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公开(公告)号：US20210033837A1
公开(公告)日：2021-02-04
申请号：US16622542
申请日：2018-06-15
发明人： Kishan DHOLAKIA
摘要： A light sheet imaging system, such as a light sheet microscope, comprises an illumination arrangement for generating a light sheet for three-photon excitation of a fluorescent sample, and a fluorescence collection arrangement for collecting fluorescence generated in the sample as a result of three-photon excitation by the light sheet. The light sheet may be a non-diffractive, propagation-invariant light sheet. The light sheet may be formed from and/or comprise a Bessel beam. A method of light sheet imaging comprises using a light sheet for three-photon excitation of a fluorescent sample, and collecting fluorescence generated in the sample as a result of three-photon excitation of the sample by the light sheet. Such a method may be used for light sheet microscopy.
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公开(公告)号：US20190242752A1
公开(公告)日：2019-08-08
申请号：US16333192
申请日：2017-09-13
发明人： Kishan DHOLAKIA , Mingzhou CHEN
CPC分类号： G01J3/4412 , G01J3/0218 , G01J3/0262 , G01J3/0272 , G01J3/44 , G01J3/4406 , G01N21/65 , G01N2021/651
摘要： A Raman system for use in performing Raman spectroscopy on a sample, comprises an optical source, a spectrometer, and an optical system for coupling light from the optical source to a sample and for coupling light from the sample to the spectrometer and a further spectrometer. A Raman system for use in performing Raman spectroscopy on a sample, comprises an optical source, a spectrometer and an optical system for coupling light from the optical source and a further optical source to a sample and for coupling light from the sample to the spectrometer. The optical system may be configured for coupling light from the optical source and the further optical source to the sample and for coupling light from the sample to the spectrometer and the further spectrometer. The Raman system may be portable and/or may be configured to be transported and/or carried and/or may be handheld.
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公开(公告)号：US10236454B2
公开(公告)日：2019-03-19
申请号：US14944427
申请日：2015-11-18
发明人： Eli Zysman-Colman , Adam Henwood
摘要： Cationic iridium III complexes including a ligand according to formula I are provided. The linking group Z is a hydrocarbylene linking group comprising at least two carbon atoms in a chain. Ligands according to formula I have increased rigidity about the central bond linking the two five membered rings by virtue of the linking group Z, when compared to previous biimidazole related ligands. Increased photoluminescence quantum yield may been obtained in cationic iridium III complexes provided with these ligands.
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公开(公告)号：US10019217B2
公开(公告)日：2018-07-10
申请号：US13999355
申请日：2014-02-12
发明人： Jakub Dostal , Per Ola Kristensson , Aaron Quigley
CPC分类号： G06F3/1423 , G06F3/013 , G09G5/00 , G09G5/10 , G09G5/14 , G09G2320/103 , G09G2340/10 , G09G2340/12 , G09G2340/14 , G09G2354/00
摘要： A computer processor based method for controlling a plurality of computer displays in response to user behavior, the method comprising identifying at least one display that is unattended by the user by determining the user's visual focus, and applying an overlay window to the unattended display to control visualization of the identified unattended display.
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公开(公告)号：US09814385B2
公开(公告)日：2017-11-14
申请号：US14889730
申请日：2014-05-02
申请人： London School of Hygiene and Tropical Medicine , The Greater Glasgow Health Board , The University Court of the University of St Andrews
CPC分类号： A61B3/14 , A61B3/0008 , A61B3/0025 , A61B3/12 , A61B3/145 , A61B2576/02 , G06T3/4053
摘要： The invention relates to an ophthalmoscope comprising a camera and an associated illumination device; the invention further concerns a novel method for processing a plurality of images of the eye taken by said device; and software, typically included in said ophthalmoscope, for executing said method.
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公开(公告)号：US20170261761A1
公开(公告)日：2017-09-14
申请号：US15388745
申请日：2016-12-22
IPC分类号： G02B27/58
CPC分类号： G02B27/58 , G02B2207/125
摘要： A method of minimizing cross-talk between optical modes propagating in a multi-mode optical fiber, comprises superimposing a plurality of optical wavefunctions; determining a relationship between superpositions of at least some of the optical wavefunctions and at least one measure of orthogonality of the optical modes at an output of the multi-mode optical fiber; and identifying a superposition of at least some of the optical wavefunctions that provides a desired or optimized value of the at least one measure of orthogonality using the determined relationship. The method further comprises generating, using light from a laser and at least one optical component, the identified superposition of at least some of the optical wavefunctions that provides the desired or optimized value of the at least one measure of orthogonality.
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公开(公告)号：US09670109B2
公开(公告)日：2017-06-06
申请号：US14428013
申请日：2013-09-11
CPC分类号： C07C1/20 , C07C37/003 , C07C37/50 , C07C39/19 , C07C41/03 , C07C2531/22 , C07C2531/28 , Y02P30/42 , C07C11/02 , C07C11/12 , C07C11/21 , C07C39/06 , C07C43/23
摘要： The invention provides a method of alkene metathesis comprising contacting at least a first alkene, which is cardanol and/or anacardic acid, with an alkylidene ruthenium alkene metathesis catalyst comprising two ligands P1 and P2, which may be the same or different and of formula P(R1)3, in which P is a phosphorus atom coordinated to the ruthenium ion and each R1 is independently an optionally substituted alkyl or alkoxy group; or two R1 groups within one P1 or P2 ligand constitute an optionally substituted bicycloalkyl.
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98.发明授权公开(公告)号：US09669118B2
公开(公告)日：2017-06-06
申请号：US14125978
申请日：2012-06-11
申请人： David O'Hagan , Xiang-Guo Li
发明人： David O'Hagan , Xiang-Guo Li
CPC分类号： A61K51/0491 , A61K51/08 , A61K51/088
摘要： The invention provides a conjugate of a biologically active molecule and a 5-fluoro-5-deoxypentose or a 3-fluoro-3-deoxypentose, wherein the biologically active molecule is selected from the group consisting of proteins, peptides, nucleic acids, oligosaccharides and polysaccharides.
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公开(公告)号：US09581796B2
公开(公告)日：2017-02-28
申请号：US13497578
申请日：2010-09-03
CPC分类号： G02B17/086 , G02B1/002 , G02B3/0087 , G02B27/58
摘要： The resolution of conventional imaging devices is restricted by the diffraction limit. ‘Perfect’ imaging devices which can achieve a resolution beyond the diffraction limit have been considered impossible to implement. However, the present disclosure provides an imaging device which can achieve improved resolution beyond the diffraction limit and which can be implemented in practice. Said imaging device comprises: a. a lens having a refractive index that varies according to a predetermined refractive index profile; b. a source; c. an outlet for decoupling waves from the device; and d. a reflector provided around the lens, the source and the outlet, wherein the reflector and the refractive index profile of the lens are together arranged to direct waves transmitted in any of a plurality of directions from the source to the outlet.
摘要翻译： 常规成像装置的分辨率受到衍射极限的限制。 可以实现超出衍射极限的分辨率的“完美”成像装置被认为是不可能实现的。 然而，本公开提供了一种成像装置，其可以实现超出衍射极限的改进的分辨率，并且可以在实践中实现。 所述成像装置包括：a。 具有根据预定折射率分布变化的折射率的透镜; b。 来源; C。 用于将波从设备中去耦的出口; 和d。 设置在透镜周围的反射器，源和出口，其中反射器和透镜的折射率分布在一起布置成将从多个方向中的任一个方向传输的波导向出射口。
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公开(公告)号：US09568741B2
公开(公告)日：2017-02-14
申请号：US13640453
申请日：2011-04-13
CPC分类号： G02B27/58 , G02B2207/125
摘要： A method of optimising at least one measure that is a quadratic function of a wavefunction, such as the spot size of a laser, the method comprising: superimposing a plurality of wavefunctions; determining a relationship between the superimposed wavefunctions and the quadratic measure, and using the determined relationship to identify the superimposed wavefunctions that provide a desired or optimised quadratic measure.
摘要翻译： 一种优化作为波函数的二次函数的至少一个度量的方法，例如激光器的光斑尺寸，该方法包括：叠加多个波函数; 确定叠加的波函数和二次测量之间的关系，并且使用确定的关系来识别提供期望或优化的二次方法的叠加波函数。
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