公开(公告)号：US09439620B2

公开(公告)日：2016-09-13

申请号：US13992083

申请日：2011-12-01

申请人： Marie Tabaru ,  Takashi Azuma ,  Hideki Yoshikawa ,  Kunio Hashiba

发明人： Marie Tabaru ,  Takashi Azuma ,  Hideki Yoshikawa ,  Kunio Hashiba

IPC分类号： A61B8/00 ,  A61B8/08 ,  G01S7/52

CPC分类号： A61B8/08 ,  A61B8/0825 ,  A61B8/0891 ,  A61B8/485 ,  G01S7/52049 ,  G01S7/52071 ,  G01S7/52073

摘要： When multiple tissues having differing speeds of sound are intermixed in the viewing field of a measured subject such as a living body, the invention measures hardness, such as modulus of elasticity or viscosity, with high precision.

摘要翻译： 当具有不同声速的多个组织混合在诸如生物体的被测量对象的视野中时，本发明以高精度测量诸如弹性模量或粘度的硬度。

公开(公告)号：US09165363B2

公开(公告)日：2015-10-20

申请号：US14236347

申请日：2012-07-24

申请人： Hideki Yoshikawa ,  Takashi Azuma

发明人： Hideki Yoshikawa ,  Takashi Azuma

IPC分类号： G06K9/32 ,  G06T7/00 ,  A61B6/03 ,  A61B6/00 ,  A61B8/08 ,  A61B5/055

CPC分类号： G06T7/003 ,  A61B5/055 ,  A61B6/032 ,  A61B6/461 ,  A61B6/469 ,  A61B6/481 ,  A61B6/486 ,  A61B6/5211 ,  A61B6/5235 ,  A61B6/5241 ,  A61B6/5264 ,  A61B6/58 ,  A61B8/485 ,  A61B8/5207 ,  A61B8/5215 ,  A61B8/5246 ,  A61B2576/00 ,  G06T7/337 ,  G06T2200/24 ,  G06T2207/20104 ,  G06T2207/30004

摘要： Provided is an image diagnostic device with which it is possible to correct location misalignment of an image capture subject, and to improve the reliability of the result of the correction, in time series image data. An image diagnostic device may include an input part (13) which receives image data input; a correction unit (14) which computes a correction vector which denotes location misalignment of an image capture subject, and selects image data used with an image correction unit; an image correction part (20) which carries out a correction process on the image data based on the correction vector and creates corrected image data; a control part (21) which controls the correction unit and the image correction part; a memory (22) which stores the corrected image data and measurement data as stored data; an output unit (23) which outputs the stored data externally; a display unit (24) which displays the stored data; and an external input device (30) where an operator makes an input operation.

摘要翻译： 提供了一种图像诊断装置，可以在时间序列图像数据中校正图像拍摄对象的位置未对准，并且提高校正结果的可靠性。 图像诊断装置可以包括接收图像数据输入的输入部分（13） 校正单元（14），其计算表示图像拍摄对象的位置未对准的校正矢量，并选择与图像校正单元一起使用的图像数据; 图像校正部（20），其基于所述校正矢量对所述图像数据进行校正处理，并生成校正后的图像数据; 控制部件（21），其控制校正单元和图像校正部件; 存储校正图像数据和测量数据作为存储数据的存储器（22）; 输出单元（23），其从外部输出所存储的数据; 显示单元（24），显示所存储的数据; 以及操作者进行输入操作的外部输入装置（30）。

公开(公告)号：US20140219539A1

公开(公告)日：2014-08-07

申请号：US14342087

申请日：2012-06-26

申请人： Hideki Yoshikawa

发明人： Hideki Yoshikawa

IPC分类号： G06T7/00

CPC分类号： G06T7/0012 ,  A61B5/055 ,  A61B5/489 ,  A61B6/481 ,  A61B6/504 ,  A61B8/06 ,  A61B8/481 ,  G01R33/5601 ,  G01R33/5635 ,  G06K2009/00932 ,  G06K2209/05 ,  G06T7/0016 ,  G06T2207/10016 ,  G06T2207/10081 ,  G06T2207/10088 ,  G06T2207/10132 ,  G06T2207/30104

摘要： Provided is an image diagnostic device with which the start and end of the in-flow of a contrast medium are automatically assessed. An image diagnostic device assesses the start and end times of the in-flow of a contrast medium into organs in a lifeform which is a subject. The image diagnostic device comprises: an input unit (11) which receives an input of a signal from a contrast medium which is acquired from such as an image acquisition unit (22); a luminosity evaluation unit (13) which creates a luminosity curve that denotes a change over time in signal strength; a function evaluation unit (14) which approximates the luminosity curve with an S-shaped function and creates a model function; an assessment unit (12), further comprising a circulation evaluation unit (15) which uses a tangent line at an inflection point of the model function and assesses the start and end of the in-flow of the contrast medium; and a display unit (19) which displays the result which is evaluated with the assessment unit (12). The present invention allows automatically assessing the start and end times of the in-flow of the contrast medium.

摘要翻译： 提供了一种图像诊断装置，其中自动评估造影剂的流入的开始和结束。 图像诊断装置评估作为受试者的生命方式中造影剂进入器官的流入的开始和结束时间。 图像诊断装置包括：输入单元（11），其从诸如图像获取单元（22）等获取的造影剂接收信号的输入; 光度评估单元（13），其产生指示信号强度随时间变化的亮度曲线; 函数评估单元（14），其用S形函数近似亮度曲线并产生模型函数; 评估单元（12），还包括循环评估单元（15），其在所述模型函数的拐点处使用切线，并且评估所述造影剂的流入的开始和结束; 以及显示单元（19），其显示由评估单元（12）评估的结果。 本发明允许自动评估造影剂的流入的开始和结束时间。

公开(公告)号：US08660162B2

公开(公告)日：2014-02-25

申请号：US13189637

申请日：2011-07-25

申请人： Masayuki Hata ,  Hideki Yoshikawa

发明人： Masayuki Hata ,  Hideki Yoshikawa

IPC分类号： H01S5/00

CPC分类号： H01S5/4093 ,  H01L2224/73265 ,  H01L2924/10155 ,  H01S5/02236 ,  H01S5/0224 ,  H01S5/02256 ,  H01S5/02276 ,  H01S5/0683 ,  H01S5/4031

摘要： In this semiconductor laser apparatus, a first wire-bonding portion is arranged at a position in a fourth direction from a first semiconductor laser device and in a first direction from a photodetector, and a second wire-bonding portion is arranged at a position in the fourth direction from the first semiconductor laser device and in a third direction from the first wire-bonding portion. A third wire-bonding portion is arranged at a position in a second direction from a third semiconductor laser device and in the first direction from the photodetector, and a fourth wire-bonding portion is arranged at a position in the second direction from the third semiconductor laser device and in the third direction from the third wire-bonding portion.

摘要翻译： 在该半导体激光装置中，第一引线接合部配置在从第一半导体激光装置向第四方向的位置，在第一方向配置于光检测器，第二引线接合部配置在 从第一半导体激光器件的第四方向和从第一引线接合部分的第三方向。 第三引线接合部分布置在距离第三半导体激光器件的第二方向的位置处，并且在第一方向上被布置在从光电检测器的第一方向上，并且第四引线接合部分布置在从第三半导体 激光装置，并且从第三引线接合部向第三方向。

公开(公告)号：US20130317361A1

公开(公告)日：2013-11-28

申请号：US13982801

申请日：2011-12-28

申请人： Marie Tabaru ,  Takashi Azuma ,  Hideki Yoshikawa ,  Kunio Hashiba

发明人： Marie Tabaru ,  Takashi Azuma ,  Hideki Yoshikawa ,  Kunio Hashiba

IPC分类号： A61B8/08

CPC分类号： A61B8/485 ,  A61B8/42 ,  A61B8/469 ,  A61B8/5246 ,  G01S7/52042

摘要： An ultrasound diagnostic apparatus with which elastic modulus can be measured when measuring elastic modulus using shear wave generation. The ultrasound diagnostic apparatus includes an ultrasound probe that sends and receives echo signals, a strain-computing unit that receives an echo signal from the body by radiating a first displacement-detecting beam and computes strain information in a Region 1, a measurement position-selecting unit that selects a Region 2, within Region 1, based on the strain information, a displacement-generating unit that radiates a focused beam into the body and displaces the tissue, an elastic modulus-computing unit that receives an echo signal from the body by radiating a second displacement-detecting beam, detects the shear wave displacement that results from the focused beam, and computes the elastic modulus in Region 2, and a display unit that displays the strain image that is based on the strain information in Region 1 and the elastic modulus.

摘要翻译： 一种使用剪切波产生测量弹性模量时可以测量弹性模量的超声波诊断装置。 超声波诊断装置包括发送和接收回波信号的超声波探头，应变计算单元，其通过辐射第一位移检测光束从身体接收回波信号，并计算区域1中的应变信息，测量位置选择 基于应变信息在区域1内选择区域2的单元，将聚焦光束照射到体内并使组织发生位移的位移产生单元，弹性模量计算单元，其从身体接收回波信号， 辐射第二位移检测光束，检测由聚焦光束产生的剪切波位移，并计算区域2中的弹性模量;以及显示单元，其显示基于区域1中的应变信息的应变图像，以及 弹性模量。

公开(公告)号：US08460191B2

公开(公告)日：2013-06-11

申请号：US11914962

申请日：2006-05-18

申请人： Hideki Yoshikawa ,  Takashi Azuma ,  Kenichi Kawabata ,  Kazuaki Sasaki ,  Shinichiro Umemura

发明人： Hideki Yoshikawa ,  Takashi Azuma ,  Kenichi Kawabata ,  Kazuaki Sasaki ,  Shinichiro Umemura

IPC分类号： A61B8/00

CPC分类号： A61B8/5207 ,  A61B5/11 ,  A61B8/08 ,  A61B8/461 ,  A61B8/463 ,  G06T5/50 ,  G06T7/223 ,  G06T2207/10132 ,  G06T2207/30101

摘要： An diagnostic imaging apparatus for imaging information changing with time and displaying it in real time, composed of an ultrasonic probe (2), having piezoelectric elements arranged in an array form that transmit ultrasonic waves to a target object (1) and acquires a reflection signal from the target object; a body movement measuring unit (12) that constitutes a two-dimensional ultrasonic image using the reflection signal acquired by the ultrasonic probe, sets, in the image plane, a plurality of measuring areas used for measuring the body movement of the target object, and measures the body movement and deformation amounts in the measuring areas; and an image accumulating (subtracting) unit for accumulating or subtracting images using body movement measured by the body movement measurement unit.

摘要翻译： 一种诊断成像装置，用于对随时间变化的图像信息随时间变化并实时显示，该超声波探头由超声波探头（2）组成，该超声波探头具有排列成阵列形式的压电元件，以将超声波传送到目标物体（1）并获取反射信号 从目标对象; 使用由超声波探头取得的反射信号构成二维超声波图像的身体运动测量单元（12）在图像平面中设置用于测量目标物体的身体运动的多个测量区域，以及 测量测量区域的身体运动和变形量; 以及用于通过由身体运动测量单元测量的身体运动来累积或减去图像的图像累积（减去）单元。

公开(公告)号：US07794711B2

公开(公告)日：2010-09-14

申请号：US10533584

申请日：2003-08-22

申请人： Hideki Yoshikawa ,  Takahiro Miyaji

发明人： Hideki Yoshikawa ,  Takahiro Miyaji

IPC分类号： A61K39/395

CPC分类号： C07K16/26

摘要： The present invention relates to a novel agent for treating chondroma and chondrosarcoma containing a substance which inhibits binding of parathyroid hormone related peptide to its receptor for improving the prognosis of chondroma or chondrosarcoma.

摘要翻译： 本发明涉及一种用于治疗软骨瘤和软骨肉瘤的新型药剂，其含有抑制甲状旁腺激素相关肽与其受体结合以改善软骨瘤或软骨肉瘤预后的物质。

公开(公告)号：US20090168966A1

公开(公告)日：2009-07-02

申请号：US12083661

申请日：2006-10-17

申请人： Masakazu Suzuki ,  Hideki Yoshikawa

发明人： Masakazu Suzuki ,  Hideki Yoshikawa

IPC分类号： H05G1/58

CPC分类号： A61B6/4233 ,  A61B6/032 ,  A61B6/06 ,  A61B6/14 ,  A61B6/501

摘要： In a medical digital X-ray imaging apparatus having a plurality of imaging modes including computed tomography mode, a supporter supports an X-ray source and a digital X-ray sensor having a two-dimensional detection plane for detecting X-rays, while interposing an object between them. An image reconstructor acquires data from the digital X-ray sensor and reconstructs an image based on the acquired data. An operator selects one of a first imaging mode and a second imaging mode. The second imaging mode has an irradiation field different from the first imaging mode and has an area to be read in the digital X-ray sensor smaller than that in the first imaging mode.

摘要翻译： 在具有包括计算机断层摄影模式的多种成像模式的医用数字X射线成像设备中，支持者支持X射线源和具有用于检测X射线的二维检测平面的数字X射线传感器，同时插入 他们之间的对象。 图像重构器从数字X射线传感器获取数据，并且基于获取的数据重建图像。 操作者选择第一成像模式和第二成像模式之一。 第二成像模式具有与第一成像模式不同的照射场，并且在数字X射线传感器中要具有要读取的区域小于第一成像模式中的区域。

公开(公告)号：US07088568B2

公开(公告)日：2006-08-08

申请号：US11082970

申请日：2005-03-18

申请人： Hideki Yoshikawa ,  Hiroshi Nonoue ,  Kenichiro Wakisaka

发明人： Hideki Yoshikawa ,  Hiroshi Nonoue ,  Kenichiro Wakisaka

IPC分类号： H01G4/005 ,  H01G4/06 ,  C03B29/00

CPC分类号： H01G4/30 ,  H01G4/129 ,  H05K1/0306 ,  H05K1/16 ,  H05K3/382 ,  H05K3/4611 ,  H05K3/4629 ,  H05K2201/0769

摘要： A method for manufacturing a multilayer ceramic substrate including the steps of providing multilayers of ceramic green sheets each having an electrode layer formed on a dielectric layer such that, after firing, at least one electrode layer which is separated by the dielectric layer from the adjacent electrode layer in the substrate has an overlapping area of 0.4 mm2 or smaller with the adjacent electrode; and firing the multilayers of the ceramic green sheets at a selected temperature such that, after firing, an interface between the dielectric layer and the electrode layer in the substrate has irregularities with a roughness Rmax of 6 μm or less per 100 μm standard length and the dielectric layer has a saturation sintered density.

摘要翻译： 一种制造多层陶瓷基板的方法，包括以下步骤：提供陶瓷生片的多层，每层陶瓷生片均具有在电介质层上形成的电极层，使得在烧制之后，至少一个由电介质层与相邻电极隔开的电极层 衬底中的层与相邻电极具有0.4mm 2或更小的重叠面积; 并且在选定的温度下烧制陶瓷生片的多层，使得在烧结之后，介电层和基板中的电极层之间的界面具有不规则性，每100mum标准长度的粗糙度Rmax为6μm或更小，并且 电介质层具有饱和烧结密度。

公开(公告)号：US20050159820A1

公开(公告)日：2005-07-21

申请号：US10513695

申请日：2003-05-12

申请人： Hideki Yoshikawa ,  Akira Myoi ,  Noriyuki Tamai

发明人： Hideki Yoshikawa ,  Akira Myoi ,  Noriyuki Tamai

IPC分类号： A61L27/12 ,  A61L27/56 ,  A61F2/28 ,  C12N5/08

CPC分类号： A61L27/56 ,  A61L27/12 ,  A61L2430/06

摘要： A regeneration member which, under nearly natural surroundings, is integrated into adjacent, surrounding, existent articular cartilage under good conditions and which is capable of early regenerating articular cartilage having an original thickness under continuous conditions, and a production method thereof are provided. Also, a regeneration method and a cultivation method, of articular cartilage, in vivo and in vitro are provided. Furthermore, an artificial articular cartilage obtained by these methods is provided. Using a member for articular cartilage regeneration having a hydroxyapatite porous element, having a number of pores distributed therein, substantially all of said pores being three-dimensionally communicated to each other through open portions, a porosity of from 50% to 90%, both inclusive, and an average pore diameter of from 100 μm to 600 μm, both inclusive, articular cartilage is regenerated and cultivated.

摘要翻译： 一种再生部件，其在近乎自然的环境下，在良好的条件下整合到相邻的，周围存在的关节软骨中，并且能够在连续条件下能够早期再生具有原始厚度的关节软骨，并且提供了其生产方法。 此外，提供了体内和体外的关节软骨的再生方法和培养方法。 此外，提供通过这些方法获得的人造关节软骨。 使用具有羟基磷灰石多孔元件的关节软骨再生的成员，其中分布有许多孔，基本上所有的孔通过开口部彼此三维地连通，孔隙率为50％至90％，包括 ，平均孔径为100〜600μm，包括关节软骨再生和培养。