-
公开(公告)号:US20220365093A1
公开(公告)日:2022-11-17
申请号:US17721054
申请日:2022-04-14
摘要: Methods of identifying a compound, such as a test compound, and applications thereof are provided. For example, methods of identifying a compound that preferentially affects, increases, or decreases a level of association of a macromolecule with one or more target condensates or methods of identifying a compound that preferentially causes a macromolecule to associate or disassociate with one or more target condensates are provided. Additionally, methods of designing and/or identifying and/or making a compound, or portion thereof, with a desired characteristic are provided.
-
公开(公告)号:US11459400B2
公开(公告)日:2022-10-04
申请号:US15745496
申请日:2016-07-15
发明人: Shohei Koide , Shun-Ichi Tanaka , Akiko Koide
IPC分类号: G01N33/53 , G01N33/569 , G01N33/573 , C07K16/40 , C12Q1/26 , C12Q1/34 , C12Q1/48 , C12Q1/527 , C12Q1/533 , C12Q1/00 , C12N9/38 , C07K14/78 , C12N9/20 , C12Q1/25 , G01N33/58 , G01N33/60
摘要: Aspects of the disclosure relate to compositions of enzyme-binding polypeptides (EBPs) that modify the substrate specificity of an enzyme and a method for identifying an EBP that modifies substrate specificity of an enzyme binding at least one substrate, the method comprising: contacting the enzyme with a polypeptide library comprising a plurality of EBPs that bind different epitopes of the enzyme; identifying EBPs that bind to the enzyme to form an EBP-enzyme complex; assaying for the activity level and substrate specificity of the EBP-enzyme complex; and identifying EBPs that modify the substrate specificity of the enzyme by identifying EBPs that, when in an EBP-enzyme complex, have a different substrate specificity than un-complexed EBP; wherein the catalytic rate constant of the EBP-enzyme complex is ≥50% of the un-complexed enzyme for at least one substrate and/or wherein the EBP-enzyme complex retains binding to a substrate.
-
公开(公告)号:US20220298216A1
公开(公告)日:2022-09-22
申请号:US17832813
申请日:2022-06-06
申请人: James L. Hougland
发明人: James L. Hougland
IPC分类号: C07K14/63 , G01N33/58 , G01N33/573 , G01N33/60
摘要: Imaging agents that can bind to ghrelin O-acyltransferase (GOAT) without binding to the ghrelin receptor (GHS-R1a). The imaging agents comprise a base structure for selective binding to GOAT that is coupled via an amino acid linker to a chemical group to enable imaging such as a fluorescent label, radioactive tracer, or metal chelator. For example, the imaging agent may comprise a ghrelin substrate mimetic inhibitor incorporating an unmodified 2,3-diaminopropanoic acid (Dap) group at the site analogous to serine 3. These agents enable specific detection and imaging of GOAT versus the GHS-R1a receptor in a variety of biological contexts.
-
公开(公告)号:US20220236259A1
公开(公告)日:2022-07-28
申请号:US17658119
申请日:2022-04-06
发明人: Kayla Cortese , Saji Cherian , Paul D'Agostino , Gabriel Hammarquist , Aili Han , Kuldeep Jaggi , Maral Poladian , Niver Sahakian , Seema Sinha , Prakash Tewari , Haekyung Lee
IPC分类号: G01N33/543 , G01N33/58 , G01N33/60
摘要: Disclosed herein are immunoassays for detecting an anti-thyroid peroxidase antibody in a biological sample from a subject and/or diagnosing a thyroid disease in a subject. The disclosed immunoassays employ a recombinant cynomolgus monkey thyroid peroxidase (rTPO) and assess the level of anti-thyroid peroxidase antibody-induced formation or disruption of complexes comprising a solid support and the rTPO.
-
5.
公开(公告)号:US11385144B2
公开(公告)日:2022-07-12
申请号:US16079451
申请日:2017-02-23
申请人: NOUL CO., LTD.
发明人: Dong Young Lee , Chan Yang Lim , Kyung Hwan Kim
IPC分类号: G01N1/31 , G01N1/30 , C12Q1/6844 , C12Q1/6848 , G01N33/50 , G01N21/77 , G01N33/558 , B01L3/00 , G01N15/06 , G01N33/52 , G01N33/574 , G01N15/14 , G01N33/49 , G01N33/60 , C12Q1/686 , C07K16/30 , C12Q1/70 , G01N33/483 , G06T7/00 , G01N33/53 , G01N33/533 , B01L7/00 , G01N15/00
摘要: The present disclosure relates to an immunoassay method for performing immunoassay by using a patch that contains antibodies. An immunoassay method according to an aspect of the present disclosure performs diagnosis by detecting a target protein from a sample to be diagnosed by using a patch which includes a mesh structural body forming micro-cavities and is configured to contain a liquid substance in the micro-cavities, and includes placing the sample to be diagnosed in a reaction region, and providing an antibodies that react specifically with a target protein to the reaction region by using a patch that contains the antibodies.
-
6.
公开(公告)号:US11353457B2
公开(公告)日:2022-06-07
申请号:US16916273
申请日:2020-06-30
发明人: Jyotsna S. Shah , Song Liu
IPC分类号: G01N33/569 , G01N33/58 , G01N33/68 , G01N33/60
摘要: Compositions and methods for the detection and identification of Tick-Borne Relapsing Fever Borrelia sp. antibodies.
-
公开(公告)号:US20220024882A1
公开(公告)日:2022-01-27
申请号:US17298321
申请日:2019-11-28
发明人: Martina Benesova , Cristina Müller , Christoph Umbricht , Roger Schibli , Konstantin Zhernosekov , Luisa Maria Deberle
IPC分类号: C07D257/02 , A61K51/04 , A61P35/00 , G01N33/60
摘要: The present invention provides compounds according to General Formula (1)(i) or (1)(ii): wherein A is a diagnostic or therapeutic agent comprising a binding site for a tumor antigen, and the spacer comprises at least one C—N bond.
-
公开(公告)号:US11084873B2
公开(公告)日:2021-08-10
申请号:US16426585
申请日:2019-05-30
发明人: Feng-Shiun Shie , Tsu-An Hsu , Chuan Shih , Santai Shen
摘要: An isolated antibody, comprising a light-chain CDR1 (L-CDR1) having the sequence of SEQ ID NO: 1, SEQ ID NO: 7, or SEQ ID NO: 14; a light-chain CDR2 (L-CDR2) having the sequence of SEQ ID NO: 2 or SEQ ID NO: 15; a light-chain CDR3 (L-CDR3) having the sequence of SEQ ID NO: 3, SEQ ID NO: 8, SEQ ID NO: 21, or SEQ ID NO: 24; a heavy-chain CDR1 (H-CDR1) having the sequence of SEQ ID NO: 4, SEQ ID NO: 9, SEQ ID NO: 11, SEQ ID NO: 16, or SEQ ID NO: 25; a heavy-chain CDR2 (H-CDR2) having the sequence of SEQ ID NO: 5, SEQ ID NO: 12, SEQ ID NO: 17, SEQ ID NO: 19, SEQ ID NO: 22, or SEQ ID NO: 26; and a heavy-chain CDR3 (H-CDR3) having the sequence of SEQ ID NO: 6, SEQ ID NO: 10, SEQ ID NO: 13, SEQ ID NO: 18, SEQ ID NO: 20, SEQ ID NO: 23, or SEQ ID NO: 27, wherein the antibody specifically binds to Aβ1-42 or an N-terminal modified form thereof.
-
公开(公告)号:US20210208153A1
公开(公告)日:2021-07-08
申请号:US17203005
申请日:2021-03-16
摘要: Methods of identifying a compound, such as a test compound, and applications thereof are provided. For example, methods of identifying a compound that preferentially affects, increases, or decreases a level of association of a macromolecule with one or more target condensates or methods of identifying a compound that preferentially causes a macromolecule to associate or disassociate with one or more target condensates are provided. Additionally, methods of designing and/or identifying and/or making a compound, or portion thereof, with a desired characteristic are provided.
-
公开(公告)号:US11040119B2
公开(公告)日:2021-06-22
申请号:US14774510
申请日:2014-03-12
申请人: Biogen MA Inc.
发明人: Ajay Verma , Jack Hoppin
摘要: The invention provides compositions and methods for evaluating neuromuscular function in a subject, e.g., a subject at risk for or suffering from a neuromuscular disorder.
-
-
-
-
-
-
-
-
-