公开(公告)号：US10047126B2

公开(公告)日：2018-08-14

申请号：US15301310

申请日：2015-04-01

Applicant: Monash University

Inventor： Jian Li ,  Roger Nation ,  Tony Velkov ,  Philip Thompson ,  Kade D. Roberts

IPC: C07K7/62 ,  A61K38/12 ,  A61K38/00

Abstract: The present invention relates to antimicrobial compounds and their uses, and in particular to peptide antibiotics which may be used in the treatment of bacterial infections such as Gram-negative bacterial infections, particularly those caused by multidrug-resistant (MDR) pathogens.

公开(公告)号：US20180223287A1

公开(公告)日：2018-08-09

申请号：US15747697

申请日：2016-07-29

Applicant: Monash University

Inventor： Siew Yeen Chai ,  Robert Widdop ,  Tracey Gaspari ,  Huey Wen Lee

IPC: C12N15/113 ,  A61P9/00 ,  A61P13/12 ,  A61P1/16 ,  A61K31/4433 ,  A61K31/351 ,  A61K31/395

CPC classification number: C12N15/1137 ,  A61K31/351 ,  A61K31/395 ,  A61K31/4433 ,  A61K31/4709 ,  A61K31/55 ,  A61P1/16 ,  A61P9/00 ,  A61P13/12 ,  C12N2310/14

Abstract: The present invention relates to a method for the treatment of fibrosis, in particular cardiac fibrosis, comprising the administration of an inhibitor of insulin-regulated aminopeptidase (IRAP). Preferable the IRAP inhibitor is chosen from the group including HFI-419, HA-08, AL-40, HFI-437, Val-Tyr-Ile-His-Pro-Phe (otherwise known as angiotensin IV or ANG IV), c[Cys-Tyr-Cys]-His-Pro-Phe, and c[Hcy-Tyr-Hcy]-His-Pro-Phe.

公开(公告)号：US10011602B2

公开(公告)日：2018-07-03

申请号：US14413164

申请日：2013-07-05

Applicant: THE UNIVERSITY OF MELBOURNE ,  MONASH UNIVERSITY ,  THE UNIVERSITY OF QUEENSLAND

Inventor： Lars Kjer-Nielsen ,  James McCluskey ,  Alexandra Corbett ,  Jamie Rossjohn ,  Patel Onisha ,  David Paul Fairlie ,  Ligong Liu

IPC: C07D475/02 ,  C07D475/04 ,  G01N33/50 ,  A61K38/17 ,  C07K14/74 ,  C12N5/0783 ,  G01N33/569

CPC classification number: C07D475/04 ,  A61K38/1774 ,  C07D475/02 ,  C07K14/70539 ,  C07K2299/00 ,  C12N5/0636 ,  C12N2500/46 ,  G01N33/505 ,  G01N33/56972 ,  G01N2333/70539

Abstract: The present invention provides a ligand which binds to MR1 wherein said binding results in binding of the MR1 to MAIT cells.

公开(公告)号：US20170335001A1

公开(公告)日：2017-11-23

申请号：US15205966

申请日：2016-07-08

Applicant: KaloBios Pharmaceuticals, Inc. ,  Monash University ,  Ludwig Institute for Cancer Research

Inventor： Martin Lackmann ,  Andrew Mark Scott ,  Catherine To ,  Christopher R. Bebbington ,  Geoffrey T. Yarranton ,  Mark Baer ,  Varghese Palath

IPC: C07K16/28 ,  G01N33/574

CPC classification number: C07K16/2866 ,  G01N33/57492 ,  G01N2333/70585 ,  G01N2333/70589 ,  G01N2800/52

Abstract: The invention provides methods and compositions for detecting non-hematopoietic, non-tumor EphA3-expressing cells in cancer patients and for monitoring the prognosis of patients using EphA3.

公开(公告)号：US20170190698A1

公开(公告)日：2017-07-06

申请号：US15321693

申请日：2015-06-26

Applicant: MONASH UNIVERSITY ,  UNIVERSITY OF SOUTH AUSTRALIA ,  SA PATHOLOGY

Inventor： Bernard Luke Flynn ,  Luigi Aurelio ,  Carmen Vittoria Scullino ,  Bing Hui Wang ,  Stuart Maxwell Pitson ,  Melissa Rose Pitman

IPC: C07D419/12 ,  C07D285/135 ,  C07D271/07 ,  C07D285/08 ,  C07D271/10 ,  C07D413/12 ,  C07D413/10 ,  C07D271/107 ,  C07D271/113 ,  C07D277/56

CPC classification number: C07D285/08 ,  C07D271/06 ,  C07D271/07 ,  C07D271/10 ,  C07D271/107 ,  C07D271/113 ,  C07D277/56 ,  C07D285/135 ,  C07D413/10 ,  C07D413/12 ,  C07D419/12

Abstract: The present disclosure relates generally, but not exclusively, to compounds and their use as enzyme interacting agents, in particular, agents which interact with one or more enzymes in the sphingolipid biosynthesis pathway. The disclosure further relates to the use of such compounds as research tools, use in therapy, to compositions and agents comprising said compounds, and to methods of treatment using said compounds.

公开(公告)号：US20170144112A1

公开(公告)日：2017-05-25

申请号：US15129890

申请日：2015-04-22

Applicant: MONASH UNIVERSITY

Inventor： Huanting WANG ,  Kun WANG

IPC: B01D71/68 ,  C08J5/22 ,  B01D69/02 ,  B01J41/13 ,  B01D61/14 ,  B01D69/14

CPC classification number: B01D71/68 ,  B01D61/145 ,  B01D69/02 ,  B01D69/141 ,  B01D71/16 ,  B01D71/34 ,  B01D71/42 ,  B01D71/82 ,  B01D2323/02 ,  B01D2325/16 ,  B01D2325/20 ,  B01D2325/36 ,  B01J41/13 ,  C08J5/22 ,  C08J5/2256 ,  C08J2381/06 ,  C08J2481/06

Abstract: An ultrafiltration membrane comprising: (i) a first polymer, and (ii) a second, charged polymer wherein the first polymer and second polymer have different hydrophobicities.

公开(公告)号：US20170116444A1

公开(公告)日：2017-04-27

申请号：US15331140

申请日：2016-10-21

Applicant: Monash University

Inventor： Nemai Chandra Karmakar ,  Mohammad Zomorrodi

IPC: G06K7/10

CPC classification number: G06K7/10356 ,  G01S3/00 ,  G01S3/08 ,  G01S13/74 ,  G06K7/10316 ,  G06K7/10366 ,  G06K19/0672 ,  H01Q1/00 ,  H01Q1/2216 ,  H01Q1/2225 ,  H01Q15/0006 ,  H04B5/0062 ,  H04B7/00 ,  H04B7/04 ,  H04B7/10

Abstract: A mm-wave RFID tag interrogation apparatus includes multiple transmitting antennas, and multiple receiving antennas. The transmitting and receiving antennas are spatially distributed and oriented in orthogonal polarisation states. A transmitter is coupled to the transmitting antennas, and transmits a corresponding multiple number of separable mm-wave signals. A receiver coupled to the receiving antennas is configured to extract separable components of received mm-wave signals. A processing unit processes the extracted signal components using a synthetic aperture algorithm. An RFID tag, readable by the interrogation apparatus, includes meander-line conductive elements arranged to encode information spatially on a substrate.

公开(公告)号：US20170020438A1

公开(公告)日：2017-01-26

申请号：US15302364

申请日：2014-05-02

Applicant: Monash University

Inventor： Stephen Jia Wang

IPC: A61B5/00 ,  G01L1/00 ,  G06F3/01 ,  A61B5/103 ,  A61B5/117

CPC classification number: A61B5/4561 ,  A61B5/0022 ,  A61B5/1036 ,  A61B5/1116 ,  A61B5/117 ,  A61B5/6891 ,  A61B5/743 ,  A61B2562/0247 ,  A61B2562/046 ,  A61G7/057 ,  A61G2203/34 ,  G01L1/00 ,  G01L1/2287 ,  G06F3/011

Abstract: A posture of a user is monitored by obtaining first pressure sensor information from a plurality of sensors upon a first item of furniture occupied by the user at a first time. First sensor position information defining the relative positions of the sensors upon the first item of furniture is also obtained. The first pressure sensor information and the first sensor position information are processed to determine a first user posture upon the first item of furniture. User posture is monitored over time and/or upon different items of furniture, and a cumulative load upon the user's spine over time is determined.

Abstract translation: 通过在第一时间由用户占用的第一家具件获得来自多个传感器的第一压力传感器信息来监视用户的姿势。 还获得了第一传感器位置信息，其定义了传感器在第一物品上的相对位置。 处理第一压力传感器信息和第一传感器位置信息以确定第一物品上的第一用户姿势。 随着时间的推移和/或在不同的家具项目上监视用户姿势，并确定用户脊柱随时间的累积负荷。

公开(公告)号：US20160074346A1

公开(公告)日：2016-03-17

申请号：US14785059

申请日：2014-04-16

Applicant: Monash University

Inventor： Johanna Elisabeth FRASER ,  David Andrew JANS ,  Kylie Michelle WAGSTAFF

IPC: A61K31/167 ,  A61K31/203

CPC classification number: A61K31/167 ,  A61K31/203 ,  Y02A50/382 ,  Y02A50/385 ,  Y02A50/387 ,  Y02A50/389 ,  Y02A50/393

Abstract: This invention relates to methods of treating or preventing viral infections caused by flaviviruses, such as dengue virus, yellow fever virus, West Nile virus or Japanese encephalitis virus or infections caused by Chikungunya virus (CHIKV). The methods involve the administration of retinoic acid analogues to subjects who have, are suspected of having a flavivirus infection or infection with CHIKV, or to those who are at risk of becoming infected with a flavivirus or becoming infected with CHIKV.

Abstract translation: 本发明涉及治疗或预防由诸如登革热病毒，黄热病病毒，西尼罗河病毒或日本脑炎病毒或基孔肯雅病毒（CHIKV）引起的感染引起的病毒感染的方法。 所述方法涉及将具有怀疑患有黄病毒感染或感染CHIKV的受试者或具有被感染黄病毒或被感染CHIKV的风险的受试者施用视黄酸类似物。

公开(公告)号：US09108978B2

公开(公告)日：2015-08-18

申请号：US14346646

申请日：2012-09-21

Applicant: ADELAIDE RESEARCH & INNOVATION PTY LTD ,  MONASH UNIVERSITY

Inventor： Andrew Abell ,  Steven Polyak ,  Grant Booker ,  John Wallace ,  Tatiana Soares da Costa ,  Angie Jarrad ,  William Tieu ,  Kelly Lee Keeling ,  Daniel Sejer Pedersen ,  Nicole Pendini ,  Matthew Wilce ,  Min Yin Yap

IPC: C07D495/04 ,  C07F9/6561 ,  C07H19/20 ,  C07H19/167

CPC classification number: C07D495/04 ,  C07D519/00 ,  C07F9/6561 ,  C07F9/65616 ,  C07H19/167

Abstract: A new class of biotin protein ligase (BPL) inhibitors that have antibacterial activity against multiple Staphylococcus aureus isolates, including clinically important methicillin-resistant S. aureus (MRSA) are disclosed that are non-toxic.

Abstract translation: 公开了一类对多种金黄色葡萄球菌分离株具有抗菌活性的新型生物素蛋白连接酶（BPL）抑制剂，包括临床上重要的耐甲氧西林金黄色葡萄球菌（MRSA），无毒性。