig H. Day ,  Thomas S. Vedvick ,  Darrick Carter ,  Samuel X. Li ,  Aijun Wang ,  Yasir A. W. Skeiky ,  William T. Hepler ,  John Hural ,  Patricia D. McNeill ,  Raymond L. Houghton ,  Carlota Vinals y de Bassols ,  Teresa M. Foy ,  Yoshihiro Watanabe ,  Madeleine Joy Meagher ,  Ta Deng

IPC分类号： C12Q1/68 ,  C12N1/20 ,  C12N15/00 ,  C12N5/00 ,  C07H21/02

CPC分类号： C07K14/005 ,  A61K38/00 ,  A61K39/00 ,  A61K48/00 ,  A61K2035/124 ,  A61K2039/505 ,  A61K2039/5156 ,  A61K2039/53 ,  C07K14/47 ,  C07K14/4748 ,  C07K14/705 ,  C07K16/3069 ,  C07K2317/34 ,  C07K2319/00 ,  C12N9/6424 ,  C12N2710/14143 ,  C12N2760/16022

摘要： Compositions and methods for the therapy and diagnosis of cancer, particularly prostate cancer, are disclosed. Illustrative compositions comprise one or more prostate-specific polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases, particularly prostate cancer.

摘要翻译： 公开了用于治疗和诊断癌症，特别是前列腺癌的组合物和方法。 说明性组合物包含一种或多种前列腺特异性多肽，其免疫原性部分，编码此类多肽的多核苷酸，表达此类多肽的抗原呈递细胞，以及对表达此类多肽的细胞特异的T细胞。 所公开的组合物可用于例如疾病，特别是前列腺癌的诊断，预防和/或治疗。

公开(公告)号：US06943236B2

公开(公告)日：2005-09-13

申请号：US10012896

申请日：2001-12-10

申请人： Jiangchun Xu ,  Davin C. Dillon ,  Jennifer L. Mitcham ,  Susan L. Harlocker ,  Yuqiu Jiang ,  Michael D. Kalos ,  Gary R. Fanger ,  Marc W. Retter ,  John A. Stolk ,  Craig H. Day ,  Thomas S. Vedvick ,  Darrick Carter ,  Samuel X. Li ,  Aijun Wang ,  Yasir A. W. Skeiky ,  William T. Hepler ,  Robert A. Henderson ,  John Hural ,  Patricia D. McNeill ,  Raymond L. Houghton ,  Carlota Vinals y de Bassols ,  Teresa M. Foy ,  Yoshihiro Watanabe ,  Madeleine Joy Meagher

发明人： Jiangchun Xu ,  Davin C. Dillon ,  Jennifer L. Mitcham ,  Susan L. Harlocker ,  Yuqiu Jiang ,  Michael D. Kalos ,  Gary R. Fanger ,  Marc W. Retter ,  John A. Stolk ,  Craig H. Day ,  Thomas S. Vedvick ,  Darrick Carter ,  Samuel X. Li ,  Aijun Wang ,  Yasir A. W. Skeiky ,  William T. Hepler ,  Robert A. Henderson ,  John Hural ,  Patricia D. McNeill ,  Raymond L. Houghton ,  Carlota Vinals y de Bassols ,  Teresa M. Foy ,  Yoshihiro Watanabe ,  Madeleine Joy Meagher

IPC分类号： A61K35/12 ,  A61K38/00 ,  A61K39/00 ,  A61K48/00 ,  C07K14/11 ,  C07K14/47 ,  C07K14/705 ,  C07K16/30 ,  C12N9/64 ,  C07K14/00 ,  C07H21/02 ,  C12Q1/68 ,  C12N1/20

CPC分类号： C07K14/005 ,  A61K38/00 ,  A61K39/00 ,  A61K48/00 ,  A61K2035/124 ,  A61K2039/505 ,  A61K2039/5156 ,  A61K2039/53 ,  C07K14/47 ,  C07K14/4748 ,  C07K14/705 ,  C07K16/3069 ,  C07K2317/34 ,  C07K2317/73 ,  C07K2319/00 ,  C12N9/6424 ,  C12N2760/16022

摘要： Compositions and methods for the therapy and diagnosis of cancer, particularly prostate cancer, are disclosed. Illustrative compositions comprise one or more prostate-specific polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases, particularly prostate cancer.