-
公开(公告)号:US20060276421A1
公开(公告)日:2006-12-07
申请号:US10568226
申请日:2004-09-29
CPC分类号: A61K31/713 , C12N15/111 , C12N2310/11 , C12N2310/14 , C12N2310/53 , C12N2320/51
摘要: Conventional oligonucleotides are opened at both ends and thereby unstable. The stability of them against catabolic enzymes is increased by phosphorothioate modification, but such phosphorothioate causes toxicity. The present invention provides oligonucleotides and medicaments in which these problems are improved. That is, it provides a staple oligonucleotides and medicaments containing the same as the active ingredient. Specifically, it provides transcription factor inhibitors, antisense oligonucleotides and siRNAs. More specifically, it provides agents for preventing, treating or improving inflammation, autoimmune diseases, central diseases, reperfusion injury in ischaemic diseases, worsened prognosis after organ transplantation or organ surgery, or restenosis after PTCA. Further specifically, it provides agents for preventing, treating or improving arthritis, dermatitis, nephritis, hepatitis, renal failure, cystitis, prostatitis, urethritis, ulcerative colitis, Crohn disease, chronic rheumatoid arthritis, osteoarthritis, atopic dermatitis, contact dermatitis, psoriasis, cutaneous ulcer or decubitus.
摘要翻译: 常规寡核苷酸在两端开放,从而不稳定。 它们对分解代谢酶的稳定性被硫代磷酸酯修饰增加,但是这种硫代磷酸酯引起毒性。 本发明提供了改善这些问题的寡核苷酸和药物。 也就是说,它提供了含有与活性成分相同的主要寡核苷酸和药物。 具体来说,它提供转录因子抑制剂,反义寡核苷酸和siRNA。 更具体地说,它提供用于预防,治疗或改善炎症,自身免疫性疾病,中枢性疾病,缺血性疾病中的再灌注损伤,器官移植或器官手术后的预后恶化或PTCA后的再狭窄的药剂。 更具体地说,它提供预防,治疗或改善关节炎,皮炎,肾炎,肝炎,肾衰竭,膀胱炎,前列腺炎,尿道炎,溃疡性结肠炎,克罗恩病,慢性类风湿性关节炎,骨关节炎,特应性皮炎,接触性皮炎,牛皮癣,皮肤 溃疡或褥疮。
-
公开(公告)号:US07595301B2
公开(公告)日:2009-09-29
申请号:US10568226
申请日:2004-09-29
CPC分类号: A61K31/713 , C12N15/111 , C12N2310/11 , C12N2310/14 , C12N2310/53 , C12N2320/51
摘要: Conventional oligonucleotides are opened at both ends and thereby unstable. Their stability against catabolic enzymes is increased by phosphorothioate modification, but such phosphorothioate causes toxicity. The present invention provides oligonucleotides and medicaments in which these problems are improved. That is, it provides staple oligonucleotides and medicaments containing the same as the active ingredient. Specifically, it provides transcription factor inhibitors, antisense oligonucleotides and siRNAs. More specifically, it provides agents for preventing, treating or improving inflammation, autoimmune diseases, central diseases, reperfusion injury in ischaemic diseases, worsened prognosis after organ transplantation or organ surgery, or restenosis after PTCA. Further specifically, it provides agents for preventing, treating or improving arthritis, dermatitis, nephritis, hepatitis, renal failure, cystitis, prostatitis, urethritis, ulcerative colitis, Crohn disease, chronic rheumatoid arthritis, osteoarthritis, atopic dermatitis, contact dermatitis, psoriasis, cutaneous ulcer or decubitus.
摘要翻译: 常规寡核苷酸在两端开放,从而不稳定。 它们对分解代谢酶的稳定性通过硫代磷酸酯修饰而增加,但是这种硫代磷酸酯会引起毒性。 本发明提供了改善这些问题的寡核苷酸和药物。 也就是说,它提供含有与活性成分相同的主要寡核苷酸和药物。 具体来说,它提供转录因子抑制剂,反义寡核苷酸和siRNA。 更具体地说,它提供用于预防,治疗或改善炎症,自身免疫性疾病,中枢性疾病,缺血性疾病中的再灌注损伤,器官移植或器官手术后的预后恶化或PTCA后的再狭窄的药剂。 更具体地说,它提供预防,治疗或改善关节炎,皮炎,肾炎,肝炎,肾衰竭,膀胱炎,前列腺炎,尿道炎,溃疡性结肠炎,克罗恩病,慢性类风湿性关节炎,骨关节炎,特应性皮炎,接触性皮炎,牛皮癣,皮肤 溃疡或褥疮。
-
公开(公告)号:US20070293447A1
公开(公告)日:2007-12-20
申请号:US10570052
申请日:2004-08-27
申请人: Yasuo Kunugiza , Naruya Tomita , Hideki Yoshikawa , Yoshiaki Taniyama , Katsuto Tamai , Ryuichi Morishita
发明人: Yasuo Kunugiza , Naruya Tomita , Hideki Yoshikawa , Yoshiaki Taniyama , Katsuto Tamai , Ryuichi Morishita
CPC分类号: A61K9/0024 , A61K31/7088 , A61K48/0075
摘要: The present invention provides highly useful clinical methods for treating skin disorders, particularly intractable skin disorders. Specifically, the methods comprise injecting/subcutaneously introducing a 10 μg to 10 mg dose of a polynucleotide, such as a DNA, oligonucleotide, RNA, siRNA, and antisense, around a lesion associated with a skin disorder, such as a wound, cutaneous ulcer, or psoriasis, using a needleless syringe that injects a pharmaceutical liquid by using gas pressure or the elastic force of an elastic member to drive a piston.
摘要翻译: 本发明提供用于治疗皮肤病症,特别是顽固性皮肤病症的非常有用的临床方法。 具体地说,所述方法包括将注射/皮下注射10μg至10mg剂量的多核苷酸,例如DNA,寡核苷酸,RNA,siRNA和反义,在与皮肤病症如伤口,皮肤溃疡相关的病变周围 或牛皮癣,使用无针注射器,其通过使用气体压力或弹性构件的弹力来驱动活塞而喷射药液。
-
4.
公开(公告)号:US20060241066A1
公开(公告)日:2006-10-26
申请号:US10516208
申请日:2003-05-20
CPC分类号: A61K31/7088 , A61K38/1709 , A61K48/005
摘要: It is intended to efficiently treat an inflammatory disease without causing side effects. This object can be achieved by providing a medicinal composition for treating and preventing an inflammatory disease and disorders, and disorders caused by the disease and disorders which contains at least one decoy of NF-κB or an analogous transcriptional factor and a pharmaceutically acceptable carrier; and a method of treating and preventing an inflammatory disease and disorders, and disorders caused by the disease and disorders which comprises the step of administering to a patient a composition containing at least one decoy of NF-κB or an analogous transcriptional factor and a pharmaceutically acceptable carrier.
摘要翻译: 旨在有效地治疗炎性疾病而不引起副作用。 该目的可以通过提供一种用于治疗和预防炎性疾病和病症的药物组合物,以及由包含至少一种NF-κB诱变物或类似转录因子和药学上可接受的载体的疾病和病症引起的疾病, 以及治疗和预防炎性疾病和病症以及由疾病和病症引起的疾病的方法,其包括向患者施用含有至少一种NF-κB诱变物或类似转录因子和药学上可接受的组合物的步骤 载体
-
公开(公告)号:US09439620B2
公开(公告)日:2016-09-13
申请号:US13992083
申请日:2011-12-01
申请人: Marie Tabaru , Takashi Azuma , Hideki Yoshikawa , Kunio Hashiba
发明人: Marie Tabaru , Takashi Azuma , Hideki Yoshikawa , Kunio Hashiba
CPC分类号: A61B8/08 , A61B8/0825 , A61B8/0891 , A61B8/485 , G01S7/52049 , G01S7/52071 , G01S7/52073
摘要: When multiple tissues having differing speeds of sound are intermixed in the viewing field of a measured subject such as a living body, the invention measures hardness, such as modulus of elasticity or viscosity, with high precision.
摘要翻译: 当具有不同声速的多个组织混合在诸如生物体的被测量对象的视野中时,本发明以高精度测量诸如弹性模量或粘度的硬度。
-
公开(公告)号:US09165363B2
公开(公告)日:2015-10-20
申请号:US14236347
申请日:2012-07-24
申请人: Hideki Yoshikawa , Takashi Azuma
发明人: Hideki Yoshikawa , Takashi Azuma
CPC分类号: G06T7/003 , A61B5/055 , A61B6/032 , A61B6/461 , A61B6/469 , A61B6/481 , A61B6/486 , A61B6/5211 , A61B6/5235 , A61B6/5241 , A61B6/5264 , A61B6/58 , A61B8/485 , A61B8/5207 , A61B8/5215 , A61B8/5246 , A61B2576/00 , G06T7/337 , G06T2200/24 , G06T2207/20104 , G06T2207/30004
摘要: Provided is an image diagnostic device with which it is possible to correct location misalignment of an image capture subject, and to improve the reliability of the result of the correction, in time series image data. An image diagnostic device may include an input part (13) which receives image data input; a correction unit (14) which computes a correction vector which denotes location misalignment of an image capture subject, and selects image data used with an image correction unit; an image correction part (20) which carries out a correction process on the image data based on the correction vector and creates corrected image data; a control part (21) which controls the correction unit and the image correction part; a memory (22) which stores the corrected image data and measurement data as stored data; an output unit (23) which outputs the stored data externally; a display unit (24) which displays the stored data; and an external input device (30) where an operator makes an input operation.
摘要翻译: 提供了一种图像诊断装置,可以在时间序列图像数据中校正图像拍摄对象的位置未对准,并且提高校正结果的可靠性。 图像诊断装置可以包括接收图像数据输入的输入部分(13) 校正单元(14),其计算表示图像拍摄对象的位置未对准的校正矢量,并选择与图像校正单元一起使用的图像数据; 图像校正部(20),其基于所述校正矢量对所述图像数据进行校正处理,并生成校正后的图像数据; 控制部件(21),其控制校正单元和图像校正部件; 存储校正图像数据和测量数据作为存储数据的存储器(22); 输出单元(23),其从外部输出所存储的数据; 显示单元(24),显示所存储的数据; 以及操作者进行输入操作的外部输入装置(30)。
-
公开(公告)号:US20140219539A1
公开(公告)日:2014-08-07
申请号:US14342087
申请日:2012-06-26
申请人: Hideki Yoshikawa
发明人: Hideki Yoshikawa
IPC分类号: G06T7/00
CPC分类号: G06T7/0012 , A61B5/055 , A61B5/489 , A61B6/481 , A61B6/504 , A61B8/06 , A61B8/481 , G01R33/5601 , G01R33/5635 , G06K2009/00932 , G06K2209/05 , G06T7/0016 , G06T2207/10016 , G06T2207/10081 , G06T2207/10088 , G06T2207/10132 , G06T2207/30104
摘要: Provided is an image diagnostic device with which the start and end of the in-flow of a contrast medium are automatically assessed. An image diagnostic device assesses the start and end times of the in-flow of a contrast medium into organs in a lifeform which is a subject. The image diagnostic device comprises: an input unit (11) which receives an input of a signal from a contrast medium which is acquired from such as an image acquisition unit (22); a luminosity evaluation unit (13) which creates a luminosity curve that denotes a change over time in signal strength; a function evaluation unit (14) which approximates the luminosity curve with an S-shaped function and creates a model function; an assessment unit (12), further comprising a circulation evaluation unit (15) which uses a tangent line at an inflection point of the model function and assesses the start and end of the in-flow of the contrast medium; and a display unit (19) which displays the result which is evaluated with the assessment unit (12). The present invention allows automatically assessing the start and end times of the in-flow of the contrast medium.
摘要翻译: 提供了一种图像诊断装置,其中自动评估造影剂的流入的开始和结束。 图像诊断装置评估作为受试者的生命方式中造影剂进入器官的流入的开始和结束时间。 图像诊断装置包括:输入单元(11),其从诸如图像获取单元(22)等获取的造影剂接收信号的输入; 光度评估单元(13),其产生指示信号强度随时间变化的亮度曲线; 函数评估单元(14),其用S形函数近似亮度曲线并产生模型函数; 评估单元(12),还包括循环评估单元(15),其在所述模型函数的拐点处使用切线,并且评估所述造影剂的流入的开始和结束; 以及显示单元(19),其显示由评估单元(12)评估的结果。 本发明允许自动评估造影剂的流入的开始和结束时间。
-
公开(公告)号:US08660162B2
公开(公告)日:2014-02-25
申请号:US13189637
申请日:2011-07-25
申请人: Masayuki Hata , Hideki Yoshikawa
发明人: Masayuki Hata , Hideki Yoshikawa
IPC分类号: H01S5/00
CPC分类号: H01S5/4093 , H01L2224/73265 , H01L2924/10155 , H01S5/02236 , H01S5/0224 , H01S5/02256 , H01S5/02276 , H01S5/0683 , H01S5/4031
摘要: In this semiconductor laser apparatus, a first wire-bonding portion is arranged at a position in a fourth direction from a first semiconductor laser device and in a first direction from a photodetector, and a second wire-bonding portion is arranged at a position in the fourth direction from the first semiconductor laser device and in a third direction from the first wire-bonding portion. A third wire-bonding portion is arranged at a position in a second direction from a third semiconductor laser device and in the first direction from the photodetector, and a fourth wire-bonding portion is arranged at a position in the second direction from the third semiconductor laser device and in the third direction from the third wire-bonding portion.
摘要翻译: 在该半导体激光装置中,第一引线接合部配置在从第一半导体激光装置向第四方向的位置,在第一方向配置于光检测器,第二引线接合部配置在 从第一半导体激光器件的第四方向和从第一引线接合部分的第三方向。 第三引线接合部分布置在距离第三半导体激光器件的第二方向的位置处,并且在第一方向上被布置在从光电检测器的第一方向上,并且第四引线接合部分布置在从第三半导体 激光装置,并且从第三引线接合部向第三方向。
-
公开(公告)号:US20130317361A1
公开(公告)日:2013-11-28
申请号:US13982801
申请日:2011-12-28
申请人: Marie Tabaru , Takashi Azuma , Hideki Yoshikawa , Kunio Hashiba
发明人: Marie Tabaru , Takashi Azuma , Hideki Yoshikawa , Kunio Hashiba
IPC分类号: A61B8/08
CPC分类号: A61B8/485 , A61B8/42 , A61B8/469 , A61B8/5246 , G01S7/52042
摘要: An ultrasound diagnostic apparatus with which elastic modulus can be measured when measuring elastic modulus using shear wave generation. The ultrasound diagnostic apparatus includes an ultrasound probe that sends and receives echo signals, a strain-computing unit that receives an echo signal from the body by radiating a first displacement-detecting beam and computes strain information in a Region 1, a measurement position-selecting unit that selects a Region 2, within Region 1, based on the strain information, a displacement-generating unit that radiates a focused beam into the body and displaces the tissue, an elastic modulus-computing unit that receives an echo signal from the body by radiating a second displacement-detecting beam, detects the shear wave displacement that results from the focused beam, and computes the elastic modulus in Region 2, and a display unit that displays the strain image that is based on the strain information in Region 1 and the elastic modulus.
摘要翻译: 一种使用剪切波产生测量弹性模量时可以测量弹性模量的超声波诊断装置。 超声波诊断装置包括发送和接收回波信号的超声波探头,应变计算单元,其通过辐射第一位移检测光束从身体接收回波信号,并计算区域1中的应变信息,测量位置选择 基于应变信息在区域1内选择区域2的单元,将聚焦光束照射到体内并使组织发生位移的位移产生单元,弹性模量计算单元,其从身体接收回波信号, 辐射第二位移检测光束,检测由聚焦光束产生的剪切波位移,并计算区域2中的弹性模量;以及显示单元,其显示基于区域1中的应变信息的应变图像,以及 弹性模量。
-
公开(公告)号:US08460191B2
公开(公告)日:2013-06-11
申请号:US11914962
申请日:2006-05-18
IPC分类号: A61B8/00
CPC分类号: A61B8/5207 , A61B5/11 , A61B8/08 , A61B8/461 , A61B8/463 , G06T5/50 , G06T7/223 , G06T2207/10132 , G06T2207/30101
摘要: An diagnostic imaging apparatus for imaging information changing with time and displaying it in real time, composed of an ultrasonic probe (2), having piezoelectric elements arranged in an array form that transmit ultrasonic waves to a target object (1) and acquires a reflection signal from the target object; a body movement measuring unit (12) that constitutes a two-dimensional ultrasonic image using the reflection signal acquired by the ultrasonic probe, sets, in the image plane, a plurality of measuring areas used for measuring the body movement of the target object, and measures the body movement and deformation amounts in the measuring areas; and an image accumulating (subtracting) unit for accumulating or subtracting images using body movement measured by the body movement measurement unit.
摘要翻译: 一种诊断成像装置,用于对随时间变化的图像信息随时间变化并实时显示,该超声波探头由超声波探头(2)组成,该超声波探头具有排列成阵列形式的压电元件,以将超声波传送到目标物体(1)并获取反射信号 从目标对象; 使用由超声波探头取得的反射信号构成二维超声波图像的身体运动测量单元(12)在图像平面中设置用于测量目标物体的身体运动的多个测量区域,以及 测量测量区域的身体运动和变形量; 以及用于通过由身体运动测量单元测量的身体运动来累积或减去图像的图像累积(减去)单元。
-
-
-
-
-
-
-
-
-