摘要:
The present invention describes novel cyclic diol derivatives represented by formula I and II: ##STR1## in which Y represents O, S, SO, SO.sub.2, (CH.sub.2).sub.m wherein m is zero or an integer of 1 to 5, or NR.sup.a group wherein R.sup.a is hydrogen, lower alkyl, lower alkoxycarbonyl, aryl, arylalkyl or acyl;R.sup.1 represents an alkyl or alkylcarbamoyl group;R.sup.2 represents a group having formula T--(CH.sub.2).sub.n --V (X.sup.-)q, wherein T refers to a simple covalent bond, a CO, PO.sub.3.sup.-, C(O)O, or CONR.sup.b group wherein R.sup.b is hydrogen, lower alkyl or acyl;n refers to an integer of from 1 to 10;V represents either (i) the group indicated by formula --.sup.+ NR.sup.5 R.sup.6 R.sup.7 wherein R.sup.5, R.sup.6 and R.sup.7 stands for identical or different lower alkyl group, or two or three of R.sup.5, R.sup.6 and R.sup.7 taken together with the adjacent nitrogen form heterocyclic ammonio group, or (ii) the group indicated by the formula ##STR2## wherein R.sup.8 represents lower alkyl group;q is one or zero;X.sup.- represents a pharmaceutically acceptable anion.These compounds are potent PAF antagonists and thus useful for the treatment of the diseases in which PAF is involved.
摘要:
Tridecyloxy- or tetradecyloxy-propane derivatives of the formula: ##STR1## wherein R.sup.1 is tridecyl or tetradecyl, R.sup.2 is hydrogen or --OCH.sub.3, and R.sup.3, R.sup.4 and R.sup.5 independently represent hydrogen or C.sub.1-3 alkyl, or ##STR2## represents cyclic ammonio, and their salts, have inhibitory activity to multiplication of tumor cells and antimicrobial activity.
摘要:
An .omega.-perfluoroalkane sulfonamido-alkane phosphonic or phosphinic acid or salt of the formula ##EQU1## in which R.sub.F is a perfluoroalkyl radical with from 1 to 12 carbon atoms;x and n each independently is 0 or 1,Y is hydrogen or a lower aliphatic radical with up to 5 carbon atoms,Z is an aliphatic radical with up to 5 carbon atoms, a cycloaliphatic, araliphatic or aromatic radical, andR is hydrogen, an alkali metal, alkaline earth metal or ammonium radical.The compounds are useful as surfactants in depressing the surface tension of water.
摘要:
Multi-layered compositions having a plurality of pillared metal complexes disposed on a supporting substrate, the pillars comprising divalent electron acceptor moieties with a phosphonate or arsenate at each end. Each layer of parallel pillars is separated by a layer of a group (IVA), (IVB), (IIIA) or (IIIB) metal or a lanthanide. The compositions can further comprise particles of at least one Group VIII metal at zero valence entrapped within each layer of the complex. The complexes can also incorporate "stalactites" and "stalagmites" of capped arsonato or phosphonato ligands interspersed with the pillars providing a series of interstices about each electron accepting group. The supporting substrate can be comprised of an organic polymer template. The complexes are useful for the conversion and storage of solar energy, for the production of photocurrents, and as catalysts for reduction reactions, for example, the production of hydrogen peroxide from oxygen and hydrogen gases, the production of H.sub.2 gas from water, and the reduction of ketones to form alcohols.
摘要:
A method for the production of hydrogen peroxide from a source of hydrogen and a source of oxygen in the presence of a catalyst comprising the formula:(Y.sup.1 O.sub.3 --Z--Y.sup.2 O.sub.3)(Y.sup.3 O.sub.3 R.sup.3)MeY.sup.1, Y.sup.2 and Y.sup.3 being phosphorus or arsenic; Z being a divalent group containing two conjugated cationic centers; R.sup.3 being a capping group and Me being a trivalent or tetravalent metal.
摘要:
Novel 2,2-disubstituted glycerol-like compounds are disclosed for use as anti-allergic and anti-inflammatory compounds. The compounds are antagonists of platelet activating factor ("PAF"). Also disclosed are methods of synthesizing and using the compounds of the invention as well as pharmaceutical compositions thereof. The compounds have the formula ##STR1## wherein R.sup.1, R.sup.2, R.sup.3, and R.sup.4 are as defined in the specification.
摘要:
The invention is a compound of R or S enantiomers or racemic mixtures of compounds of the formula: ##STR1## wherein: (A) X is(i) C.sub.1 -C.sub.24(ii) C.sub.1 -C.sub.24 alkoxy;(iii) C.sub.1 -C.sub.24 carboamoyloxy; ##STR2## wherein n is an integer from 1 to 25 and m is an integer from 0 to 24 and the sum of n and m is less than or equal to 25;(v) phenyl;(vi) mono-or polysubstituted phenyl substituted with C.sub.1 -C.sub.20 alkoxy, halogen, trifluoromethyl, phenyl, or benzyloxy;(vii) phenoxy;(viii) mono- or polysubstituted phenoxy substituted with C.sub.1 -C.sub.20 alkyl, C.sub.1 -C.sub.20 alkoxy, halogen, trifluoromethyl, phenyl, or benzyloxy;(ix) naphthaloxy;(x) mono- or polysubstituted naphthaloxy substituted with C.sub.1 -C.sub.20 alkyl, C.sub.1 -C.sub.20 alkoxy or halogen;(B) i is an integer from 1 to 3 and j is an integer from 1 to 6;(C) Q is --OR.sub.2, ##STR3## or O--C--R.sub.2, wherein R.sub.2 is hydrogen, C.sub.1 -C.sub.6 alkyl or C.sub.1 -C.sub.6 alkenyl;(D) Y is the divalent radical ##STR4## (E) the moiety R.sub.3 represents one or more C.sub.1 -C.sub.5 alkyl, C.sub.1 -C.sub.5 alkoxy or halogen substituents of the aromatic ring;(F) the moiety --CH.sub.2 A may be in the ortho, meta or para position wherein A is the(i) ##STR5## which are PAF inhibitors.