公开(公告)号：US20140142048A1

公开(公告)日：2014-05-22

申请号：US13934828

申请日：2013-07-03

Applicant: University Of Illinois At Chicago ,  Trustees Of Tufts College

Inventor： David L. KAPLAN ,  Jia HUANG ,  Cheryl WONG PO FOO ,  Rajesh NAIK ,  Anne GEORGE

IPC: C07K14/435

CPC classification number: A61L27/48 ,  A61L27/446 ,  A61L27/46 ,  A61L27/54 ,  A61L2430/00 ,  C07K14/43518 ,  C07K14/51 ,  C07K14/78 ,  C07K2319/00

Abstract: The claimed invention provides a fusion polypeptide comprising a fibrous protein domain and a mineralization domain. The fusion is used to form an organic-inorganic composite. These organic-inorganic composites can be constructed from the nano- to the macro-scale depending on the size of the fibrous protein fusion domain used. In one embodiment, the composites can also be loaded with other compounds (e.g., dyes, drugs, enzymes) depending on the goal for the materials, to further enhance function. This can be achieved during assembly of the material or during the mineralization step in materials formation.

Abstract translation: 要求保护的发明提供了包含纤维蛋白结构域和矿化结构域的融合多肽。 该融合用于形成有机 - 无机复合材料。 这些有机 - 无机复合材料可以根据所使用的纤维蛋白融合结构域的大小从纳米级到大规模构建。 在一个实施方案中，根据材料的目标，复合材料还可以加载其它化合物（例如染料，药物，酶），以进一步增强功能。 这可以在组装材料期间或在矿化步骤期间在材料形成中实现。

公开(公告)号：US20150038043A1

公开(公告)日：2015-02-05

申请号：US14293308

申请日：2014-06-02

Applicant: Trustees of Tufts College

Inventor： David L. KAPLAN ,  Ung-Jin KIM ,  Jaehyung PARK ,  Hyoung-Joon JIN

IPC: A61L27/22 ,  B29D7/01 ,  B29C39/20 ,  B29C39/00 ,  B29C55/00

CPC classification number: A61L27/227 ,  A61L27/3604 ,  A61L27/38 ,  A61L27/52 ,  A61L27/56 ,  A61L2430/02 ,  B29C39/003 ,  B29C39/203 ,  B29C55/005 ,  B29D7/01 ,  B29K2089/00 ,  B29L2007/00 ,  B29L2009/00 ,  C07K14/43536 ,  C07K14/43586 ,  C08J3/07 ,  C08J3/075 ,  C08J5/18 ,  C08J9/0061 ,  C08J9/26 ,  C08J9/28 ,  C08J2201/0444 ,  C08J2201/0504 ,  C08J2205/022 ,  C08J2389/00 ,  C08L89/00 ,  D01D5/0007 ,  D01F4/02 ,  Y10T428/249921 ,  Y10T442/10 ,  Y10T442/60

Abstract: The present invention provides for concentrated aqueous silk fibroin solutions and an all-aqueous mode for preparation of concentrated aqueous fibroin solutions that avoids the use of organic solvents, direct additives, or harsh chemicals. The invention further provides for the use of these solutions in production of materials, e.g., fibers, films, foams, meshes, scaffolds and hydrogels.

公开(公告)号：US20130287835A1

公开(公告)日：2013-10-31

申请号：US13706675

申请日：2012-12-06

Applicant: Trustees of Tufts College

Inventor： David L. KAPLAN ,  Xianyan WANG

IPC: A61J3/00

CPC classification number: A61L31/10 ,  A61J3/00 ,  A61L15/32 ,  A61L15/44 ,  A61L27/3604 ,  A61L27/50 ,  A61L31/16 ,  A61L2300/416 ,  A61L2300/43 ,  A61L2400/12 ,  A61L2400/18 ,  C09D189/00 ,  Y10T428/31768

Abstract: The invention provides a method for the controlled assembly of layered silk fibroin coatings using aqueous silk fibroin material. The methods described herein can be used to coat substrates of any material, shape, or size. Importantly, the described methods enable control of the biomaterial surface chemistry, thickness, morphology and structure using layered thin film coatings, or bulk coatings. Furthermore, the methods can be performed in all water and do not require intensive chemical processing enabling controlled entrapment of labile molecules such as, drugs, cytokines, and even cells or viruses to generate functional coatings that can be used in a variety of applications.

公开(公告)号：US20180359850A1

公开(公告)日：2018-12-13

申请号：US15942242

申请日：2018-03-30

Applicant: THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS ,  TRUSTEES OF TUFTS COLLEGE

Inventor： John A. ROGERS ,  Rak-Hwan KIM ,  Dae-Hyeong KIM ,  David L. KAPLAN ,  Fiorenzo G. OMENETTO

IPC: H05K1/02 ,  H01L23/31

CPC classification number: H05K1/0283 ,  A61B5/0422 ,  A61B5/6806 ,  A61B5/6867 ,  A61B5/6883 ,  A61B2562/02 ,  A61B2562/0233 ,  A61B2562/0257 ,  A61B2562/0271 ,  A61B2562/066 ,  A61B2562/12 ,  A61B2562/164 ,  A61N1/05 ,  A61N1/18 ,  A61N1/36 ,  F21K9/00 ,  H01L23/3121 ,  H01L23/3192 ,  H01L27/1218 ,  H01L29/78603 ,  H01L29/7869 ,  H01L2924/0002 ,  H01L2924/09701 ,  H01L2924/12044 ,  H01L2924/19041 ,  H01L2924/3011 ,  H01L2924/3025 ,  H05K1/147 ,  H05K3/323 ,  H05K2201/09263 ,  H05K2201/10106 ,  H05K2203/1316 ,  Y10T29/49128 ,  H01L2924/00

Abstract: Described herein are flexible and stretchable LED arrays and methods utilizing flexible and stretchable LED arrays. Assembly of flexible LED arrays alongside flexible plasmonic crystals is useful for construction of fluid monitors, permitting sensitive detection of fluid refractive index and composition. Co-integration of flexible LED arrays with flexible photodetector arrays is useful for construction of flexible proximity sensors. Application of stretchable LED arrays onto flexible threads as light emitting sutures provides novel means for performing radiation therapy on wounds.