公开(公告)号：US20240216909A1

公开(公告)日：2024-07-04

申请号：US18604885

申请日：2024-03-14

申请人： Hangzhou Biotest Biotech Co., LTD.

发明人： Shujiang WU ,  John WU ,  Yangyu ZHU ,  Lorraine C. COGAN ,  Liang HONG

IPC分类号： B01L3/00 ,  B01L9/00 ,  G01N33/94

CPC分类号： B01L3/5023 ,  B01L3/502723 ,  B01L3/502746 ,  B01L9/523 ,  G01N33/946 ,  G01N33/948 ,  G01N33/9486 ,  B01L2200/141 ,  B01L2300/0816 ,  B01L2300/0825 ,  B01L2300/0851 ,  B01L2300/0858 ,  B01L2300/0887 ,  B01L2300/12 ,  B01L2300/123 ,  B01L2400/082

摘要： The present invention discloses a detection apparatus, comprising a base layer, wherein the base layer comprises a groove for containing a testing element and a sample chamber for collecting a fluid sample. The detection apparatus can achieve fast, efficient and accurate detection of analytes in liquid samples, make operators to perform testing conveniently and freely, without causing incorrect results. In some preferred modes, the sample chamber comprises a liquid channel.

公开(公告)号：US11980884B2

公开(公告)日：2024-05-14

申请号：US17539430

申请日：2021-12-01

申请人： Hangzhou Biotest Biotech Co., LTD.

发明人： Shujiang Wu ,  John Wu ,  Yangyu Zhu ,  Lorraine C. Cogan ,  Liang Hong

IPC分类号： B01L3/00 ,  B01L9/00 ,  G01N33/94

CPC分类号： B01L3/5023 ,  B01L3/502723 ,  B01L3/502746 ,  B01L9/523 ,  G01N33/946 ,  G01N33/948 ,  G01N33/9486 ,  B01L2200/141 ,  B01L2300/0816 ,  B01L2300/0825 ,  B01L2300/0851 ,  B01L2300/0858 ,  B01L2300/0887 ,  B01L2300/12 ,  B01L2300/123 ,  B01L2400/082

摘要： The present invention discloses a detection apparatus, comprising a base layer, wherein the base layer comprises a groove for containing a testing element and a sample chamber for collecting a fluid sample. The detection apparatus can achieve fast, efficient and accurate detection of analytes in liquid samples, make operators to perform testing conveniently and freely, without causing incorrect results. In some preferred modes, the sample chamber comprises a liquid channel.

公开(公告)号：US11754560B2

公开(公告)日：2023-09-12

申请号：US17408844

申请日：2021-08-23

申请人： HEALGEN SCIENTIFIC LIMITED ,  ZHEJIANG ORIENT GENE BIOTECH CO., LTD

发明人： Siyu Lei ,  Jianqiu Fang ,  Lili Shen

IPC分类号： G01N1/00 ,  G01N33/543 ,  G01N33/94

CPC分类号： G01N33/54366 ,  G01N33/946

摘要： The present invention provides an apparatus for detecting an analyte in a fluid sample, comprising a fluid sample collection element, comprising a fluid sample collection element that comprises an absorbing element; a carrier for accommodating a testing element; and a chamber for accommodating a testing element carrier, wherein the testing element carrier is located in the chamber, and the carrier further comprises an extrusion structure that is in contact with the absorbing element and extrudes the absorbing element.

公开(公告)号：US20230236182A1

公开(公告)日：2023-07-27

申请号：US17999728

申请日：2021-05-26

申请人： COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES ,  UNIVERSITE GRENOBLE ALPES ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE

发明人： Thomas ALAVA ,  Pascal MAILLEY ,  Yanxia HOU-BROUTIN ,  Loic LEROY

IPC分类号： G01N33/543 ,  G01N33/569 ,  G01N33/94 ,  G01N21/552

CPC分类号： G01N33/54373 ,  G01N33/56911 ,  G01N33/946 ,  G01N21/553 ,  G01N2333/245 ,  G01N2333/974

摘要： A sensor may include a prism having a first face; a metal first layer covering, via a contact face, the first face; a light source; and a matrix-array detector; the device may include a dielectric second layer on which rests a transistor including a sheet made of a two-dimensional material, intended to form a channel region, a front face of the sheet comprising a specific functionalization via which specific targets are liable to be adsorbed, the specific functionalization being suitable for placing the adsorbed specific targets at a smaller distance Dd below which detection via electrical measurement by means of the specific transistor and via measurement of resonance of surface plasmons is possible.

公开(公告)号：US20180011079A1

公开(公告)日：2018-01-11

申请号：US15611327

申请日：2017-06-01

申请人： Healgen Scientific Limited ,  Zhejiang Orient Gene Biotech Co., LTD.

发明人： Jianqiu Fang ,  Siyu Lei

IPC分类号： G01N33/493 ,  A61B10/00 ,  B01L3/00 ,  G01N33/94

CPC分类号： G01N33/493 ,  A61B10/007 ,  A61B10/0096 ,  A61B2010/0003 ,  A61B2010/0009 ,  B01L3/502 ,  B01L3/508 ,  B01L3/50853 ,  B01L2200/025 ,  B01L2200/141 ,  B01L2200/143 ,  B01L2200/145 ,  B01L2300/041 ,  B01L2300/046 ,  B01L2300/0609 ,  B01L2300/0627 ,  B01L2300/0663 ,  B01L2300/0825 ,  B01L2300/0832 ,  B01L2300/0848 ,  B01L2300/123 ,  B65D41/0471 ,  G01N33/94 ,  G01N33/946 ,  G01N33/948 ,  G01N33/9486

摘要： The present invention provides an apparatus for detecting the presence or absence of an analyte in liquid sample, including: a collection chamber, including an opening for collecting a liquid sample; a testing element for testing the analyte in liquid sample; and a cover for covering the opening of the collection chamber; wherein the apparatus further includes a prompting device for prompting if the cover is covered to a specified location, and the prompting device shall at least includes a first element and a second element, the first element is in contact with the second element, wherein one element vibrates to produce a sound. In some preferred ways, the second element produces friction with the first element, to cause one of the elements to generate vibrations. The apparatus in the present invention can allow the prompting sound to be clear and loud.

公开(公告)号：US09804178B2

公开(公告)日：2017-10-31

申请号：US14930242

申请日：2015-11-02

申请人： Daniel Roncancio ,  Haixiang Yu ,  Xiaowen Xu ,  Yi Xiao

发明人： Daniel Roncancio ,  Haixiang Yu ,  Xiaowen Xu ,  Yi Xiao

IPC分类号： C07H21/02 ,  C07H21/04 ,  G01N33/94 ,  C12N15/115 ,  A61K31/70

CPC分类号： G01N33/946 ,  C12N15/115 ,  C12N2310/16 ,  C12N2320/10

摘要： The invention pertains to a rapid and specific aptamer-based method for one-step cocaine detection with minimal reagent requirements based on an aptamer sensor that reports the presence of cocaine via the displacement and unquenching of a bound fluorophore molecule. In certain embodiments, the invention provides novel aptamers, which have reduced background fluorescence, bind a fluorophore molecule tightly, and show an increased signal gain in the presence of cocaine.

公开(公告)号：US09599628B2

公开(公告)日：2017-03-21

申请号：US15064532

申请日：2016-03-08

申请人： University of Utah Research Foundation

发明人： Jennifer M. Heemstra

IPC分类号： C12Q1/68 ,  G01N33/53 ,  G01N33/94 ,  G01N33/74 ,  C12N15/115

CPC分类号： G01N33/9486 ,  C12N15/115 ,  C12N2310/16 ,  C12N2310/351 ,  C12N2320/10 ,  G01N33/53 ,  G01N33/5308 ,  G01N33/743 ,  G01N33/94 ,  G01N33/946 ,  G01N2400/00

摘要： Methods, assays, and products for the detection of small molecules are provided. In one aspect, for example, a method of detecting a small molecule in a sample can include reacting together a first half of a DNA split aptamer having a first reactive group coupled thereto, a second half of a DNA split aptamer having a second reactive group coupled thereto, where the DNA split aptamer is selective for the small molecule, and a sample containing the small molecule. The first half and the second half bind to the small molecule and the first reactive group and the second reactive group react to form an aptamer ligation product of the first half and the second half. The method can also include assaying for the aptamer ligation product in order to detect the small molecule presence in the sample.

公开(公告)号：US20160375131A1

公开(公告)日：2016-12-29

申请号：US15189930

申请日：2016-06-22

申请人： ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY ,  REGENTS OF THE UNIVERSITY OF MINNESOTA

发明人： Yung Chang ,  Sidney Hecht ,  Joseph Leal ,  Viswanath Arutla ,  Xiaowei Liu ,  Sriram Sokalingam ,  Paul Pentel

IPC分类号： A61K39/385 ,  G01N33/94 ,  G06F19/16 ,  G06F19/18 ,  C07D401/14 ,  A61K47/48

CPC分类号： A61K39/385 ,  A61K39/0013 ,  A61K47/646 ,  A61K2039/6012 ,  C07D401/14 ,  G01N33/946 ,  G06F19/16 ,  G06F19/18

摘要： Provided herein are methods for rational design of nicotine haptens. More particularly, provided herein are methods for designing, selecting, and synthesizing nicotine haptens and nicotine hapten conjugates. Also provided herein are novel nicotine haptens and methods for using nicotine haptens to treat nicotine addiction.

摘要翻译： 本文提供了尼古丁半抗原合理设计的方法。 更具体地，本文提供了用于设计，选择和合成尼古丁半抗原和尼古丁半抗原共轭物的方法。 本文还提供了新型尼古丁半抗原以及使用尼古丁半抗原来治疗尼古丁成瘾的方法。

公开(公告)号：US09279805B2

公开(公告)日：2016-03-08

申请号：US14288240

申请日：2014-05-27

申请人： University of Utah Research Foundation

发明人： Jennifer M. Heemstra

IPC分类号： C12N15/115 ,  G01N33/53 ,  G01N33/94 ,  G01N33/74

CPC分类号： G01N33/9486 ,  C12N15/115 ,  C12N2310/16 ,  C12N2310/351 ,  C12N2320/10 ,  G01N33/53 ,  G01N33/5308 ,  G01N33/743 ,  G01N33/94 ,  G01N33/946 ,  G01N2400/00

摘要： Methods, assays, and products for the detection of small molecules are provided. In one aspect, for example, a method of detecting a small molecule in a sample can include reacting together a first half of a DNA split aptamer having a first reactive group coupled thereto, a second half of a DNA split aptamer having a second reactive group coupled thereto, where the DNA split aptamer is selective for the small molecule, and a sample containing the small molecule. The first half and the second half bind to the small molecule and the first reactive group and the second reactive group react to form an aptamer ligation product of the first half and the second half. The method can also include assaying for the aptamer ligation product in order to detect the small molecule presence in the sample.

摘要翻译： 提供了用于检测小分子的方法，测定和产物。 在一个方面，例如，检测样品中的小分子的方法可以包括将具有与其偶联的第一反应性基团的DNA裂解适体的第一半一起反应，具有第二反应性基团的DNA裂解适体的第二半 其中DNA裂解适体对小分子是选择性的，以及含有小分子的样品。 上半部和第二半部分与小分子结合，第一反应基团和第二反应基团反应形成上半部和下半部分的适体连接产物。 该方法还可以包括测定适体连接产物以检测样品中的小分子存在。

公开(公告)号：US20160025752A1

公开(公告)日：2016-01-28

申请号：US14747659

申请日：2015-06-23

申请人： Seed Research and Development, LLC

发明人： Frank Santiago ,  Leanna M. Levine ,  Rafael de la Torre Fornell ,  Magin Farre Albaladejo

IPC分类号： G01N33/94

CPC分类号： G01N33/948 ,  B01L3/5023 ,  B01L2200/027 ,  B01L2300/043 ,  B01L2300/047 ,  B01L2300/0825 ,  B01L2400/0406 ,  B01L2400/0683 ,  G01N15/0612 ,  G01N21/8483 ,  G01N33/94 ,  G01N33/946 ,  G01N2015/0065 ,  G01N2021/8488 ,  G01N2035/00108 ,  G08C17/02

摘要： The present disclosure relates to devices and methods for determining a target analyte in a sample (e.g., a bodily fluid sample such as sweat, blood, urine, lavage, plasma, saliva, tears) using an analysis device (e.g., a bodily fluid analysis device). The device may include a lateral flow assay in some embodiments. Certain embodiments involve determining a concentration of a target analyte in a sample by generating a volumetric calculation of the sample and/or by use of a non-target analyte. The devices and methods can be used for obtaining and processing a sample to determine the presence and/or concentration of such analytes. In some cases, the methods and/or devices can be used to determine impairment (e.g., drug impairment) in a subject.

摘要翻译： 本公开涉及使用分析装置（例如，体液分析法）来确定样品中的目标分析物（例如，体液样品，例如汗液，血液，尿液，灌洗液，血浆，唾液，眼泪）的装置和方法 设备）。 在一些实施方案中，该装置可以包括侧流测定。 某些实施方案涉及通过产生样品的体积计算和/或通过使用非目标分析物来确定样品中目标分析物的浓度。 这些装置和方法可用于获得和处理样品以确定这些分析物的存在和/或浓度。 在某些情况下，方法和/或装置可用于确定受试者的损伤（例如药物损伤）。