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公开(公告)号：US20240018130A1
公开(公告)日：2024-01-18
申请号：US18368362
申请日：2023-09-14
发明人： Lei Chen , Dongliang Guan , Hua Bai , Jun Gou , Weifeng Zhao , Zhongli Wang , Long Ling , Yutao Ma
IPC分类号： C07D403/14 , C07D403/12 , C07D471/10 , C07D487/10 , A61K31/506 , A61P35/00 , C07D403/04
CPC分类号： C07D403/14 , C07D403/12 , C07D471/10 , C07D487/10 , A61K31/506 , A61P35/00 , C07D403/04 , Y02P20/55
摘要： The present invention relates to a pyrimidine derivative, a method for preparing same and use thereof in medicine. In particular, the present invention relates to a pyrimidine derivative represented by general formula (I), a method for preparing same and a pharmaceutically acceptable salt thereof as well as use thereof as a therapeutic agent, in particular as a FGFR4 kinase inhibitor, definitions of each substituent in the general formula (I) being the same as those defined in the description.
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公开(公告)号：US11827625B2
公开(公告)日：2023-11-28
申请号：US17218380
申请日：2021-03-31
发明人： Lei Chen , Dongliang Guan , Hua Bai , Jun Gou , Weifeng Zhao , Zhongli Wang , Long Ling , Yutao Ma
IPC分类号： A61K31/506 , C07D403/14 , C07D403/12 , C07D471/10 , C07D487/10 , A61P35/00 , C07D403/04
CPC分类号： C07D403/14 , A61K31/506 , A61P35/00 , C07D403/04 , C07D403/12 , C07D471/10 , C07D487/10 , Y02P20/55
摘要： The present invention relates to a pyrimidine derivative, a method for preparing same and use thereof in medicine. In particular, the present invention relates to a pyrimidine derivative represented by general formula (I), a method for preparing same and a pharmaceutically acceptable salt thereof as well as use thereof as a therapeutic agent, in particular as a FGFR4 kinase inhibitor, definitions of each substituent in the general formula (I) being the same as those defined in the description.
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公开(公告)号：US20210221797A1
公开(公告)日：2021-07-22
申请号：US17218380
申请日：2021-03-31
发明人： Lei Chen , Dongliang Guan , Hua Bai , Jun Gou , Weifeng Zhao , Zhongli Wang , Long Ling , Yutao Ma
IPC分类号： C07D403/14 , C07D403/12 , C07D471/10 , C07D487/10 , A61K31/506 , A61P35/00 , C07D403/04
摘要： The present invention relates to a pyrimidine derivative, a method for preparing same and use thereof in medicine. In particular, the present invention relates to a pyrimidine derivative represented by general formula (I), a method for preparing same and a pharmaceutically acceptable salt thereof as well as use thereof as a therapeutic agent, in particular as a FGFR4 kinase inhibitor, definitions of each substituent in the general formula (I) being the same as those defined in the description.
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公开(公告)号：US10364219B2
公开(公告)日：2019-07-30
申请号：US15835649
申请日：2017-12-08
发明人： Hua Bai , Xuyang Zhao , Yuncai Zhang , Xufei Li , Yong Zhang , Dezhou Xu , Li Zhang , Xiaojie Xu , Qifeng Zhu , Xiaoming Wang , Zhiqing Yang , Zehua Zhong , Jian Zhang
IPC分类号： C07D205/08 , C07C67/30 , C07C67/343 , C07C69/65 , C07C69/732 , C07C51/367 , C07C59/56 , C07C67/327
摘要： Disclosed is a new method for preparing an azetidinone compound represented by formula (I). The carboxylic ketoester represented by formula (II) serves as the raw material and is subjected to Grignard addition, stereoselective dehydration, ester group reduction, hydroxyl group protection, addition with imine after condensation with a chiral auxiliary, cyclization and deprotection to obtain the compound represented by formula (I). The present invention has advantages of easily available raw material, a few synthetic steps, simple operation, high yield, good stereoselectivity and low cost, and can be used for industrial production.
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公开(公告)号：US10214515B2
公开(公告)日：2019-02-26
申请号：US15741639
申请日：2016-08-19
发明人： Lei Chen , Dongliang Guan , Hua Bai , Xing Yan , Shuai Miao , Songsong Zhu
IPC分类号： A61K31/4155 , C07D231/38 , C07D403/14 , A61K31/4184 , A61P35/00 , C07D233/06 , C07D233/28 , C07D233/46 , C07D233/48 , C07D401/14
摘要： An indole derivative as expressed by Formula (I), a preparation method thereof, a pharmaceutical salt, and use thereof as a therapeutic agent, especially as a FGFR inhibitor. Each substituent in Formula (I) has identical definition as specified in the specification.
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公开(公告)号：US20180291019A1
公开(公告)日：2018-10-11
申请号：US15766692
申请日：2016-10-11
发明人： Dongliang Guan , Shouyi Sheng , Hua Bai
IPC分类号： C07D471/04 , A61P35/00
摘要： The present invention relates to an acrylic acid derivative as shown in general formula (I), a stereoisomer, tautomer or pharmaceutically acceptable salt thereof, the preparation method thereof, a pharmaceutical composition containing same, and the use thereof as therapeutic agents, in particular as selective estrogen receptor degraders (SERD), wherein the substituents of general formula (I) are the same as those defined in the description.
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公开(公告)号：US09821062B2
公开(公告)日：2017-11-21
申请号：US14758427
申请日：2013-02-06
IPC分类号： C07B47/00 , C07D487/22 , A61K41/00 , C09B23/04 , C07D403/14 , C07D209/60
CPC分类号： A61K41/0057 , A61K41/0071 , C07D209/60 , C07D403/14 , C07D487/22 , C09B23/04
摘要： Disclosed are a cyanine dye compound and a preparation method therefor, and a dual-function agent for photodynamic therapy and a preparation method therefor. The provided cyanine dye compound is connected to multiple markers, which improves the accuracy of combination of dye and tumor cells, effectively reduces the background value, and avoids excessive residues in the liver. The provided cyanine dye compound is conjugated with the photosensitizer at 2′″ position, so that tumor highly absorbs the conjugates.
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公开(公告)号：US09643992B2
公开(公告)日：2017-05-09
申请号：US14389345
申请日：2013-04-01
发明人： Guobin Ren , Changliang Dai , Jinyao Chen , Feng Chen , Minghui Qi , Wenming Zhu , Minghuang Hong , Hua Bai
IPC分类号： C07J17/00
CPC分类号： C07J17/005 , C07B2200/13
摘要： Provided are ginsenoside C-K polymorphic forms and a method for preparing same. The ginsenoside C-K polymorphic forms are crystal form D and crystal form H.
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公开(公告)号：US20150191480A1
公开(公告)日：2015-07-09
申请号：US14411783
申请日：2013-07-03
发明人： Hua Bai , Xuyang Zhao , Jinqing Zhong , Yongxiang Gong , Qifeng Zhu , Xiaoyu Liu , Xiaohe Zheng , Lifei Liu
IPC分类号： C07D491/056 , C07D491/113
CPC分类号： C07D491/056 , A61K31/435 , A61K31/4523 , C07D401/06 , C07D491/04 , C07D491/113
摘要： Provided in the present invention are novel benzodioxole derivatives and preparation methods thereof. These compounds represented by formula (I) or pharmaceutically acceptable salts thereof have acetylcholinesterase inhibitory activity, so can be used in the treatment or prevention of Alzheimer's disease. The definitions of R1, R2 and A of formula (I) can be seen in the description.
摘要翻译： 本发明提供新的苯并间二氧杂环戊烯衍生物及其制备方法。 由式（I）表示的这些化合物或其药学上可接受的盐具有乙酰胆碱酯酶抑制活性，因此可用于治疗或预防阿尔茨海默氏病。 在描述中可以看出式（I）的R1，R2和A的定义。
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公开(公告)号：US09982314B2
公开(公告)日：2018-05-29
申请号：US15028577
申请日：2014-10-14
发明人： Hao Xu , Fei Tang , Peijun Zhan , Jianhong Hu , Huijun Ren , Hongmei Fan , Linghui Zheng , Hua Bai
摘要： A bacterial strain of Actinoplanes sp. and and the use thereof. The bacterial strain is named Actinoplanes sp. HS-16-20, whose preservation number is CGMCC (China General Microbiological Culture Collection Center) No. 7294. The bacterial strain can be used to generate Fidaxomicin or analogs thereof or compositions containing Fidaxomicin, such as by aerobically fermenting the strain in nutrient medium containing assimilable carbon and/or nitrogen sources. Fidaxomicin has an inhibitory effect on various gram positive bacteria pathogens, and in particular, on Clostridium difficile.
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